Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer's Disease

American Journal of Pathology

Volumn 164, Issue 4, 2004, Pages 1495-1502

  Schmitz, Christoph ^a,b,c   Rutten, Bart P F ^a,c,d   Pielen, Andrea ^d   Schäfer, Stephanie ^c,e   Wirths, Oliver ^c,e   Tremp, Günter ^f   Czech, Christian ^f,i   Blanchard, Veronique ^f   Multhaup, Gerd ^g   Rezaie, Payam ^h   Korr, Hubert ^c,d   Steinbusch, Harry W M ^a,c   Pradier, Laurent ^f   Bayer, Thomas A ^c,e  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF ROSTOCK   (Germany)

^c European Graduate School of Neuroscience   (Netherlands)

^d RWTH AACHEN UNIVERSITY   (Germany)

^e SAARLAND UNIVERSITY   (Germany)

^f SANOFI   (France)

^g FREIE UNIVERSITÄT BERLIN   (Germany)

^h KING'S COLLEGE LONDON   (United Kingdom)

ⁱ F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN 751; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; HIPPOCAMPUS; HYPOTHESIS; MOUSE; NERVE CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; SENILE PLAQUE; TRANSGENIC MOUSE;

EID: 12144288683     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63235-X     Document Type: Article

References (31)

1. Selkoe DJ: Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001, 81:741-766
2. Cummings JL, Cole G: Alzheimer disease. JAMA 2002, 287:2335-2338
3. Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356
4. Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St. George Hyslop P, Selkoe DJ: Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nat Med 1997, 3:67-72
5. van Leuven F: Single and multiple transgenic mice as models for Alzheimer's disease. Prog Neurobiol 2000, 61:305-312
6. Bayer TA, Wirths O, Majtenyi K, Hartmann T, Multhaup G, Beyreuther K, Czech C: Key factors in Alzheimer's disease: β-amyloid precursor protein processing, metabolism, and intraneuronal transport. Brain Pathol 2001, 11:1-11
7. Robinson SR, Bishop GM: The search for an amyloid solution. Science 2002, 298:962-964
8. Urbanc B, Cruz L, Le R, Sanders J, Ashe KH, Duff K, Stanley HE, Irizarry MC, Hyman BT: Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease. Proc Natl Acad Sci USA 2002, 99:13990-13995
9. Calhoun ME, Wiederhold KH, Abramowski D, Phinney AL, Probst A, Sturchler-Pierrat C, Staufenbiel M, Sommer B, Jucker M: Neuron loss in APP transgenic mice. Nature 1998, 395:755-756
10. Irizarry MC, Soriano F, McNamara M, Page KJ, Schenk D, Games D, Hyman BT: Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J Neurosci 1997, 17:7053-7059
11. Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DM, Hyman BT, Iwatsubo T: Age-related amyloid β deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid β precursor protein Swedish mutant is not associated with global neuronal loss. Am J Pathol 2000, 157:331-339
12. Chui DH, Tanahashi H, Ozawa K, Ikeda S, Checler F, Ueda O, Suzuki H, Araki W, Inoue H, Shirotani K, Takahashi K, Gallyas F, Tabira T: Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nat Med 1999, 5:560-564
13. Wirths O, Multhaup G, Czech C, Blanchard V, Moussaoui S, Tremp G, Pradier L, Beyreuther K, Bayer TA: Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci Lett 2001, 306:116-120
14. Blanchard V, Moussaoui S, Czech C, Touchet N, Bonici B, Planche M, Canton T, Jedidi I, Gohin M, Wirths O, Bayer TA, Langui D, Duyckaerts C, Tremp G, Pradier L: Time sequence of maturation of dystrophic neurites associated with Aβ deposits in APP/PS1 transgenic mice. Exp Neurol 2003, 184:247-263
15. Van de Berg WD, Schmitz C, Steinbusch HW, Blanco CE: Perinatal asphyxia induced neuronal loss by apoptosis in the neonatal rat striatum: a combined TUNEL and stereological study. Exp Neurol 2002, 174:29-36
16. Rutten BP, Wirths O, Van de Berg WD, Lichtenthaler SF, Vehoff J, Steinbusch HW, Korr H, Beyreuther K, Multhaup G, Bayer TA, Schmitz C: No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the β-cleaved C-terminal APP fragment. Neurobiol Dis 2003, 12:110-120
17. Borchardt T, Camakaris J, Cappai R, Masters CL, Beyreuther K, Multhaup G: Copper inhibits β-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion. Biochem J 1999, 344:461-467
18. Acarin L, Vela JM, Gonzalez B, Castellano B: Demonstration of poly-N-acetyltactosamine residues in ameboid and ramified microglial cells in rat brain by tomato lectin binding. J Histochem Cytochem 1994, 42:1033-1041
19. Gundersen HJ, Jensen EB: The efficiency of systematic sampling in stereology and its prediction. J Microsc 1987, 147:229-263
20. Schmitz C, Hof PR: Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach. J Chem Neuroanat 2000, 20:93-114
21. Miles RE, Davy PJ: Precise and general conditions for the validity of a comprehensive set of stereological fundamental formulae. J Microsc 1976, 107:211-226
22. Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT: Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 1997, 41: 17-24
23. Domenici MR, Paradisi S, Sacchetti B, Gaudi S, Balduzzi M, Bernardo A, Ajmone-Cat MA, Minghetti L, Malchiodi-Albedi F: The presence of astrocytes enhances β amyloid-induced neurotoxicity in hippocampal cell cultures. J Physiol (Paris) 2002, 96:313-316
24. Wyss-Coray T, Loike JD, Brionne TC, Lu E, Anankov R, Yan F, Silverstein SC, Husemann J: Adult mouse astrocytes degrade amyloid-β in vitro and in situ. Nat Med 2003, 9:453-457
25. McGeer PL, McGeer EG: Local neuroinflammation and the progression of Alzheimer's disease. J Neurovirol 2002, 8:529-538
26. Meda L, Baron P, Scarlato G: Glial activation in Alzheimer's disease: the role of Aβ and its associated proteins. Neurobiol Aging 2001, 22:885-893
27. Stalder M, Phinney A, Probst A, Sommer B, Staufenbiel M, Jucker J: Association of microglia with amyloid plaques in brains of APP23 transgenic mice. Am J Pathol 1999, 154:1673-1684
28. Moechars D, Dewachter I, Lorent K, Reverse D, Baekelandt V, Naidu A, Tesseur I, Spittaels K, Haute CV, Checler F, Godaux E, Cordell B, Van Leuven F: Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem 1999, 274:6483-6492
29. Pratico D, Uryu K, Leight S, Trojanoswki JQ, Lee VM: Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J Neurosci 2001, 21:4183-4187
30. McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, Bush AI, Masters CL: Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol 1999, 46:860-866
31. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG: Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 2003, 300:486-489