A biochemical and genetic model for parasite resistance to antifolates: Toxoplasma gondii provides insights into pyrimethamine and cycloguanil resistance in plasmodium falciparum

Journal of Biological Chemistry

Volumn 273, Issue 6, 1998, Pages 3461-3469

  Reynolds, Mary G ^a   Roos, David S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASPARAGINE; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; PYRIMETHAMINE; VALINE;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; GENETIC MODEL; GENETIC POLYMORPHISM; MALARIA FALCIPARUM; NONHUMAN; PHYLOGENY; PLASMODIUM FALCIPARUM; POINT MUTATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TOXOPLASMA GONDII;

ALLELES; ANIMALS; BINDING SITES; DRUG RESISTANCE; ESCHERICHIA COLI; FOLIC ACID; FOLIC ACID ANTAGONISTS; GENETIC COMPLEMENTATION TEST; KINETICS; MODELS, GENETIC; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NAD; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; RECOMBINANT PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA; TRIAZINES;

EID: 0032488994     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.6.3461     Document Type: Article

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