Importance of substrate and cofactor polarization in the active site of dihydrofolate reductase

Journal of Molecular Biology

Volumn 327, Issue 2, 2003, Pages 549-560

  Garcia Viloca, Mireia ^a   Truhlar, Donald G ^a   Gao, Jiali ^a  

^a University of Minnesota   (United States)

Author keywords

Dihydrofolate reductase; Enzyme catalysis; Polarization effect; Substrate enzyme binding

Indexed keywords

DIHYDROFOLATE REDUCTASE; GLUTAMIC ACID; PTERIN;

ARTICLE; CALCULATION; CATALYSIS; CRYSTAL STRUCTURE; DECOMPOSITION; DENSITY; ELECTRIC FIELD; ENERGY; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; MOLECULAR DYNAMICS; POLARIZATION; PRIORITY JOURNAL; SIMULATION;

EID: 0037459224     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00123-2     Document Type: Article

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