메뉴 건너뛰기




Volumn 18, Issue 5, 1999, Pages 1280-1291

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β

Author keywords

Bacterial infections; Gene targeting; Inflammation; SMAD3; TGF signaling

Indexed keywords

ACTIVIN RECEPTOR; MUTANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033104503     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (773)

References (61)
  • 1
    • 0030613249 scopus 로고    scopus 로고
    • TGF-βRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
    • Abdollah, S., Macias-Silva, M., Tsukazaki, T. Hayashi, H., Attisano, L. and Wrana, J.L. (1997) TGF-βRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J. Biol. Chem., 22, 27678-27685.
    • (1997) J. Biol. Chem. , vol.22 , pp. 27678-27685
    • Abdollah, S.1    Macias-Silva, M.2    Tsukazaki, T.3    Hayashi, H.4    Attisano, L.5    Wrana, J.L.6
  • 2
    • 0032498328 scopus 로고    scopus 로고
    • Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers
    • Arai, T., Akiyama, Y., Okabe, S., Ando, M., Endo, M. and Yuasa, Y. (1998) Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers. Cancer Lett., 122, 157-163.
    • (1998) Cancer Lett. , vol.122 , pp. 157-163
    • Arai, T.1    Akiyama, Y.2    Okabe, S.3    Ando, M.4    Endo, M.5    Yuasa, Y.6
  • 3
    • 0029829230 scopus 로고    scopus 로고
    • A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway
    • Baker, J.C. and Harland, R.M. (1996) A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev., 10, 1880-1889.
    • (1996) Genes Dev. , vol.10 , pp. 1880-1889
    • Baker, J.C.1    Harland, R.M.2
  • 4
    • 0025776228 scopus 로고
    • Type I transforming growth factor-beta receptors on neutrophils mediate chemotaxis to transforming growth factor-beta
    • Brandes, M.E., Mai, U.E., Ohura, K. and Wahl, S.M. (1991) Type I transforming growth factor-beta receptors on neutrophils mediate chemotaxis to transforming growth factor-beta. J. Immunol., 147, 1600-1606.
    • (1991) J. Immunol. , vol.147 , pp. 1600-1606
    • Brandes, M.E.1    Mai, U.E.2    Ohura, K.3    Wahl, S.M.4
  • 5
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptional partner for MAD proteins in TGF-β signalling
    • Chen, X., Rubock, M.J. and Whitman, M. (1996) A transcriptional partner for MAD proteins in TGF-β signalling. Nature, 383, 691-696.
    • (1996) Nature , vol.383 , pp. 691-696
    • Chen, X.1    Rubock, M.J.2    Whitman, M.3
  • 7
    • 0029031681 scopus 로고
    • Peripheral deletion of antigen-reactive T cells in oral tolerance
    • Chen, Y., Inobe, J., Marks, R., Gonnella, P., Kuchroo, V.K. and Weiner, H.L. (1995) Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature, 376, 177-180.
    • (1995) Nature , vol.376 , pp. 177-180
    • Chen, Y.1    Inobe, J.2    Marks, R.3    Gonnella, P.4    Kuchroo, V.K.5    Weiner, H.L.6
  • 8
    • 0024446350 scopus 로고
    • Transforming growth factor β specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes
    • Coffman, R.L., Lebman, D.A. and Shrader, B. (1989) Transforming growth factor β specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J. Exp. Med., 170, 1039-1044.
    • (1989) J. Exp. Med. , vol.170 , pp. 1039-1044
    • Coffman, R.L.1    Lebman, D.A.2    Shrader, B.3
  • 9
    • 0002091098 scopus 로고
    • Disorders of granulocyte function and granulopoisis
    • Nathan, D and Oski, F. (eds), W.B. Saunders, PA
    • Curnutte, J. (1993) Disorders of granulocyte function and granulopoisis. In Nathan, D and Oski, F. (eds), Hematology of Infancy and Childhood. W.B. Saunders, PA, pp. 904-977.
    • (1993) Hematology of Infancy and Childhood , pp. 904-977
    • Curnutte, J.1
  • 10
    • 0028598814 scopus 로고
    • Murine FGFR-1 is required for early postimplantation growth and axial organization
    • Deng, C., Wynshaw-Boris, A., Shen, M.M., Daugherty, C., Ornitz, D.M. and Leder, P. (1994) Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev., 8, 3045-3057.
