Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer

British Journal of Cancer

Volumn 73, Issue 3, 1996, Pages 294-300

  Betticher, D C ^a,c   Heighway, J ^a   Hasleton, P S ^b   Altermatt, H J ^c   Ryder, W D J ^a   Cerny, T ^c   Thatcher, N ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b WYTHENSHAWE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

CCND1; Cell cycle regulation; Cyclin D1; Local relapse; Non small cell lung carcinoma; Prognostic factor

Indexed keywords

CYCLINE;

ADULT; AGED; ARTICLE; CELL CYCLE; CONTROLLED STUDY; FEMALE; GENE; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG CANCER; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; RESTRICTION FRAGMENT; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SOUTHERN BLOTTING;

EID: 0030043970     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.52     Document Type: Article

References (69)

1. ADÉLAIDE J, MONGES G, DÉRDÉRIAN C, SEITZ JF AND BIRNBAUM D. (1995). Oesophageal cancer and amplification of the human cyclin D gene CCND1 PRAD1. Br. J. Cancer, 71, 64-68.
2. 1. Genes Dev., 7, 812-821.
3. BANNO S, YOSHIKAWA K, NAKAMURA S, YAMAMOTO K, SEITO T, NITTA M, TAKAHASHI T, UEDA R AND SETO M. (1994). Monoclonal antibody against PRAD1 cyclin D1 stains nuclei of tumor cells with translocation or amplification at BCL-1 locus. Jpn. J. Cancer Res., 85, 918-926.
4. BARTKOVA J, LUKAS J, STRAUSS M AND BARTEK J. (1994). The PRAD-1 Cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas. Int. J. Cancer, 58, 568-573.
5. BARTKOVA J, LUKAS J, STRAUSS M AND BARTEK J. (1945). Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene, 10, 775-778.
6. BATES S, PARRY D, BONETTA L, VOUSDEN K, DICKSON C AND PETERS G. (1994). Absence of cyclin D CDK complexes in cells lacking functional retinoblastoma protein. Oncogene, 9, 1633-1640.
7. BLIN N AND STAFFORD DW. (1976). A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res., 3, 2303-2308.
8. BOSCH F, JARES P, CAMPO E, LOPEZ-GUILLERMO A, PIRIS MA, VILLAMOR N, TASSIES D, JAFFE ES, MONTSERRAT E, ROZMAN C AND CARDESA A. (1994). PRAD-1 cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma. Blood, 84, 2726-2732.
9. CALLENDER T, EL-NAGGAR AK, LEE MS, FRANKENTHALER R, LUNA MA AND BATSAKIS JG. (1994). PRAD-1 (CCND1)/Cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma. Cancer, 74, 152-158.
10. COX DR. (1972). Regression models and life-tables (with discussion). J. R. Statist. Soc. B., 34, 187-220.
11. DE BOER CJ, LOYSON S, KLUIN PM, KLUIN-NELEMAN HC, SCHUURING E AND VAN KRIEKEN JHJM. (1993). Multiple breakpoints with the bcl-1 locus in B-cell lymphoma: rearrangements of the cyclin D1 gene. Cancer Res., 53, 4148-4152.
12. DE BOER CJ, VAN KRIEKEN JHJM, KLUIN-NELEMAN HC, KLUIN PM AND SCHUURING E. (1995). Cyclin D1 messenger RNA overexpression as a marker for mantle cell lymphoma. Oncogene, 10, 1833-1840.
13. DELMER A, AJCHENBAUM-CYMBALISTA F, TANG R, RAMOND S AND FAUSSAT AM. (1995). Over-expression of cyclin D1 in chronic B-cell malignancies with abnormality of chromosome 11q13. Br. J. Haematol., 89, 798-804.
14. DULIC V, DRULLINGER LE, LEES E, REED SI AND STEIN GH. (1993). Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes. Proc. Natl Acad. Sci. USA, 90, 11034-11038.
15. EDWARDS MC AND GIBBS RA. (1994). Multiplex PCR: advantages, development and applications. PCR Methods Appl., 3, S65-S75.
16. FREEMAN RS, ESTUS S AND JOHNSON EM. (1994). Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron, 12, 343-355.
17. GILLETT C, FANTL V, SMITH R, FISHER C, BARTEK J, DICKSON C, BARNES D AND PETERS G. (1994). Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res., 54, 1812-1817.
18. GINSBERG RJ, KRIS MG AND ARMSTRONG JG. (1993). Cancer of the lung, non-small cell lung cancer. In Cancer: Principles and Practice of Oncology, fourth edn., VT de Vita Jr, S Hellman and SA Rosenberg (eds). pp. 673-723. JB Lippincott: Philadelphia.
