The somatic mutation frequency of the transforming growth factor β receptor type II gene varies widely among different cancers with microsatellite instability

European Journal of Surgical Oncology

Volumn 22, Issue 5, 1996, Pages 474-477

  Abe, Tadayoshi ^a   Ouyang, Hong ^a   Migita, Takashi ^a   Kato, Yo ^b   Kimura, Mitsuhiro ^a   Shiiba, Kenichi ^a   Sunamura, Makoto ^a   Matsuno, Seiki ^a   Horii, Akira ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CANCER INSTITUTE   (Japan)

Author keywords

Colorectal cancer; Gastric cancer; MSI; RII

Indexed keywords

MICROSATELLITE DNA; POLYADENYLIC ACID; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; BASE MISPAIRING; CANCER; CARCINOGENESIS; COLORECTAL CANCER; DNA REPAIR; ENDOMETRIUM CANCER; GENE DELETION; GENE FREQUENCY; GROWTH REGULATION; HUMAN; LUNG CANCER; PANCREAS CANCER; PRIORITY JOURNAL; SOMATIC MUTATION; STOMACH CANCER;

EID: 0029853786     PISSN: 07487983     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0748-7983(96)92824-3     Document Type: Article

References (21)

1. Markowitz SD, Myeroff J. Kochera M, Lutterbaugh J, Swiriduk M. Willson JKV. A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-β independence without inactivating the p53 tumour suppressor gene. J Clin Invest 1994; 93: 1005-13.
2. Moses H, Yang E. and Pietenpol J. TGF-β stimulation and inhibition of cell proliferation: new mechanistic insights. Cell 1990; 63: 245-47.
3. Bassing CH. Howe DJ, Segarini PR, Donahoe PK, Wang XF. A single heterometric complex is sufficient to mediate biological effects of transforming growth factor-β ligand. J Biol Chem 1994; 269: 14861-4.
4. Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell 1992; 68: 775-85.
5. LuZhe S, Gengfei W, James KVW, et al. Expression of transforming growth factor-β type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. J Biol Chem 1994; 269: 26449-55.
6. Sue SR, Chari RS. Kong F, Mills JJ, Fine RL, Jirtle RL, Meyers WC. Transforming growth factor-β receptors and mannose 6-phosphate/insulin-like growth factor-II receptor expression in human hepatocellular carcinoma. Ann Surg 1995; 222: 171-8.
7. MacKay SLD, Yaswen LR, Tarnuzzer RW, Moldawer LL, Bland KI, Copeland III EM, Schultz GS. colon cancer cells that are not growth inhibited by TGF-β lack functional type I and type II TGF-β receptors. Ann Surg 1995; 221: 767-77.
8. Aaltonen LA, Peltomäki P, Leach FS, et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993; 260: 812-16.
9. Ionov Y, Peinado MA, Malkhosyan S. Shibata D, Perucho M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonie carcinogenesis. Nature 1993; 363: 558-61.
10. Han H-J, Yanagisawa A, Kato Y, Park J-G, Nakamura Y. Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Res 1993; 53: 5087-9.
11. Thibodeau SN, Bren G. Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993; 260: 816-19.
12. Markowitz S, Wang J. Mycroff L. et al. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science (Washington DC) 1995; 268: 1336-8.
13. Mathew S, Murty VVVS, Cheiletz S, George D, Massaguè J, Chuganti RSK. Transforming growth factor receptor gene TGF-β R2 maps to human chromosome band 3p22. Genomics 1994: 20: 114-15.
14. Yamakawa K, Takahashi T, Horio Y, Murata Y. et al. Frequent homozygous deletions in lung cancer cell lines detected by a DNA markers located at 3p21.3-p22. Oncogene 1993; 8: 327-30.
15. Yamakawa K, Morita R, Takahashi EI, Hori TA, Ishikawa J, Nakamura Y. A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer Res 1991: 51: 4707-11.
16. Sato T, Tanigami A, Yamakawa K, Akiyama F, Kasumi F, Sakamoto G, Nakamura Y, Allelotype of breast cancer: Cumulative allele losses promote tumour progression in primary breast cancer. Cancer Res 1990; 50: 7184-9.
17. Goelz SE, Hamilton SR, Vogelstein B. Purification of DNA from formaldehyde fixed and parafiin embedded human tissue. Biochem Biophys Res Commun 1985; 130: 118-26.
18. Yanagisawa A, Kato Y, Ohtake K. et al. c-Ki-ras point mutations in ductectalic type mucinous cystic neoplasms of the pancreas. Jpn J Cancer Res 1991; 82: 1057-60.
19. Horii A, Han H-J, Shimada M. et al. Frequent replication errors at microsatellite loci in tumors of patients with multiple primary cancers. Cancer Res 1994; 54: 3373-5.
20. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 1977; 74: 5463-7.
21. Paul M, Mismatch repair, genetic stability, and cancer. Science 1994; 266: 1959-60.