Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum

Journal of Medicinal Chemistry

Volumn 43, Issue 14, 2000, Pages 2738-2744

  Yuthavong, Yongyuth ^a   Vilaivan, Tirayut ^b   Chareonsethakul, Netnapa ^b   Kamchonwongpaisan, Sumalee ^a   Sirawaraporn, Worachart ^c   Quarrell, Rachel ^d   Lowe, Gordon ^d  

^a NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^b CHULALONGKORN UNIVERSITY   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE INHIBITOR; HYDROXYL GROUP; METHYL GROUP; PHENYL GROUP; PYRIMETHAMINE;

ANTIBIOTIC RESISTANCE; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; MUTANT; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIMALARIALS; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; MUTATION; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES;

EID: 0034644146     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0009181     Document Type: Article

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