메뉴 건너뛰기




Volumn 25, Issue 3, 2006, Pages 435-457

Transforming growth factor-β in cancer and metastasis

Author keywords

Invasion; Pro oncogene; Proliferation; TGF ; Tumor suppressor

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; 7 [4 (4 CYANOPHENYL)PHENOXY]HEPTANOHYDROXAMIC ACID; ANTISENSE OLIGODEOXYNUCLEOTIDE; AP 12009; COMPLEMENTARY DNA; COMPLEMENTARY RNA; HTS 466284; IMATINIB; IMIDAZOLE DERIVATIVE; IMMUNOTOXIN; INTERLEUKIN 2; LY 364947; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PROTEOGLYCAN; PYRIDINE DERIVATIVE; RECOMBINANT BETAGLYCAN; RECOMBINANT PROTEIN; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA; SB 505124; SD 093; SKF 104365; SMAD2 PROTEIN; SMAD4 PROTEIN; TRANILAST; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRITERPENOID; UNINDEXED DRUG; VASCULOTROPIN;

EID: 33845524970     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10555-006-9006-2     Document Type: Review
Times cited : (464)

References (211)
  • 1
    • 0029853786 scopus 로고    scopus 로고
    • The somatic mutation frequency of the transforming growth factor β receptor type II gene varies widely among different cancers with microsatellite instability
    • Abe, T., Ouyang, H., Migita, T., Kato, Y., Kimura, M., Shiiba, K., et al. (1996). The somatic mutation frequency of the transforming growth factor β receptor type II gene varies widely among different cancers with microsatellite instability. European Journal of Surgical Oncology, 22, 474-477.
    • (1996) European Journal of Surgical Oncology , vol.22 , pp. 474-477
    • Abe, T.1    Ouyang, H.2    Migita, T.3    Kato, Y.4    Kimura, M.5    Shiiba, K.6
  • 2
    • 0037696460 scopus 로고    scopus 로고
    • Mitochondrial and microsomal derived reactive oxygen species mediate apoptosis induced by transforming growth factor β1 in immortalized rat hepatocytes
    • Albright, C. D., Salganik, R. I., Craciunescu, C. N., Mar, M. H., & Zeisel, S. H. (2003). Mitochondrial and microsomal derived reactive oxygen species mediate apoptosis induced by transforming growth factor β1 in immortalized rat hepatocytes. Journal of Cellular Biochemistry, 89, 254-261.
    • (2003) Journal of Cellular Biochemistry , vol.89 , pp. 254-261
    • Albright, C.D.1    Salganik, R.I.2    Craciunescu, C.N.3    Mar, M.H.4    Zeisel, S.H.5
  • 3
    • 0032500010 scopus 로고    scopus 로고
    • Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development
    • Amendt, C., Schirmacher, P., Weber, H., & Blessing, M. (1998). Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development. Oncogene, 17, 25-34.
    • (1998) Oncogene , vol.17 , pp. 25-34
    • Amendt, C.1    Schirmacher, P.2    Weber, H.3    Blessing, M.4
  • 5
    • 0026656525 scopus 로고
    • Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor β1
    • Arrick, B. A., Lopez, A. R., Elfman, F., Ebner, R., Damsky, C. H., & Derynck, R. (1992). Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor β1. Journal of Cell Biology, 118, 715-726.
    • (1992) Journal of Cell Biology , vol.118 , pp. 715-726
    • Arrick, B.A.1    Lopez, A.R.2    Elfman, F.3    Ebner, R.4    Damsky, C.H.5    Derynck, R.6
  • 6
    • 0027569092 scopus 로고
    • Transforming growth factor β1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice
    • Arteaga, C. L., Carty-Dugger, T., Moses, H. L., Hurd, S. D., & Pietenpol, J. A. (1993). Transforming growth factor β1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice. Cell Growth & Differentiation, 4, 193-201.
    • (1993) Cell Growth & Differentiation , vol.4 , pp. 193-201
    • Arteaga, C.L.1    Carty-Dugger, T.2    Moses, H.L.3    Hurd, S.D.4    Pietenpol, J.A.5
  • 7
    • 0025477164 scopus 로고
    • Growth stimulation of human breast cancer cells with anti-transforming growth factor β antibodies: Evidence for autocrine negative regulation by transforming growth factor β
    • Arteaga, C. L., Coffey, R. J. Jr., Dugger, T. C., McCutchen, C. M., Moses, H. L., & Lyons, R. M. (1990). Growth stimulation of human breast cancer cells with anti-transforming growth factor β antibodies: Evidence for autocrine negative regulation by transforming growth factor β. Cell Growth & Differentiation, 1, 367-374.
    • (1990) Cell Growth & Differentiation , vol.1 , pp. 367-374
    • Arteaga, C.L.1    Coffey Jr., R.J.2    Dugger, T.C.3    McCutchen, C.M.4    Moses, H.L.5    Lyons, R.M.6
  • 8
    • 0027137485 scopus 로고
    • Anti-transforming growth factor (TGF)-β antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-β interactions in human breast cancer progression
    • Arteaga, C. L., Hurd, S. D., Winnier, A. R., Johnson, M. D., Fendly, B. M., & Forbes, J. T. (1993). Anti-transforming growth factor (TGF)-β antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-β interactions in human breast cancer progression. Journal of Clinical Investigation, 92, 2569-2576.
    • (1993) Journal of Clinical Investigation , vol.92 , pp. 2569-2576
    • Arteaga, C.L.1    Hurd, S.D.2    Winnier, A.R.3    Johnson, M.D.4    Fendly, B.M.5    Forbes, J.T.6
  • 10
    • 14944363173 scopus 로고    scopus 로고
    • Systemic administration of a soluble recombinant betaglycan suppressed tumor growth, angiogenesis, and matrix metalloproteinase expression in a human xenograft model of prostate cancer
    • Bandyopadhyay, A., Wang, L., Lopez-Casillas, F., Mendoza, V., Yeh, I. T., & Sun, L. Z. (2005). Systemic administration of a soluble recombinant betaglycan suppressed tumor growth, angiogenesis, and matrix metalloproteinase expression in a human xenograft model of prostate cancer. Prostate, 63, 81-90.
    • (2005) Prostate , vol.63 , pp. 81-90
    • Bandyopadhyay, A.1    Wang, L.2    Lopez-Casillas, F.3    Mendoza, V.4    Yeh, I.T.5    Sun, L.Z.6
  • 11
    • 0033215194 scopus 로고    scopus 로고
    • A soluble transforming growth factor β type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells
    • Bandyopadhyay, A., Zhu, Y., Cibull, M. L., Bao, L. W., Chen, C. G., & Sun, L. Z. (1999). A soluble transforming growth factor β type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells. Cancer Research, 59, 5041-5046.
    • (1999) Cancer Research , vol.59 , pp. 5041-5046
    • Bandyopadhyay, A.1    Zhu, Y.2    Cibull, M.L.3    Bao, L.W.4    Chen, C.G.5    Sun, L.Z.6
  • 12
    • 0037118579 scopus 로고    scopus 로고
    • Extracellular domain of TGF-β type III receptor inhibits angiogenesis and tumor growth in human cancer cells
    • Bandyopadhyay, A., Zhu, Y., Malik, S. N., Kreisberg, J., Brattain, M. G., Sprague, E. A., et al. (2002). Extracellular domain of TGF-β type III receptor inhibits angiogenesis and tumor growth in human cancer cells. Oncogene, 21, 3541-3551.
    • (2002) Oncogene , vol.21 , pp. 3541-3551
    • Bandyopadhyay, A.1    Zhu, Y.2    Malik, S.N.3    Kreisberg, J.4    Brattain, M.G.5    Sprague, E.A.6
  • 13
    • 12344310463 scopus 로고    scopus 로고
    • Integrative radiation carcinogenesis: Interactions between cell and tissue responses to DNA damage
    • Barcellos-Hoff, M. H. (2005). Integrative radiation carcinogenesis: Interactions between cell and tissue responses to DNA damage. Seminars in Cancer Biology, 15, 138-148.
    • (2005) Seminars in Cancer Biology , vol.15 , pp. 138-148
    • Barcellos-Hoff, M.H.1
  • 14
    • 20144372620 scopus 로고    scopus 로고
    • High-throughput mapping of a dynamic signaling network in mammalian cells
    • Barrios-Rodiles, M., Brown, K. R., Ozdamar, B., Bose, R., Liu, Z., Donovan, R. S., et al. (2005). High-throughput mapping of a dynamic signaling network in mammalian cells. Science, 307, 1621-1625.
    • (2005) Science , vol.307 , pp. 1621-1625
    • Barrios-Rodiles, M.1    Brown, K.R.2    Ozdamar, B.3    Bose, R.4    Liu, Z.5    Donovan, R.S.6
  • 15
  • 16
    • 0842288323 scopus 로고    scopus 로고
    • TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    • Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., et al. (2004). TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science, 303, 775-777.
    • (2004) Science , vol.303 , pp. 775-777
    • Bhowmick, N.A.1    Chytil, A.2    Plieth, D.3    Gorska, A.E.4    Dumont, N.5    Shappell, S.6
  • 17
    • 8444229365 scopus 로고    scopus 로고
    • Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model
    • Biglari, A., Bataille, D., Naumann, U., Weller, M., Zirger, J., Castro, M. G., et al. (2004). Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model. Cancer Gene Therapy, 11, 721-732.
    • (2004) Cancer Gene Therapy , vol.11 , pp. 721-732
    • Biglari, A.1    Bataille, D.2    Naumann, U.3    Weller, M.4    Zirger, J.5    Castro, M.G.6
  • 18
    • 0031441041 scopus 로고    scopus 로고
    • Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor β receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]- anthracene
    • Böttinger, E. P., Jakubczak, J. L., Haines, D. C., Bagnall, K., & Wakefield, L. M. (1997). Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor β receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene. Cancer Research, 57, 5564-5570.
    • (1997) Cancer Research , vol.57 , pp. 5564-5570
    • Böttinger, E.P.1    Jakubczak, J.L.2    Haines, D.C.3    Bagnall, K.4    Wakefield, L.M.5
  • 19
    • 20444433569 scopus 로고    scopus 로고
    • Smad7 abrogates transforming growth factor-β1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein
    • Boyer Arnold, N., & Korc, M. (2005). Smad7 abrogates transforming growth factor-β1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein. Journal of Biological Chemistry, 280, 21858-21866.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 21858-21866
    • Boyer Arnold, N.1    Korc, M.2
  • 20
    • 0035450143 scopus 로고    scopus 로고
    • Role of endogenous transforming growth factor β (TGFβ)1 in prostatic stromal cells
    • Bretland, A. J., Reid, S. V., Chapple, C. R., & Eaton, C. I. (2001). Role of endogenous transforming growth factor β (TGFβ)1 in prostatic stromal cells. Prostate, 48, 297-304.
    • (2001) Prostate , vol.48 , pp. 297-304
    • Bretland, A.J.1    Reid, S.V.2    Chapple, C.R.3    Eaton, C.I.4
  • 21
    • 0029991682 scopus 로고    scopus 로고
    • Microsatellite instability and the role of hMSH2 in sporadic colorectal cancer
    • Bubb, V. J., Curtis, L. J., Cunningham, C., Dunlop, M. G., Carothers, A. D., Morris, R. G., et al. (1996). Microsatellite instability and the role of hMSH2 in sporadic colorectal cancer. Oncogene, 12, 2641-2649.
    • (1996) Oncogene , vol.12 , pp. 2641-2649
    • Bubb, V.J.1    Curtis, L.J.2    Cunningham, C.3    Dunlop, M.G.4    Carothers, A.D.5    Morris, R.G.6
  • 23
    • 0027250810 scopus 로고
    • Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-β activities
    • Chen, R. H., Ebner, R., & Derynck, R. (1993). Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-β activities. Science, 260, 1135-1338.
    • (1993) Science , vol.260 , pp. 1135-1338
    • Chen, R.H.1    Ebner, R.2    Derynck, R.3
  • 24
    • 0032213514 scopus 로고    scopus 로고
    • Transforming growth factor β type I receptor kinase mutant associated with metastatic breast cancer
    • Chen, T., Carter, D., Garrigue-Antar, L., & Reiss, M. (1998). Transforming growth factor β type I receptor kinase mutant associated with metastatic breast cancer. Cancer Research, 58, 4805-4810.
