Reduction of soluble Aβ and tau, but not soluble Aβ alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

Journal of Biological Chemistry

Volumn 281, Issue 51, 2006, Pages 39413-39423

  Oddo, Salvatore ^a   Vasilevko, Vitaly ^a   Caccamo, Antonella ^a   Kitazawa, Masashi ^a   Cribbs, David H ^a   LaFerla, Frank M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE (AD); AMELIORATES; IMMUNOTHERAPY; SOLUBLE TAU;

BIOCHEMISTRY; IMMUNIZATION; MEDICAL PROBLEMS; PATHOLOGY; PROTEINS; REDUCTION;

LIVING SYSTEMS STUDIES;

AMYLOID BETA42; IMMUNOMODULATING AGENT; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; CYTOKINE; TAU PROTEIN;

ACTIVE IMMUNIZATION; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG EFFECT; MOUSE; NEUROFIBRILLARY TANGLE; NONHUMAN; PASSIVE IMMUNIZATION; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; ANIMAL; ANIMAL BEHAVIOR; CHEMISTRY; DISEASE MODEL; HIPPOCAMPUS; HUMAN; IMMUNOTHERAPY; METABOLISM; NERVE CELL; PHYSIOLOGY; PROTEIN BINDING; TRANSGENIC MOUSE;

MUS MUSCULUS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BEHAVIOR, ANIMAL; CYTOKINES; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; IMMUNOTHERAPY; MICE; MICE, TRANSGENIC; NEURONS; PHENOTYPE; PROTEIN BINDING; TAU PROTEINS;

EID: 33846015514     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M608485200     Document Type: Article

References (45)

