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Journal of the American Chemical Society

Volumn 123, Issue 15, 2001, Pages 3418-3428

Energetically most likely substrate and active-site protonation sites and pathways in the catalytic mechanism of dihydrofolate reductase

(2) Cummins, P L a Gready, J E a

a Australian National University (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLATION; CATALYSIS; ENZYMES; GEOMETRY; IONIZATION; PERMITTIVITY; POLARIZATION;

PROTONATION;

REDUCTION;

ASPARTIC ACID; CARBOXYLIC ACID DERIVATIVE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; OXYGEN; PROTON;

ARTICLE; CALCULATION; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; DIELECTRIC CONSTANT; ENERGY; ENZYME ACTIVE SITE; ENZYME STABILITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; GEOMETRY; HYDROGEN BOND; MICHAELIS MENTEN KINETICS; MOLECULAR MODEL; NONHUMAN; POLARIZATION; PROTON TRANSPORT; QUANTUM MECHANICS; REACTION ANALYSIS; REDUCTION; SIMULATION; X RAY ANALYSIS;

EID: 84961978282 PISSN: 00027863 EISSN: None Source Type: Journal
DOI: 10.1021/ja0038474 Document Type: Article

Times cited : (58)

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