메뉴 건너뛰기




Volumn 12, Issue 3, 2000, Pages 157-167

Smad protein expression and activation in transforming growth factor-β refractory human squamous cell carcinoma cells

Author keywords

Head neck cancer; Mutation; Receptor; Smad; Squamous cell carcinoma; Transforming growth factor

Indexed keywords

DNA BINDING PROTEIN; SMAD2 PROTEIN; SMAD2 PROTEIN, HUMAN; SMAD4 PROTEIN; SMAD4 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

EID: 0034568227     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/096504001108747639     Document Type: Article
Times cited : (23)

References (84)
  • 1
    • 0025609085 scopus 로고
    • High frequency of resistance of human squamous carcinoma cells to the anti-proliferative action of transforming growth factor-β
    • Reiss, M.; Stash, E. B. High frequency of resistance of human squamous carcinoma cells to the anti-proliferative action of transforming growth factor-β. Cancer Commun. 2:363-369; 1990.
    • (1990) Cancer Commun. , vol.2 , pp. 363-369
    • Reiss, M.1    Stash, E.B.2
  • 2
    • 0027421280 scopus 로고
    • Resistance to inhibition of cell growth by transforming growth factor-β and its role in oncogenesis
    • Fynan, T. M.; Reiss, M. Resistance to inhibition of cell growth by transforming growth factor-β and its role in oncogenesis. Crit. Rev. Oncog. 4:493-540; 1993.
    • (1993) Crit. Rev. Oncog. , vol.4 , pp. 493-540
    • Fynan, T.M.1    Reiss, M.2
  • 3
    • 0031303927 scopus 로고    scopus 로고
    • Transforming growth factor-beta and cancer: A love-hate relationship?
    • Reiss, M. Transforming growth factor-beta and cancer: A love-hate relationship? Oncol. Res. 9:447-457; 1997.
    • (1997) Oncol. Res. , vol.9 , pp. 447-457
    • Reiss, M.1
  • 4
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signaling from cell membrane to nucleus through SMAD proteins
    • Heldin, C.-H.; Miyazono, K.; ten Dijke, P. TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature 390: 465-471; 1997.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.-H.1    Miyazono, K.2    Ten Dijke, P.3
  • 6
    • 0028168242 scopus 로고
    • p151NK4B is a potential effector of TGF-β-induced cell cycle arrest
    • Hannon, G. J.; Beach, D. p151NK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 371:257-261; 1994.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 7
    • 0029073142 scopus 로고
    • Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
    • Datto, M. B.; Li, Y.; Panus, J. F.; Howe, D. J.; Xiong, Y.; Wang, X. F. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA 92:5545-5549; 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5545-5549
    • Datto, M.B.1    Li, Y.2    Panus, J.F.3    Howe, D.J.4    Xiong, Y.5    Wang, X.F.6
  • 8
    • 0027374766 scopus 로고
    • TGF-β inhibition of cdk4 synthesis is linked to cell cycle arrest
    • Ewen, M. E.; Sluss, H. K.; Whitehouse, L. L.; Livingston, D. M. TGF-β inhibition of cdk4 synthesis is linked to cell cycle arrest. Cell 74:1009-1020; 1993.
    • (1993) Cell , vol.74 , pp. 1009-1020
    • Ewen, M.E.1    Sluss, H.K.2    Whitehouse, L.L.3    Livingston, D.M.4
  • 9
    • 0030978315 scopus 로고    scopus 로고
    • Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15
    • Iavarone. A.; Massagué, J. Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15. Nature 387:417-422; 1997.
    • (1997) Nature , vol.387 , pp. 417-422
    • Iavarone, A.1    Massagué, J.2
  • 10
    • 0032442852 scopus 로고    scopus 로고
    • Smads: Transcriptional activators of TGF-β responses
    • Derynck, R.; Zhang, Y.; Feng, X.-H. Smads: Transcriptional activators of TGF-β responses. Cell 95:737-740; 1998.