    • (1994) Genes Dev. , vol.8 , pp. 3045-3057
    • Deng, C.1    Wynshaw-Boris, A.2    Shen, M.M.3    Daugherty, C.4    Ornitz, D.M.5    Leder, P.6
  • 11
    • 0029917507 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 is a negative regulator of bone growth
    • Deng, C., Wynshaw-Boris, A., Zhou, F., Kuo, A. and Leder, P. (1996) Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell, 84, 911-921.
    • (1996) Cell , vol.84 , pp. 911-921
    • Deng, C.1    Wynshaw-Boris, A.2    Zhou, F.3    Kuo, A.4    Leder, P.5
  • 12
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
    • Dennier, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S. and Gauthier, J.-M. (1998) Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J., 17, 3091-3100.
    • (1998) EMBO J. , vol.17 , pp. 3091-3100
    • Dennier, S.1    Itoh, S.2    Vivien, D.3    Ten Dijke, P.4    Huet, S.5    Gauthier, J.-M.6
  • 14
    • 16044369574 scopus 로고    scopus 로고
    • MADR2 maps to 18q21 and encodes a TGF-β-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
    • Eppert, K. et al. (1996) MADR2 maps to 18q21 and encodes a TGF-β-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell, 86, 543-552.
    • (1996) Cell , vol.86 , pp. 543-552
    • Eppert, K.1
  • 16
    • 0031587828 scopus 로고    scopus 로고
    • The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
    • Hayashi, H. et al. (1997) The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell, 89, 1165-1173.
    • (1997) Cell , vol.89 , pp. 1165-1173
    • Hayashi, H.1
  • 17
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signalling from cell membrane to nucleus through SMAD proteins
    • Heldin, C.H., Miyazono, K. and ten Dijke, P. (1997) TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature, 390, 465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Dijke, P.3
  • 18
    • 0031267305 scopus 로고    scopus 로고
    • The immunoregulatory effects of NK cells: The role of TGF-β and implications for autoimmunity
    • Horwitz, D.A., Gray, J.D., Ohtsuka, K., Hirokawa, M. and Takahashi, T. (1997) The immunoregulatory effects of NK cells: the role of TGF-β and implications for autoimmunity. Immunol. Today, 18, 538-542.
    • (1997) Immunol. Today , vol.18 , pp. 538-542
    • Horwitz, D.A.1    Gray, J.D.2    Ohtsuka, K.3    Hirokawa, M.4    Takahashi, T.5
  • 19
    • 0030810959 scopus 로고    scopus 로고
    • 9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-β via RARα in a human liver stellate cell line, LI90
    • Imai, S., Okuno, M., Moriwaki, H., Muto, Y., Murakami, K., Shudo, K., Suzuki, Y. and Kojima, S. (1997) 9,13-di-cis-Retinoic acid induces the production of tPA and activation of latent TGF-β via RARα in a human liver stellate cell line, LI90, FEBS Lett., 411, 102-106.
    • (1997) FEBS Lett. , vol.411 , pp. 102-106
    • Imai, S.1    Okuno, M.2    Moriwaki, H.3    Muto, Y.4    Murakami, K.5    Shudo, K.6    Suzuki, Y.7    Kojima, S.8
  • 20
    • 0028180315 scopus 로고
    • The TGF-β superfamily: New members, new receptors and new genetic tests of function in different organisms
    • Kingsley, D.M. (1994) The TGF-β superfamily: new members, new receptors and new genetic tests of function in different organisms. Genes Dev., 8, 133-146.
    • (1994) Genes Dev. , vol.8 , pp. 133-146
    • Kingsley, D.M.1
  • 21
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn, R., Lohler, D., Rennick, K., Rajewsky, K. and Muller, W. (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell, 75, 263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, D.2    Rennick, K.3    Rajewsky, K.4    Muller, W.5
  • 22
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
    • Lagna, G., Hata, A., Hemmati-Brivanlou, A. and Massague, J. (1996) Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature, 383, 832-836.
