Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum

Acta Crystallographica Section D: Biological Crystallography

Volumn 60, Issue 4, 2004, Pages 780-783

  Chitnumsub, Penchit ^a   Yavaniyama, Jirundon ^b   Vanichtanankul, Jarunee ^a   Kamchonwongpaisan, Sumalee ^a   Walkinshaw, Malcolm D ^c   Yuthavong, Yongyuth ^a  

^a NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI; PLASMODIUM FALCIPARUM;

2'-DEOXYURIDYLIC ACID; DEOXYURIDINE PHOSPHATE; DIHYDROFOLATE REDUCTASE; MACROGOL DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PROTOZOAL PROTEIN; THYMIDYLATE SYNTHASE;

ANIMAL; ARTICLE; CHEMISTRY; CRYSTALLIZATION; ENZYMOLOGY; GENETIC ENGINEERING; MOLECULAR CLONING; PLASMODIUM FALCIPARUM; X RAY CRYSTALLOGRAPHY;

ANIMALS; CLONING, MOLECULAR; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DEOXYURACIL NUCLEOTIDES; GENETIC ENGINEERING; NADP; PLASMODIUM FALCIPARUM; POLYETHYLENE GLYCOLS; PROTOZOAN PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE;

EID: 11144285073     PISSN: 09074449     EISSN: None     Source Type: Journal    
DOI: 10.1107/S0907444904001544     Document Type: Article

References (20)

1. Bradford, M. M. (1976). Anal. Biochem. 72, 248-254.
2. Chayen, N. E., Shaw Stewart, P. D. & Blow, D. M. (1992). J. Cryst. Growth, 122, 176-180.
3. Cowman, A. F., Morry, M. J., Biggs, B. A., Cross, G. A. M. & Foote, S. J. (1988). Proc. Natl Acad. Sci. USA, 85, 9109-9113.
4. D'Arcy, A., Elmore, C., Stihle, M. & Johnston, J. E. (1996). J. Cryst. Growth, 168, 175-180.
5. Ferone, R. (1977). Bull. World Health Org. 55, 291-298.
6. Ferré-D'Amaré, A. F.-D. & Burley, S. K. (1997). Methods Enzymol. 276, 157-166.
7. Foote, S. J., Galatis, D. & Cowman, A. F. (1990). Proc. Natl Acad. Sci. USA, 87, 3014-3017.
8. Hillcoat, B. L., Nixon, P. F. & Blakley, R. L. (1967). Anal. Biochem. 21, 178-189.
9. Ivanetich, K. & Santi, D. (1990). FASEB J. 4, 1591-1597.
10. Kamchonwongpaisan, S., Quarrell, R., Charoensetakul, N., Ponsinet, R., Vilaivan, T., Vanichtanankul, J., Tarnchompoo, B., Sirawaraporn, W., Lowe, G. & Yuthavong, Y. (2004). J. Med. Chem. 47, 673-680.
11. Meek, T. D., Garvey, E. P. & Santi, D. V. (1985). Biochemistry, 24, 678-686.
12. Otwinowski, Z. & Minor, W. (1997). Methods Enzymol. 276, 307-326.
13. Peterson, D. S., Milhous, W. K. & Wellems, T. E. (1990). Proc. Natl Acad. Sci. USA, 87, 3018-3022.
14. Peterson, D. S., Walliker, D. & Wellems, T. E. (1988). Proc. Natl Acad. Sci. USA, 85, 9114-9118.
15. Rastelli, G., Sirawaraporn, W., Sompornpisut, P., Vilaivan, T., Kamchonwongpaisan, S., Quarrell, R., Lowe, G., Thebtaranonth, Y. & Yuthavong, Y. (2000). Bioorg. Med. Chem. 8, 1117-1128.
16. Roberts, D. (1966). Biochemistry, 8, 3546-3548.
17. Sirawaraporn, W., Sathitkul, T., Sirawaraporn, R., Yuthavong, Y. & Santi, D. V. (1997). Proc. Natl Acad. Sci. USA, 94, 1124-1129.
18. Sirawaraporn, W., Sirawaraporn, R., Cowman, A. F., Yuthavong, Y. & Santi, D. V. (1990). Biochemistry, 29, 10779-10785.
19. Warhurst, D. (2002). Sci. Prog. 85, 89-111.
20. Yuvaniyama, J., Chitnumsub, P., Kamchonwongpaisan, S., Vanichtanankul, J., Sirawaraporn, W., Taylor, P., Walkinshaw, M. & Yuthavong, Y. (2003). Nature Struct. Biol. 10, 357-365.