    • (1998) Cell , vol.95 , pp. 737-740
    • Derynck, R.1    Zhang, Y.2    Feng, X.-H.3
  • 11
    • 0033377548 scopus 로고    scopus 로고
    • TGF-β and cancer
    • Reiss, M. TGF-β and cancer. Microbes Infect. 1:1327-1347; 1999.
    • (1999) Microbes Infect. , vol.1 , pp. 1327-1347
    • Reiss, M.1
  • 12
    • 0028556486 scopus 로고
    • Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to growth inhibition by TGF-beta
    • Park, K.; Kim, S. J.; Bang, Y. J.; Park, J. G.; Kim, N. K.; Roberts, A. B.; Sporn, M. B. Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to growth inhibition by TGF-beta. Proc. Natl. Acad. Sci. USA 91:8772-8776; 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8772-8776
    • Park, K.1    Kim, S.J.2    Bang, Y.J.3    Park, J.G.4    Kim, N.K.5    Roberts, A.B.6    Sporn, M.B.7
  • 16
    • 0030634624 scopus 로고    scopus 로고
    • Frequent inactivation of the transforming growth factor beta type II receptor in small-cell lung carcinoma cells
    • de Jonge, R. R.; Garrigue-Antar, L.; Vellucci, V. F.; Reiss, M. Frequent inactivation of the transforming growth factor beta type II receptor in small-cell lung carcinoma cells. Oncol. Res. 9:89-98; 1997.
    • (1997) Oncol. Res. , vol.9 , pp. 89-98
    • Jonge, R.R.1    Garrigue-Antar, L.2    Vellucci, V.F.3    Reiss, M.4
  • 17
    • 0033119429 scopus 로고    scopus 로고
    • Truncation of the TGF-beta type II receptor gene results in insensitivity to TGF-beta in human gastric cancer cells
    • Yang, H. K.; Kang, S.H.; Kim, Y. S.; Won, K.; Bang, Y. J.; Kim, S. J. Truncation of the TGF-beta type II receptor gene results in insensitivity to TGF-beta in human gastric cancer cells. Oncogene 18:2213-2219; 1999.
    • (1999) Oncogene , vol.18 , pp. 2213-2219
    • Yang, H.K.1    Kang, S.H.2    Kim, Y.S.3    Won, K.4    Bang, Y.J.5    Kim, S.J.6
  • 19
    • 0029762628 scopus 로고    scopus 로고
    • Loss of transforming growth factor-beta type II receptor gene expression in primary human esophageal cancer
    • Garrigue-Antar, L.; Souza, R. F.; Vellucci, V. F.; Meltzer, S. J.; Reiss, M. Loss of transforming growth factor-beta type II receptor gene expression in primary human esophageal cancer. Lab. Invest. 75:263-272; 1996.
    • (1996) Lab. Invest. , vol.75 , pp. 263-272
    • Garrigue-Antar, L.1    Souza, R.F.2    Vellucci, V.F.3    Meltzer, S.J.4    Reiss, M.5
  • 20
    • 0030005435 scopus 로고    scopus 로고
    • Lack of expression of transforming growth factor-beta type II receptor associated with malignant progression in human salivary gland cell clones
    • Azuina, M.; Yuki, T.; Tamatani, T.; Motegi, K.; Yoshida, H.; Sato, M. Lack of expression of transforming growth factor-beta type II receptor associated with malignant progression in human salivary gland cell clones. Int. J. Cancer 66:802-805; 1996.
    • (1996) Int. J. Cancer , vol.66 , pp. 802-805
    • Azuina, M.1    Yuki, T.2    Tamatani, T.3    Motegi, K.4    Yoshida, H.5    Sato, M.6
  • 21
    • 0030979568 scopus 로고    scopus 로고
    • Down-regulation of protein and mRNA expression for transforming growth factor-beta (TGF-betal) type I and type II receptors in human prostate cancer
    • Guo, Y.; Jacobs, S. C.; Kyprianou, N. Down-regulation of protein and mRNA expression for transforming growth factor-beta (TGF-betal) type I and type II receptors in human prostate cancer. Int. J. Cancer 71:573-579; 1997.