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hemmati-Brivanlou, A.3    Massague, J.4
  • 23
    • 0020609316 scopus 로고
    • Measurement of leukocyte motility and chemotaxis parameters with a linear under-agarose migration assay
    • Lauffenburger, D.C.R. and Zigmond, S.H. (1983) Measurement of leukocyte motility and chemotaxis parameters with a linear under-agarose migration assay. J. Immunol., 131, 940-947.
    • (1983) J. Immunol. , vol.131 , pp. 940-947
    • Lauffenburger, D.C.R.1    Zigmond, S.H.2
  • 24
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-β
    • Letterio, J.J. and Roberts, A.B. (1998) Regulation of immune responses by TGF-β. Annu. Rev. Immunol., 16, 137-161.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 25
    • 0029931509 scopus 로고    scopus 로고
    • Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes
    • Liu, F., Hata, A., Baker, J.C., Doody, J., Carcamo, J., Harland, R.M. and Massague, J. (1996) Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes. Nature, 381, 620-623.
    • (1996) Nature , vol.381 , pp. 620-623
    • Liu, F.1    Hata, A.2    Baker, J.C.3    Doody, J.4    Carcamo, J.5    Harland, R.M.6    Massague, J.7
  • 26
    • 0030690337 scopus 로고    scopus 로고
    • Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells
    • Liu, F., Pouponnot, C. and Massague, J. (1997) Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Genes Dev., 11, 3157-3167.
    • (1997) Genes Dev. , vol.11 , pp. 3157-3167
    • Liu, F.1    Pouponnot, C.2    Massague, J.3
  • 27
    • 0030886204 scopus 로고    scopus 로고
    • Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells
    • Liu, X., Sun, Y., Constantinescu, S.N., Karam, E., Weinberg, R.A. and Lodish, H.F. (1997) Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc. Natl Acad. Sci. USA, 94, 10669-10674.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 10669-10674
    • Liu, X.1    Sun, Y.2    Constantinescu, S.N.3    Karam, E.4    Weinberg, R.A.5    Lodish, H.F.6
  • 28
    • 0032481351 scopus 로고    scopus 로고
    • The L3 loop: A structural motif determining specific interactions between SMAD proteins and TGF-β receptors
    • Lo, R.S., Chen, Y.G., Shi, Y. Pavletich, N.P. and Massague, J. (1998) The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-β receptors. EMBO J., 17, 996-1005.
    • (1998) EMBO J. , vol.17 , pp. 996-1005
    • Lo, R.S.1    Chen, Y.G.2    Shi, Y.3    Pavletich, N.P.4    Massague, J.5
  • 29
    • 0030300115 scopus 로고    scopus 로고
    • MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signaling
    • Macias-Silva, M., Abdollah, S., Hoodless, P.A., Pirone, R., Attisano, L. and Wrana, J.L. (1996) MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell, 87, 1215-1224.
    • (1996) Cell , vol.87 , pp. 1215-1224
    • Macias-Silva, M.1    Abdollah, S.2    Hoodless, P.A.3    Pirone, R.4    Attisano, L.5    Wrana, J.L.6
  • 30
    • 0031685620 scopus 로고    scopus 로고
    • TGF-β signal transduction
    • Massague, J. (1998) TGF-β signal transduction. Annu. Rev. Biochem., 67, 753-791.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 753-791
    • Massague, J.1
  • 31
    • 0026542168 scopus 로고
    • Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen-specific triggering
    • Miller, A., Lider, O., Roberts, A.B., Sporn, M.B. and Weiner, H.L. (1992) Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen-specific triggering. Proc. Natl Acad. Sci. USA, 89, 421-425.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 421-425
    • Miller, A.1    Lider, O.2    Roberts, A.B.3    Sporn, M.B.4    Weiner, H.L.5
  • 32
    • 0027216054 scopus 로고
    • Activin A suppresses proliferation of interleukin-3-responsive granulocyte-macrophage colony-forming progenitors and stimulates proliferation and differentiation of interleukin-3-responsive erythroid burst-forming progenitors in the peripheral blood
    • Mizuguchi, T., Kosaka, M. and Saito, S. (1993) Activin A suppresses proliferation of interleukin-3-responsive granulocyte-macrophage colony-forming progenitors and stimulates proliferation and differentiation of interleukin-3-responsive erythroid burst-forming progenitors in the peripheral blood. Blood, 81, 2891-2897.
