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Volumn 64, Issue 13, 2004, Pages 4523-4530

Smad-binding defective mutant of transforming growth factor β type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

EID: 3042738106     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-0030     Document Type: Article
Times cited : (70)

References (40)
  • 1
    • 0042307513 scopus 로고    scopus 로고
    • The two faces of transforming growth factor β in carcinogenesis
    • Roberts AB, Wakefield LM. The two faces of transforming growth factor β in carcinogenesis. Proc Natl Acad Sci USA 2003;100:8621-3.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8621-8623
    • Roberts, A.B.1    Wakefield, L.M.2
  • 2
    • 0036467496 scopus 로고    scopus 로고
    • TGF-β signaling: Positive and negative effects on tumorigenesis
    • Wakefield LM, Roberts AB. TGF-β signaling: positive and negative effects on tumorigenesis. Curr Opin Genet Dev 2002;12:22-9.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 22-29
    • Wakefield, L.M.1    Roberts, A.B.2
  • 3
    • 0031441041 scopus 로고    scopus 로고
    • Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor β receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]- anthracene
    • Bottinger EP, Jakubczak JL, Haines DC, Bagnall K, Wakefield LM. Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor β receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene. Cancer Res 1997;57:5564-70.
    • (1997) Cancer Res , vol.57 , pp. 5564-5570
    • Bottinger, E.P.1    Jakubczak, J.L.2    Haines, D.C.3    Bagnall, K.4    Wakefield, L.M.5
  • 4
    • 0036304111 scopus 로고    scopus 로고
    • Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    • Oft M, Akhurst RJ, Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol 2002;4:487-94.
    • (2002) Nat Cell Biol , vol.4 , pp. 487-494
    • Oft, M.1    Akhurst, R.J.2    Balmain, A.3
  • 5
    • 0035199487 scopus 로고    scopus 로고
    • Invasion and metastasis of a mammary tumor involves TGF-β signaling
    • McEarchem JA, Kobie JJ, Mack V, et al. Invasion and metastasis of a mammary tumor involves TGF-β signaling. Int J Cancer 2001;91:76-82.
    • (2001) Int J Cancer , vol.91 , pp. 76-82
    • McEarchem, J.A.1    Kobie, J.J.2    Mack, V.3
  • 6
    • 0030926005 scopus 로고    scopus 로고
    • A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-ā intracellular signaling specificity
    • Feng XH, Derynck R. A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-ā intracellular signaling specificity. EMBO J 1997;16:3912-23.
    • (1997) EMBO J , vol.16 , pp. 3912-3923
    • Feng, X.H.1    Derynck, R.2
  • 7
    • 0037423374 scopus 로고    scopus 로고
    • Elucidation of Smad requirement in transforming growth factor-β type I receptor-induced responses
    • Itoh S, Thorikay M, Kowanetz M, et al. Elucidation of Smad requirement in transforming growth factor-β type I receptor-induced responses. J Biol Chem 2003;278:3751-61.
    • (2003) J Biol Chem , vol.278 , pp. 3751-3761
    • Itoh, S.1    Thorikay, M.2    Kowanetz, M.3
  • 8
    • 0037099745 scopus 로고    scopus 로고
    • TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-β responses
    • Yu L, Hebert MC, Zhang YE. TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-β responses. EMBO J 2002;21:3749-59.
    • (2002) EMBO J , vol.21 , pp. 3749-3759
    • Yu, L.1    Hebert, M.C.2    Zhang, Y.E.3
  • 9
    • 0032213514 scopus 로고    scopus 로고
    • Transforming growth factor β type I receptor kinase mutant associated with metastatic breast cancer
    • Chen T, Carter D, Garrigue-Antar L, Reiss M. Transforming growth factor β type I receptor kinase mutant associated with metastatic breast cancer. Cancer Res 1998; 58:4805-10.
    • (1998) Cancer Res , vol.58 , pp. 4805-4810
    • Chen, T.1    Carter, D.2    Garrigue-Antar, L.3    Reiss, M.4
  • 10
    • 0030044330 scopus 로고    scopus 로고
    • MCF10AT: A model for the evolution of cancer from proliferative breast disease
    • Dawson PJ, Wolman SR, Tait L, Heppner GH, Miller FR. MCF10AT: a model for the evolution of cancer from proliferative breast disease. Am J Pathol 1996;148: 313-9.
