Screening for presenilin inhibitors using the free-living nematode, Caenorhabditis elegans

Journal of Biomolecular Screening

Volumn 9, Issue 2, 2004, Pages 147-152

  Ellerbrock, Brenda R ^a   Coscarelli, Eileen M ^b   Gurney, Mark E ^c   Geary, Timothy G ^b  

^a PFIZER INC   (United States)

^b ZOETIS   (United States)

^c DECODE GENETICS   (Iceland)

Author keywords

C. elegans; Chitinase; Egg laying; Inhibitor; Presenilin

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTHELMINTIC AGENT; CHITINASE; POTASSIUM CHANNEL; PRESENILIN 1; PRESENILIN INHIBITOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; HOP 1 PROTEIN, C ELEGANS; HOP-1 PROTEIN, C ELEGANS; MEMBRANE PROTEIN; SEL 12 PROTEIN, C ELEGANS; SEL-12 PROTEIN, C ELEGANS; SPE 4 PROTEIN, C ELEGANS; SPE-4 PROTEIN, C ELEGANS;

ALZHEIMER DISEASE; ARTICLE; AUTOMATION; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; EGG LAYING; ENZYME RELEASE; GENE; GENE LOSS; GENE MUTATION; HATCHING; HERMAPHRODITISM; HIGH THROUGHPUT SCREENING; IC 50; MUTANT; NEMATODE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; SEL 12 GENE; TECHNIQUE; VALIDATION PROCESS; WILD TYPE; ANIMAL; DRUG ANTAGONISM; GENETICS; METABOLISM;

CAENORHABDITIS ELEGANS;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHITINASE; GENES, HELMINTH; MEMBRANE PROTEINS; PRESENILIN-1;

EID: 16544386054     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/1087057103261038     Document Type: Article

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