    • (1998) Cancer Research , vol.58 , pp. 4805-4810
    • Chen, T.1    Carter, D.2    Garrigue-Antar, L.3    Reiss, M.4
  • 25
    • 0035875035 scopus 로고    scopus 로고
    • Transforming growth factor-β receptor type I gene is frequently mutated in ovarian carcinomas
    • Chen, T., Triplett, T., Dehner, B., Hurst, B., Colligan, B., Pemberton, J., et al. (2001). Transforming growth factor-β receptor type I gene is frequently mutated in ovarian carcinomas. Cancer Research, 61, 4679-4682.
    • (2001) Cancer Research , vol.61 , pp. 4679-4682
    • Chen, T.1    Triplett, T.2    Dehner, B.3    Hurst, B.4    Colligan, B.5    Pemberton, J.6
  • 26
    • 0035452460 scopus 로고    scopus 로고
    • Novel inactivating mutations of transforming growth factor-β type I receptor gene in head-and-neck cancer metastases
    • Chen, T., Yan, W., Wells, R. G., Rimm, D. L., McNiff, J., Leffell, D., et al. (2001). Novel inactivating mutations of transforming growth factor-β type I receptor gene in head-and-neck cancer metastases. International Journal of Cancer, 93, 653-661.
    • (2001) International Journal of Cancer , vol.93 , pp. 653-661
    • Chen, T.1    Yan, W.2    Wells, R.G.3    Rimm, D.L.4    McNiff, J.5    Leffell, D.6
  • 27
    • 0037183984 scopus 로고    scopus 로고
    • Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-β in pancreatic tumor cells
    • Chen, W. B., Lenschow, W., Tiede, K., Fischer, J. W., Kalthoff, H., & Ungefroren, H. (2002). Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-β in pancreatic tumor cells. Journal of Biological Chemistry, 277, 36118-38128.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 36118-38128
    • Chen, W.B.1    Lenschow, W.2    Tiede, K.3    Fischer, J.W.4    Kalthoff, H.5    Ungefroren, H.6
  • 28
    • 23744452875 scopus 로고    scopus 로고
    • Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and HGF-mediated signaling networks
    • Cheng, N., Bhowmick, N. A., Chytil, A., Gorska, A. E., Brown, K. A., Muraoka, R., et al. (2005). Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and HGF-mediated signaling networks. Oncogene, 24, 5053-5068.
    • (2005) Oncogene , vol.24 , pp. 5053-5068
    • Cheng, N.1    Bhowmick, N.A.2    Chytil, A.3    Gorska, A.E.4    Brown, K.A.5    Muraoka, R.6
  • 29
    • 0029795881 scopus 로고    scopus 로고
    • Microsatellite instability-associated mutations associate preferentially with the intestinal type of primary gastric carcinomas in a high-risk population
    • Chung, Y. J., Song, J. M., Lee, J. Y., Jung, Y. T., Seo, E. J., Choi, S. W., et al. (1996). Microsatellite instability-associated mutations associate preferentially with the intestinal type of primary gastric carcinomas in a high-risk population. Cancer Research, 56, 4662-4665.
    • (1996) Cancer Research , vol.56 , pp. 4662-4665
    • Chung, Y.J.1    Song, J.M.2    Lee, J.Y.3    Jung, Y.T.4    Seo, E.J.5    Choi, S.W.6
  • 30
    • 0034049120 scopus 로고    scopus 로고
    • Transforming growth factor-β induces growth inhibition and IGF-binding protein-3 production in prostatic stromal cells: Abnormalities in cells cultured from benign prostatic hyperplasia tissues
    • Cohen, P., Nunn, S. E., & Peehl, D. M. (2000). Transforming growth factor-β induces growth inhibition and IGF-binding protein-3 production in prostatic stromal cells: Abnormalities in cells cultured from benign prostatic hyperplasia tissues. Journal of Endocrinology, 164, 215-223.
    • (2000) Journal of Endocrinology , vol.164 , pp. 215-223
    • Cohen, P.1    Nunn, S.E.2    Peehl, D.M.3
  • 31
    • 0030598681 scopus 로고    scopus 로고
    • TGFβ1 inhibits the formation of benign skin tumors but enhances progression to invasive spindle cell carcinomas in transgenic mice
    • Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., et al. (1996). TGFβ1 inhibits the formation of benign skin tumors but enhances progression to invasive spindle cell carcinomas in transgenic mice. Cell, 86, 531-542.
    • (1996) Cell , vol.86 , pp. 531-542
    • Cui, W.1    Fowlis, D.J.2    Bryson, S.3    Duffie, E.4    Ireland, H.5    Balmain, A.6
  • 32
    • 20544444943 scopus 로고    scopus 로고
    • Selective inhibition of TGF-β responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP
    • Cui, Q., Lim, S. K., Zhao, B., & Hoffmann, F. M. (2005). Selective inhibition of TGF-β responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP. Oncogene, 24, 3864-3874.
    • (2005) Oncogene , vol.24 , pp. 3864-3874
    • Cui, Q.1    Lim, S.K.2    Zhao, B.3    Hoffmann, F.M.4
  • 33
    • 1342265719 scopus 로고    scopus 로고
    • SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7
    • Da Costa Byfield, S., Major, C., Laping, N. J., & Roberts, A. B. (2004). SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7. Molecular Pharmacology, 65, 744-752.
    • (2004) Molecular Pharmacology , vol.65 , pp. 744-752
    • Da Costa Byfield, S.1    Major, C.2    Laping, N.J.3    Roberts, A.B.4
  • 34
    • 0027742864 scopus 로고
    • Immunocytochemical localization of secreted transforming growth factor-β1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma
    • Dalal, B. I., Keown, P. A., & Greenberg, A. H. (1993). Immunocytochemical localization of secreted transforming growth factor-β1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma. American Journal of Pathology, 143, 381-389.
    • (1993) American Journal of Pathology , vol.143 , pp. 381-389
    • Dalal, B.I.1    Keown, P.A.2    Greenberg, A.H.3
  • 35
    • 0032934979 scopus 로고    scopus 로고
    • Targeted disruption of Smad3 reveals an essential role in transforming growth factor β-mediated signal transduction
    • Datto, M. B., Frederick, J. P., Pan, L., Borton, A. J., Zhuang, Y., & Wang, X.-F. (1999). Targeted disruption of Smad3 reveals an essential role in transforming growth factor β-mediated signal transduction. Molecular and Cellular Biology, 19, 2495-2504.
    • (1999) Molecular and Cellular Biology , vol.19 , pp. 2495-2504
    • Datto, M.B.1    Frederick, J.P.2    Pan, L.3    Borton, A.J.4    Zhuang, Y.5    Wang, X.-F.6
  • 36
    • 3142664714 scopus 로고    scopus 로고
    • Transforming growth factor β receptor type II inactivation promotes the establishment and progression of colon cancer
    • Diswas, S., Chytil, A., Washington, K., Romero-Gallo, J., Gorska, A. E., Wirth, P. S., et al. (2004). Transforming growth factor β receptor type II inactivation promotes the establishment and progression of colon cancer. Cancer Research, 64, 4687-4692.
    • (2004) Cancer Research , vol.64 , pp. 4687-4692
    • Diswas, S.1    Chytil, A.2    Washington, K.3    Romero-Gallo, J.4    Gorska, A.E.5    Wirth, P.S.6
  • 37
    • 0037326526 scopus 로고    scopus 로고
    • Transforming growth factor β1-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-β-activated kinase 1 and mitogen-activated protein kinase kinase 3
    • Edlund, S., Bu, S., Schuster, N., Aspenstrom, P., Heuchel, R., Heldin, N.-E., et al. (2003). Transforming growth factor β1-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-β-activated kinase 1 and mitogen-activated protein kinase kinase 3. Molecular Biology of the Cell, 14, 529-544.
    • (2003) Molecular Biology of the Cell , vol.14 , pp. 529-544
    • Edlund, S.1    Bu, S.2    Schuster, N.3    Aspenstrom, P.4    Heuchel, R.5    Heldin, N.-E.6
  • 38
    • 2342436038 scopus 로고    scopus 로고
    • Smad7 is required for TGF-β-induced activation of the small GTPase Cdc42
    • Edlund, S., Landstrom, M., Heldin, C. H., & Aspenstrom, P. (2004). Smad7 is required for TGF-β-induced activation of the small GTPase Cdc42. Journal of Cell Science, 117, 1835-1847.
    • (2004) Journal of Cell Science , vol.117 , pp. 1835-1847
    • Edlund, S.1    Landstrom, M.2    Heldin, C.H.3    Aspenstrom, P.4
  • 40
    • 0037312899 scopus 로고    scopus 로고
    • The not-so innocent bystander: The microenvironment as a therapeutic target in cancer
    • Erickson, A. C., & Barcellos-Hoff, M. H. (2003). The not-so innocent bystander: The microenvironment as a therapeutic target in cancer. Expert Opinion on Therapeutic Targets, 7, 71-88.
    • (2003) Expert Opinion on Therapeutic Targets , vol.7 , pp. 71-88
    • Erickson, A.C.1    Barcellos-Hoff, M.H.2
  • 41
    • 25144457206 scopus 로고    scopus 로고
    • Proliferation of estrogen receptor-α-positive mammary epithelial cells is restained by transforming growth factor β1 in adult mice
    • Ewan, K. B., Oketch-Rabah, H. A., Ravani, S. A., Shyamala, G., Moses, H. L., & Barcellos-Hoff, M. H. (2005). Proliferation of estrogen receptor-α-positive mammary epithelial cells is restained by transforming growth factor β1 in adult mice. American Journal of Pathology, 167, 409-417.
    • (2005) American Journal of Pathology , vol.167 , pp. 409-417
    • Ewan, K.B.1    Oketch-Rabah, H.A.2    Ravani, S.A.3    Shyamala, G.4    Moses, H.L.5    Barcellos-Hoff, M.H.6
  • 42
    • 0032102902 scopus 로고    scopus 로고
    • Conversion of SB-203580-insensitive MAP kinase family members to drug sensitive forms by a single amino acid substitution
    • Eyes, P. A., Craxton, M., Morrice, N., Cihen, P., & Goedert, M. (1998). Conversion of SB-203580-insensitive MAP kinase family members to drug sensitive forms by a single amino acid substitution. Chemistry & Biology, 5, 321-328.
    • (1998) Chemistry & Biology , vol.5 , pp. 321-328
    • Eyes, P.A.1    Craxton, M.2    Morrice, N.3    Cihen, P.4    Goedert, M.5
  • 43
    • 0027399717 scopus 로고
    • A glycosylation-deficient endothelial cell mutant with modified responses to transforming growth factor-β and other growth inhibitory cytokines: Evidence for multiple growth inhibitory signal transduction pathways
    • Fafeur, V., O'Hara, B., & Böhlen, P. (1993). A glycosylation-deficient endothelial cell mutant with modified responses to transforming growth factor-β and other growth inhibitory cytokines: Evidence for multiple growth inhibitory signal transduction pathways. Molecular Biology of the Cell, 4, 135-144.
    • (1993) Molecular Biology of the Cell , vol.4 , pp. 135-144
    • Fafeur, V.1    O'Hara, B.2    Böhlen, P.3
  • 45
    • 0034596993 scopus 로고    scopus 로고
    • Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-β
    • Feng, X., Lin, X., & Derynck, R. (2000). Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-β. EMBO Journal, 19, 5178-5193.
    • (2000) EMBO Journal , vol.19 , pp. 5178-5193
    • Feng, X.1    Lin, X.2    Derynck, R.3
  • 46
    • 10744233540 scopus 로고    scopus 로고
    • Interference with transforming growth factor-β/Smad3 signaling results in accelerated healing of wounds in previously irradiated skin
    • Flanders, K. C., Major, C. D., Arabshahi, A., Aburime, E. E., Okada, M. H., Fujii, M., et al. (2003). Interference with transforming growth factor-β/Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. American Journal of Pathology, 163, 2247-2257.
    • (2003) American Journal of Pathology , vol.163 , pp. 2247-2257
    • Flanders, K.C.1    Major, C.D.2    Arabshahi, A.3    Aburime, E.E.4    Okada, M.H.5    Fujii, M.6
  • 48
    • 16844373628 scopus 로고    scopus 로고
    • Effect of conditional knockout of the type II TGF-β receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis
    • Forrester, E., Chytil, A., Bierie, B., Aakre, M., Gorska, A. E., Sharif-Afshar, A. R., et al. (2005). Effect of conditional knockout of the type II TGF-β receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. Cancer Research, 65, 2296-2302.