    • (1996) Am J Pathol , vol.148 , pp. 313-319
    • Dawson, P.J.1    Wolman, S.R.2    Tait, L.3    Heppner, G.H.4    Miller, F.R.5
  • 11
    • 0035129885 scopus 로고    scopus 로고
    • Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCFIOAT cells
    • Santner SJ, Dawson PJ, Tait L, et al. Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCFIOAT cells. Breast Cancer Res Treat 2001;65:101-10.
    • (2001) Breast Cancer Res Treat , vol.65 , pp. 101-110
    • Santner, S.J.1    Dawson, P.J.2    Tait, L.3
  • 12
    • 0347626102 scopus 로고    scopus 로고
    • Reduction in smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines
    • Tian F, DaCosta BS, Parks WT, et al. Reduction in smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines. Cancer Res 2003;63:8284-92.
    • (2003) Cancer Res , vol.63 , pp. 8284-8292
    • Tian, F.1    DaCosta, B.S.2    Parks, W.T.3
  • 13
    • 0029662049 scopus 로고    scopus 로고
    • TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
    • Oft M, Peli J, Rudaz C, Schwarz H, Beug H, Reichmann E. TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev 1996;10:2462-77.
    • (1996) Genes Dev , vol.10 , pp. 2462-2477
    • Oft, M.1    Peli, J.2    Rudaz, C.3    Schwarz, H.4    Beug, H.5    Reichmann, E.6
  • 14
    • 0034194304 scopus 로고    scopus 로고
    • Roles of autocrine TGF-β receptor and Smad signaling in adipocyte differentiation
    • Choy L, Skillington J, Derynck R. Roles of autocrine TGF-β receptor and Smad signaling in adipocyte differentiation. J Cell Biol 2000;149:667-82.
    • (2000) J Cell Biol , vol.149 , pp. 667-682
    • Choy, L.1    Skillington, J.2    Derynck, R.3
  • 15
    • 0024509262 scopus 로고
    • Immunodetection and quantitation of the two forms of transforming growth factor-β (TGF-β 1 and TGF-β 2) secreted by cells in culture
    • Danielpour D, Dart LL, Flanders KC, Roberts AB, Sporn MB. Immunodetection and quantitation of the two forms of transforming growth factor-β (TGF-β 1 and TGF-β 2) secreted by cells in culture. J Cell Physiol 1989;138:79-86.
    • (1989) J Cell Physiol , vol.138 , pp. 79-86
    • Danielpour, D.1    Dart, L.L.2    Flanders, K.C.3    Roberts, A.B.4    Sporn, M.B.5
  • 16
    • 0036085920 scopus 로고    scopus 로고
    • SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    • Inman GJ, Nicolas FJ, Callahan JF, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 2002;62:65-74.
    • (2002) Mol Pharmacol , vol.62 , pp. 65-74
    • Inman, G.J.1    Nicolas, F.J.2    Callahan, J.F.3
  • 17
    • 0032014216 scopus 로고    scopus 로고
    • Human Smad3 and Smad4 are sequence-specific transcription activators
    • Zawel L, Dai JL, Buckhaults P, et al. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1998;1:611-7.
    • (1998) Mol Cell , vol.1 , pp. 611-617
    • Zawel, L.1    Dai, J.L.2    Buckhaults, P.3
  • 18
    • 0032110463 scopus 로고    scopus 로고
    • Smad2 and Smad3 positively and negatively regulate TGF β-dependent transcription through the forkhead DNA-binding protein FAST2
    • Labbe E, Silvestri C, Hoodless PA, Wrana JL, Attisano L. Smad2 and Smad3 positively and negatively regulate TGF β-dependent transcription through the forkhead DNA-binding protein FAST2. Mol Cell 1998;2:109-20.
    • (1998) Mol Cell , vol.2 , pp. 109-120
    • Labbe, E.1    Silvestri, C.2    Hoodless, P.A.3    Wrana, J.L.4    Attisano, L.5
  • 19
    • 0037085441 scopus 로고    scopus 로고
    • Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
    • Korchynskyi O, ten Dijke P. Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J Biol Chem 2002;277:4883-91.
