Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

Nature Genetics

Volumn 17, Issue 3, 1997, Pages 263-264

  Bales, Kelly R ^a   Verina, Tatyana ^b   Dodel, Richard C ^c,d   Du, Yansheng ^a   Altstiel, Larry ^a   Bender, Mark ^a   Hyslop, Paul ^a   Johnstone, Edward M ^a   Little, Sheila P ^a   Cummins, David J ^a   Piccardo, Pedro ^b   Ghetti, Bernardino ^b   Paul, Steven M ^a,c  

^a ELI LILLY AND COMPANY   (United States)

^b Pathology and Laboratory Medicine   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; MESSENGER RNA;

AGE; ALZHEIMER DISEASE; ANIMAL; BIOSYNTHESIS; BRAIN; C57BL MOUSE; DBA MOUSE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LETTER; METABOLISM; MOUSE; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOLIPOPROTEINS E; BRAIN; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0031278270     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1197-263     Document Type: Letter

References (14)

1. Strittmatter, W.J. & Roses, A.D. Proc. Natl. Acad. Sci. USA 92, 4725-4727 (1995).
2. Weisgraber, K.H. & Mahley, R.W. FASEB J. 10, 1485-1494(1996).
3. Zhang, S.H., Reddick, R.L., Piedrahita, J.A. & Maeda, N. Science 258, 468-471 (1992)
4. Games, D. et al. Nature 373, 523-527 (1995).
5. Hyman, B.T., Tanzi, R.E., Marzloff, K., Barbour, R. & Schenk, D. J. Neuropathol. Exp. Neurol. 51, 76-83 (1992).
6. Kim, K.S. et al. Neurosci. Res. Comm. 51, 113-122 (1990).
7. Hyman, B.T. et al. Proc. Natl. Acad. Sci. USA 92, 3586-3590(1995).
8. Johnson-Wood, K. et al. Proc. Natl. Acad. Sci. USA 94, 1550-1555 (1997).
9. Motter, R. et al. Ann. Neurol. 38, 643-648 (1995).
10. Brown, B.M. & Hettmansperger, T.P. J. Am. Stat. Assoc. 91, 1668-1675(1996).
11. Poirier, J. et al. Lancet 342, 697-699 (1993).
12. LaDu, MJ. et al. J. Biol. Chem. 270, 9039-9042 (1995).
13. Ma, J. et al. Nature 372, 92-94 (1994).
14. Selkoe, D.J. Annu. Rev. Neurosci. 17, 489-517 (1994).