Homology modeling of wild type and pyrimethamine/cycloguanil-cross resistant mutant type Plasmodium falciparum dihydrofolate reductase. A model for antimalarial chemotherapy resistance

Biophysical Chemistry

Volumn 91, Issue 3, 2001, Pages 305-317

  Santos Filho, Osvaldo Andrade ^a   De Alencastro, Ricardo Bicca ^b   Figueroa Villar, Jose Daniel ^a  

^a MILITARY INSTITUTE OF ENGINEERING   (Brazil)

^b Lab 609   (Brazil)

Author keywords

Chemotherapy; Dihydrofolate reductase; Homology modeling; Malaria; Plasmodium falciparum; Resistance

Indexed keywords

CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; PYRIMETHAMINE;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CHICKEN; DIELECTRIC CONSTANT; ENZYME ACTIVE SITE; MALARIA FALCIPARUM; MOLECULAR DYNAMICS; MUTATION; NONHUMAN; PLASMODIUM FALCIPARUM; POINT MUTATION; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ANTIMALARIALS; BINDING SITES; CHICKENS; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; HUMANS; LIVER; MALARIA; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES;

GALLUS GALLUS; PLASMODIUM FALCIPARUM;

EID: 0035942985     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-4622(01)00180-6     Document Type: Article

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