    • (1997) Int. J. Cancer , vol.71 , pp. 573-579
    • Guo, Y.1    Jacobs, S.C.2    Kyprianou, N.3
  • 22
    • 0030954029 scopus 로고    scopus 로고
    • Human malignant thyroid tumors displayed reduced levels of transforming growth factor beta receptor type II messenger RNA and protein
    • Lazzereschi, D.; Ranieri, A.; Mincione, G.; Taccogna, S.; Nardi, F.; Colletta, G. Human malignant thyroid tumors displayed reduced levels of transforming growth factor beta receptor type II messenger RNA and protein. Cancer Res. 57:2071-2076; 1997.
    • (1997) Cancer Res. , vol.57 , pp. 2071-2076
    • Lazzereschi, D.1    Ranieri, A.2    Mincione, G.3    Taccogna, S.4    Nardi, F.5    Colletta, G.6
  • 23
    • 0032213514 scopus 로고    scopus 로고
    • Transforming growth factor-β type I receptor kinase mutant associated with metastatic breast cancer
    • Chen, T.; Carter, D.; Garriguc-Antar, L.; Reiss, M. Transforming growth factor-β type I receptor kinase mutant associated with metastatic breast cancer. Cancer Res. 58:4805-4810; 1998.
    • (1998) Cancer Res. , vol.58 , pp. 4805-4810
    • Chen, T.1    Carter, D.2    Garriguc-Antar, L.3    Reiss, M.4
  • 24
    • 0032404111 scopus 로고    scopus 로고
    • Genetic alterations of the transforming growth factor β receptor genes in pancreatic and biliary adenocarcinomas
    • Goggins, M.; Shekher, M.; Turnacioglu, K.; Yeo, C. J.; Hruban, R. H.; Kern, S. E. Genetic alterations of the transforming growth factor β receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res. 58:5329-5332; 1998.
    • (1998) Cancer Res. , vol.58 , pp. 5329-5332
    • Goggins, M.1    Shekher, M.2    Turnacioglu, K.3    Yeo, C.J.4    Hruban, R.H.5    Kern, S.E.6
  • 25
    • 0032878291 scopus 로고    scopus 로고
    • A Deletion in the gene for transforming growth factor beta type I receptor abolishes growth regulation by transforming growth factor beta in a cutaneous T-cell lymphoma
    • Schiemann, W. P.; Pfeifer, W. M.; Levi, E.; Kadin, M. E.; Lodish, H. F. A Deletion in the gene for transforming growth factor beta type I receptor abolishes growth regulation by transforming growth factor beta in a cutaneous T-cell lymphoma. Blood 94: 2854-2861; 1999.
    • (1999) Blood , vol.94 , pp. 2854-2861
    • Schiemann, W.P.1    Pfeifer, W.M.2    Levi, E.3    Kadin, M.E.4    Lodish, H.F.5
  • 27
  • 30
    • 0030991288 scopus 로고    scopus 로고
    • Transfer of chromosome 18 into human head and neck squamous carcinoma cells: Evidence for tumor suppression by Smad4/DPC4
    • Reiss, M.; Santoro, V.; De Jonge, R. R.; Vellucci, V. F. Transfer of chromosome 18 into human head and neck squamous carcinoma cells: Evidence for tumor suppression by Smad4/DPC4. Cell Growth Differ. 8:407-415; 1997.
    • (1997) Cell Growth Differ. , vol.8 , pp. 407-415
    • Reiss, M.1    Santoro, V.2    De Jonge, R.R.3    Vellucci, V.F.4
  • 36
    • 0034032009 scopus 로고    scopus 로고
    • Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression
    • Wilentz, R. E.; lacobuzio-Donahue, C. A.; Argani, P.; McCarthy, D. M.; Parsons, J. L.; Yeo, C. J.; Kern, S. E.; Hruban, R. H. Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res. 60:2002-2006; 2000.