    • (2002) J Biol Chem , vol.277 , pp. 4883-4891
    • Korchynskyi, O.1    Ten Dijke, P.2
  • 20
    • 0027421280 scopus 로고
    • Resistance to inhibition of cell growth by transforming growth factor-β and its role in oncogenesis
    • Fynan TM, Reiss M. Resistance to inhibition of cell growth by transforming growth factor-β and its role in oncogenesis. Crit Rev Oncog 1993;4:493-540.
    • (1993) Crit Rev Oncog , vol.4 , pp. 493-540
    • Fynan, T.M.1    Reiss, M.2
  • 21
    • 0035129885 scopus 로고    scopus 로고
    • Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells
    • Santner SJ, Dawson PJ, Tait L, et al. Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells. Breast Cancer Res Treat 2001;65:101-10.
    • (2001) Breast Cancer Res Treat , vol.65 , pp. 101-110
    • Santner, S.J.1    Dawson, P.J.2    Tait, L.3
  • 22
    • 0026425631 scopus 로고
    • Tumor invasion and metastasis: An imbalance of positive and negative regulation
    • Liotta LA, Stetler-Stevenson WG. Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res 1991;51:5054-9s.
    • (1991) Cancer Res , vol.51 , pp. 5054-509s
    • Liotta, L.A.1    Stetler-Stevenson, W.G.2
  • 23
    • 0035872426 scopus 로고    scopus 로고
    • Transforming growth factor β1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation
    • Ellenrieder V, Hendler SF, Boeck W, et al. Transforming growth factor β1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation. Cancer Res 2001;61:4222-8.
    • (2001) Cancer Res , vol.61 , pp. 4222-4228
    • Ellenrieder, V.1    Hendler, S.F.2    Boeck, W.3
  • 24
    • 0034612789 scopus 로고    scopus 로고
    • Role of transforming growth factor-β signaling in cancer
    • de Caestecker MP, Piek E, Roberts AB. Role of transforming growth factor-β signaling in cancer. J Natl Cancer Inst 2000;92:1388-402.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1388-1402
    • De Caestecker, M.P.1    Piek, E.2    Roberts, A.B.3
  • 25
    • 0032547895 scopus 로고    scopus 로고
    • TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
    • Oft M, Heider KH, Beug H. TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol 1998;8:1243-52.
    • (1998) Curr Biol , vol.8 , pp. 1243-1252
    • Oft, M.1    Heider, K.H.2    Beug, H.3
  • 26
    • 0242285692 scopus 로고    scopus 로고
    • TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
    • Tang B, Vu M, Booker T, et al. TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. J Clin Investig 2003;112:1116-24.
    • (2003) J Clin Investig , vol.112 , pp. 1116-1124
    • Tang, B.1    Vu, M.2    Booker, T.3
  • 27
    • 0025866180 scopus 로고
    • Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-β 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression
    • Overall CM, Wrana JL, Sodek J. Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-β 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression. J Biol Chem 1991;266:14064-71.
    • (1991) J Biol Chem , vol.266 , pp. 14064-14071
    • Overall, C.M.1    Wrana, J.L.2    Sodek, J.3
  • 28
    • 0034788236 scopus 로고    scopus 로고
    • Suppressor and oncogenic roles of transforming growth factor-β and its signaling pathways in tumorigenesis
    • Piek E, Roberts AB. Suppressor and oncogenic roles of transforming growth factor-β and its signaling pathways in tumorigenesis. Adv Cancer Res 2001;83:1-54.
    • (2001) Adv Cancer Res , vol.83 , pp. 1-54
    • Piek, E.1    Roberts, A.B.2
  • 29
    • 0035914339 scopus 로고    scopus 로고
    • Transforming growth factor-β repression of matrix metalloproteinase-I in dermal fibroblasts involves Smad3
    • Yuan W, Varga J. Transforming growth factor-β repression of matrix metalloproteinase-I in dermal fibroblasts involves Smad3. J Biol Chem 2001;276:38502-10.
    • (2001) J Biol Chem , vol.276 , pp. 38502-38510
    • Yuan, W.1    Varga, J.2
  • 30
    • 0032882539 scopus 로고    scopus 로고
    • Autocrine TGF-β-regulated expression of adhesion receptors and integrin-linked kinase in HT-144 melanoma cells correlates with their metastatic phenotype
    • Janji B, Melchior C, Gouon V, Vallar L, Kieffer N. Autocrine TGF-β-regulated expression of adhesion receptors and integrin-linked kinase in HT-144 melanoma cells correlates with their metastatic phenotype. Int J Cancer 1999;83:255-62.
