A Genomic Screen for Modifiers of Tauopathy Identifies Puromycin-Sensitive Aminopeptidase as an Inhibitor of Tau-Induced Neurodegeneration

Neuron

Volumn 51, Issue 5, 2006, Pages 549-560

  Karsten, Stanislav L ^a   Sang, Tzu Kang ^a   Gehman, Lauren T ^a   Chatterjee, Shreyasi ^a   Liu, Jiankai ^a   Lawless, George M ^a   Sengupta, Soma ^c   Berry, Robert W ^c   Pomakian, Justine ^a   Oh, Hyun S ^d   Schulz, Cordula ^e   Hui, Koon Sea ^f   Wiedau Pazos, Martina ^a   Vinters, Harry V ^a   Binder, Lester I ^c   Geschwind, Daniel H ^a,b   Jackson, George R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d Gachon University College of Medicine   (South Korea)

^e Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^f NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

HUMDISEASE; MOLNEURO

Indexed keywords

AMINOPEPTIDASE; PUROMYCIN; PUROMYCIN SENSITIVE AMINOPEPTIDASE; TAU PROTEIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DISEASE EXACERBATION; DROSOPHILA; ENZYME INHIBITION; FUNCTIONAL ASSESSMENT; FUNCTIONAL GENOMICS; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC SCREENING; GENOME ANALYSIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; SPECIES DIFFERENCE; TAUOPATHY; VALIDATION PROCESS;

AMINOPEPTIDASES; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; BRAIN; DROSOPHILA; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, TRANSGENIC; NERVE DEGENERATION; NEUROFIBRILLARY TANGLES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TAU PROTEINS; TAUOPATHIES;

EID: 33748174617     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2006.07.019     Document Type: Article

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