    • (2000) Cancer Res. , vol.60 , pp. 2002-2006
    • Wilentz, R.E.1    Lacobuzio-Donahue, C.A.2    Argani, P.3    McCarthy, D.M.4    Parsons, J.L.5    Yeo, C.J.6    Kern, S.E.7    Hruban, R.H.8
  • 37
    • 0033891752 scopus 로고    scopus 로고
    • Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: A new marker of DPC4 inactivation
    • Wilentz, R. E.; Su, G. H.; Dai, J. L.; Sparks, A. B.; Argani, P.; Sohn, T. A.; Yeo, C. J.; Kern, S. E.; Hruban, R. H. Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: A new marker of DPC4 inactivation. Am. J. Pathol. 156:37-43; 2000.
    • (2000) Am. J. Pathol. , vol.156 , pp. 37-43
    • Wilentz, R.E.1    Su, G.H.2    Dai, J.L.3    Sparks, A.B.4    Argani, P.5    Sohn, T.A.6    Yeo, C.J.7    Kern, S.E.8    Hruban, R.H.9
  • 39
  • 40
    • 0017412603 scopus 로고
    • One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice
    • Fogh, J.; Fogh, J. M.; Orfeo, T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J. Natl. Cancer Inst. 59:221-226; 1977.
    • (1977) J. Natl. Cancer Inst. , vol.59 , pp. 221-226
    • Fogh, J.1    Fogh, J.M.2    Orfeo, T.3
  • 41
    • 0000798020 scopus 로고
    • Chromosome observations on three epithelial cell cultures derived from carcinomas of the cervix
    • Auersperg, N.; Hawryluk, A. P. Chromosome observations on three epithelial cell cultures derived from carcinomas of the cervix. J. Natl. Cancer Inst. 28:605-628; 1962.
    • (1962) J. Natl. Cancer Inst. , vol.28 , pp. 605-628
    • Auersperg, N.1    Hawryluk, A.P.2
  • 42
    • 0015251378 scopus 로고
    • A new human cell line (FaDu) from a hypopharyngeal carcinoma
    • Rangan, S. R. A new human cell line (FaDu) from a hypopharyngeal carcinoma. Cancer 29:117-121; 1972.
    • (1972) Cancer , vol.29 , pp. 117-121
    • Rangan, S.R.1
  • 44
    • 0021832286 scopus 로고
    • Modulation of the terminal differentiation of human squamous carcinoma cells in vitro by all-trans retinoic acid
    • Reiss, M.; Pitman, S. W.; Sartorelli, A. C. Modulation of the terminal differentiation of human squamous carcinoma cells in vitro by all-trans retinoic acid. J. Natl. Cancer Inst. 74:1015-1023; 1985.
    • (1985) J. Natl. Cancer Inst. , vol.74 , pp. 1015-1023
    • Reiss, M.1    Pitman, S.W.2    Sartorelli, A.C.3
  • 45
    • 0023152810 scopus 로고
    • Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA
    • Pirisi, L.; Yasumoto, S.; Feller, M.; Doniger, J.; DiPaolo, J. A. Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. J. Virol. 61:1061-1066; 1987.
    • (1987) J. Virol. , vol.61 , pp. 1061-1066
    • Pirisi, L.1    Yasumoto, S.2    Feller, M.3    Doniger, J.4    DiPaolo, J.A.5
  • 46
    • 0017346890 scopus 로고
    • In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain
    • Chen, T. R. In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. Exp. Cell Res. 104: 255-262; 1977.
