Recombinant Plasmodium falciparum dihydrofolate reductase-based in vitro screen for antifolate antimalarials

Molecular and Biochemical Parasitology

Volumn 81, Issue 2, 1996, Pages 225-237

  Brobey, Reynolds K B ^a   Sano, Gen Ichiro ^a   Itoh, Fumio ^b   Aso, Kazuyoshi ^b   Kimura, Masatsugu ^c   Mitamura, Toshihide ^a   Horii, Toshihiro ^a  

^a OSAKA UNIVERSITY   (Japan)

^b TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

antimalarials; dihydrofolate reductase; drug resistance; Plasmodium falciparum; pyrrolo 2,3 d pyrimidine antifolates; synthetic gene

Indexed keywords

ANTIMALARIAL AGENT; CYCLOGUANIL; DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; METHOTREXATE; PYRIMETHAMINE; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESISTANCE; DRUG SCREENING; DRUG SELECTIVITY; ENZYME ACTIVITY; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; MALARIA; MOUSE; NONHUMAN; PARASITE CULTIVATION; PARASITE DEVELOPMENT; PARASITEMIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANIMALIA; ESCHERICHIA COLI; MAMMALIA; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM;

EID: 0030607416     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-6851(96)02704-1     Document Type: Article

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