    • (2005) Cancer Research , vol.65 , pp. 2296-2302
    • Forrester, E.1    Chytil, A.2    Bierie, B.3    Aakre, M.4    Gorska, A.E.5    Sharif-Afshar, A.R.6
  • 49
    • 0035091656 scopus 로고    scopus 로고
    • Down-regulation of transforming growth factor β type II receptor in laryngeal carcinogenesis
    • Franchi, A., Gallo, O., Sardi, I., & Santucci, M. (2001). Down-regulation of transforming growth factor β type II receptor in laryngeal carcinogenesis. Journal of Clinical Pathology, 54, 201-204.
    • (2001) Journal of Clinical Pathology , vol.54 , pp. 201-204
    • Franchi, A.1    Gallo, O.2    Sardi, I.3    Santucci, M.4
  • 51
    • 0842327812 scopus 로고    scopus 로고
    • Regulation of rat prostate stromal cell myodifferentiation by androgen and TGF-β1
    • Gerdes, M. J., Larsen, M., Dang, T. D., Ressler, S. J., Tuxhorn, J. A., & Rowley, D. R. (2004). Regulation of rat prostate stromal cell myodifferentiation by androgen and TGF-β1. Prostate, 58, 299-307.
    • (2004) Prostate , vol.58 , pp. 299-307
    • Gerdes, M.J.1    Larsen, M.2    Dang, T.D.3    Ressler, S.J.4    Tuxhorn, J.A.5    Rowley, D.R.6
  • 52
    • 0036689042 scopus 로고    scopus 로고
    • Transforming growth factor β mimetics: Discovery of 7-[4-(4-cyanophenyl)phenoxy]-heptanohydroxamin acid, a biaryl hydroxamate inhibitor of histone deacetylase
    • Glaser, K. B., Li, J., Aakre, M. E., Morgan, D. W., Sheppard, G., Stewart, K. D., et al. (2002). Transforming growth factor β mimetics: discovery of 7-[4-(4-cyanophenyl)phenoxy]-heptanohydroxamin acid, a biaryl hydroxamate inhibitor of histone deacetylase. Mol Cancer Ther, 1, 759-768.
    • (2002) Mol Cancer Ther , vol.1 , pp. 759-768
    • Glaser, K.B.1    Li, J.2    Aakre, M.E.3    Morgan, D.W.4    Sheppard, G.5    Stewart, K.D.6
  • 53
    • 0024755673 scopus 로고
    • Retinoic acid induces transforming growth factor-β2 in cultured keratinocytes and mouse epidermis
    • Glick, A. B., Flanders, K. C., Danielpour, D., Yuspa, S. H., & Sporn, M. B. (1989). Retinoic acid induces transforming growth factor-β2 in cultured keratinocytes and mouse epidermis. Cell Regulation, 1, 617-626.
    • (1989) Cell Regulation , vol.1 , pp. 617-626
    • Glick, A.B.1    Flanders, K.C.2    Danielpour, D.3    Yuspa, S.H.4    Sporn, M.B.5
  • 54
    • 0028171401 scopus 로고
    • Targeted deletion of the TGF-β1 gene causes rapid progression to squamous cell carcinoma
    • Glick, A. B., Lee, M. M., Darwiche, N., Kulkarni, A. B., Karlsson, S., & Yuspa, S. H. (1994). Targeted deletion of the TGF-β1 gene causes rapid progression to squamous cell carcinoma. Genes & Development, 8, 2429-2440.
    • (1994) Genes & Development , vol.8 , pp. 2429-2440
    • Glick, A.B.1    Lee, M.M.2    Darwiche, N.3    Kulkarni, A.B.4    Karlsson, S.5    Yuspa, S.H.6
  • 55
    • 0033564547 scopus 로고    scopus 로고
    • Blocking transforming growth factor β signaling in transgenic epidermis accelerates chemical carcinogenesis: A mechanism associated with increased angiogenesis
    • Go, C., Li, P., & Wang, X.-J. (1999). Blocking transforming growth factor β signaling in transgenic epidermis accelerates chemical carcinogenesis: A mechanism associated with increased angiogenesis. Cancer Research, 59, 2861-2868.
    • (1999) Cancer Research , vol.59 , pp. 2861-2868
    • Go, C.1    Li, P.2    Wang, X.-J.3
  • 57
    • 0032404111 scopus 로고    scopus 로고
    • Genetic alterations of the transforming growth factor β receptor genes in pancreatic and biliary adenocarcinomas
    • Goggins, M. (1998). Genetic alterations of the transforming growth factor β receptor genes in pancreatic and biliary adenocarcinomas. Cancer Research, 58, 5329-5332.
    • (1998) Cancer Research , vol.58 , pp. 5329-5332
    • Goggins, M.1
  • 58
    • 0027053058 scopus 로고
    • Immunohistochemical for transforming growth factor-β1 associates with disease progression in human breast cancer
    • Gorsch, S. M., Memoli, V. A., Stukel, K. A., Gold, L. I., & Arrick, B. A. (1992). Immunohistochemical for transforming growth factor-β1 associates with disease progression in human breast cancer. Cancer Research, 52, 6949-6952.
    • (1992) Cancer Research , vol.52 , pp. 6949-6952
    • Gorsch, S.M.1    Memoli, V.A.2    Stukel, K.A.3    Gold, L.I.4    Arrick, B.A.5
  • 59
    • 0141537150 scopus 로고    scopus 로고
    • Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-β receptor exhibit impaired mammary development and enhanced mammary tumor formation
    • Gorska, A. E., Jensen, R. A., Shyr, Y., Aakre, M. E., Bhowmick, N. A., & Moses, H. L. (2003). Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-β receptor exhibit impaired mammary development and enhanced mammary tumor formation. American Journal of Pathology, 163, 1539-1549.
    • (2003) American Journal of Pathology , vol.163 , pp. 1539-1549
    • Gorska, A.E.1    Jensen, R.A.2    Shyr, Y.3    Aakre, M.E.4    Bhowmick, N.A.5    Moses, H.L.6
  • 60
    • 0032479464 scopus 로고    scopus 로고
    • A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF-β signals
    • Goto, D., Yagi, K., Inoue, H., Iwamoto, I., Kawabata, M., Miyazono, K., et al. (1998). A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF-β signals. FEBS Letters, 430, 201-204.
    • (1998) FEBS Letters , vol.430 , pp. 201-204
    • Goto, D.1    Yagi, K.2    Inoue, H.3    Iwamoto, I.4    Kawabata, M.5    Miyazono, K.6
  • 61
    • 0242330126 scopus 로고    scopus 로고
    • Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFβ/ALK5 signaling
    • Goumans, M. J., Valdimarsdottir, G., Itoh, S., Lebrin, F., Larsson, J., Mummery, C., et al. (2003). Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFβ/ALK5 signaling. Molecular Cell, 12, 817-828.
    • (2003) Molecular Cell , vol.12 , pp. 817-828
    • Goumans, M.J.1    Valdimarsdottir, G.2    Itoh, S.3    Lebrin, F.4    Larsson, J.5    Mummery, C.6
  • 62
    • 0033555627 scopus 로고    scopus 로고
    • Mutational inactivation of transforming growth factor β receptor type II in microsatellite stable colon cancers
    • Grady, W. M., Myeroff, L. L., Swinler, S. E., Rajput, A., Thiagalingam, S., Lutterbaugh, J. D., et al. (1999). Mutational inactivation of transforming growth factor β receptor type II in microsatellite stable colon cancers. Cancer Research, 59, 320-324.
    • (1999) Cancer Research , vol.59 , pp. 320-324
    • Grady, W.M.1    Myeroff, L.L.2    Swinler, S.E.3    Rajput, A.4    Thiagalingam, S.5    Lutterbaugh, J.D.6
  • 63
    • 25844512657 scopus 로고    scopus 로고
    • Adhesion and Rac1-dependent regulation of biglycan gene expression by TGF-β. Evidence for oxidative signaling through NADPH oxidase
    • Groth, S., Schulze, M., Kalthoff, H., Faendrich, F., & Ungefroren, H. (2005). Adhesion and Rac1-dependent regulation of biglycan gene expression by TGF-β. Evidence for oxidative signaling through NADPH oxidase. Journal of Biological Chemistry, 280, 33190-33199.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 33190-33199
    • Groth, S.1    Schulze, M.2    Kalthoff, H.3    Faendrich, F.4    Ungefroren, H.5
  • 64
    • 0032848660 scopus 로고    scopus 로고
    • Repression of the gene encoding the TGF-β type II receptor is a major target of the EW-FLIi oncoprotein
    • Hahm, K. B., Cho, K., Lee, C., Im, Y. H., Chang, J., Choi, S. G., et al. (1999). Repression of the gene encoding the TGF-β type II receptor is a major target of the EW-FLIi oncoprotein. Nature Genetics, 23, 222-227.
    • (1999) Nature Genetics , vol.23 , pp. 222-227
    • Hahm, K.B.1    Cho, K.2    Lee, C.3    Im, Y.H.4    Chang, J.5    Choi, S.G.6
  • 66
    • 1442332673 scopus 로고    scopus 로고
    • Loss of Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer
    • Han, S. U., Kim, H. T., Seong Do, H., Kim, Y. S., Park, Y. S., Bang, Y. J., et al. (2004). Loss of Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer. Oncogene, 23, 1333-1341.
    • (2004) Oncogene , vol.23 , pp. 1333-1341
    • Han, S.U.1    Kim, H.T.2    Seong Do, H.3    Kim, Y.S.4    Park, Y.S.5    Bang, Y.J.6
  • 67
    • 0344625381 scopus 로고    scopus 로고
    • TGF-β signaling and cancer: Structural and functional consequences of mutations in Smads
    • Hata, A., Shi, Y., & Massagué, J. (1998). TGF-β signaling and cancer: Structural and functional consequences of mutations in Smads. Molecular Medicine Today, 4, 257-262.
    • (1998) Molecular Medicine Today , vol.4 , pp. 257-262
    • Hata, A.1    Shi, Y.2    Massagué, J.3
  • 68
    • 0043234699 scopus 로고    scopus 로고
    • The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins
    • He, J., Tegen, S. B., Krawitz, A. R., Martin, G. S., & Luo, K. (2003). The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins. Journal of Biological Chemistry, 278, 30540-30547.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 30540-30547
    • He, J.1    Tegen, S.B.2    Krawitz, A.R.3    Martin, G.S.4    Luo, K.5
  • 69
    • 5144226551 scopus 로고    scopus 로고
    • Development and possible clinical use of antagonists for PDGF and TGF-β
    • Heldin, C.-H. (2004). Development and possible clinical use of antagonists for PDGF and TGF-β. Upsala Journal of Medical Science, 109, 165-178.
    • (2004) Upsala Journal of Medical Science , vol.109 , pp. 165-178
    • Heldin, C.-H.1
  • 70
    • 0032524069 scopus 로고    scopus 로고
    • Mutations in the Smad4/DPC4 gene in juvenile polyposis
    • Howe, J. R. (1998). Mutations in the Smad4/DPC4 gene in juvenile polyposis. Science, 280, 1086-1088.
    • (1998) Science , vol.280 , pp. 1086-1088
    • Howe, J.R.1
  • 71
    • 2342559112 scopus 로고    scopus 로고
    • Attenuated type II TGF-β receptor signaling in human malignant oral keratinocytes induces a less differentiated and more aggressive phenotype that is associated with metastatic dissemination
    • Huntley, S., Davies, M., Matthews, J. B., Thomas, G., Marshall, J., Robinson, C. M., et al. (2004). Attenuated type II TGF-β receptor signaling in human malignant oral keratinocytes induces a less differentiated and more aggressive phenotype that is associated with metastatic dissemination. International Journal of Cancer, 110, 170-176.
    • (2004) International Journal of Cancer , vol.110 , pp. 170-176
    • Huntley, S.1    Davies, M.2    Matthews, J.B.3    Thomas, G.4    Marshall, J.5    Robinson, C.M.6
  • 72
    • 0034710545 scopus 로고    scopus 로고
    • Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signaling pathway associated with progression to undifferentiated carcinomas
    • Iglesias, M., Frontelo, P., Gamallo, C., & Quintanilla, M. (2000). Blockade of Smad4 in transformed keratinocytes containing a Ras oncogene leads to hyperactivation of the Ras-dependent Erk signaling pathway associated with progression to undifferentiated carcinomas. Oncogene, 19, 4134-4145.