1. Selkoe, D. J. (2001) Physiol. Rev. 81, 741-766
2. Cleary, J. P., Walsh, D. M., Hofmeister, J. J., Shankar, G. M., Kuskowski, M. A., Selkoe, D. J., and Ashe, K. H. (2005) Nat. Neurosci. 8, 79-84
3. Lesne, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., and Ashe, K. H. (2006) Nature 440, 352-357
4. Walsh, D. M., and Selkoe, D. J. (2004) Neuron 44, 181-193
5. Cairns, N. J., Lee, V. M., and Trojanowski, J. Q. (2004) J. Pathol. 204, 438-449
6. Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., and LaFerla, F. M. (2005) Neuron 45, 675-688
7. Arriagada, P. V., Marzloff, K., and Hyman, B. T. (1992) Neurology 42, 1681-1688
8. McKee, A. C., Kosik, K. S., and Kowall, N. W. (1991) Ann. Neurol. 30, 156-165
9. Santacruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., DeTure, M., Ramsden, M., McGowan, E., Forster, C., Yue, M., Orne, J., Janus, C., Mariash, A., Kuskowski, M., Hyman, B., Hutton, M., and Ashe, K. H. (2005) Science 309, 476-481
10. Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., Kholodenko, D., Lee, M., Liao, Z., Lieberburg, I., Motter, R., Mutter, L., Soriano, F., Shopp, G., Vasquez, N., Vandevert, C., Walker, S., Wogulis, M., Yednock, T., Games, D., and Seubert, P. (1999) Nature 400, 173-177
11. Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C., Hardy, J., Duff, K., Jantzen, P., DiCarlo, G., Wilcock, D., Connor, K., Hatcher, J., Hope, C., Gordon, M., and Arendash, G. W. (2000) Nature 408, 982-985
12. Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., Mount, H. T., Nixon, R. A., Mercken, M., Bergeron, C., Fraser, P. E., St George-Hyslop, P., and Westaway, D. (2000) Nature 408, 979-982
13. DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J. C., Paul, S. M., and Holtzman, D. M. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 8850-8855
14. Bard, F., Cannon, C., Barbour, R., Burke, R. L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., Kholodenko, D., Lee, M., Lieberburg, I., Motter, R., Nguyen, M., Soriano, F., Vasquez, N., Weiss, K., Welch, B., Seubert, P., Schenk, D., and Yednock, T. (2000) Nat. Med 6, 916-919
15. Check, E. (2002) Nature 415, 462
16. Nitsch, R. M. (2004) Alzheimer Dis. Assoc. Disord. 18, 185-189
17. Schenk, D. (2002) Nat. Rev. Neurosci 3, 824-828
18. Cribbs, D. H., Ghochikyan, A., Vasilevko, V., Tran, M., Petrushina, I., Sadzikava, N., Babikyan, D., Kesslak, P., Kieber-Emmons, T., Cotman, C. W., and Agadjanyan, M. G. (2003) Int. Immunol. 15, 505-514
19. Oddo, S., Billings, L., Kesslak, J. P., Cribbs, D. H., and LaFerla, F. M. (2004) Neuron 43, 321-332
20. Oddo, S., Caccamo, A., Smith, I. F., Green, K. N., and Laferla, F. M. (2006) Am. J. Pathol. 168, 184-194
21. Oddo, S., Caccamo, A., Green, K. N., Liang, K., Tran, L., Chen, Y., Leslie, F. M., and LaFerla, F. M. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 3046-3051
22. Lalonde, R. (2002) Neurosci. Biobehav Rev. 26, 91-104
23. McGaugh, J. L., McIntyre, C. K., and Power, A. E. (2002) Neurobiol. Learn. Mem. 78, 539-552
24. Kawarabayashi, T., Shoji, M., Younkin, L. H., Wen-Lang, L., Dickson, D. W., Murakami, T., Matsubara, E., Abe, K., Ashe, K. H., and Younkin, S. G. (2004) J. Neurosci. 24, 3801-3809
25. Kotilinek, L. A., Bacskai, B., Westerman, M., Kawarabayashi, T., Younkin, L., Hyman, B. T., Younkin, S., and Ashe, K. H. (2002) J. Neurosci. 22, 6331-6335
26. Koistinaho, M., Ort, M., Cimadevilla, J. M., Vondrous, R., Cordell, B., Koistinaho, J., Bures, J., and Higgins, L. S. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 14675-14680
27. McLean, C. A., Cherny, R. A., Fraser, F. W., Fuller, S. J., Smith, M. J., Beyreuther, K., Bush, A. I., and Masters, C. L. (1999) Ann. Neurol. 46, 860-866
28. Lue, L. F., Kuo, Y. M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., Beach, T., Kurth, J. H., Rydel, R. E., and Rogers, J. (1999) Am. J. Pathol. 155, 853-862
29. Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G. Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., and Mucke, L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3228-3233
30. Oddo, S., Caccamo, A., Tran, L., Lambert, M. P., Glabe, C. G., Klein, W. L., and LaFerla, F. M. (2006) J. Biol. Chem. 281, 1599-1604
31. Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., and LaFerla, F. M. (2003) Neuron 39, 409-421
32. Ferrer, I., Boada Rovira, M., Sanchez Guerra, M. L., Rey, M. J., and Costa-Jussa, F. (2004) Brain Pathol. 14, 11-20
33. Masliah, E., Hansen, L., Adame, A., Crews, L., Bard, F., Lee, C., Seubert, P., Games, D., Kirby, L., and Schenk, D. (2005) Neurology 64, 129-131
34. Nicoll, J. A., Wilkinson, D., Holmes, C., Steart, P., Markham, H., and Weller, R. O. (2003) Nat. Med. 9, 448-452
35. Dodart, J. C., Bales, K. R., Gannon, K. S., Greene, S. J., DeMattos, R. B., Mathis, C., DeLong, C. A., Wu, S., Wu, X., Holtzman, D. M., and Paul, S. M. (2002) Nat. Neurosci. 5, 452-457
36. Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., and Selkoe, D. J. (2002) Nature 416, 535-539
37. Westerman, M. A., Cooper-Blacketer, D., Mariash, A., Kotilinek, L., Kawarabayashi, T., Younkin, L. H., Carlson, G. A., Younkin, S. G., and Ashe, K. H. (2002) J. Neurosci. 22, 1858-1867
38. Das, P., Murphy, M. P., Younkin, L. H., Younkin, S. G., and Golde, T. E. (2001) Neurobiol. Aging 22, 721-727
39. Higuchi, M., Lee, V. M., and Trojanowski, J. Q. (2002) Neuromol. Med. 2, 131-150
40. Mandelkow, E., Song, Y. H., Schweers, O., Marx, A., and Mandelkow, E. M. (1995) Neurobiol. Aging 16, 347-354
41. Mandelkow, E. M., Stamer, K., Vogel, R., Thies, E., and Mandelkow, E. (2003) Neurobiol. Aging 24, 1079-1085
42. Wittmann, C. W., Wszolek, M. F., Shulman, J. M., Salvaterra, P. M., Lewis, J., Hutton, M., and Feany, M. B. (2001) Science 293, 711-714
43. Gilman, S., Koller, M., Black, R. S., Jenkins, L., Griffith, S. G., Fox, N. C., Eisner, L., Kirby, L., Rovira, M. B., Forette, F., and Orgogozo, J. M. (2005) Neurology 64, 1553-1562
44. Hock, C., Konietzko, U., Streffer, J. R., Tracy, J., Signorell, A., Muller-Tillmanns, B., Lemke, U., Henke, K., Moritz, E., Garcia, E., Wollmer, M. A., Umbricht, D., de Quervain, D. J., Hofmann, M., Maddalena, A., Papassotiropoulos, A., and Nitsch, R. M. (2003) Neuron 38, 547-554
45. Ganzer, S., Arlt, S., Schoder, V., Buhmann, C., Mandelkow, E. M., Finckh, U., Beisiegel, U., Naber, D., and Muller-Thomsen, T. (2003) J. Neural. Transm. 110, 1149-1160