Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 2, 2003, Pages 217-224

  Vilaivan, Tirayut ^a   Saesaengseerung, Neungruthai ^a   Jarprung, Deanpen ^b   Kamchonwongpaisan, Sumalee ^b   Sirawaraporn, Worachart ^c   Yuthavong, Yongyuth ^b  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^c Mahidol University   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DIAMINO 3',4' DICHLOROPHENYL 1,2 DIHYDRO 2 METHYL 1,3,5 TRIAZINE; 4,6 DIAMINO 3',4' DICHLOROPHENYL 1,2 DIHYDRO 2 PHENYL 1,3,5 TRIAZINE; DIHYDROFOLATE REDUCTASE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; BIGUANIDE DERIVATIVE; CYCLOGUANIL; FOLIC ACID ANTAGONIST;

ARTICLE; COMBINATORIAL LIBRARY; DRUG EFFECT; DRUG SYNTHESIS; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERIZATION; SCREENING; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPARATIVE STUDY; CYCLIZATION; ENZYMOLOGY; GENETICS; METABOLISM; METHODOLOGY; MUTATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIMALARIALS; BIGUANIDES; COMBINATORIAL CHEMISTRY TECHNIQUES; CYCLIZATION; FOLIC ACID ANTAGONISTS; MUTATION; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES;

EID: 0037449359     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00344-9     Document Type: Article

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