    • (2000) Oncogene , vol.19 , pp. 4134-4145
    • Iglesias, M.1    Frontelo, P.2    Gamallo, C.3    Quintanilla, M.4
  • 73
    • 0031590968 scopus 로고    scopus 로고
    • Microsatellite instability and mutated type II transforming growth factor-β receptor gene in gliomas
    • Izumoto, S., Arita, N., Ohnishi, T., Hiraga, S., Taki, T., Tomita, N., et al. (1997). Microsatellite instability and mutated type II transforming growth factor-β receptor gene in gliomas. Cancer Letters, 112, 251-256.
    • (1997) Cancer Letters , vol.112 , pp. 251-256
    • Izumoto, S.1    Arita, N.2    Ohnishi, T.3    Hiraga, S.4    Taki, T.5    Tomita, N.6
  • 74
    • 0028980025 scopus 로고
    • Transforming growth factor-β-mediated regulation of human peripheral blood mononuclear cell proliferation as detected with phosphorothioate antisense oligodeoxynucleotides
    • Jachimczak, P., Fabel-Schulte, K., Hessdorfer, B., Brysch, W., Schlingensiepen, K. H., Blesch, A., et al. (1995). Transforming growth factor-β-mediated regulation of human peripheral blood mononuclear cell proliferation as detected with phosphorothioate antisense oligodeoxynucleotides. Cellular Immunology, 165, 125-133.
    • (1995) Cellular Immunology , vol.165 , pp. 125-133
    • Jachimczak, P.1    Fabel-Schulte, K.2    Hessdorfer, B.3    Brysch, W.4    Schlingensiepen, K.H.5    Blesch, A.6
  • 75
    • 0030021142 scopus 로고    scopus 로고
    • Transforming growth factor-β-mediated autocrine growth regulation of gliomas as detected with phosphorothioate antisense oligonucleotides
    • Jachimczak, P., Hessdorfer, B., Fabel-Schulte, K., Wismeth, C., Brysch, W., Schlingensiepen, K. H., et al. (1996). Transforming growth factor-β-mediated autocrine growth regulation of gliomas as detected with phosphorothioate antisense oligonucleotides. International Journal of Cancer, 65, 332-337.
    • (1996) International Journal of Cancer , vol.65 , pp. 332-337
    • Jachimczak, P.1    Hessdorfer, B.2    Fabel-Schulte, K.3    Wismeth, C.4    Brysch, W.5    Schlingensiepen, K.H.6
  • 76
    • 0031804982 scopus 로고    scopus 로고
    • Reduction in transforming growth factor-β type II receptor in mouse lung carcinogenesis
    • Jakowlew, S. B., Moody, T. W., You, L., & Mariano, J. M. (1998). Reduction in transforming growth factor-β type II receptor in mouse lung carcinogenesis. Molecular Carcinogenesis, 22, 46-56.
    • (1998) Molecular Carcinogenesis , vol.22 , pp. 46-56
    • Jakowlew, S.B.1    Moody, T.W.2    You, L.3    Mariano, J.M.4
  • 77
    • 0031804499 scopus 로고    scopus 로고
    • Transforming growth factor-beta expression in mouse lung carcinogenesis
    • Jakowlew, S. B., Moody, T. W., You, L., & Mariano, J. M. (1998). Transforming growth factor-beta expression in mouse lung carcinogenesis. Experimental Lung Research, 24, 579-593.
    • (1998) Experimental Lung Research , vol.24 , pp. 579-593
    • Jakowlew, S.B.1    Moody, T.W.2    You, L.3    Mariano, J.M.4
  • 78
    • 12544257249 scopus 로고    scopus 로고
    • Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-β-mediated Smad-dependent growth inhibition of human breast cancer cells in vivo
    • Kamaraju, A. K., & Roberts, A. B. (2005). Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-β-mediated Smad-dependent growth inhibition of human breast cancer cells in vivo. Journal of Biological Chemistry, 280, 1024-1036.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 1024-1036
    • Kamaraju, A.K.1    Roberts, A.B.2
  • 79
    • 0000031048 scopus 로고    scopus 로고
    • Transcriptional repression of the transforming growth factor β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer
    • Kang, S. H., Bang, Y. J., Im, Y. H., Yang, H. K., Lee, D. A., Lee, H. Y., et al. (1999). Transcriptional repression of the transforming growth factor β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer. Oncogene, 18, 7280-7286.
    • (1999) Oncogene , vol.18 , pp. 7280-7286
    • Kang, S.H.1    Bang, Y.J.2    Im, Y.H.3    Yang, H.K.4    Lee, D.A.5    Lee, H.Y.6
  • 80
    • 0033757753 scopus 로고    scopus 로고
    • Enhanced tumorigenesis and reduced transforming growth factor-β type II receptor in lung tumors from mice with reduced gene dosage of transforming growth factor-β1
    • Kang, Y., Mariano, J. M., Andgisen, J., Moody, T. W., Diwan, B. A., Wakefield, L. M., et al. (2000). Enhanced tumorigenesis and reduced transforming growth factor-β type II receptor in lung tumors from mice with reduced gene dosage of transforming growth factor-β1. Molecular Carcinogenesis, 29, 112-126.
    • (2000) Molecular Carcinogenesis , vol.29 , pp. 112-126
    • Kang, Y.1    Mariano, J.M.2    Andgisen, J.3    Moody, T.W.4    Diwan, B.A.5    Wakefield, L.M.6
  • 81
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: Twist in development and metastasis
    • Kang, Y., & Massagué, J. (2004). Epithelial-mesenchymal transitions: Twist in development and metastasis. Cell, 118, 277-279.
    • (2004) Cell , vol.118 , pp. 277-279
    • Kang, Y.1    Massagué, J.2
  • 82
    • 0032622519 scopus 로고    scopus 로고
    • Mutation analysis of the transforming growth factor β type II receptor, Smad2, and Smad4 in hepatocellular carcinoma
    • Kawate, S., Ohwada, S., Hamada, K., Takenoshita, S., Morishita, Y., & Hagiwara, K. (1999). Mutation analysis of the transforming growth factor β type II receptor, Smad2, and Smad4 in hepatocellular carcinoma. International Journal of Oncology, 14, 127-131.
    • (1999) International Journal of Oncology , vol.14 , pp. 127-131
    • Kawate, S.1    Ohwada, S.2    Hamada, K.3    Takenoshita, S.4    Morishita, Y.5    Hagiwara, K.6
  • 83
    • 26644431598 scopus 로고    scopus 로고
    • Smad-dependent cooperative regulation of interleukin-2 receptor α chain gene expression by T cell receptor and TGF-β
    • Kim, H.-P., Kim, B.-G., Letterio, J., & Leonard, W. J. (2005). Smad-dependent cooperative regulation of interleukin-2 receptor α chain gene expression by T cell receptor and TGF-β. Journal of Biological Chemistry, 280, 34042-34047.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 34042-34047
    • Kim, H.-P.1    Kim, B.-G.2    Letterio, J.3    Leonard, W.J.4
  • 84
    • 3142741044 scopus 로고    scopus 로고
    • Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-β-induced apoptosis in hepatoma cells
    • Kim, K. Y., Kim, B. C., Xu, Z., & Kim, S.-J. (2004). Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-β-induced apoptosis in hepatoma cells. Journal of Biological Chemistry, 279, 29478-29484.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 29478-29484
    • Kim, K.Y.1    Kim, B.C.2    Xu, Z.3    Kim, S.-J.4
  • 85
    • 0034027480 scopus 로고    scopus 로고
    • Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis
    • Kim, S.-J., Im, Y.-H., Markowitz, S. D., & Bang, Y. J. (2000). Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis. Cytokine & Growth Factor Reviews, 11, 159-168.
    • (2000) Cytokine & Growth Factor Reviews , vol.11 , pp. 159-168
    • Kim, S.-J.1    Im, Y.-H.2    Markowitz, S.D.3    Bang, Y.J.4
  • 86
    • 0033598408 scopus 로고    scopus 로고
    • The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer
    • Kleeff, J., Ishiwata, T., Maruyama, H., Friess, H., Truong, P., Buchler, M. W., et al. (1999). The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. Oncogene, 18, 5363-5372.
    • (1999) Oncogene , vol.18 , pp. 5363-5372
    • Kleeff, J.1    Ishiwata, T.2    Maruyama, H.3    Friess, H.4    Truong, P.5    Buchler, M.W.6
  • 89
    • 0033671655 scopus 로고    scopus 로고
    • A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif
    • Larisch, S., Yi, Y., Lotan, R., Kerner, H., Eimerl, S., Parks, T. W., et al. (2000). A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nature Cell Biology, 2, 915-921.
    • (2000) Nature Cell Biology , vol.2 , pp. 915-921
    • Larisch, S.1    Yi, Y.2    Lotan, R.3    Kerner, H.4    Eimerl, S.5    Parks, T.W.6
  • 90
    • 0036888908 scopus 로고    scopus 로고
    • Rapamycin potentiates transforming growth factor β-induced growth arrest in non-transformed, oncogene-transformed, and human cancer cells
    • Law, B. K., Chytil, A., Dumont, N., Hamilton, E. G., Waltner-Law, M. E., Aakre, M. E., et al. (2002). Rapamycin potentiates transforming growth factor β-induced growth arrest in non-transformed, oncogene-transformed, and human cancer cells. Molecular and Cellular Biology, 22, 8184-8198.
    • (2002) Molecular and Cellular Biology , vol.22 , pp. 8184-8198
    • Law, B.K.1    Chytil, A.2    Dumont, N.3    Hamilton, E.G.4    Waltner-Law, M.E.5    Aakre, M.E.6
  • 91
    • 22944447140 scopus 로고    scopus 로고
    • Signaling and endocytosis: A team effort for cell migration
    • Le Roy, C., & Wrana, J. L. (2005). Signaling and endocytosis: a team effort for cell migration. Developments in Cell, 9, 167-168.
    • (2005) Developments in Cell , vol.9 , pp. 167-168
    • Le Roy, C.1    Wrana, J.L.2
  • 93
    • 0037167792 scopus 로고    scopus 로고
    • Autocrine TGFβ supports growth and survival of human breast cancer MDA-MB-231 cells
    • Lei, X., Bandyopadhyay, A., Le, T., & Sun, L. (2002). Autocrine TGFβ supports growth and survival of human breast cancer MDA-MB-231 cells. Oncogene, 21, 7514-7523.
    • (2002) Oncogene , vol.21 , pp. 7514-7523
    • Lei, X.1    Bandyopadhyay, A.2    Le, T.3    Sun, L.4
  • 95
    • 21244447539 scopus 로고    scopus 로고
    • Global analysis of Smad2/3-dependent TGF-β signaling in living mice reveals prominent tissue-specific responses to injury
    • Lin, A. H., Luo, J., Mondshein, L. H., ten Dijke, P., Vivien, D., Contag, C. H., et al. (2005). Global analysis of Smad2/3-dependent TGF-β signaling in living mice reveals prominent tissue-specific responses to injury. Journal of Immunology, 175, 547-554.
    • (2005) Journal of Immunology , vol.175 , pp. 547-554
    • Lin, A.H.1    Luo, J.2    Mondshein, L.H.3    Ten Dijke, P.4    Vivien, D.5    Contag, C.H.6
  • 96
    • 0345275872 scopus 로고    scopus 로고
    • Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma
    • Liu, X., Lee, J., Cooley, M., Bhogte, E., Hartley, S., & Glick, A. (2003). Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma. Cancer Research, 63, 7760-7768.
    • (2003) Cancer Research , vol.63 , pp. 7760-7768
    • Liu, X.1    Lee, J.2    Cooley, M.3    Bhogte, E.4    Hartley, S.5    Glick, A.6
  • 97
    • 0033563132 scopus 로고    scopus 로고
    • Overexpression of cyclins D1 and e is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development
    • Lonardo, F., Rusch, V., Langenfeld, J., Dmitrovsky, E., & Klimstra, D. S. (1999). Overexpression of cyclins D1 and E is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development. Cancer Research, 59, 2470-2476.
    • (1999) Cancer Research , vol.59 , pp. 2470-2476
    • Lonardo, F.1    Rusch, V.2    Langenfeld, J.3    Dmitrovsky, E.4    Klimstra, D.S.5
  • 98
    • 0029793062 scopus 로고    scopus 로고
    • Genomic structure of the transforming growth factor β type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers
    • Lu, S. L., Zhang, W. C., Akiyama, Y., Nomizu, T., & Yuasa, Y. (1996). Genomic structure of the transforming growth factor β type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers. Cancer Research, 56, 4595-4598.
