Pyrimethamine analogs as strong inhibitors of double and quadruple mutants of dihydrofolate reductase in human malaria parasites

Organic and Biomolecular Chemistry

Volumn 1, Issue 6, 2003, Pages 960-964

  Sardarian, Alireza ^a   Douglas, Kenneth T ^a   Read, Martin ^a   Sims, Paul F G ^a   Hyde, John E ^a   Chitnumsub, Penchit ^b   Sirawaraporn, Rachada ^c   Sirawaraporn, Worachart ^c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CONTROLLED DRUG DELIVERY; DISEASES; DRUG PRODUCTS; SUBSTITUTION REACTIONS;

DIHYDROFOLATE REDUCTASE; DOUBLE MUTANTS; HUMAN MALARIA PARASITES; INHIBITORS; META-SUBSTITUTED ANALOGS; PLASMODIUM FALCIPARUM CULTURES; PYRIMETHAMINE; QUADRUPLE MUTANTS;

AMINES;

PLASMODIUM FALCIPARUM;

ANTIMALARIAL AGENT; DIHYDROFOLATE REDUCTASE; DRUG DERIVATIVE; FOLIC ACID ANTAGONIST; PYRIMETHAMINE;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; DRUG EFFECT; DRUG RESISTANCE; ENZYMOLOGY; GENETICS; HUMAN; PLASMODIUM FALCIPARUM; POINT MUTATION;

ANIMALS; ANTIMALARIALS; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; POINT MUTATION; PYRIMETHAMINE; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0042320464     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b211636g     Document Type: Article

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