    • (1977) Exp. Cell Res. , vol.104 , pp. 255-262
    • Chen, T.R.1
  • 47
    • 0030613249 scopus 로고    scopus 로고
    • TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
    • Abdollah, S.; Macias-Silva, M.; Tsukazaki, T.; Hayashi, H.; Attisano, L.; Wrana, J. L. TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J. Biol. Chem. 272:27678-27685; 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 27678-27685
    • Abdollah, S.1    Macias-Silva, M.2    Tsukazaki, T.3    Hayashi, H.4    Attisano, L.5    Wrana, J.L.6
  • 48
    • 0030613262 scopus 로고    scopus 로고
    • Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling
    • Souchelnytskyi, S.; Tamaki, K.; Engstrom, U.; Wernstedt, C.; ten Dijke, P.; Heldin, C. H. Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling. J. Biol. Chem. 272:28107-28115; 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28107-28115
    • Souchelnytskyi, S.1    Tamaki, K.2    Engstrom, U.3    Wernstedt, C.4    Ten Dijke, P.5    Heldin, C.H.6
  • 49
    • 0030886204 scopus 로고    scopus 로고
    • Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells
    • Liu, X.; Sun, Y.; Constantinescu, S. N.; Karam, E.; Weinberg, R. A.; Lodish, H. F. Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc. Natl. Acad. Sci. USA 94:10669-10674; 1997.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10669-10674
    • Liu, X.1    Sun, Y.2    Constantinescu, S.N.3    Karam, E.4    Weinberg, R.A.5    Lodish, H.F.6
  • 50
    • 0003382946 scopus 로고    scopus 로고
    • Production of antibodies that recognize specific tyrosine phosphorylated peptides
    • vol. unit 18.6. New York: John Wiley & Sons;
    • DiGiovanna, M. P.; Roussel, R. R.; Stern, D. F. Production of antibodies that recognize specific tyrosine phosphorylated peptides. In: Current protocols in molecular biology, vol. unit 18.6. New York: John Wiley & Sons; 1996:1-19.
    • (1996) Current Protocols in Molecular Biology , pp. 1-19
    • DiGiovanna, M.P.1    Roussel, R.R.2    Stern, D.F.3
  • 51
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P.; Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159; 1987.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 53
    • 0032080855 scopus 로고    scopus 로고
    • Functional characterization of transforming growth factor beta type II receptor mutants in human cancer
    • De, M.; Yan, W.; de Jonge, R. R.; Garrigue-Antar, L.; Vellucci, V. F.; Reiss, M. Functional characterization of transforming growth factor beta type II receptor mutants in human cancer. Cancer Res. 58:1986-1992; 1998.
    • (1998) Cancer Res. , vol.58 , pp. 1986-1992
    • De, M.1    Yan, W.2    De Jonge, R.R.3    Garrigue-Antar, L.4    Vellucci, V.F.5    Reiss, M.6
  • 54
    • 0027163949 scopus 로고
    • Resistance of human squamous carcinoma cells to the anti-proliferative effect of transforming growth factor-β is a recessive phcnotype
    • Reiss, M.; Mu-oz-Antonia, T.; Cowan, J. M.; Wilkins, P. C.; Zhou, Z.-L.; Vellucci, V. F. Resistance of human squamous carcinoma cells to the anti-proliferative effect of transforming growth factor-β is a recessive phcnotype. Proc. Natl. Acad. Sci. USA 90: 6280-6284; 1993.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6280-6284
    • Reiss, M.1    Mu-oz-Antonia, T.2    Cowan, J.M.3    Wilkins, P.C.4    Zhou, Z.-L.5    Vellucci, V.F.6
  • 55
    • 0029834067 scopus 로고    scopus 로고
    • Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways
    • Lagna, G.; Hata, A.; Hemmati-Brivanlou, A.; Massague, J. Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature 383:832-836; 1996.
    • (1996) Nature , vol.383 , pp. 832-836
    • Lagna, G.1    Hata, A.2    Hemmati-Brivanlou, A.3    Massague, J.4
  • 56
    • 0031128153 scopus 로고    scopus 로고
    • The tumor suppressor Smad4/ DPC4 as a central mediator of Smad function
    • Zhang, Y.; Musci, T.; Derynck, R. The tumor suppressor Smad4/ DPC4 as a central mediator of Smad function. Curr. Biol. 7:270-276; 1997.