    • (1996) Cancer Research , vol.56 , pp. 4595-4598
    • Lu, S.L.1    Zhang, W.C.2    Akiyama, Y.3    Nomizu, T.4    Yuasa, Y.5
  • 99
    • 0035004797 scopus 로고    scopus 로고
    • Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPCβ4 genes during pancreatic carcinogenesis
    • Luttges, J., Galehdari, H., Brocker, V., Schwarte-Waldhoff, I., Henne-Bruns, D., Kloppel, G., et al. (2001). Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPCβ4 genes during pancreatic carcinogenesis. American Journal of Pathology, 158, 1677-1683.
    • (2001) American Journal of Pathology , vol.158 , pp. 1677-1683
    • Luttges, J.1    Galehdari, H.2    Brocker, V.3    Schwarte-Waldhoff, I.4    Henne-Bruns, D.5    Kloppel, G.6
  • 100
    • 0033814963 scopus 로고    scopus 로고
    • Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease
    • Maitra, A., Molberg, K., Albores-Saavedra, J., & Lindberg, G. (2000). Loss of Dpc4 expression in colonic adenocarcinomas correlates with the presence of metastatic disease. American Journal of Pathology, 157, 1105-1111.
    • (2000) American Journal of Pathology , vol.157 , pp. 1105-1111
    • Maitra, A.1    Molberg, K.2    Albores-Saavedra, J.3    Lindberg, G.4
  • 101
    • 17144400393 scopus 로고    scopus 로고
    • TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    • Marie, J. C., Letterio, J. J., Gavin, M., & Rudensky, A. Y. (2005). TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. Journal of Experimental Medicine, 201, 1061-1067.
    • (2005) Journal of Experimental Medicine , vol.201 , pp. 1061-1067
    • Marie, J.C.1    Letterio, J.J.2    Gavin, M.3    Rudensky, A.Y.4
  • 102
    • 0029066689 scopus 로고
    • Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability
    • Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., et al. (1995). Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science, 268, 1336-1338.
    • (1995) Science , vol.268 , pp. 1336-1338
    • Markowitz, S.1    Wang, J.2    Myeroff, L.3    Parsons, R.4    Sun, L.5    Lutterbaugh, J.6
  • 103
    • 0030802978 scopus 로고    scopus 로고
    • Antisense oligonuceotides specific for transforming growth factor β2 inhibit the growth of malignant mesothelioma both in vitro and in vivo
    • Marzo, A. L., Fitzpatrick, D. R., Robinson, B. W., & Scott, B. (1997). Antisense oligonuceotides specific for transforming growth factor β2 inhibit the growth of malignant mesothelioma both in vitro and in vivo. Cancer Research, 57, 3200-3207.
    • (1997) Cancer Research , vol.57 , pp. 3200-3207
    • Marzo, A.L.1    Fitzpatrick, D.R.2    Robinson, B.W.3    Scott, B.4
  • 104
    • 0034644472 scopus 로고    scopus 로고
    • TGF-β signaling in growth control, cancer, and heritable disorders
    • Massagué, J., Blain, S. W., & Lo, R. S. (2000). TGF-β signaling in growth control, cancer, and heritable disorders. Cell, 103, 295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massagué, J.1    Blain, S.W.2    Lo, R.S.3
  • 105
    • 10744225133 scopus 로고    scopus 로고
    • SB-431542 and Gleevec inhibit transforming growth factor-β-induced proliferation of human osteosarcoma cells
    • Matsuyama, S., Iwadate, M., Kondo, M., Saitoh, M., Hanyu, A., Shimizu, K., et al. (2003). SB-431542 and Gleevec inhibit transforming growth factor-β-induced proliferation of human osteosarcoma cells. Cancer Research, 63, 7791-7798.
    • (2003) Cancer Research , vol.63 , pp. 7791-7798
    • Matsuyama, S.1    Iwadate, M.2    Kondo, M.3    Saitoh, M.4    Hanyu, A.5    Shimizu, K.6
  • 106
    • 0035879276 scopus 로고    scopus 로고
    • Stress-inducible transcription factor CHOP/GADD153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms
    • Maytin, E. V., Ubeda, M., Lin, J. C., & Habener, J. F. (2001). Stress-inducible transcription factor CHOP/GADD153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms. Experimental Cell Research, 267, 193-204.
    • (2001) Experimental Cell Research , vol.267 , pp. 193-204
    • Maytin, E.V.1    Ubeda, M.2    Lin, J.C.3    Habener, J.F.4
  • 107
    • 23144461051 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to lung
    • Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., et al. (2005). Genes that mediate breast cancer metastasis to lung. Nature, 436, 518-524.
    • (2005) Nature , vol.436 , pp. 518-524
    • Minn, A.J.1    Gupta, G.P.2    Siegel, P.M.3    Bos, P.D.4    Shu, W.5    Giri, D.D.6
  • 109
    • 0034618406 scopus 로고    scopus 로고
    • Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4
    • Morén, A., Itoh, S., Moustakas, A., ten Dijke, P., Heldin, C.-H. (2000). Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4. Oncogene, 19, 4396-4404.
    • (2000) Oncogene , vol.19 , pp. 4396-4404
    • Morén, A.1    Itoh, S.2    Moustakas, A.3    Ten Dijke, P.4    Heldin, C.-H.5
  • 110
    • 0035312976 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor β signaling through interaction with CREB-binding protein/p300
    • Mori, N., Morishita, M., Tsukazaki, T., Giam, C. Z., Kumatori, A., Tanaka, Y., et al. (2001). Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor β signaling through interaction with CREB-binding protein/p300. Blood, 97, 2137-2144.
    • (2001) Blood , vol.97 , pp. 2137-2144
    • Mori, N.1    Morishita, M.2    Tsukazaki, T.3    Giam, C.Z.4    Kumatori, A.5    Tanaka, Y.6
  • 111
    • 0002927539 scopus 로고
    • Type β transforming growth factor is a growth stimulator and a growth inhibitor
    • J. Feramisco, B. Ozanne & C. Stiles (Eds.), Cold Spring Harbor, Cold Spring Harbor Laboratory
    • Moses, H. L., Tucker, R. F., Leof, E. B., Coffey, R. J. Jr., Halper, J., & Shipley, G. D. (1985). Type β transforming growth factor is a growth stimulator and a growth inhibitor. In J. Feramisco, B. Ozanne & C. Stiles (Eds.), Cancer Cells 3. (pp. 67-71). Cold Spring Harbor, Cold Spring Harbor Laboratory.
    • (1985) Cancer Cells , vol.3 , pp. 67-71
    • Moses, H.L.1    Tucker, R.F.2    Leof, E.B.3    Coffey Jr., R.J.4    Halper, J.5    Shipley, G.D.6
  • 116
    • 10844224603 scopus 로고    scopus 로고
    • Conditional overexpression of active transforming growth factor β1 accelerates metastases of transgenic mammary tumors
    • Muraoka-Cook, R. S., Kurokawa, H., Koh, Y., Rorbes, J. T., Roebuck, L. R., Barcellos-Hoff, M. H., et al. (2004). Conditional overexpression of active transforming growth factor β1 accelerates metastases of transgenic mammary tumors. Cancer Research, 64, 9002-9011.
    • (2004) Cancer Research , vol.64 , pp. 9002-9011
    • Muraoka-Cook, R.S.1    Kurokawa, H.2    Koh, Y.3    Rorbes, J.T.4    Roebuck, L.R.5    Barcellos-Hoff, M.H.6
  • 117
    • 0037049877 scopus 로고    scopus 로고
    • Enhancement of tumorigenic, metastatic and in vitro invasive capacity of rat mammary tumor cells by transforming growth factor-β
    • Nakata, D., Hamada, J., Ba, Y., Matsushita, K., Shibata, T., Hosokawa, M., et al. (2002). Enhancement of tumorigenic, metastatic and in vitro invasive capacity of rat mammary tumor cells by transforming growth factor-β. Cancer Letters, 175, 95-106.
    • (2002) Cancer Letters , vol.175 , pp. 95-106
    • Nakata, D.1    Hamada, J.2    Ba, Y.3    Matsushita, K.4    Shibata, T.5    Hosokawa, M.6
  • 120
    • 0032547895 scopus 로고    scopus 로고
    • TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
    • Oft, M., Heider, K. H., & Beug, H. (1998). TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis. Current Biology, 8, 1243-1252.
    • (1998) Current Biology , vol.8 , pp. 1243-1252
    • Oft, M.1    Heider, K.H.2    Beug, H.3
  • 121
    • 0027960437 scopus 로고
    • Overexpression of human cyclin D1 reduces the transforming growth factor β (TGF-β) type II receptor and growth inhibition by TGF-β1 in an immortalized human esophageal epithelial cell line
    • Okamoto, A., Jiang, W., Kim, S.-J., Spillare, E. A., Stoner, G. D., Weinstein, I. B., et al. (1994). Overexpression of human cyclin D1 reduces the transforming growth factor β (TGF-β) type II receptor and growth inhibition by TGF-β1 in an immortalized human esophageal epithelial cell line. Proceedings of the National Academy of Sciences of the United States of America, 91, 11576-11580.
    • (1994) Proceedings of the National Academy of Sciences of the United States of America , vol.91 , pp. 11576-11580
    • Okamoto, A.1    Jiang, W.2    Kim, S.-J.3    Spillare, E.A.4    Stoner, G.D.5    Weinstein, I.B.6
  • 122
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity
    • Ozdamar, B., Bose, R., Barrios-Rodiles, M., Wang, H. R., Zhang, Y., & Wrana, J. L. (2005). Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity. Science, 307, 1603-1609.
    • (2005) Science , vol.307 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.R.4    Zhang, Y.5    Wrana, J.L.6
  • 123
    • 20144379460 scopus 로고    scopus 로고
    • Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(WAF1/Cip1)
    • Pardali, K., Kowanetz, M., Heldin, C.-H., & Moustakas, A. (2005). Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(WAF1/Cip1). Journal of Cellular Physiology, 204, 260-272.
    • (2005) Journal of Cellular Physiology , vol.204 , pp. 260-272
    • Pardali, K.1    Kowanetz, M.2    Heldin, C.-H.3    Moustakas, A.4
  • 124
    • 0034703083 scopus 로고    scopus 로고
    • Role of smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor β
    • Pardali, K., Kurisaki, A., Morén, A., ten Dijke, P., Kardassis, D., & Moustakas, A. (2000). Role of smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor β. Journal of Biological Chemistry, 275, 29244-29256.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 29244-29256
    • Pardali, K.1    Kurisaki, A.2    Morén, A.3    Ten Dijke, P.4    Kardassis, D.5    Moustakas, A.6
  • 125
    • 0037092964 scopus 로고    scopus 로고
    • Transforming growth factor β signaling is disabled early in human endometrial carcinogenesis concomitant with loss of growth inhibition
    • Parekh, T. V., Gama, P., Wen, X., Demopoulos, R., Munger, J. S., Carcangiu, M. L., et al. (2002). Transforming growth factor β signaling is disabled early in human endometrial carcinogenesis concomitant with loss of growth inhibition. Cancer Research, 62, 2778-2790.
    • (2002) Cancer Research , vol.62 , pp. 2778-2790
    • Parekh, T.V.1    Gama, P.2    Wen, X.3    Demopoulos, R.4    Munger, J.S.5    Carcangiu, M.L.6
  • 126
    • 0030639334 scopus 로고    scopus 로고
    • Expression of an antisense transforming growth factor-β1 transgene reduces tumorigenicity of EMT6 mammary tumor cells
    • Park, J. A., Wang, E., Kurt, R. A., Schluter, S. F., Hersh, E. M., Akporiaye, E. T. (1997). Expression of an antisense transforming growth factor-β1 transgene reduces tumorigenicity of EMT6 mammary tumor cells. Cancer Gene Therapy, 4, 42-50.
    • (1997) Cancer Gene Therapy , vol.4 , pp. 42-50
    • Park, J.A.1    Wang, E.2    Kurt, R.A.3    Schluter, S.F.4    Hersh, E.M.5    Akporiaye, E.T.6
  • 127
    • 23044437149 scopus 로고    scopus 로고
    • Endoglin null endothelial cells proliferate and are more responsive to transforming growth factor β with higher affinity receptors and an activated ALK1 pathway
    • Pece-Barbara, N., Vera, S., Kathirkamathamby, K., Liebner, S., Di Gugliemo, G. M., Dejana, E., et al. (2005). Endoglin null endothelial cells proliferate and are more responsive to transforming growth factor β with higher affinity receptors and an activated ALK1 pathway. Journal of Biological Chemistry, 280, 27800-27808.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 27800-27808
    • Pece-Barbara, N.1    Vera, S.2    Kathirkamathamby, K.3    Liebner, S.4    Di Gugliemo, G.M.5    Dejana, E.6
  • 128
    • 20044375562 scopus 로고    scopus 로고
    • Kinetic characterization of novel pyrazole TGF-β receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition
    • Peng, S. B., Yan, L., Xia, X., Watkins, S. A., Brooks, H. B., Beight, D., et al. (2005). Kinetic characterization of novel pyrazole TGF-β receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition. Biochemistry, 44, 2293-2304.