    • (1993) Blood , vol.81 , pp. 2891-2897
    • Mizuguchi, T.1    Kosaka, M.2    Saito, S.3
  • 33
    • 0027922467 scopus 로고
    • Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
    • Mombaerts, P., Mizoguchi, E., Grusby, M.J., Glimcher, L.H., Bhan, A.K. and Tonegawa, S. (1993) Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell, 75, 274-282.
    • (1993) Cell , vol.75 , pp. 274-282
    • Mombaerts, P.1    Mizoguchi, E.2    Grusby, M.J.3    Glimcher, L.H.4    Bhan, A.K.5    Tonegawa, S.6
  • 34
    • 0030768644 scopus 로고    scopus 로고
    • TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4
    • Nakao, A. et al. (1997a) TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J., 16, 5353-5362.
    • (1997) EMBO J. , vol.16 , pp. 5353-5362
    • Nakao, A.1
  • 35
    • 0031034589 scopus 로고    scopus 로고
    • Identification of Smad2, a human Mad-related protein in the transforming growth factor β signaling pathway
    • Nakao, A., Roijer, E., Imamura, T., Souchelnytskyi, S., Stenman, G., Heldin, C.H. and ten Dijke, P. (1997b) Identification of Smad2, a human Mad-related protein in the transforming growth factor β signaling pathway. J. Biol. Chem., 272, 2896-2900.
    • (1997) J. Biol. Chem. , vol.272 , pp. 2896-2900
    • Nakao, A.1    Roijer, E.2    Imamura, T.3    Souchelnytskyi, S.4    Stenman, G.5    Heldin, C.H.6    Ten Dijke, P.7
  • 36
    • 0030018425 scopus 로고    scopus 로고
    • Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells
    • Newfeld, S.J., Chartoff, E.H., Graff, J.M., Melton, D.A. and Gelbart, W.M. (1996) Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells. Development, 122, 2099-2108.
    • (1996) Development , vol.122 , pp. 2099-2108
    • Newfeld, S.J.1    Chartoff, E.H.2    Graff, J.M.3    Melton, D.A.4    Gelbart, W.M.5
  • 37
    • 0032565859 scopus 로고    scopus 로고
    • Smad2 role in mesoderm formation, left-right patterning and craniofacial development
    • Nomura, M. and Li, E. (1998) Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature, 393, 786-970.
    • (1998) Nature , vol.393 , pp. 786-970
    • Nomura, M.1    Li, E.2
  • 38
    • 0022004835 scopus 로고
    • Defective neutrophil and monocyte motility in patients with early onset periodontitis
    • Page, R.C., Sims, T.J., Geissler, F., Altman, L.C. and Baab, D.A. (1985) Defective neutrophil and monocyte motility in patients with early onset periodontitis. Infect. Immun., 47, 169-175.
    • (1985) Infect. Immun. , vol.47 , pp. 169-175
    • Page, R.C.1    Sims, T.J.2    Geissler, F.3    Altman, L.C.4    Baab, D.A.5
  • 39
    • 0028330331 scopus 로고
    • Neutrophil chemotaxis in response to TGF-β isoforms (TGF-β1, TGF-β2, TGF-β3) is mediated by fibronectin
    • Parekh, R., Saxena, B., Reibman, J., Cronstein, B.N. and Gold, L. (1994) Neutrophil chemotaxis in response to TGF-β isoforms (TGF-β1, TGF-β2, TGF-β3) is mediated by fibronectin. J. Immunol., 152, 2456-2466.
    • (1994) J. Immunol. , vol.152 , pp. 2456-2466
    • Parekh, R.1    Saxena, B.2    Reibman, J.3    Cronstein, B.N.4    Gold, L.5
  • 40
    • 0029956024 scopus 로고    scopus 로고
    • A critical role for transforming growth factor-β but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB (low) CD4+ T cells
    • Powrie, F., Carlino, J., Leach, M.W., Mauze, S. and Coffman, R.L. (1996) A critical role for transforming growth factor-β but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB (low) CD4+ T cells. J. Exp. Med., 183, 2669-2674.
