Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: Structural basis of antifolate resistance

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 5, 2000, Pages 1117-1128

  Rastelli, Giulio ^a   Sirawaraporn, Worachart ^b   Sompornpisut, Pornthep ^c   Vilaivan, Tirayut ^c   Kamchonwongpaisan, Sumalee ^d   Quarrell, Rachel ^e   Lowe, Gordon ^e   Thebtaranonth, Yodhathai ^b   Yuthavong, Yongyuth ^d  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b MAHIDOL UNIVERSITY   (Thailand)

^c CHULALONGKORN UNIVERSITY   (Thailand)

^d NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DIAMINO 1,2 DIHYDRO 2,2 DIMETHYL 1 [3 (2,4,5 TRICHLOROPHENOXY)PROPOXY] 1,3,5 TRIAZINE; ANTIMALARIAL AGENT; CYCLOGUANIL; CYCLOGUANIL DERIVATIVE; DIHYDROFOLATE REDUCTASE; PYRIMETHAMINE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; CROSS RESISTANCE; DRUG BINDING; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; INHIBITION KINETICS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MODEL; MUTATION; PLASMODIUM FALCIPARUM; SEQUENCE HOMOLOGY; STEREOCHEMISTRY;

AMINO ACID SEQUENCE; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PYRIMETHAMINE; SEQUENCE HOMOLOGY, AMINO ACID; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES;

PLASMODIUM FALCIPARUM;

EID: 0034074798     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00022-5     Document Type: Article

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