    • (2005) Biochemistry , vol.44 , pp. 2293-2304
    • Peng, S.B.1    Yan, L.2    Xia, X.3    Watkins, S.A.4    Brooks, H.B.5    Beight, D.6
  • 129
    • 0028221238 scopus 로고
    • Vascular endothelial growth factor is induced in response to transforming growth factor β in fibroblastic and epithelial cells
    • Pertovaara, L., Kaipainen, A., Mustonen, T., Orpana, A., Ferrara, N., Saksela, O., et al. (1994). Vascular endothelial growth factor is induced in response to transforming growth factor β in fibroblastic and epithelial cells. Journal of Biological Chemistry, 269, 6271-6274.
    • (1994) Journal of Biological Chemistry , vol.269 , pp. 6271-6274
    • Pertovaara, L.1    Kaipainen, A.2    Mustonen, T.3    Orpana, A.4    Ferrara, N.5    Saksela, O.6
  • 132
    • 0025348820 scopus 로고
    • TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains
    • Pietenpol, J. A., Stein, R. W., Moran, E., Yaciuk, P., Schlegel, R., Lyons, R. M., et al. (1990). TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell, 61, 777-785.
    • (1990) Cell , vol.61 , pp. 777-785
    • Pietenpol, J.A.1    Stein, R.W.2    Moran, E.3    Yaciuk, P.4    Schlegel, R.5    Lyons, R.M.6
  • 133
    • 0035400114 scopus 로고    scopus 로고
    • N-[3,4-dimethyloxycinnamoyl]-anthranilic acid (tranilast) inhibits transforming growth factor-β release and reduces migration and invasiveness of human malignant glioma cells
    • Platten, M., Wild-Bode, C., Wick, W., Leitlein, J., Dichgans, J., & Weller, M. (2001). N-[3,4-dimethyloxycinnamoyl]-anthranilic acid (tranilast) inhibits transforming growth factor-β release and reduces migration and invasiveness of human malignant glioma cells. International Journal of Cancer, 93, 53-61.
    • (2001) International Journal of Cancer , vol.93 , pp. 53-61
    • Platten, M.1    Wild-Bode, C.2    Wick, W.3    Leitlein, J.4    Dichgans, J.5    Weller, M.6
  • 135
    • 0033551691 scopus 로고    scopus 로고
    • Evidence that Smad2 is a tumor-suppressor implicated in the control of cellular invasion
    • Prunier, C., Mazars, A., Noe, V., Bruyneel, E., Mareel, M., Gespach, C., et al. (1999). Evidence that Smad2 is a tumor-suppressor implicated in the control of cellular invasion. Journal of Biological Chemistry, 274, 22919-22922.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 22919-22922
    • Prunier, C.1    Mazars, A.2    Noe, V.3    Bruyneel, E.4    Mareel, M.5    Gespach, C.6
  • 136
    • 0033377548 scopus 로고    scopus 로고
    • TGF-β and cancer
    • Reiss, M. (1999). TGF-β and cancer. Microbes and Infection, 1, 1327-1347.
    • (1999) Microbes and Infection , vol.1 , pp. 1327-1347
    • Reiss, M.1
  • 137
    • 0033521118 scopus 로고    scopus 로고
    • Transforming growth factor-β-mediated p15(INK4B) induction and growth inhibition in astrocytes is Smad3-dependent and a pathway prominently altered in human glioma cell lines
    • Rich, J. N., Zhang, M., Datto, M. B., Bigner, D. D., & Wang, X.-F. (1999). Transforming growth factor-β-mediated p15(INK4B) induction and growth inhibition in astrocytes is Smad3-dependent and a pathway prominently altered in human glioma cell lines. Journal of Biological Chemistry, 274. 35053-35058.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 35053-35058
    • Rich, J.N.1    Zhang, M.2    Datto, M.B.3    Bigner, D.D.4    Wang, X.-F.5
  • 141
    • 0034803035 scopus 로고    scopus 로고
    • Soluble type II transforming growth factor-β (TGF-β) receptor inhibits TGF-β signaling in COLO-357 pancreatic cancer cells in vitro and attenuates tumor formation
    • Rowland-Goldsmith, M. A., Maruyama, H., Kusama, T., Ralli, S., & Korc, M. (2001). Soluble type II transforming growth factor-β (TGF-β) receptor inhibits TGF-β signaling in COLO-357 pancreatic cancer cells in vitro and attenuates tumor formation. Clinical Cancer Research, 7, 2931-2940.
    • (2001) Clinical Cancer Research , vol.7 , pp. 2931-2940
    • Rowland-Goldsmith, M.A.1    Maruyama, H.2    Kusama, T.3    Ralli, S.4    Korc, M.5
  • 142
    • 0036050857 scopus 로고    scopus 로고
    • Soluble type II transforming growth factor-β receptor attenuates expression of metastasis-associated genes and suppresses pancreatic cancer cell metastasis
    • Rowland-Goldsmith, M. A., Maruyama, H., Matsuda, K., Idezawa, T., Ralli, M., Ralli, S., et al. (2002). Soluble type II transforming growth factor-β receptor attenuates expression of metastasis-associated genes and suppresses pancreatic cancer cell metastasis. Mol Cancer Ther, 1, 161-167.
    • (2002) Mol Cancer Ther , vol.1 , pp. 161-167
    • Rowland-Goldsmith, M.A.1    Maruyama, H.2    Matsuda, K.3    Idezawa, T.4    Ralli, M.5    Ralli, S.6
  • 143
    • 15644373914 scopus 로고    scopus 로고
    • Expression of cell cycle proteins in 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone-induced mouse lung tumors
    • Sabourin, C. L. K., Wang, O.-S., Ralston, S. L., Evans, J., Coate, J., Herzog, C. R., et al. (1998). Expression of cell cycle proteins in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumors. Experimental Lung Research, 24, 499-521.
    • (1998) Experimental Lung Research , vol.24 , pp. 499-521
    • Sabourin, C.L.K.1    Wang, O.-S.2    Ralston, S.L.3    Evans, J.4    Coate, J.5    Herzog, C.R.6
  • 144
    • 0034480072 scopus 로고    scopus 로고
    • An elevated serum level of transforming growth factor-β1 (TGF-β1) significantly correlated with lymph node matastasis and poor prognosis in patients with gastric carcinoma
    • Saito, H., Tsujitani, S., Oka, S., Kondo, A., Ikeguchi, M., Maeta, M., et al. (2000). An elevated serum level of transforming growth factor-β1 (TGF-β1) significantly correlated with lymph node matastasis and poor prognosis in patients with gastric carcinoma. Anticancer Research, 20, 4489-4493.
    • (2000) Anticancer Research , vol.20 , pp. 4489-4493
    • Saito, H.1    Tsujitani, S.2    Oka, S.3    Kondo, A.4    Ikeguchi, M.5    Maeta, M.6
  • 146
    • 0032878291 scopus 로고    scopus 로고
    • A deletion in the gene for transforming growth factor β type I receptor abolishes growth regulation by transforming growth factor β in a cutaneous T-cell lymphoma
    • Schiemann, W. P., Pfeifer, W. M., Levi, E., Kadin, M. E., & Lodish, H. F. (1999). A deletion in the gene for transforming growth factor β type I receptor abolishes growth regulation by transforming growth factor β in a cutaneous T-cell lymphoma. Blood, 94, 2854-2861.
    • (1999) Blood , vol.94 , pp. 2854-2861
    • Schiemann, W.P.1    Pfeifer, W.M.2    Levi, E.3    Kadin, M.E.4    Lodish, H.F.5
  • 147
    • 22044456529 scopus 로고    scopus 로고
    • Intracerebral and intrathecal infusion of the TGF-β2-specific antisense phosphorothioate oligonucleotide AP12009 in rabbits and primates
    • Schlingensiepen, R., Goldbrunner, M., Szyrach, M. N., Stauder, G., Jachimczak, P., Bogahn, U., et al. (2005). Intracerebral and intrathecal infusion of the TGF-β2-specific antisense phosphorothioate oligonucleotide AP12009 in rabbits and primates. Oligonucleotides, 15, 94-104.
    • (2005) Oligonucleotides , vol.15 , pp. 94-104
    • Schlingensiepen, R.1    Goldbrunner, M.2    Szyrach, M.N.3    Stauder, G.4    Jachimczak, P.5    Bogahn, U.6
  • 149
    • 0030858765 scopus 로고    scopus 로고
    • Long-lasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin
    • Seon, B. K., Matsuno, F., Haruta, Y., Kondo, M., & Barcos, M. (1997). Long-lasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin. Clinical Cancer Research, 3, 1031-1044.
    • (1997) Clinical Cancer Research , vol.3 , pp. 1031-1044
    • Seon, B.K.1    Matsuno, F.2    Haruta, Y.3    Kondo, M.4    Barcos, M.5
  • 150
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-β1 gene results in inflammatory disease
    • Shull, M. M., Ornsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., et al. (1992). Targeted disruption of the mouse transforming growth factor-β1 gene results in inflammatory disease. Nature, 359, 693-699.
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1    Ornsby, I.2    Kier, A.B.3    Pawlowski, S.4    Diebold, R.J.5    Yin, M.6
  • 152
    • 0344496021 scopus 로고    scopus 로고
    • Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)
    • Singh, J., Chuaqui, C. E., Boriack-Sjodin, P. A., Lee, W. C., Pontz, T., Corbley, M. J., et al. (2003). Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI). Bioorganic & Medicinal Chemistry Letters, 13, 4355-4359.
    • (2003) Bioorganic & Medicinal Chemistry Letters , vol.13 , pp. 4355-4359
    • Singh, J.1    Chuaqui, C.E.2    Boriack-Sjodin, P.A.3    Lee, W.C.4    Pontz, T.5    Corbley, M.J.6
  • 153
    • 0034695483 scopus 로고    scopus 로고
    • Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor β-related signaling
    • Sirard, C., Kim, S., Mirtsos, C., Tadich, P., Hoodless, P. A., Itie, A., et al. (2000). Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor β-related signaling. Journal of Biological Chemistry, 275, 2063-2070.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 2063-2070
    • Sirard, C.1    Kim, S.2    Mirtsos, C.3    Tadich, P.4    Hoodless, P.A.5    Itie, A.6
  • 155
    • 0031717878 scopus 로고    scopus 로고
    • Decorin gene transfer-mediated suppression of TGF-β synthesis abrogates experimental malignant glioma growth in vivo
    • Stander, M., Naumann, U., Dumitrescu, L., Heneka, M., Loschmann, P., Gulbins, E., et al. (1998). Decorin gene transfer-mediated suppression of TGF-β synthesis abrogates experimental malignant glioma growth in vivo. Gene Therapy, 5, 1187-1194.
    • (1998) Gene Therapy , vol.5 , pp. 1187-1194
    • Stander, M.1    Naumann, U.2    Dumitrescu, L.3    Heneka, M.4    Loschmann, P.5    Gulbins, E.6
  • 156
    • 0033032231 scopus 로고    scopus 로고
    • Role of interleukin 10 and transforming growth factor β1 in the angiogenesis and metastasis of human prostate primary tumor cell lines from orthotopic implants in severe combined immunodeficiency mice
    • Stearns, M. E., Garcia, F. U., Fudge, K., Rhim, J., & Wang, M. (1999). Role of interleukin 10 and transforming growth factor β1 in the angiogenesis and metastasis of human prostate primary tumor cell lines from orthotopic implants in severe combined immunodeficiency mice. Clinical Cancer Research, 5, 711-720.
    • (1999) Clinical Cancer Research , vol.5 , pp. 711-720
    • Stearns, M.E.1    Garcia, F.U.2    Fudge, K.3    Rhim, J.4    Wang, M.5
  • 157
    • 0029961995 scopus 로고    scopus 로고
    • Regulation of basic fibroblast growth factor expression by transforming growth factor β in cultured human prostate stromal cells
    • Story, M. T., Hopp, K. A., & Meier, D. A. (1996). Regulation of basic fibroblast growth factor expression by transforming growth factor β in cultured human prostate stromal cells. Prostate, 28, 219-226.
