Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice

Cancer Research

Volumn 59, Issue 24, 1999, Pages 6113-6117

  Takaku, Kazuaki ^a   Miyoshi, Hiroyuki ^b   Matsunaga, Akihiro ^a   Oshima, Masanobu ^b   Sasaki, Nobuya ^a   Taketo, Makoto M ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CHROMOSOME 18Q; DUODENUM; GENE DELETION; GENE MUTATION; HETEROZYGOSITY LOSS; INTESTINE POLYP; KNOCKOUT MOUSE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOMACH POLYP; TUMOR SUPPRESSOR GENE;

ANIMALS; DNA-BINDING PROTEINS; DUODENAL NEOPLASMS; GENES, TUMOR SUPPRESSOR; HETEROZYGOTE; HUMANS; INTESTINAL POLYPS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POLYPS; SMAD4 PROTEIN; STOMACH NEOPLASMS; TRANS-ACTIVATORS;

EID: 0033572255     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Hahn, S. A., Schutte, M., Hoque, A. T., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., and Kern, S. E. DPC4, a candidate tumor suppressor gene at human chromosome at 18q21.1. Science (Washington DC), 271: 350-353, 1996.
2. Riggins, G. J., Thiagalingam, S., Rozenblum, E., Weinstein, C. L., Kern, S. E., Hamilton, S. R., Willson, J. K., Markowitz, S. D., Kinzler, K. W., and Vogelstein, B. Mad-related genes in the human. Nat. Genet., 13: 347-349, 1996.
3. Zhang, V., Feng, X. H., Wu, R. V., and Derynck, R. Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature (Lond.), 383: 168-172, 1996.
4. Massagué, J., Hata, A., and Liu, F. TGF-β signalling through the Smad pathway. Trends. Cell Biol., 7: 187-192, 1997.
5. Massagué, J. TGFβ signal transduction. Annu. Rev. Biochem., 67: 753-791, 1998.
6. Fynan, T. M., and Reiss, M. Resistance to inhibition of cell growth by transforming growth factor β and its role in oncogenesis. Crit. Rev. Oncol., 4: 493-540, 1993.
7. Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., Brattain, M., and Willson, J. K. V. Inactivation of the type II TGFβ receptor in colon cancer cells with microsatellite instability. Science (Washington DC), 268: 1336-1338, 1995.
8. Miyaki, M., Iijima, T., Konishi, M., Sakai, K., Ishii, A., Yasuno, M., Hishima, T., Koike, M., Shitara, N., Iwama, T., Utsunomiya, J., Kuroki, T., and Mori, T. Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Oncogene, 18: 3098-3103, 1999.
9. Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M. F., and Taketo, M. M. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell, 92: 645-656, 1998.
10. Haggit, R. C., and Reid, B. J. Hereditary gastrointestinal polyposis syndromes. Am. J. Surg. Pathol., 10: 871-887, 1986.
11. Howe, J. R., Roth, S., Ringold, J. C., Summers, R. W., Jarvinen. H. J., Sistonen, P., Tomlinson, I. P., Houlston, R. S., Bevan, S., Mitros, F. A., Stone, E. M., and Aaltonen, L. A. Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science (Washington DC), 280: 1086-1088, 1998.
12. Friedl, W., Kruse, R., Uhlhaas, S., Stolte, M., Schartmann, B., Keller, K. M., Jungck, M., Stern, M., Loff, S., Back, W., Propping, P., and Jenne, D. E. Frequent 4-bp deletion in exon 9 of the SMAD4/MADH4 gene in familial juvenile polyposis patients. Genes Chromosomes Cancer, 25: 403-406, 1999.
13. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L. M., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M., Eng, C., and Parsons, R. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet., 16: 64-67, 1997.
14. Marsh, D. J., Dahia, P. L., Zheng, Z., Liaw, D., Parsons, R., Gorlin, R. J., and Eng, C. Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat. Genet. 16: 333-334, 1997.
15. Di Cristofano, A., Pesce, B., Cordon-Cardo, C., and Pandolfi, P. P. Pten is essential for embryonic development and tumor suppression. Nat. Genet., 19: 348-355, 1998.
16. Oshima, M., Oshima, H., Kitagawa, K., Kobayashi, M., Itakura, C., and Taketo, M. Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncation Apc gene. Proc. Natl. Acad. Sci. USA, 92: 4482-4486, 1995.