    • (1996) J. Exp. Med. , vol.183 , pp. 2669-2674
    • Powrie, F.1    Carlino, J.2    Leach, M.W.3    Mauze, S.4    Coffman, R.L.5
  • 41
    • 15844387270 scopus 로고    scopus 로고
    • Mad-related genes in the human
    • Riggins, GJ. et al. (1996) Mad-related genes in the human. Nature Genet., 13, 347-349.
    • (1996) Nature Genet. , vol.13 , pp. 347-349
    • Riggins, G.J.1
  • 42
    • 0000116653 scopus 로고
    • The transforming growth factors-β
    • Sporn, M.B. and Roberts, A.B. (eds), Springer-Verlag, Heidelberg
    • Roberts, A.B. and Sporn, M.B. (1990) The transforming growth factors-β. In Sporn, M.B. and Roberts, A.B. (eds), Handbook of Experimental Pharmacology. Springer-Verlag, Heidelberg, Vol. 95, pp. 418-472.
    • (1990) Handbook of Experimental Pharmacology , vol.95 , pp. 418-472
    • Roberts, A.B.1    Sporn, M.B.2
  • 43
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A.C. and Horak, I. (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell, 75, 253-261.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 44
    • 0030058914 scopus 로고    scopus 로고
    • Caenorhabditis elegans genes sma-2, sma-3 and sma-4 define a conserved family of transforming growth factor β pathway components
    • Savage, C., Das, P., Finelli, A.L., Townsend, S.R., Sun, C.Y., Baird, S.E. and Padgett, R.W. (1996) Caenorhabditis elegans genes sma-2, sma-3 and sma-4 define a conserved family of transforming growth factor β pathway components. Proc. Natl Acad. Sci. USA, 93, 790-794.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 790-794
    • Savage, C.1    Das, P.2    Finelli, A.L.3    Townsend, S.R.4    Sun, C.Y.5    Baird, S.E.6    Padgett, R.W.7
  • 45
    • 0032526354 scopus 로고    scopus 로고
    • Factors involved in the differentiation of TGF-βs producing cells from naive CD4+ T cells: IL-4 and IFN-γ have opposing effects, while TGF-β positively regulates its own production
    • Seder, R., Marth, T., Sieve, M., Letterio, J., Strober, W. and Kelsall, B. (1998) Factors involved in the differentiation of TGF-βs producing cells from naive CD4+ T cells: IL-4 and IFN-γ have opposing effects, while TGF-β positively regulates its own production. J. Immunol., 160, 5719-5728.
    • (1998) J. Immunol. , vol.160 , pp. 5719-5728
    • Seder, R.1    Marth, T.2    Sieve, M.3    Letterio, J.4    Strober, W.5    Kelsall, B.6
  • 46
    • 15444348295 scopus 로고    scopus 로고
    • The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
    • Sirard, C. et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev., 12, 107-119.
    • (1998) Genes Dev. , vol.12 , pp. 107-119
    • Sirard, C.1
  • 47
    • 0030613262 scopus 로고    scopus 로고
    • Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-β signaling
    • Souchelnytskyi, S., Tamaki, K., Engstrom, U., Wernstedt, C. ten Dijke, P. and Heldin, C.H. (1997) Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-β signaling. J. Biol. Chem., 272, 28107-28115.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28107-28115
    • Souchelnytskyi, S.1    Tamaki, K.2    Engstrom, U.3    Wernstedt, C.4    Ten Dijke, P.5    Heldin, C.H.6
  • 50
    • 0031943966 scopus 로고    scopus 로고
    • Characterization of lymphocytes in the adult rat testis by flow cytometry: Effects of activin and transforming growth factor β on lymphocyte subsets in vitro
    • Tompkins, A.B., Hutchinson, P., de Kietser, D.M. and Hedger, M.P. (1998) Characterization of lymphocytes in the adult rat testis by flow cytometry: effects of activin and transforming growth factor β on lymphocyte subsets in vitro. Biol. Reprod., 58, 943-951.
    • (1998) Biol. Reprod. , vol.58 , pp. 943-951
    • Tompkins, A.B.1    Hutchinson, P.2    De Kietser, D.M.3    Hedger, M.P.4
  • 51
    • 0030632109 scopus 로고    scopus 로고
    • Molecular factors associated with compartmentalization of gingival immune responses and transepithelial neutrophil migration
    • Tonetti, M.S. (1997) Molecular factors associated with compartmentalization of gingival immune responses and transepithelial neutrophil migration. J. Periodontal Res., 32, 104-109.
