TGF-β Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

Science

Volumn 303, Issue 5659, 2004, Pages 848-851

  Bhowmick, Neil A ^a,b   Chytil, Anna ^a   Plieth, David ^a   Gorska, Agnieszka E ^a,b   Dumont, Nancy ^a,b   Shappell, Scott ^a,b   Washington, M Kay ^a,b   Neilson, Eric G ^a,b   Moses, Harold L ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGENS; CELLS; GENES; GROWTH KINETICS; TISSUE;

FIBROBLASTS;

ONCOLOGY;

SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA;

SIGNALING;

ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL INTERACTION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; FEMALE; FIBROBLAST; GENE INACTIVATION; MALE; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROSTATE CARCINOMA; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; STOMACH CARCINOMA; STROMA CELL;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; EPITHELIAL CELLS; FEMALE; FIBROBLASTS; HEPATOCYTE GROWTH FACTOR; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOPLASMS, GLANDULAR AND EPITHELIAL; PROSTATE; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROTO-ONCOGENE PROTEINS C-MET; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINATION, GENETIC; SIGNAL TRANSDUCTION; STOMACH; STOMACH NEOPLASMS; STROMAL CELLS; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 0842288323     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1090922     Document Type: Article

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26. This work was supported by a Department of Defense grant BC991184 (to N.A.B.), NIH grants CA85492 and CA102162 (to H.L.M.), DK46282 (to E.G.N.), Vanderbilt-Ingram Cancer Center support grant CA68485 and the T. J. Martell Foundation. The Cell Imaging and Mouse Pathology Cores were supported by NIH grants CA68485 and AR41943, respectivety, and we thank Y. Shyr for assistance with statistical analyses.