Lead discovery of inhibitors of the dihydrofolate reductase domain of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase

Biochemical and Biophysical Research Communications

Volumn 235, Issue 3, 1997, Pages 515-519

  Toyoda, Tetsuro ^a   Brobey, Reynolds K B ^b   Sano, Gen ichiro ^b   Horii, Toshihiro ^b   Tomioka, Nobuo ^a   Itai, Akiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1,4 DIHYDRO 4,4,7,8 TETRAMETHYLTRIAZINOL[1,2 A]BENZIMIDAZOLE; 3 AMINO 1 METHYL 5H PYRIDO[4,3 B]INDOLE; ASPARTIC ACID; DIHYDROFOLATE REDUCTASE; ENZYME INHIBITOR; RECOMBINANT PROTEIN; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; COMPUTER ANALYSIS; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; HYDROGEN BOND; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTON TRANSPORT; STRUCTURE ACTIVITY RELATION;

PLASMODIUM FALCIPARUM; RUMEX;

EID: 0031587932     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1997.6814     Document Type: Article

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