19. HAYASHI N, SUGIMOTO Y, TSUCHIYA E, OGAWA M AND NAKAMURA Y. (1994). Somatic mutations of the MTS (Multiple Tumor Suppressor) 1/CDK41 (Cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas. Biochem. Biophys. Res. Commun., 202, 1426-1430.
20. HEIGHWAY J. (1991). HaeIII polymorphism within 3′untranslated region of PRAD1. Nucleic Acids Res., 19, 5451.
21. HINDS PW, DOWDY SF, EATON EN, ARNOLD A AND WEINBERG RA. (1994). Function of a human cyclin gene as an oncogene. Proc. Natl Acad. Sci. USA, 91, 709-713.
22. HUNTER T AND PINES J. (1994). Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell, 79, 573-582.
23. JAKOBSEN KS, BREIVOLD E AND HORNES E. (1990). Purification of mRNA directly from crude plant tissues in 15 minutes using magnetic oligo dT microspheres. Nucleic Acids Res., 18, 3669.
24. JARES P, FERNANDEZ PL, CAMPO E, NADAL A, BOSCH F, AIZA G, NAYACH I, TRASERRA J AND CARDESA A. (1994). PRAD-1/ cyclin D1 gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas. Cancer Res., 54, 4813-4817.
25. JIANG W, KAHN SM, TOMITA N, ZHANG YJ, LU SH AND WEINSTEIN IB. (1992). Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res., 52, 2980-2983.
26. JIANG W, ZHANG YJ, KAHN SM, HOLLSTEIN MC, SANTELLA RM, LU SH, HARRIS CC, MONTESANO R AND WEINSTEIN IB. (1993). Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc. Natl Acad. Sci. USA., 90, 9026-9030.
27. KANDA Y, NISHIYAMA Y, SHIMADA Y, IMAMURA M, NOMURA H, HIAI H AND FUKUMOTO M. (1994). Analysis of gene amplification and overexpression in human esophageal-carcinoma cell lines. Int. J. Cancer, 58, 291-297.
28. KAY R AND SCHUMACHER M. (1983). Unbiased assessment of treatment effects on disease recurrence and survival in clinical trials. Stat. Med., 2, 41-58.
29. LAMMIE GA, FANTL V, SMITH R, SCHUURING E, BROOKES S, MICHALIDES R, DICKSON C, ARNOLD A AND PETERS G. (1991). D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to bcl-1. Oncogene, 6, 439-444.
30. LEE JS, RO JY, SAHIN A, HITTELMAN W, BROWN BW, MOUNTAIN CF AND HONG KW. (1989). Expression of epidermal growth factor receptor (EGFR): a favorable prognostic factor for surgically resected non-small cell lung cancer (NSCLC). Proc. Am. Soc. Clin. Oncol., 8, 226 (A878).
31. 1 cyclin (Cln) function in yeast. Cell, 66, 1197-1206.
32. LOVEC H, SEWING A, LUCIBELLO FC, MÜLLER R AND MÖRÖY T. (1994). Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation. Oncogene, 9, 323-326.
33. LUCIBELLO FC, SEWING A, BRÜSSELBACH S, BÜRGER C AND MÜLLER R. (1993). Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts. J. Cell Sci., 105, 123-133.
34. 1 phase control of B-cell neoplasms carrying the t(11;14) translocation. Oncogene, 9, 2159-2167.
35. 1 phase progression in specific cell types. Oncogene, 10, 2125-2134.
36. MARX J. (1994). How cells cycle toward cancer. Science, 263, 319-321.
37. 1 phase of the cell cycle. Cell, 65, 701-713.
38. MICHALIDES R, VAN VEELEN N, HART A, LOFTUS B, WIENTJENS E AND BALM A. (1995). Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck. Cancer Res., 55, 975-978.
39. MORI T, MIURA K, AOKI T, NISHIHIRA T, MORI S AND NAKAMURA Y. (1994). Frequent somatic mutation of the MTS1/CDK41 (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res., 54, 3396-3397.
40. MOTOKURA T AND ARNOLD A. (1993a). Cyclin D and oncogenesis. Curr. Opin. Gen. Develop., 3, 5-10.
41. MOTOKURA T AND ARNOLD A. (1993b). Cyclins and oncogenesis. Biochim. Biophys. Acta, 1155, 63-78.
42. MOTOKURA T, BLOOM T, KIM HG, JÜPPNER H, RUDERMAN JV. KRONENBERG HM AND ARNOLD A. (1991). A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature, 350, 512-515.
43. MÜLLER D, MILLON R, LIDEREAU R, ENGELMANN A, BRONNER G, FLESCH H, EBER M, METHLIN G AND ABECASSIS J. (1994). Frequent amplification of 11q13 DNA markers is associated with lymph node involvement in human head and neck squamous cell carcinomas. Eur. J. Cancer B. Oral Oncol., 30, 113-120.
