A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF-β signals

FEBS Letters

Volumn 430, Issue 3, 1998, Pages 201-204

  Goto, Daisuke ^a   Yagi, Ken ^a   Inoue, Hirofumi ^a   Iwamoto, Itsuo ^b   Kawabata, Masahiro ^a   Miyazono, Kohei ^a   Kato, Mitsuyasu ^a  

^a CANCER INSTITUTE   (Japan)

^b CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cancer; Dominant negative mutant; Smad; Transforming growth factor

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CELL PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; GROWTH INHIBITION; INHIBITION KINETICS; MALIGNANT TRANSFORMATION; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0032479464     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(98)00658-9     Document Type: Article

References (35)

1. Roberts A.B., Sporn M.B. Growth Factors. 8:1993;1-9.
2. Heldin C.-H., Miyazono K., ten Dijke P. Nature. 390:1997;465-471.
3. Massagué J., Hata A., Liu F. Trends Cell Biol. 7:1997;187-191.
4. Eppert K., Scherer S.W., Ozcelik H., Pirone R., Hoodless P., Kim H., Tsui L.C., Bapat B., Gallinger S., Andrulis I.L., Thomsen G.H., Wrana J.L., Attisano L. Cell. 86:1996;543-552.
5. Macías-Silva M., Abdollah S., Hoodless P.A., Pirone R., Attisano L., Wrana J.L. Cell. 87:1996;1215-1224.
6. Zhang Y., Feng X., We R., Derynck R. Nature. 383:1996;168-172.
7. Lagna G., Hata A., Hemmati-Brivanlou A., Massagué J. Nature. 383:1996;832-836.
8. Nakao A., Roijer E., Imamura T., Souchelnytskyi S., Stenman G., Heldin C.-H., ten Dijke P. J. Biol. Chem. 272:1997;2896-2900.
9. Nakao A., Imamura T., Souchelnytskyi S., Kawabata M., Ishisaki A., Oeda E., Tamaki K., Hanai J.-i., Heldin C.-H., Miyazono K., ten Dijke P. EMBO J. 16:1997;5353-5362.
10. Abdollah S., Macías-Silva M., Tsukazaki T., Hayashi H., Attisano L., Wrana J.L. J. Biol. Chem. 272:1997;27678-27685.
11. Souchelnytskyi S., Tamaki K., Engström U., Wernstedt C., ten Dijle P., Heldin C.-H. J. Biol. Chem. 272:1997;28107-28115.
12. Yingling J.M., Datto M.B., Wong C., Frederick J.P., Liberati N.T., Wang X.-F. Mol. Cell. Biol. 17:1997;7019-7028.
13. Liu F., Pouponnot C., Massagué J. Genes Dev. 11:1997;3157-3167.
14. Liu X., Sun Y., Constantinescu S.N., Karam E., Weinberg R.A., Lodish H.F. Proc. Natl. Acad. Sci. USA. 94:1997;10669-10674.
15. Markowitz S.D., Roberts A.B. Cytokine Growth Factor Rev. 7:1996;93-102.
16. Markowitz S., Wang J., Myeroff L., Parsons R., Sun L., Lutterbaugh J., Fan R.S., Zborowska E., Kinzler K.W., Vogelstein B., Brattain M., Willson J.K.V. Science. 268:1995;1336-1338.
17. Wang J., Sun L., Myeroff L., Wang X., Gentry L.E., Yang J., Liang J., Zborowska E., Markowitz S., Willson J.K.V., Brattain G. J. Biol. Chem. 270:1995;22044-22049.
18. Hahn S.A., Schutte M., Shamsul-Hoque A.T.M., Moskaluk C.A., da Costa L.T., Rozenblum E., Weinstein C.L., Fischer A., Yeo C.J., Hruban R.H., Kern S.E. Science. 271:1996;350-353.
19. Wu R.Y., Zhang Y., Feng X.H., Derynck R. Mol. Cell. Biol. 17:1997;2521-2528.
20. Thiagalingam S., Lengauer C., Leach F.S., Schutte M., Hahn S.A., Overhauser J., Willson J.K., Markowitz S., Hamilton S.R., Kern S.E., Kinzler K.W., Vogelstein B. Nature Genet. 13:1996;343-346.
21. Takagi Y., Kohmura H., Futamura M., Kida H., Tanemura H., Shimokawa K., Saji S. Gastroenterology. 111:1996;1369-1372.
22. Nagatake M., Takagi Y., Osada H., Uchida K., Mitsudomi T., Saji S., Shimokata K., Takahashi T., Takahashi T. Cancer Res. 56:1996;2718-2720.
23. Schutte M., Hruban R.H., Hedrick L., Cho K.R., Nadasdy G.M., Weinstein C.L., Bova G.S., Isaacs W.B., Cairns P., Nawroz H., Sidransky D., Casero R.J., Meltzer P.S., Hahn S.A., Kern S.E. Cancer Res. 56:1996;2527-2530.
24. Kim S.K., Fan Y., Papadimitrakopoulou V., Clayman G., Hittelman W.N., Hong W.K., Lotan R., Mao L. Cancer Res. 56:1996;2519-2521.
25. de Caestecker M.P., Hemmati P., Larisch-Bloch S., Ajmera R., Roberts A.B., Lechleider R.J. J. Biol. Chem. 272:1997;13690-13696.
26. de Winter J.P., Roelen B.A.J., ten Dijke P., van der Burg B., van den Eijnden-van Raaij A.J.M. Oncogene. 14:1997;1891-1899.
27. Uchida K., Nagatake M., Osada H., Yatabe Y., Kondo M., Mitsudomi T., Masuda A., Takahashi T., Takahashi T. Cancer Res. 56:1996;5583-5585.
28. Riggins G.J., Kinzler K.W., Vogelstein B., Thiagalingam S. Cancer Res. 57:1997;2578-2580.
29. Arai T., Akiyama Y., Okabe S., Ando M., Endo M., Yuasa Y. Cancer Lett. 122:1998;157-163.
30. Shi Y., Hata A., Lo R.S., Massagué J., Pavletich N.P. Nature. 388:1997;87-93.
31. Kato M., Ishizaki A., Hellman U., Wernstedt C., Kyogoku M., Miyazono K., Heldin C.-H., Funa K. J. Biol. Chem. 270:1995;12373-12379.
32. Roger S., Lo Y.-G., Chen Y., Shi N., Pavletich P., Massagué J. EMBO J. 17:1998;996-1005.
33. Imamura T., Takase M., Nishihara A., Oeda E., Hanai J.-i., Kawabata M., Miyazono K. Nature. 389:1997;622-626.
34. Nakao A., Afrakhte M., Morén A., Nakayama T., Christian J.L., Heuchel R., Itoh S., Kawabata M., Heldin N.-E., Heldin C.-H., ten Dijke P. Nature. 389:1997;631-635.
35. Hayashi H., Abdollah S., Qiu Y., Cai J., Xu Y.Y., Grinnell B.W., Richardson M.A., Topper J.N., Gimbrone M.J., Wrana J.L., Falb D. Cell. 89:1997;1165-1173.