    • (1996) Prostate , vol.28 , pp. 219-226
    • Story, M.T.1    Hopp, K.A.2    Meier, D.A.3
  • 158
    • 3442894138 scopus 로고    scopus 로고
    • Targeting endogenous transforming growth factor β receptor signaling in Smad4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype
    • Subramanian, G., Schwarz, R. E., Higgins, L., McEnroe, G., Chakravarty, S., Dugar, S., et al. (2004). Targeting endogenous transforming growth factor β receptor signaling in Smad4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype. Cancer Research, 64, 5200-5211.
    • (2004) Cancer Research , vol.64 , pp. 5200-5211
    • Subramanian, G.1    Schwarz, R.E.2    Higgins, L.3    McEnroe, G.4    Chakravarty, S.5    Dugar, S.6
  • 160
    • 0028075837 scopus 로고
    • Expression of transforming growth factor β type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells
    • Sun, L., Wu, G., Willson, J. K., Zborowska, E., Yang, J., Rajkarunanayake, I., et al. (1994). Expression of transforming growth factor β type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. Journal of Biological Chemistry, 269, 26449-26455.
    • (1994) Journal of Biological Chemistry , vol.269 , pp. 26449-26455
    • Sun, L.1    Wu, G.2    Willson, J.K.3    Zborowska, E.4    Yang, J.5    Rajkarunanayake, I.6
  • 162
    • 0030965529 scopus 로고    scopus 로고
    • Roles of the transforming growth factor-β1 and its type I and II receptors in the development of a pulmonary adenocarcinoma: Results of an immunohistochemical study
    • Takanami, I., Tanaka, F., Hashizume, & T., Kodaira, S. (1997). Roles of the transforming growth factor-β1 and its type I and II receptors in the development of a pulmonary adenocarcinoma: results of an immunohistochemical study. Journal of Surgical Oncology, 64, 262-267.
    • (1997) Journal of Surgical Oncology , vol.64 , pp. 262-267
    • Takanami, I.1    Tanaka, F.2    Hashizume, T.3    Kodaira, S.4
  • 163
    • 0037011062 scopus 로고    scopus 로고
    • Smad-dependent GADD45β expression mediates delayed activation of p38 MAP kinase by TGF-β
    • Takekawa, M., Tatebayashi, K., Itoh, F., Adachi, M., Imai, K., & Saito, H. (2002). Smad-dependent GADD45β expression mediates delayed activation of p38 MAP kinase by TGF-β. EMBO Journal, 21, 6473-6482.
    • (2002) EMBO Journal , vol.21 , pp. 6473-6482
    • Takekawa, M.1    Tatebayashi, K.2    Itoh, F.3    Adachi, M.4    Imai, K.5    Saito, H.6
  • 164
    • 2642614530 scopus 로고    scopus 로고
    • Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency
    • Tang, B., Böttinger, E. P., Jakowlew, S. B., Bagnall, K. M., Mariano, J., Anver, M. R., et al. (1998). Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency. Natural Medicines, 4, 802-807.
    • (1998) Natural Medicines , vol.4 , pp. 802-807
    • Tang, B.1    Böttinger, E.P.2    Jakowlew, S.B.3    Bagnall, K.M.4    Mariano, J.5    Anver, M.R.6
  • 165
    • 0033214970 scopus 로고    scopus 로고
    • Loss of responsiveness to transforming growth factor β induces malignant transformation of nontumorigenic rat prostate epithelial cells
    • Tang, B., de Castro, K., Barnes, H. E., Parks, W. T., Stewart, L., Böttinger, E. P., et al. (1999). Loss of responsiveness to transforming growth factor β induces malignant transformation of nontumorigenic rat prostate epithelial cells. Cancer Research, 59, 4834-4842.
    • (1999) Cancer Research , vol.59 , pp. 4834-4842
    • Tang, B.1    De Castro, K.2    Barnes, H.E.3    Parks, W.T.4    Stewart, L.5    Böttinger, E.P.6
  • 166
    • 0242285692 scopus 로고    scopus 로고
    • TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
    • Tang, B. W., Vu, M., Booker, T., Santer, S. J., Miller, F. R., Anver, M. R., et al. (2003). TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. Journal of Clinical Investigation, 112, 1116-1124.
    • (2003) Journal of Clinical Investigation , vol.112 , pp. 1116-1124
    • Tang, B.W.1    Vu, M.2    Booker, T.3    Santer, S.J.4    Miller, F.R.5    Anver, M.R.6
  • 167
    • 3042738106 scopus 로고    scopus 로고
    • Smad-binding defective mutant of transforming growth factor β type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines
    • Tian, F., Byfield, S. D., Parks, W. T., Stuelten, C. H., Nemani, D., Zhang, Y. E., et al. (2004). Smad-binding defective mutant of transforming growth factor β type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines. Cancer Research, 64, 4523-4530.
    • (2004) Cancer Research , vol.64 , pp. 4523-4530
    • Tian, F.1    Byfield, S.D.2    Parks, W.T.3    Stuelten, C.H.4    Nemani, D.5    Zhang, Y.E.6
  • 168
    • 0347626102 scopus 로고    scopus 로고
    • Reduction in Smad2/3 signaling enhances tumorigenesis but suppressed metastasis of breast cancer cell lines
    • Tian, F., DaCosta Byfield, S., Parks, W. T, Yoo, S., Felici, A., Tang, B., et al. (2003). Reduction in Smad2/3 signaling enhances tumorigenesis but suppressed metastasis of breast cancer cell lines. Cancer Research, 63. 8284-8292.
    • (2003) Cancer Research , vol.63 , pp. 8284-8292
    • Tian, F.1    DaCosta Byfield, S.2    Parks, W.T.3    Yoo, S.4    Felici, A.5    Tang, B.6
  • 170
  • 171
    • 0021720359 scopus 로고
    • Growth inhibitor from BSC-1 cells closely related to type β transforming growth factor
    • Tucker, R. F., Shipley, G. D., Moses, H. L., & Holley, R. W. (1984). Growth inhibitor from BSC-1 cells closely related to type β transforming growth factor. Science, 226, 705-707.
    • (1984) Science , vol.226 , pp. 705-707
    • Tucker, R.F.1    Shipley, G.D.2    Moses, H.L.3    Holley, R.W.4
  • 172
    • 0033524356 scopus 로고    scopus 로고
    • Overexpression of transforming growth factor β-type II receptor reduces tumorigenicity and metastatic potential of K-ras-transformed thyroid cells
    • Turco, A., Coppa, A., Aloe, S., Baccheschi, G., Morrone, S., Zupi, G., et al. (1999). Overexpression of transforming growth factor β-type II receptor reduces tumorigenicity and metastatic potential of K-ras-transformed thyroid cells. International Journal of Cancer, 80, 85-91.
    • (1999) International Journal of Cancer , vol.80 , pp. 85-91
    • Turco, A.1    Coppa, A.2    Aloe, S.3    Baccheschi, G.4    Morrone, S.5    Zupi, G.6
  • 173
    • 0036828120 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-β activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model
    • Tuxhorn, J. A., McAlhany, S. J., Yang, F., Dang, T. D., & Rowley, D. R. (2002). Inhibition of transforming growth factor-β activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model. Cancer Research, 62, 6021-6025.
    • (2002) Cancer Research , vol.62 , pp. 6021-6025
    • Tuxhorn, J.A.1    McAlhany, S.J.2    Yang, F.3    Dang, T.D.4    Rowley, D.R.5
  • 174
    • 0029731630 scopus 로고    scopus 로고
    • Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers
    • Uchida, K., Nagatake, M., Osada, H., Yatabe, Y., Kondo, M., Mitsudomi, T., et al. (1996). Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers. Cancer Research, 56, 5583-5585.
    • (1996) Cancer Research , vol.56 , pp. 5583-5585
    • Uchida, K.1    Nagatake, M.2    Osada, H.3    Yatabe, Y.4    Kondo, M.5    Mitsudomi, T.6
  • 175
    • 0026712153 scopus 로고
    • Excessive production of transforming growth factor β1 can play an important role in the development of tumorigenesis by its action for angiogenesis. Validity of neutralizing antibodies to block tumor growth
    • Ueki, N., Nakazato, M., Ohkawa, T., Ikeda, T., Amuro, Y., Hada, T., et al. (1992). Excessive production of transforming growth factor β1 can play an important role in the development of tumorigenesis by its action for angiogenesis. Validity of neutralizing antibodies to block tumor growth. Biochimica et Biophysica Acta, 1137, 189-196.
    • (1992) Biochimica et Biophysica Acta , vol.1137 , pp. 189-196
    • Ueki, N.1    Nakazato, M.2    Ohkawa, T.3    Ikeda, T.4    Amuro, Y.5    Hada, T.6
  • 176
    • 7444226411 scopus 로고    scopus 로고
    • SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo
    • Uhl, M., Aulwurm, S., Wischhusen, J., Weiler, M., Ma, J. Y., Almirez, R., et al. (2004). SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Research, 64, 7954-7961.
    • (2004) Cancer Research , vol.64 , pp. 7954-7961
    • Uhl, M.1    Aulwurm, S.2    Wischhusen, J.3    Weiler, M.4    Ma, J.Y.5    Almirez, R.6
  • 177
    • 16344378397 scopus 로고    scopus 로고
    • TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
    • Valcourt, U., Kowanetz, M., Niimi, H., Heldin, C.-H., & Moustakas, A. (2005). TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Molecular Biology of the Cell, 16, 1987-2002
    • (2005) Molecular Biology of the Cell , vol.16 , pp. 1987-2002
    • Valcourt, U.1    Kowanetz, M.2    Niimi, H.3    Heldin, C.-H.4    Moustakas, A.5
  • 178
    • 0037742433 scopus 로고    scopus 로고
    • Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model
    • Vijaychandra, K., Lee, J., & Glick, A. (2003). Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model. Cancer Research, 63, 3447-3452.
    • (2003) Cancer Research , vol.63 , pp. 3447-3452
    • Vijaychandra, K.1    Lee, J.2    Glick, A.3
  • 180
    • 0036257378 scopus 로고    scopus 로고
    • Irradiated homozygous TGF-β1 knockout fibroblasts show enhanced clonogenic survival as compared with TGF-β1 wild-type fibroblasts
    • Von Pfeil, A., Hakenjos, L., Herskind, C., Dittmann, K., Weller, M., & Rodemann, H. P. (2002). Irradiated homozygous TGF-β1 knockout fibroblasts show enhanced clonogenic survival as compared with TGF-β1 wild-type fibroblasts. International Journal of Radiation Oncology, 78, 331-339.
    • (2002) International Journal of Radiation Oncology , vol.78 , pp. 331-339
    • Von Pfeil, A.1    Hakenjos, L.2    Herskind, C.3    Dittmann, K.4    Weller, M.5    Rodemann, H.P.6
  • 181
    • 0030056048 scopus 로고    scopus 로고
    • Reduced expression of transforming growth factor β type I receptor contributes to the malignancy of human colon carcinoma cells
    • Wang, J., Han, W., Zborowska, E., Liang, J., Wang, X., Willson, J. K. V., et al. (1996). Reduced expression of transforming growth factor β type I receptor contributes to the malignancy of human colon carcinoma cells. Journal of Biological Chemistry, 271, 17366-17371.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 17366-17371
    • Wang, J.1    Han, W.2    Zborowska, E.3    Liang, J.4    Wang, X.5    Willson, J.K.V.6
  • 182
    • 0029131403 scopus 로고
    • Demonstration that mutation of the type II transforming growth factor β receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells
    • Wang, J., Sun, L., Myeroff, L., Wang, X., Gentry, L. E., Yang, J., et al. (1995). Demonstration that mutation of the type II transforming growth factor β receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. Journal of Biological Chemistry, 270, 22044-22049.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 22044-22049
    • Wang, J.1    Sun, L.2    Myeroff, L.3    Wang, X.4    Gentry, L.E.5    Yang, J.6
  • 183
    • 0035887461 scopus 로고    scopus 로고
    • Inducible expression of transforming growth factor β1 in papillomas causes rapid metastasis
    • Weeks, B. H., He, W., Olson, K. L., & Wang, X. J. (2001). Inducible expression of transforming growth factor β1 in papillomas causes rapid metastasis. Cancer Research, 61, 7435-7443.
