Transforming growth factor-β-mediated autocrine growth regulation of gliomas as detected with phosphorothioate antisense oligonucleotides

International Journal of Cancer

Volumn 65, Issue 3, 1996, Pages 332-337

  Jachimczak, Piotr ^a   Hessdörfer, Birgit ^a   Fabel Schulter, Klaus ^a   Wismeth, Cäcilie ^a   Brysch, Wolfgang ^b   Schlingensiepen, Karl Hermann ^c   Bauer, Albrecht ^a   Blesch, Armin ^a   Bogdahn, Ulrich ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Biognostik GmbH   (Germany)

^c MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOROTHIOATE ANTISENSES OLIGONUCLEOTIDE; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

ARTICLE; AUTOCRINE EFFECT; GLIOMA; GROWTH INHIBITION; GROWTH REGULATION; HUMAN; PRIORITY JOURNAL; TUMOR CELL LINE;

BASE SEQUENCE; CELL DIVISION; GLIOMA; HUMANS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES, ANTISENSE; THIONUCLEOTIDES; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 0030021142     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960126)65:3<332::AID-IJC10>3.0.CO;2-C     Document Type: Article

References (25)

1. AGRAWAL, S. and IYER, R.P., Modified oligonucleotides as therapeutic and diagnostic agents. Curr. Opin. Biotechonol., 6, 12-19 (1995).
2. BEHL, CH., WINKLER, J., BOGDAHN, U., MEIXENSBERGER, J., SCHLINGENSIEPEN, K-H. and BRYSCH, W., Autocrine growth regulation in neuroectodermal tumors as detected with oligodeoxynucleotide antisense molecules. Neurosurgery, 33, 679-684 (1993).
3. BERGOT, B.J. and EGAN, W., Separation of synthetic phosphorothioate oligodeoxynucleotides from their oxygenated (phosphodiester) defect species by strong-anion-exchange high-performance liquid chromatography. J. Chromatogr., 599, 34-42 (1992).
4. BODMER, S., STROMMER, K., FREI, K., SIEPL, C., DE TRIBOLET, N., HEID, I. and FONTANA, A., Immunosuppression and transforming growth factor-β in glioblastoma. Preferential production of transforming growth factor-β2. J. Immunol., 143, 3222-3229 (1989).
5. c-erb-B-2 proto-oncogene expression by antisense oligodeoxynucleotides down-regulates p185-associated tyrosine-kinase activity and strongly inhibits mammary tumor-cell proliferation. Cancer Gene Ther., 1, 99-105 (1994).
6. CHOMCZYNSKI, P. and SACCHI, N., Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159 (1987).
7. CONSTAM, D.B., PHILIPP, J., MALIPIERO, U.V., TEN DIJKE, P., SCHACHNER, M. and FONTANA, A., Differential expression of transformins growth factor-β1, -β2, and -β3 by glioblastoma cells, astrocytes, and microglia. J. ImmunoL, 148, 1404-1410 (1992).
8. HERMANSON, M., FUNA, K., HARTMAN, M., CLAESSON-WELSH, L., HELDIN, C-H., WESTERMARK, B. and NISTER, M., Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res., 52, 3213-3219 (1992).
9. JACHIMCZAK, P., BOGDAHN, U., SCHNEIDER, J., BEHL, CH., MEIXENSBERGER, J., APFEL, J., DÖRRIES, J., SCHLINGENSIEPEN, K-H, and BRYSCH, W., The effect of transforming growth factor-β2-specific phosphorothioate-antisense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma. J. Neurosurg., 78, 944-951 (1993).
10. JACHIMCZAK, P., SCHWULERA, U. and BOGDAHN, U., In vitro studies of cytokine-mediated interactions between malignant glioma and autologous peripheral blood mononuclear cells. J. Neurosurg., 81, 579-586 (1994).
11. JENINNGS, M.T., MACIUNAS, R.J., CARVER, R., BASCOM, CH.C., JUNEAU, P. and MOSES, H.L., TGF-β1 and TGF-β2 are potential growthregulators for low-grade and malignant gliomas in vitro: evidence in support of autocrine hypothesis. Int. J. Cancer, 49, 129-139 (1991).
12. LEON, S.P., ZHU, J. and BLACK, P.M., Genetic aberrations in human brain tumors. Neurosurgery. 34, 708-722 (1994).
13. MASSAGUÉ, J., ATTISANO, L. and WRANA, J.L., The TGF-β family and its composite receptors. Trends Cell Biol., 4, 172-178 (1994).
14. MURPHY, P.R., SATO, Y. and KNEE, R.S., Phosphorothioate antisense oligonucleotides against basic fibroblast growth factor inhibit anchorage-dependent and anchorage-independent growth of a malignant glioblastoma cell line. Mol. Endocrinol., 6, 877-884 (1992).
15. OLOFSSON, A., MIYAZONO, K., KANZAKI, T., COLOSETTI, P., ENGSTRÖM, U. and HELDIN, C.H., Transforming growth factor-β, -β2, and -β3 secreted by a human glioblastoma cell line. J. biol. Chem., 267, 19482-19488 (1992).
16. POLLACK, I.F., RANDALL, M.S., KRISTOFIK, M.P., KELLY, R.H., SELKER, R.G. and VERTOSICK, F.T., Response of low-passage human malignant gliomas in vitro to stimulation and selective inhibition of growth-factor-mediated pathways. J. Neurosurg., 75, 284-293 (1991).
17. SAMBROOK, J., FRITSCH, E.F. and MANIATIS, T., Molecular cloning. A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1989).
18. SAMUELS, V., BARRETT, J.M., BOCKMAN, S., PANTAZIS, C.G. and ALLEN, M.B., Immunocytochemical study of transforming growth factor expression in benign and malignant gliomas. Amer. J. Pathol., 134, 895-902 (1989).
19. SCHLINGENSIEPEN, K-H., SCHLINGENSIEPEN, R., KUNST, M., KLINGER, J., GERDES, W., SEIFERT, W. and BRYSCH, W., Opposite functions of jun B and c-jun in growth regulation and neuronal differentiation. Devel. Genet., 14, 305-312 (1993).
20. SPORN, M.B. and ROBERTS, A.B., Transforming growth factor-β: recent progress and new challenges. J. Cell Biol., 119, 1017-1021 (1992).
21. STEIN, C.A. and NARAYANAN, R., Antisense oligodeoxynucleotides. Curr. Opin. Oncol., 6, 587-594 (1994).
22. TADA, M. and DE TRIBOLET, N., Recent advances in immunobiology of brain tumors. J. Neuro-Oncol., 17, 261-271 (1993).
23. TUCKER, M. and GILLESPIE, G.Y., Production of a bioactive high molecular weight transforming growth factor beta-like molecule by human malignant glioma cell lines. Growth Factors, 11, 153-162 (1994).
24. WAGNER, R.W., Gene inhibition using antisense oligodeoxynucleotides. Nature (Lond.), 372, 333-335 (1994).
25. YUNG, W.K.A., New approaches in brain tumor therapy using gene transfer and antisense oligonucleotides. Curr. Opin. Oncol., 6, 235-239 (1994).