Loss of TGf-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and HGF-mediated signaling networks

Oncogene

Volumn 24, Issue 32, 2005, Pages 5053-5068

  Cheng, Nikki ^a,b,c   Bhowmick, Neil A ^a,b   Chytil, Anna ^a,b   Gorksa, Agnieszka E ^a,b   Brown, Kimberly A ^a   Muraoka, Rebecca ^a   Arteaga, Carlos L ^a,b   Neilson, Eric G ^a,b   Hayward, Simon W ^a,b   Moses, Harold L ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Mammary gland; Subrenal grafting; TGF ; TGF receptor type II; Tumor progression; Tumor stromal interactions

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GEFITINIB; GROWTH FACTOR RECEPTOR; MACROPHAGE ACTIVATING FACTOR; PROTEIN CMET; PROTEIN RON; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BREAST CARCINOMA; BREAST CELL; CANCER GROWTH; CANCER INVASION; CARCINOGENESIS; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; FIBROBLAST; GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; STROMA CELL; TGFBR2 GENE; UPREGULATION;

ANIMALS; CELL DIVISION; FEMALE; GENE DELETION; GENE SILENCING; GENES, REPORTER; HEPATOCYTE GROWTH FACTOR; HOMOZYGOTE; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NUDE; MUCINS; MUSCLE PROTEINS; NEOPLASM INVASIVENESS; PEPTIDES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 23744452875     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208685     Document Type: Article

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