Antimalarial drug discovery: Development of inhibitors of dihydrofolate reductase active in drug resistance

Drug Discovery Today

Volumn 3, Issue 12, 1998, Pages 538-546

  Warhurst, David C ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; ANTIMALARIAL AGENT; CHLORCYCLOGUANIL; COTRIMOXAZOLE; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; METHOTREXATE; PROGUANIL; PYRIMETHAMINE; TRIMETHOPRIM;

DRUG DESIGN; DRUG RESISTANCE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME BINDING; MALARIA; MUTATION; PLASMODIUM FALCIPARUM; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0031734331     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(98)01268-9     Document Type: Review

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