    • (1997) Curr. Biol. , vol.7 , pp. 270-276
    • Zhang, Y.1    Musci, T.2    Derynck, R.3
  • 57
    • 0030974042 scopus 로고    scopus 로고
    • Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4
    • Wu, R. Y.; Zhang, Y.; Feng, X. H.; Derynck, R. Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol. Cell. Biol. 17:2521-2528; 1997.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2521-2528
    • Wu, R.Y.1    Zhang, Y.2    Feng, X.H.3    Derynck, R.4
  • 58
    • 0030300115 scopus 로고    scopus 로고
    • MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and sigaling
    • Macias-Silva, M.; Abdollah, S.; Hoodless, P. A.; Pirone, R.; Attisano, L.; Wrana, J. L. MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and sigaling. Cell 87:1215-1224; 1996.
    • (1996) Cell , vol.87 , pp. 1215-1224
    • Macias-Silva, M.1    Abdollah, S.2    Hoodless, P.A.3    Pirone, R.4    Attisano, L.5    Wrana, J.L.6
  • 59
    • 0030825516 scopus 로고    scopus 로고
    • Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
    • Hata, A.; Lo, R. S.; Wotton, D.; Lagna, G.; Massagué, J. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 388:82-87; 1997.
    • (1997) Nature , vol.388 , pp. 82-87
    • Hata, A.1    Lo, R.S.2    Wotton, D.3    Lagna, G.4    Massagué, J.5
  • 61
    • 0029786212 scopus 로고    scopus 로고
    • Receptor-associated Mad homologues synergize as effectors of the TGF-β response
    • Zhang, Y.; Feng, X.-H.; Wu, R.-Y.; Derynck, R. Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383:168-172; 1996.
    • (1996) Nature , vol.383 , pp. 168-172
    • Zhang, Y.1    Feng, X.-H.2    Wu, R.-Y.3    Derynck, R.4
  • 63
    • 0029114477 scopus 로고
    • Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells
    • Garrigue-Antar, L.; Munoz-Antonia, T.; Antonia, S. J.; Gesmonde, J.; Vellucci, V. F.; Reiss, M. Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells. Cancer Res. 55:3982-3987; 1995.
    • (1995) Cancer Res. , vol.55 , pp. 3982-3987
    • Garrigue-Antar, L.1    Munoz-Antonia, T.2    Antonia, S.J.3    Gesmonde, J.4    Vellucci, V.F.5    Reiss, M.6
  • 64
    • 0029902905 scopus 로고    scopus 로고
    • A mutation in the transforming growth factor beta type II receptor gene promoter associated with loss of gene expression
    • Munoz-Antonia, T.; Li, X.; Reiss, M.; Jackson, R.; Antonia, S. A mutation in the transforming growth factor beta type II receptor gene promoter associated with loss of gene expression. Cancer Res. 56:4831-4835; 1996.
    • (1996) Cancer Res. , vol.56 , pp. 4831-4835
    • Munoz-Antonia, T.1    Li, X.2    Reiss, M.3    Jackson, R.4    Antonia, S.5
  • 65
    • 0032943080 scopus 로고    scopus 로고
    • Expression of transforming-growth-factor (TGF)-beta receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF- Betal
    • Piek, E.; Westermark, U.; Kastemar, M.; Heldin, C. H.; van Zoelen, E. J.; Nister, M.; Ten Dijke, P. Expression of transforming-growth-factor (TGF)-beta receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF- betal. Int. J. Cancer 80:756-763; 1999.
    • (1999) Int. J. Cancer , vol.80 , pp. 756-763
    • Piek, E.1    Westermark, U.2    Kastemar, M.3    Heldin, C.H.4    Van Zoelen, E.J.5    Nister, M.6    Ten Dijke, P.7
  • 67
    • 0032110463 scopus 로고    scopus 로고
    • Smad2 and Smad3 positively and negatively regulate TGF-β-dependent transcription through the forkhead DNA-binding protein FAST2
    • Labbé, E.; Silvestri, C.; Hoodless, P. A.; Wrana, J. L.; Attisano, L. Smad2 and Smad3 positively and negatively regulate TGF-β-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2:109-120; 1998.
