SCOPUS 정보 검색 플랫폼

Journal of Computer-Aided Molecular Design

Volumn 15, Issue 1, 2001, Pages 1-12

A search for sources of drug resistance by the 4D-QSAR analysis of a set of antimalarial dihydrofolate reductase inhibitors

(2) Santos Filho, O A a Hopfinger, A J a

a UNIVERSITY OF ILLINOIS AT CHICAGO (United States)

Author keywords

Dihydrofolate reductase; Malaria; Mutation; Pharmacophore; QSAR

Indexed keywords

COMPUTATIONAL CHEMISTRY; DRUG THERAPY; ENZYME INHIBITION; MOLECULAR DYNAMICS; MOLECULAR GRAPHICS; PHARMACODYNAMICS;

DESCRIPTORS; DIHYDROFOLATE REDUCTASE; GRID CELLS; MALARIA; MUTATION; PHARMACOPHORES; PLASMODIUM FALCIPARUM; QSAR; QSAR ANALYSIS; WILD TYPES;

CONFORMATIONS;

AMINOPTERIN; ANTIMALARIAL AGENT; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; LIGAND; METHOTREXATE; PYRIMETHAMINE; PYRIMIDINE DERIVATIVE; TRIMETHOPRIM;

ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG CONFORMATION; DRUG RESISTANCE; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; MOLECULAR DYNAMICS; MUTANT; PHARMACOPHORE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 0035146602 PISSN: 0920654X EISSN: None Source Type: Journal
DOI: 10.1023/A:1011152818340 Document Type: Article

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