44. MUSGROVE EA, LEE CSL, BUCKLEY MF AND SUTHERLAND RL. (1994). Cyclin D1 induction in breast cancer cells shorten G1 and is sufficient for cells arrested in G1 to complete the cell cycle. Proc. Natl Acad. Sci. USA, 91, 8022-8026.
45. NAKAMURA S, SETO M, BANNO S, SUZUKI S, KOSHIKAWA T, KITOH K, KAGAMI Y, OGURA M, YATABE Y, AND KOJIMA M. (1994). Immunohistochemical analysis of cyclin D1 protein in hemalopoietic neoplasms with special reference to mantle cell lymphoma. Jpn. J. Cancer Res., 85, 1270-1279.
46. NELSON W. (1969). Hazard plotting for incomplete failure data. J. Qual. Technol., 1, 27-52.
47. NISHIDA N, FUKUDA Y, KOMEDA T, KITA R, SANDO T, FURUKAWA M, AMENOMORI M, SHIBAGAKI I, NAKAO K, IKENAGA M AND ISHIZAKI K. (1994). Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res., 54, 3107-3110.
48. OTTERSON GA, KRATZKE RA, COXON A, KIM YW AND KAYE FJ. (1994). Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype Rb. Oncogene, 9, 3375-3378.
49. PETERS G. (1994). The D-type cyclins and their role in tumorigenesis. J. Cell Sci. Suppl., 18, 89-96.
50. PEZZELLA F, TURLEY H, KUZU I, TUNGEKAR MF, DUNNILL MS, PIERCE CB, HARRIS A, GATTER KC AND MASON DY. (1993). BCL-2 protein in non-small-cell lung carcinoma. N. Engl. J. Med., 329, 690-694.
51. PINES J. (1993). Cyclins and their associated cyclin-dependent kinases in the human cell cycle. Biochem. Soc. Trans., 21, 921-925.
52. 1 phase in rodent fibroblasts. Genes Dev., 7, 1559-1571.
53. SCHUURING E, VERHOEVEN E, VAN TINTEREN H, PETERSE JL, NUNNINK B, THUNNISSEN FBJM, DEVILEE P, CORNELISSE CJ, VAN DE VIJVER M, MOOI WJ AND MICHALIDES RJAM. (1992). Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer. Cancer Res., 52, 5229-5234.
54. SERRANO M, HANNON GJ AND BEACH D. (1993). A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/ CDK4. Nature, 366, 704-707.
55. SETO M, YAMAMOTO K, IIDA S, AKAO Y, UTSUMI KR, KUBONISHI I, MIYOSHI I, OHTSUKI T, YAWATA, Y. NAMBA M, MOTOKURA T, ARNOLD A, TAKAHASHI T AND UEDA R. (1992). Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13:q32) translocation. Oncogene, 7, 1401-1406.
56. SEWING A, BÜRGER C, BRÜSSELBACH S, SCHALK C, LUCIBELLO FC AND MÜLLER R. (1993). Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP. J. Cell Sci., 104, 545-554.
57. SHAPIRO GI, EDWARDS CD, KOBZIK L, GODLESKI J, RICHARDS W, SUGARBAKER DJ AND ROLLINS BJ. (1995). Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. Cancer Res., 55, 505-509.
58. SHERR CJ. (1993). Mammalian G1 cyclins. Cell, 73, 1059-1065.
59. SHERR CJ. (1994). G1 phase progression cycling on cue. Cell, 79, 551-555.
60. SHERR CJ. (1995). D-type cyclins. Trends Biochem. Sci., 20, 187-190.
61. UICC-AMERICAN JOINT COMMITTEE ON CANCER. (1987). Manual for Staging of Cancer, 3rd edn. JB Lippincott: Philadelphia.
62. WHO (1981). Histological Typing of Lung Tumours, 2nd edn. World Health Organization: Geneva.
63. WILLIAMS ME, GAFFEY MJ, WEISS LM, WILCZYNSKI SP, SCHUURING E AND LEVINE PA. (1993). Chromosome 11q13 amplification in head and neck squamous cell carcinoma. Arch. Otolaryngol. Head Neck Surg., 119, 1238-1243.
64. WIMAN KG. (1993). The retinoblastoma gene: role in cell cycle control and cell differentiation. FASEB J., 7, 841-845.
65. WITHERS DA, HARVEY RC, FAUST JB, MELNYK O, CAREY K AND MEEKER TC. (1991). Characterization of a candidate bcl-1 gene. Mol. Cell Biol., 11, 4846-4853.
66. XIONG Y, CONNOLLY T, FUTCHER B AND BEACH D. (1991). Human D-type cyclin. Cell, 65, 691-699.
67. ZHANG SY, KLEIN-SZANTO AJP, SAUTER ER, SHAFARENKO M, MITSUNAGA S, NOBORI T, CARSON DA, RIDGE JA AND GOODROW TL. (1994). Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res., 54, 5050-5053.
68. ZHANG YJ, JIANG W, CHIEN CJ, LEE CS, KAHN SM, SANTELLA RM AND WEINSTEIN IB. (1993). Amplification and overexpression of cyclin D1 in human hepatocellular carcinoma. Biochem. Biophys. Res. Commun., 196, 1010-1016.
69. ZHOU X, TARMIN L, YIN J, JIANG HY, SUZUKI H, RHYU MG, ABRAHAM JM AND MELTZER SJ. (1994). The MTS1 gene is frequently mutated in primary human esophageal tumors. Oncogene, 9, 3737-3741.