Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6- substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors

Journal of Medicinal Chemistry

Volumn 47, Issue 14, 2004, Pages 3689-3692

  Gangjee, Aleem ^a   Lin, Xin ^a   Queener, Sherry F ^b  

^a DUQUESNE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 METHYL 6 (1 NAPHTHYLTHIO)PYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 METHYL 6 (2' METHOXYPHENYLTHIO)PYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 METHYL 6 (2',4' DICHLOROPHENYLTHIO)PYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 METHYL 6 (2',5' DIMETHOXYPHENYLTHIO)PYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 METHYL 6 (3' CHLOROPHENYLTHIO)PYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 METHYL 6 (3' METHOXYPHENYLTHIO)PYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 METHYL 6 (4' CHLOROPHENYLTHIO)PYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 METHYL 6 (4' METHOXYPHENYLTHIO)PYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 METHYL 6 (PHENYLTHIO)PYRROLO[2,3 D]PYRIMIDINE; 2,4 DIAMINO 5 METHYLPYRROLO[2,3 D]PYRIMIDINE; DIHYDROFOLATE REDUCTASE INHIBITOR; DIHYDROFOLIC ACID; FOLIC ACID ANTAGONIST; PHENYLTHIOL DERIVATIVE; PYRIMIDINE DERIVATIVE; THIOL DERIVATIVE; TRIMETHOPRIM; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROPHOBICITY; MYCOBACTERIUM AVIUM; NONHUMAN; OPPORTUNISTIC INFECTION; PNEUMOCYSTIS CARINII; RAT; TOXOPLASMA GONDII; X RAY CRYSTALLOGRAPHY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID ANTAGONISTS; LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM AVIUM; PNEUMOCYSTIS CARINII; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA;

EID: 3042594465     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0306327     Document Type: Article

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