Towards an understanding of drug resistance in malaria: Three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 6, 1999, Pages 1003-1011

  Lemcke, Thomas ^a   Christensen, Inge Thøger ^b   Jørgensen, Flemming Steen ^b  

^a UNIVERSITY OF HAMBURG   (Germany)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Dihydrofolate; Homology modelling; Malaria; Plasmodium falciparum; Reductase; Resistance

Indexed keywords

DIHYDROFOLATE REDUCTASE;

ARTICLE; CONTROLLED STUDY; DRUG RESISTANCE; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; POINT MUTATION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; HUMANS; MALARIA, FALCIPARUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TETRAHYDROFOLATE DEHYDROGENASE;

PLASMODIUM FALCIPARUM;

EID: 0033051342     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00018-8     Document Type: Article

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