    • (1997) J. Periodontal Res. , vol.32 , pp. 104-109
    • Tonetti, M.S.1
  • 52
    • 0029765615 scopus 로고    scopus 로고
    • Risk factors for nosocomial infections caused by Gram-negative bacilli. The Hellenic Antibiotic Resistance Group
    • Vatopoulos, A.C., Kalapothaki, V. and Legakis, N.J. (1996) Risk factors for nosocomial infections caused by Gram-negative bacilli. The Hellenic Antibiotic Resistance Group. J. Hosp. Infect., 34, 11-22.
    • (1996) J. Hosp. Infect. , vol.34 , pp. 11-22
    • Vatopoulos, A.C.1    Kalapothaki, V.2    Legakis, N.J.3
  • 54
    • 0032549806 scopus 로고    scopus 로고
    • Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
    • Waldrip, W.R., Bikoff, E.K., Hoodless, P.A., Wrana, J.L. and Robertson, E.J. (1998) Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell, 92, 797-808.
    • (1998) Cell , vol.92 , pp. 797-808
    • Waldrip, W.R.1    Bikoff, E.K.2    Hoodless, P.A.3    Wrana, J.L.4    Robertson, E.J.5
  • 55
    • 0032482751 scopus 로고    scopus 로고
    • Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppresser smad2
    • Weinstein, M. Yang, X., Li, C., Xu, X., Gotay, J. and Deng, C.X. (1998) Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppresser smad2. Proc. Natl Acad. Sci. USA, 95, 9378-9383.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 9378-9383
    • Weinstein, M.1    Yang, X.2    Li, C.3    Xu, X.4    Gotay, J.5    Deng, C.X.6
  • 56
    • 0030037438 scopus 로고    scopus 로고
    • Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye
    • Wiersdorff, V., Lecuit, T., Cohen, S.M. and Mlodzik, M. (1996) Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development, 122, 2153-2162.
    • (1996) Development , vol.122 , pp. 2153-2162
    • Wiersdorff, V.1    Lecuit, T.2    Cohen, S.M.3    Mlodzik, M.4
  • 57
    • 0032584068 scopus 로고    scopus 로고
    • The tumor suppressor SMAD4/ DPC4 is essential for epiblast proliferation and mesoderm induction in mice
    • Yang, X., Li, C., Xu, X. and Deng, C. (1998) The tumor suppressor SMAD4/ DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc. Natl Acad. Sci. USA, 95, 3667-3672.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 3667-3672
    • Yang, X.1    Li, C.2    Xu, X.3    Deng, C.4
  • 58
    • 0030697971 scopus 로고    scopus 로고
    • Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein
    • Yingling, J.M., Datto, M.B., Wong, C., Frederick, J.P., Liberati, N.T. and Wang, X.F. (1997) Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein. Mol. Cell. Biol, 17, 7019-7028.
    • (1997) Mol. Cell. Biol , vol.17 , pp. 7019-7028
    • Yingling, J.M.1    Datto, M.B.2    Wong, C.3    Frederick, J.P.4    Liberati, N.T.5    Wang, X.F.6
  • 60
    • 0029786212 scopus 로고    scopus 로고
    • Receptor-associated Mad homologues synergize as effectors of the TGF-β response
    • Zhang, Y., Feng, X., We, R. and Derynck, R. (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature, 383, 168-172.
    • (1996) Nature , vol.383 , pp. 168-172
    • Zhang, Y.1    Feng, X.2    We, R.3    Derynck, R.4
  • 61
    • 0032544448 scopus 로고    scopus 로고
    • Smad3 mutant mice develop metastatic colorectal cancer
    • Zhu, Y., Richardson, J.A., Parada, L.F. and Graff, J.M. (1998) Smad3 mutant mice develop metastatic colorectal cancer. Cell, 94, 703-714.
    • (1998) Cell , vol.94 , pp. 703-714
    • Zhu, Y.1    Richardson, J.A.2    Parada, L.F.3    Graff, J.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.