Genomic structure of the transforming growth factor β type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers

Cancer Research

Volumn 56, Issue 20, 1996, Pages 4595-4598

  Lu, Shi Long ^a   Zhang, Wen Cong ^a   Akiyama, Yoshimitsu ^a   Nomizu, Tadashi ^b   Yuasa, Yasuhito ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b HOSHI GENERAL HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; COLON CARCINOGENESIS; COLORECTAL CANCER; GENE MUTATION; GENE STRUCTURE; HUMAN; HUMAN TISSUE; MISSENSE MUTATION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADULT; BASE SEQUENCE; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MUTATIONAL ANALYSIS; EXONS; FEMALE; HUMANS; INTRONS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SEQUENCE ANALYSIS, DNA;

EID: 0029793062     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Polyak, K. Negative regulation of cell growth by TGFβ. Biochim. Biophys. Acta, 1242, 185-199, 1996.
2. Park, K , Kim, S-J., Bang, Y-J., Park, J-G , Kim, N. K , Roberts, A. B., and Sporn, M. B. Genetic changes in the transforming growth factor β (TGF-β) type II receptor gene in human gastric cancer cells, correlation with sensitivity to growth inhibition by TGF-β. Proc Natl. Acad. Sci. USA, 91: 8772-8776, 1994.
3. Garrigue-Antar, L , Munoz-Antonia, T., Antonia, S. J , Gesmonde, J., Vellucci, V. F., and Reiss, M. Missense mutations of the transforming growth factor β type II receptor in human head and neck squamous carcinoma cells Cancer Res., 55: 3982-3987, 1995.
4. Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E , Kinzler, K. W., Vogelstein, B., Brattain, M., and Willson, J. K. V. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science (Washington DC), 268: 1336-1338, 1995.
5. Myeroff, L. L , Parsons, R., Kim, S-J., Hedrick, L , Cho, K R , Orth, K., Mathis, M., Kinzler, K. W., Lutterbaugh, J., Park, K., Bang, Y-J., Lee, H., Park, J-G, Lynch, H. T., Roberts, A. B., Vogelstein, B., and Markowitz, S D. A Transforming growth factor β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res., 55: 5545-5547, 1995
6. Parsons, R., Myeroff, L. L , Liu, B., Willson, J. K., Markowitz, S. D., Kinzler, K. W., and Vogelstein, B. Microstatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer. Cancer Res., 55: 5548-5550, 1995.
7. Lu, S-L., Akiyama, Y., Nagasaki, H., Saitoh, K., and Yuasa, Y. Mutations of the transforming growth factor-β type II receptor gene and genomic instability in hereditary nonpolyposis colorectal cancer. Biochem. Biophys. Res. Commun. 216: 452-457, 1995.
8. Wang, J., Sun, L., Myeroff, L., Wang, X., Gentry, L. E., Yang, J., Liang, J., Zborowska, E., Markowitz, S., Willson, J. K , and Brattain M. Demonstration that mutation of the type II transforming growth factor β receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. J. Biol. Chem., 270, 22044-22049, 1995
9. Rhyu, M. S Molecular mechanism underlying hereditary nonpolyposis colorectal carcinoma. J. Natl Cancer Inst , 88 240-251, 1996.
10. Blin, N , and Stafford, D. W. A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res., 3: 2303-2308, 1976.
11. Siebert, P D., Chenchik, A., Kellogg, D E., Lukyanov, K. A., and Lukyanov, S. A. An improved PCR method for walking in uncloned genomic DNA Nucleic Acids Res., 23: 1087-1088, 1995.
12. Lin, H. Y., Wang, X. F., Ng-Eaton, E., Weinberg, R. A., and Lodish, H. F. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase Cell, 68: 775-785, 1992.
13. Oto, M., Miyake, S., and Yuasa, Y. Optimization of nonradioisotopic single strand conformation polymorphism analysis with a conventional minislab gel electrophoresis apparatus. Anal. Biochem., 213: 19-22, 1993.
14. Hanks, S. K., Quinn, A. M., and Hunter, T The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (Washington DC), 242: 42-52, 1988.
15. Zhang, F., Strand, A., Robbins, D., Cobb, M. H , and Goldsmith, E. J. Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. Nature (Lond), 367: 704-711, 1994.
16. Taylor, S S., Knighton, D. R., Zheng, J., Ten Eyck, L. F., and Sowadski, J. M. Structural framework for the protein kinase family. Annu Rev. Cell Biol., 8: 429-462, 1992
17. Mathew, S., Murty, V V., Cheifetz, S , George, D , Massague, J., and Chaganti, R. S. Transforming growth factor receptor gene TGFBR2 maps to human chromosome band 3p22. Genomics, 20: 114-115, 1994.
18. Maestro, R., Gasparotto, D., Vukosavljevic, T., Barzan, L., Sulfaro, S , and Boiocchi, M. Three discrete regions of deletion at 3p in head and neck cancers. Cancer Res., 53: 5775-5779, 1993.
19. Li, M., Zhang, Z-F., Reuter, V E., and Cordon-Cardo, C Chromosome 3 allelic losses and microsatellite alterations in transitional cell carcinoma of the urinary bladder Am. J Pathol , 149, 229-235, 1996.
20. Sasaki, M , Okamoto, M , Sato, C., Sugio, K., Soejima, J., Iwama, T., Ikeuchi, T., Tonomura, A., Miyaki, M., and Sasazuki, T. Loss of constitutional heterozygosity in colorectal tumors from patients with familial polyposis coli and those with nonpolyposis colorectal carcinoma Cancer Res., 49: 4402-4406, 1989.
21. Lu, S-L., Akiyama, Y , Nagasaki, H., Nomizu, T., Ikeda, E., Baba, S., Ushio, K , Iwama, T., Maruyama, K , and Yuasa, Y Loss or somatic mutations of hMSH2 occur in hereditary nonpolyposis colorectal cancers with hMSH2 germline mutations. Jpn. J Cancer Res , 87: 279-287, 1996.