Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β

EMBO Journal

Volumn 18, Issue 5, 1999, Pages 1280-1291

  Yang, Xiao ^a,b   Letterio, John J ^c   Lechleider, Robert J ^c   Chen, Lin ^a   Hayman, Russ ^d   Gu, Hua ^d   Roberts, Anita B ^c   Deng, Chuxia ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^c NATIONAL CANCER INSTITUTE   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Bacterial infections; Gene targeting; Inflammation; SMAD3; TGF signaling

Indexed keywords

ACTIVIN RECEPTOR; MUTANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ABSCESS; ARTICLE; CELL MUTANT; COLON ADENOCARCINOMA; CONTROLLED STUDY; ENTERITIS; GENE TARGETING; HISTOPATHOLOGY; IMMUNE DEFICIENCY; LETHAL MUTANT; LYMPH NODE HYPERPLASIA; MOUSE; MUCOSA INFLAMMATION; MUCOSAL IMMUNITY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMUS DISEASE;

ANIMALS; B-LYMPHOCYTES; CHEMOTAXIS; DNA-BINDING PROTEINS; GENE TARGETING; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; INTESTINAL MUCOSA; L-SELECTIN; MICE; MICE, KNOCKOUT; NEUTROPHILS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; T-LYMPHOCYTES; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033104503     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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