Inhibitors of Multiple Mutants of Plasmodium falciparum Dihydrofolate Reductase and Their Antimalarial Activities

Journal of Medicinal Chemistry

Volumn 47, Issue 3, 2004, Pages 673-680

  Kamchonwongpaisan, Sumalee ^a   Quarrell, Rachel ^d   Charoensetakul, Netnapa ^b   Ponsinet, Rachel ^d   Vilaivan, Tirayut ^b   Vanichtanankul, Jarunee ^a   Tarnchompoo, Bongkoch ^a   Sirawaraporn, Worachart ^c   Lowe, Gordon ^d   Yuthavong, Yongyuth ^a  

^a NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^b CHULALONGKORN UNIVERSITY   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,3,5 DIHYDROTRIAZINE DERIVATIVE; 2,4 DIAMINOPYRIMIDINE DERIVATIVE; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; PYRIMETHAMINE; PYRIMIDINE DERIVATIVE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CELL STRAIN KB; CONTROLLED STUDY; CYTOTOXICITY; DRUG RESISTANCE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MUTANT; NONHUMAN; PLASMODIUM FALCIPARUM; STEREOCHEMISTRY; VERO CELL;

ANIMALS; ANTIMALARIALS; CELL LINE; CERCOPITHECUS AETHIOPS; DRUG RESISTANCE; FOLIC ACID ANTAGONISTS; HUMANS; MUTATION; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES;

EID: 9144272211     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030165t     Document Type: Article

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