Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-β ligand in transgenic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 21, 2003, Pages 12462-12467

  Bacskai, Brian J ^a   Hickey, Gregory A ^a   Skoch, Jesse ^a   Kajdasz, Stephen T ^a   Wang, Yanming ^b   Huang, Guo Feng ^b   Mathis, Chester A ^b   Klunk, William E ^b   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Positron emission tomography; Senile plaques

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; BIOLOGICAL MARKER; CONTRAST MEDIUM; PITTSBURGH COMPOUND B; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DISEASE COURSE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; FOUR DIMENSIONAL MULTIPHOTON IMAGING; MOUSE; MOUSE STRAIN; MULTIPHOTON MICROSCOPY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENILE PLAQUE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANILINE COMPOUNDS; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; BRAIN; FLUORESCENT DYES; HUMANS; LIGANDS; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; PROTEIN BINDING; SENILE PLAQUES; THIAZOLES; TOMOGRAPHY, EMISSION-COMPUTED;

ANIMALIA; MUS MUSCULUS;

EID: 0142123057     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2034101100     Document Type: Article

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