17. Δ716 knockout mice. Cancer Res., 57: 1644-1649, 1997.
18. Mowry, R. W. The special value of methods that color both acidic and vicinal hydroxyl groups in the histochemical study of mucins. Ann. NY Acad. Sci., 106: 402-423, 1963.
19. van Kranen, H. J., de Gruijl, F. R., de Vries, A., Sontag, Y., Wester, P. W., Senden, H. C., Rozemuller, E., van Kreijl, C. F. Frequent p53 alterations but low incidence of ras mutations in UV-B-induced skin tumors of hairless mice. Carcinogenesis, 16: 1141-1147, 1995.
20. Smits, R., Kartheuser, A., Jagmohan-Changur, S., Leblanc, V., Breukel, C., de Vries, A., van Kranen, H., van Krieken, J. H., Williamson, S., Edelmann, W., Kucherlapati, R., Khan, P. M., and Fodde, R. Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis. Carcinogenesis, 18: 321-327, 1997.
21. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (Washington DC), 275: 1943-1947, 1997.
22. Fenoglio-Preiser, C. M., Pascal, R. R., and Perzin, K. H. Non-neoplastic polyps. In: W. H. Hartman and L. H. Sobin (eds.), Tumors of the Intestines, pp. 31-67. Washington, DC: Armed Forces Institute of Pathology, 1990.
23. Houlston, R., Bevan, S., Williams, A., Young, J., Dunlop, M., Rozen, P., Eng, C., Markie, D., Woodford-Richens, K., Rodriguez-Bigas, M. A., Leggett, B., Neale, K., Phillips, R., Sheridan, E., Hodgson, S., Iwama, T., Eccles, D., Bodmer, W., and Tomlinson, I. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases. Hum. Mol. Genet., 7: 1907-1912, 1999.
24. Polakis, P. The oncogenic activation of β-catenin. Curr. Opin. Genet. Dev., 9: 15-21, 1999.
25. Olschwang, S., Serova-Sinilnikova, O. M., Lenoir, G. M., and Thomas, G. PTEN germ-line mutations in juvenile polyposis coli. Nat. Genet., 18: 12-14, 1998.
26. Lynch, E. D., Ostermeyer, E. A., Lee, M. K., Arena, J. F., Ji, H., Dann, J., Swisshelm, K., Suchard, D., MacLeod, P. M., Kvinnsland, S., Gjertsen, B. T., Heimdal, K., Lubs, H., Moller, P., and King, M. C. Inherited mutations in PTEN that are associated with breast cancer, Cowden disease, and juvenile polyposis. Am. J. Hum. Genet., 61: 1254-1260, 1997.
27. Maehama, T., and Dixon, J. E. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-phosphatase. J. Biol. Chem., 273: 13375-13378, 1998.
28. 1 growth arrest in glioma cells. Cancer Res., 15: 5002-5008, 1998.
29. Myers, M. P., Pass, I., Batty, I. H., Van der Kaay, J., Stolarov, J. P., Hemmings, B. A., Wigler, M. H., Downes, C. P., and Tonks, N. K. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc. Natl. Acad. Sci. USA, 95: 13513-13518, 1998.
30. Nelen, M. R., van Staveren, W. C., Peeters, E. A., Hassel, M. B., Gorlin, R. J., Hamm, H., Lindboe, C. F., Fryns, J. P., Sijmons, R. H., Woods, D. G., Mariman, E. C., Padberg, G. W., and Kremer, H. Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. Hum. Mol. Genet., 6: 1383-1387, 1997.
31. Rotterdam, H. Hyperplasias and benign epithelial tumors. In: H. Rotterdam and H. T. Enterline (eds.), Pathology of the Stomach and Duodenum, pp. 117-141. New York: Springer, 1989.
32. Howe, J. R., Mitros, F. A., and Summers, R. W. The risk of gastrointestinal carcinoma in familial juvenile polyposis. Ann. Surg. Oncol., 5, 751-756, 1998.
33. Desai, D. C., Neale, K. F., Talbot, I. C., Hodgson, S. V., and Phillips, R. K. Juvenile polyposis. Br. J. Surg., 82: 14-17, 1995.
34. Walpole, I. R., and Cullity, G. Juvenile polyposis: a case with early presentation and death attributable to adenocarcinoma of the pancreas. Am. J. Med. Genet., 32: 1-8, 1989.
35. Willis, R. A. Hamartomas and hamartomatous syndromes. In: The Borderland of Embryology and Pathology, Ed. 2, pp. 351-392. London: Butlerworths, 1962.
36. Tamai, Y., Nakajima, R., Ishikawa, T., Takaku, K., Seldin, M. F., and Taketo, M. M. Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice. Cancer Res., 59: 2965-2970, 1999.
37. Eng, C., and Peacocke, M. PTEN and inherited hamartoma-cancer syndromes. Nat. Genet., 19: 223, 1998.