    • (2001) Cancer Research , vol.61 , pp. 7435-7443
    • Weeks, B.H.1    He, W.2    Olson, K.L.3    Wang, X.J.4
  • 185
    • 0034765067 scopus 로고    scopus 로고
    • Glimoa cell invasion: Regulation of metalloproteinase activity by TGF-β
    • Wick, W., Platten, M., & Weller, M. (2001). Glimoa cell invasion: Regulation of metalloproteinase activity by TGF-β. Journal of Neuro-oncology, 53, 177-185.
    • (2001) Journal of Neuro-oncology , vol.53 , pp. 177-185
    • Wick, W.1    Platten, M.2    Weller, M.3
  • 186
  • 189
    • 4344622055 scopus 로고    scopus 로고
    • Kip1 act in synergy to alter the sensitivity of naïve T-cells to TGF-β-mediated G1 arrest through modulation of IL-2 responsiveness
    • Kip1 act in synergy to alter the sensitivity of naïve T-cells to TGF-β-mediated G1 arrest through modulation of IL-2 responsiveness. Journal of Immunology, 173, 3093-3102.
    • (2004) Journal of Immunology , vol.173 , pp. 3093-3102
    • Wolfraim, L.A.1    Walz, T.M.2    James, Z.3    Fernandez, T.4    Letterio, J.J.5
  • 190
    • 0027548803 scopus 로고
    • Repression of autocrine transforming growth factor β1 and β2 in quiescent CBS colon carcinoma cells leads to progression of tumorigenic properties
    • Wu, S. P., Sun, L. Z., Wilson, J. K., Humphrey, J. L., Kerbel, R. S., & Brattain, M. G. (1993). Repression of autocrine transforming growth factor β1 and β2 in quiescent CBS colon carcinoma cells leads to progression of tumorigenic properties. Cell Death & Differentiation, 4, 115-123.
    • (1993) Cell Death & Differentiation , vol.4 , pp. 115-123
    • Wu, S.P.1    Sun, L.Z.2    Wilson, J.K.3    Humphrey, J.L.4    Kerbel, R.S.5    Brattain, M.G.6
  • 192
    • 0642306119 scopus 로고    scopus 로고
    • Transforming growth factor β-regulated gene expression in a mouse mammary gland epithelial cell line
    • Xie, L., Law, B. K., Aakre, M. E., Edgerton, M., Shyr, Y., Bhowmick, N. A., et al. (2003). Transforming growth factor β-regulated gene expression in a mouse mammary gland epithelial cell line. Breast Cancer Research, 5, R187-R198.
    • (2003) Breast Cancer Research , vol.5
    • Xie, L.1    Law, B.K.2    Aakre, M.E.3    Edgerton, M.4    Shyr, Y.5    Bhowmick, N.A.6
  • 193
    • 6944248910 scopus 로고    scopus 로고
    • Activation of the Erk pathway is required for TGF-β1-induced EMT in vitro
    • Xie, L., Law, B. K., Chyti, A. M., Brown, K. A., Aakre, M. E., & Moses, H. L. (2004). Activation of the Erk pathway is required for TGF-β1-induced EMT in vitro. Neoplasia, 6, 603-610.
    • (2004) Neoplasia , vol.6 , pp. 603-610
    • Xie, L.1    Law, B.K.2    Chyti, A.M.3    Brown, K.A.4    Aakre, M.E.5    Moses, H.L.6
  • 194
    • 0842327354 scopus 로고    scopus 로고
    • Frequent alterations of Smad signaling in human head and neck squamous cell carcinomas: A tissue microarray study
    • Xie, W., Bharathy, S., Kim, D., Haffty, B. G., Rimm, D. L., & Reiss, M. (2003). Frequent alterations of Smad signaling in human head and neck squamous cell carcinomas: a tissue microarray study. Oncology Research, 14, 61-73.
    • (2003) Oncology Research , vol.14 , pp. 61-73
    • Xie, W.1    Bharathy, S.2    Kim, D.3    Haffty, B.G.4    Rimm, D.L.5    Reiss, M.6
  • 195
    • 0037081179 scopus 로고    scopus 로고
    • Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: A tissue microarray study
    • Xie, W., Mertens, J. C., Reiss, D. J., Rimm, D. L., Camp, R. L., Haffty, B. G., et al. (2002). Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: A tissue microarray study. Cancer Research, 62, 497-505.
    • (2002) Cancer Research , vol.62 , pp. 497-505
    • Xie, W.1    Mertens, J.C.2    Reiss, D.J.3    Rimm, D.L.4    Camp, R.L.5    Haffty, B.G.6
  • 196
    • 0642306985 scopus 로고    scopus 로고
    • Loss of Smad signaling in colorectal cancer is associated with advanced disease and poor prognosis
    • Xie, W., Rimm, D. L., Lin, Y., Shih, W. J., & Reiss, M. (2003). Loss of Smad signaling in colorectal cancer is associated with advanced disease and poor prognosis. Cancer Journal, 9, 302-312.
    • (2003) Cancer Journal , vol.9 , pp. 302-312
    • Xie, W.1    Rimm, D.L.2    Lin, Y.3    Shih, W.J.4    Reiss, M.5
  • 197
    • 0034611611 scopus 로고    scopus 로고
    • Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
    • Xu, X., Brodie, S. G., Yang, X., Im, Y. H., Parks, W. T., Chen, L., et al. (2000). Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice. Oncogene, 19, 1868-1874.
    • (2000) Oncogene , vol.19 , pp. 1868-1874
    • Xu, X.1    Brodie, S.G.2    Yang, X.3    Im, Y.H.4    Parks, W.T.5    Chen, L.6
  • 199
    • 0036714017 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-β signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGF β type I receptor kinase
    • Yakymovych, I., Engstrom, U., Grimsby, S., Heldin, C.-H., & Souchelnytskyi, S. (2002). Inhibition of transforming growth factor-β signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGF β type I receptor kinase. Biochemistry, 41, 11000-11007.
    • (2002) Biochemistry , vol.41 , pp. 11000-11007
    • Yakymovych, I.1    Engstrom, U.2    Grimsby, S.3    Heldin, C.-H.4    Souchelnytskyi, S.5
  • 200
    • 0034568227 scopus 로고    scopus 로고
    • Smad protein expression and activation in transforming growth factor-β refractory human squamous cell carcinoma cells
    • Yan, W., Vellucci, V. F., & Reiss M. (2000). Smad protein expression and activation in transforming growth factor-β refractory human squamous cell carcinoma cells. Oncology Research, 12, 157-167.
    • (2000) Oncology Research , vol.12 , pp. 157-167
    • Yan, W.1    Vellucci, V.F.2    Reiss, M.3
  • 201
    • 0032588413 scopus 로고    scopus 로고
    • Suppression of TGF-β1 in human gliomas by retroviral gene transfection enhances susceptibility to LAK cells
    • Yananaka, R., Tanaka, R., Yoshida, S., Saitoh, T., Fujita, K., & Naganuma, H. (1999). Suppression of TGF-β1 in human gliomas by retroviral gene transfection enhances susceptibility to LAK cells. Journal of Neuro-Oncology, 43, 27-34.
    • (1999) Journal of Neuro-Oncology , vol.43 , pp. 27-34
    • Yananaka, R.1    Tanaka, R.2    Yoshida, S.3    Saitoh, T.4    Fujita, K.5    Naganuma, H.6
  • 202
    • 0025316140 scopus 로고    scopus 로고
    • Transforming growth factor β1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane
    • Yang, E. Y., & Moses, H. L. (1999). Transforming growth factor β1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane. Journal of Cell Biology, 111, 731-741.
    • (1999) Journal of Cell Biology , vol.111 , pp. 731-741
    • Yang, E.Y.1    Moses, H.L.2
  • 203
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang, J., Mani, S. A., Donaher, J. L., Ramaswamy, S., Itzykson, R. A., Come, C., et al. (2004). Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell, 117, 927-939.
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3    Ramaswamy, S.4    Itzykson, R.A.5    Come, C.6
  • 204
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of Smad3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
    • Yang, X., Letterio, J. J., Lechleider, R. J., Chen, L., Hayman, R., Gu, H., et al. (1999). Targeted disruption of Smad3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β. EMBO Journal, 18, 1280-1291.
    • (1999) EMBO Journal , vol.18 , pp. 1280-1291
    • Yang, X.1    Letterio, J.J.2    Lechleider, R.J.3    Chen, L.4    Hayman, R.5    Gu, H.6
  • 205
    • 0036087521 scopus 로고    scopus 로고
    • Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects
    • Yang, Y. A., Dukhanina, O., Tang, B., Mamura, M., Letterio, J. J., MacGregor, J., et al. (2002). Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects. Journal of Clinical Investigation, 109, 1607-1615.
    • (2002) Journal of Clinical Investigation , vol.109 , pp. 1607-1615
    • Yang, Y.A.1    Dukhanina, O.2    Tang, B.3    Mamura, M.4    Letterio, J.J.5    MacGregor, J.6
  • 206
    • 0032918414 scopus 로고    scopus 로고
    • TGF-β signaling blackade inhibits PTHrP secretion by breast cancer cells and bone metastases development
    • Yin, J. J., Selender, K., Chirgwin, J. M., Dallas, M., Grubbs, B. G., Wieser, R., et al. (1999). TGF-β signaling blackade inhibits PTHrP secretion by breast cancer cells and bone metastases development. Journal of Clinical Investigation, 103, 197-206.
    • (1999) Journal of Clinical Investigation , vol.103 , pp. 197-206
    • Yin, J.J.1    Selender, K.2    Chirgwin, J.M.3    Dallas, M.4    Grubbs, B.G.5    Wieser, R.6
  • 207
    • 10444261212 scopus 로고    scopus 로고
    • Development of TGF-β signalling inhibitors for cancer therapy
    • Yingling, J. M., Blanchard, K. L., & Sawyer, J. S. (2004). Development of TGF-β signalling inhibitors for cancer therapy. Nat Rev Drug Discov, 3, 1011-1022.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 1011-1022
    • Yingling, J.M.1    Blanchard, K.L.2    Sawyer, J.S.3
  • 208
    • 0242322012 scopus 로고    scopus 로고
    • Transforming growth factor β1-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation
    • Yoo, J., Ghiassi, M., Jirmanova, L., Balliet, A. G., Hoffman, B., Fornace, A. J. Jr., et al. (2003). Transforming growth factor β1-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation. Journal of Biological Chemistry, 278, 43001-43007.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 43001-43007
    • Yoo, J.1    Ghiassi, M.2    Jirmanova, L.3    Balliet, A.G.4    Hoffman, B.5    Fornace Jr., A.J.6
  • 209
    • 0037099745 scopus 로고    scopus 로고
    • TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-β responses
    • Yu, L., Herbert, M. C., & Zhang, Y. E. (2002). TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-β responses. EMBO Journal, 21, 3749-3759.
    • (2002) EMBO Journal , vol.21 , pp. 3749-3759
    • Yu, L.1    Herbert, M.C.2    Zhang, Y.E.3
  • 210
    • 0036038212 scopus 로고    scopus 로고
    • Suppression of in vivo tumorigenicity of rat hepatoma cell line KDH-8 cells by soluble TGF-β receptor type II
    • Zhao, W. L., Kobayashi, M., Ding, W., Yuan, L., Seth, P., Cornain, S., et al. (2002). Suppression of in vivo tumorigenicity of rat hepatoma cell line KDH-8 cells by soluble TGF-β receptor type II. Cancer Immunology and Immunotherapy, 51, 381-388.
    • (2002) Cancer Immunology and Immunotherapy , vol.51 , pp. 381-388
    • Zhao, W.L.1    Kobayashi, M.2    Ding, W.3    Yuan, L.4    Seth, P.5    Cornain, S.6
  • 211
    • 0141673551 scopus 로고    scopus 로고
    • Dual regulation of proliferation and growth arrest in prostatic stromal cells by transforming growth factor-β1
    • Zhou, W., Park, I., Pins, M., Kozlowski, J. M., Jovanovic, B., Zhang, J., et al. (2003). Dual regulation of proliferation and growth arrest in prostatic stromal cells by transforming growth factor-β1. Endocrinology, 144, 4280-4284.
    • (2003) Endocrinology , vol.144 , pp. 4280-4284
    • Zhou, W.1    Park, I.2    Pins, M.3    Kozlowski, J.M.4    Jovanovic, B.5    Zhang, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.