Structure, dynamics, and catalytic function of dihydrofolate reductase

Annual Review of Biophysics and Biomolecular Structure

Volumn 33, Issue , 2004, Pages 119-140

  Schnell, Jason R ^a,b   Dyson, H Jane ^a   Wright, Peter E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Enzyme dynamics; Loop structures; NMR relaxation; Substrate complexes

Indexed keywords

DIHYDROFOLATE REDUCTASE;

AMINO ACID SEQUENCE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYMOLOGY; ESCHERICHIA COLI; FLUORESCENCE; ISOMERIZATION; LIGAND BINDING; MOLECULAR DYNAMICS; MUTAGENESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEOMICS; QUANTUM CHEMISTRY; REVIEW; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; CATALYSIS; ENZYME ACTIVATION; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; MOTION; MUTATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

ESCHERICHIA COLI; NEGIBACTERIA;

EID: 3042660150     PISSN: 10568700     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.biophys.33.110502.133613     Document Type: Review

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