Rational drug design approach for overcoming drug resistance: Application to pyrimethamine resistance in malaria

Journal of Medicinal Chemistry

Volumn 41, Issue 9, 1998, Pages 1367-1370

  McKie, James H ^a   Douglas, Kenneth T ^a   Chan, Cecil ^a   Roser, Simon A ^a   Yates, Robert ^a   Read, Martin ^a   Hyde, John E ^a   Dascombe, Michael J ^a   Yuthavong, Yongyuth ^b   Sirawaraporn, Worachart ^c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORINE DERIVATIVE; DIHYDROFOLATE REDUCTASE; METHOXY DERIVATIVE; PYRIMETHAMINE; PYRIMETHAMINE DERIVATIVE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; ENZYME BINDING; ENZYME INHIBITION; MALARIA; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; SEQUENCE HOMOLOGY;

ANIMALS; ANTIMALARIALS; DRUG DESIGN; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; MALARIA; MALE; MICE; MULTIENZYME COMPLEXES; MUTATION; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; RECOMBINANT PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

EID: 15144349302     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970845u     Document Type: Article

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