    • (1998) Mol. Cell , vol.2 , pp. 109-120
    • Labbé, E.1    Silvestri, C.2    Hoodless, P.A.3    Wrana, J.L.4    Attisano, L.5
  • 68
    • 0032110707 scopus 로고    scopus 로고
    • Characterization of human FAST-1, a TGF-β and activin signal transducer
    • Zhou, S.; Zawel, L.; Lengauer, C.; Kinzler, K. W.; Vogelstein, B. Characterization of human FAST-1, a TGF-β and activin signal transducer. Mol. Cell 2:121-127; 1998.
    • (1998) Mol. Cell , vol.2 , pp. 121-127
    • Zhou, S.1    Zawel, L.2    Lengauer, C.3    Kinzler, K.W.4    Vogelstein, B.5
  • 69
    • 0033615702 scopus 로고    scopus 로고
    • Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding
    • Nagarajan, R. P.; Liu, J.; Chen, Y. Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding. J. Biol. Chem. 274:31229-31235; 1999.
    • (1999) J. Biol. Chem. , vol.274 , pp. 31229-31235
    • Nagarajan, R.P.1    Liu, J.2    Chen, Y.3
  • 71
    • 0028898203 scopus 로고
    • Potential role of WAF1/Cip1/ p21 as a mediator of TGF-beta cytoinhibitory effect
    • Li, C. Y.; Suardet, L.; Little, J. B. Potential role of WAF1/Cip1/ p21 as a mediator of TGF-beta cytoinhibitory effect. J. Biol. Chem. 270:4971-4974; 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 4971-4974
    • Li, C.Y.1    Suardet, L.2    Little, J.B.3
  • 72
    • 0030697971 scopus 로고    scopus 로고
    • Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein
    • Yingling, J. M.; Datto, M. B.; Wong, C.; Frederick, J. P.; Liberati, N. T.; Wang, X. F. Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein. Mol. Cell. Biol. 17:7019-7028; 1997.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 7019-7028
    • Yingling, J.M.1    Datto, M.B.2    Wong, C.3    Frederick, J.P.4    Liberati, N.T.5    Wang, X.F.6
  • 74
    • 0034695483 scopus 로고    scopus 로고
    • Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling
    • Sirard, C.; Kim, S.; Mirtsos, C.; Tadich, P.; Hoodless, P. A.; Iti, A.; Maxson, R.; Wrana, J. L.; Mak, T. W. Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling. J. Biol. Chem. 275:2063-2070; 2000.
    • (2000) J. Biol. Chem. , vol.275 , pp. 2063-2070
    • Sirard, C.1    Kim, S.2    Mirtsos, C.3    Tadich, P.4    Hoodless, P.A.5    Iti, A.6    Maxson, R.7    Wrana, J.L.8    Mak, T.W.9
  • 75
    • 0033082525 scopus 로고    scopus 로고
    • Independent regulation of growth and SMAD-mediated transcription by transforming growth factor β in human melanoma cells
    • Rodeck, U.; Nishiyama, T.; Mauviel, A. Independent regulation of growth and SMAD-mediated transcription by transforming growth factor β in human melanoma cells. Cancer Res. 59:547-550; 1999.
    • (1999) Cancer Res. , vol.59 , pp. 547-550
    • Rodeck, U.1    Nishiyama, T.2    Mauviel, A.3
  • 77
    • 0029658030 scopus 로고    scopus 로고
    • The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression
    • Missero, C.; Di Cunto, F.; Kiyokawa, H.; Koff, A.; Dotto, G. P. The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression. Genes Dev. 10:3065-3075; 1996.