    • (1999) Int J Cancer , vol.83 , pp. 255-262
    • Janji, B.1    Melchior, C.2    Gouon, V.3    Vallar, L.4    Kieffer, N.5
  • 31
    • 0026535245 scopus 로고
    • Autocrine induction of tumor protease production and invasion by a metallothionein-regulated TGF-β 1 (Ser223, 225)
    • Samuel SK, Hurta RA, Kondaiah P, et al. Autocrine induction of tumor protease production and invasion by a metallothionein-regulated TGF-β 1 (Ser223, 225). EMBO J 1992;11:1599-605.
    • (1992) EMBO J , vol.11 , pp. 1599-1605
    • Samuel, S.K.1    Hurta, R.A.2    Kondaiah, P.3
  • 32
    • 0030002175 scopus 로고    scopus 로고
    • Transforming growth factor β1 stimulates contrasting responses in metastatic versus primary mouse prostate cancer-derived cell lines in vitro
    • Sehgal I, Baley PA, Thompson TC. Transforming growth factor β1 stimulates contrasting responses in metastatic versus primary mouse prostate cancer-derived cell lines in vitro. Cancer Res 1996;56:3359-65.
    • (1996) Cancer Res , vol.56 , pp. 3359-3365
    • Sehgal, I.1    Baley, P.A.2    Thompson, T.C.3
  • 33
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis
    • Yu Q, Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis. Genes Dev 2000;14:163-76.
    • (2000) Genes Dev , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 34
    • 0035185853 scopus 로고    scopus 로고
    • Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
    • Bhowmick NA, Ghiassi M, Bakin A, et al. Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 2001;12:27-36.
    • (2001) Mol Biol Cell , vol.12 , pp. 27-36
    • Bhowmick, N.A.1    Ghiassi, M.2    Bakin, A.3
  • 35
    • 0033377867 scopus 로고    scopus 로고
    • TGF-(β) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
    • Piek E, Moustakas A, Kurisaki A, Heldin CH, ten Dijke P. TGF-(β) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci 1999;112(Pt 24): 4557-68.
    • (1999) J Cell Sci , vol.112 , Issue.PART 24 , pp. 4557-4568
    • Piek, E.1    Moustakas, A.2    Kurisaki, A.3    Heldin, C.H.4    Ten Dijke, P.5
  • 36
    • 0032909086 scopus 로고    scopus 로고
    • Genetic events and the role of TGF β in epithelial tumour progression
    • Akhurst RJ, Balmain A. Genetic events and the role of TGF β in epithelial tumour progression. J Pathol 1999;187:82-90.
    • (1999) J Pathol , vol.187 , pp. 82-90
    • Akhurst, R.J.1    Balmain, A.2
  • 37
    • 0029761702 scopus 로고    scopus 로고
    • Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: The potential for multiplex signalling
    • Denhardt DT. Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling. Biochem J 1996;318(Pt 3):729-47.
    • (1996) Biochem J , vol.318 , Issue.PART 3 , pp. 729-747
    • Denhardt, D.T.1
  • 38
    • 0037148532 scopus 로고    scopus 로고
    • Ras and TGF[β] cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways
    • Janda E, Lehmann K, Killisch I, et al. Ras and TGF[β] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J Cell Biol 2002;156:299-313.
    • (2002) J Cell Biol , vol.156 , pp. 299-313
    • Janda, E.1    Lehmann, K.2    Killisch, I.3
  • 39
    • 0037816160 scopus 로고    scopus 로고
    • Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
    • Siegel PM, Shu W, Cardiff RD, Muller WJ, Massague J. Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci USA 2003;100:8430-5.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8430-8435
    • Siegel, P.M.1    Shu, W.2    Cardiff, R.D.3    Muller, W.J.4    Massague, J.5
  • 40
    • 0242552529 scopus 로고    scopus 로고
    • Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor β1
    • Muraoka RS, Koh Y, Roebuck LR, et al. Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor β1. Mol Cell Biol 2003;23:8691-703.
    • (2003) Mol Cell Biol , vol.23 , pp. 8691-8703
    • Muraoka, R.S.1    Koh, Y.2    Roebuck, L.R.3


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