    • (1996) Genes Dev. , vol.10 , pp. 3065-3075
    • Missero, C.1    Di Cunto, F.2    Kiyokawa, H.3    Koff, A.4    Dotto, G.P.5
  • 78
    • 0025787969 scopus 로고
    • Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product
    • Pietenpol, J. A.; Munger, K.; Howley, P. M.; Stein, R. W.; Moses, H. L. Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product. Proc. Natl. Acad. Sci. USA 88:10227-10231; 1991.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 10227-10231
    • Pietenpol, J.A.1    Munger, K.2    Howley, P.M.3    Stein, R.W.4    Moses, H.L.5
  • 79
    • 0028173657 scopus 로고
    • Cloning of mid-G1 serum response genes and identification of a subset regulated by conditional myc expression
    • Tavtigian, S. V.; Zabludoff, S. D.; Wold, B. J. Cloning of mid-G1 serum response genes and identification of a subset regulated by conditional myc expression. Mol. Biol. Cell 5:375-388; 1994.
    • (1994) Mol. Biol. Cell , vol.5 , pp. 375-388
    • Tavtigian, S.V.1    Zabludoff, S.D.2    Wold, B.J.3
  • 80
    • 0024407086 scopus 로고
    • Stable transfection of c-myc sequences into mouse keratinocytes: Amplification of the response to epidermal growth factor
    • Reiss, M.; Dibble, C. L.; Narayanan, R. Stable transfection of c-myc sequences into mouse keratinocytes: Amplification of the response to epidermal growth factor. J. Invest. Dermatol. 93:136-141; 1989.
    • (1989) J. Invest. Dermatol. , vol.93 , pp. 136-141
    • Reiss, M.1    Dibble, C.L.2    Narayanan, R.3
  • 81
    • 0028910316 scopus 로고
    • Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1
    • Alexandrow, M. G.; Kawabata, M.; Aakre, M.; Moses, H. L. Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1. Proc. Natl. Acad. Sci. USA 92: 3239-3243; 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3239-3243
    • Alexandrow, M.G.1    Kawabata, M.2    Aakre, M.3    Moses, H.L.4
  • 82
    • 0027960437 scopus 로고
    • Overexpression of human cyclin D1 reduces the transforming growth factor beta (TGF-beta) type II receptor and growth inhibition by TGF- Beta 1 in an immortalized human esophageal epithelial cell line
    • Okamoto, A.; Jiang, W.; Kim, S. J.; Spillare, E. A.; Stoner, G. D.; Weinstein, I. B.; Harris, C. C. Overexpression of human cyclin D1 reduces the transforming growth factor beta (TGF-beta) type II receptor and growth inhibition by TGF- beta 1 in an immortalized human esophageal epithelial cell line. Proc. Natl. Acad. Sci. USA 91:11576-11580; 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11576-11580
    • Okamoto, A.1    Jiang, W.2    Kim, S.J.3    Spillare, E.A.4    Stoner, G.D.5    Weinstein, I.B.6    Harris, C.C.7
  • 83
    • 2642607872 scopus 로고    scopus 로고
    • Clinical implications of cyclins, cyclin-dependent kinases, RB and E2F1 in squamous-cell lung carcinoma
    • Volm, M.; Koomagi, R.; Rittgen, W. Clinical implications of cyclins, cyclin-dependent kinases, RB and E2F1 in squamous-cell lung carcinoma. Int. J. Cancer 79:294-299; 1998.
    • (1998) Int. J. Cancer , vol.79 , pp. 294-299
    • Volm, M.1    Koomagi, R.2    Rittgen, W.3
  • 84
    • 0026351375 scopus 로고
    • Activation of the autocrine transforming growth factor alpha pathway in human squamous carcinoma cells
    • Reiss, M.; Stash, E. B.; Vellucci, V. F.; Zhou, Z.-L. Activation of the autocrine transforming growth factor alpha pathway in human squamous carcinoma cells. Cancer Res. 51:6254-6262; 1991.
    • (1991) Cancer Res. , vol.51 , pp. 6254-6262
    • Reiss, M.1    Stash, E.B.2    Vellucci, V.F.3    Zhou, Z.-L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.