Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line

Breast Cancer Research

Volumn 5, Issue 6, 2003, Pages

  Xie, Lu ^a   Law, Brian K ^a   Aakre, Mary E ^a   Edgerton, Mary ^b,c   Shyr, Yu ^b,c   Bhowmick, Neil A ^a   Moses, Harold L ^a,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Adhesion; CDNA microarray; Cell cycle control; Epithelial; Mammary gland

Indexed keywords

ACTIN; ACTININ; ALPHA ACTININ; ALPHA INTEGRIN; BETA5 INTEGRIN; CALPAIN; CATENIN; COMPLEMENTARY DNA; CYCLIN A; CYCLIN B; CYCLIN D2; CYCLIN H; FIBRONECTIN; INHIBITOR OF DIFFERENTIATION 2; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; MYOSIN LIGHT CHAIN; PROTEIN C JUN; PROTEIN KINASE B; PROTEIN P107; TRANSCRIPTION FACTOR E2F5; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA;

ACTININ ALPHA3 GENE; AKT GENE; ALPHA ACTININ GENE; ALPHA INTEGRIN GENE; ANIMAL CELL; ARTICLE; BREAST EPITHELIUM CELL; C JUN GENE; CELL CYCLE; CONTROLLED STUDY; CYCLIN A GENE; CYCLIN B GENE; CYCLIN D2 GENE; CYCLIN H GENE; DNA MICROARRAY; DOWN REGULATION; E2F5 GENE; FEMALE; FIBRONECTIN GENE; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; ID2 GENE; IKKI GENE; INTEGRIN BETA5 GENE; IQGAP1 GENE; MCALPAIN GENE; MOUSE; MYOSIN LIGHT CHAIN GENE; NMUMG CELL; NONHUMAN; NORTHERN BLOTTING; ONCOGENE C MYC; P107 GENE; P120CAS CATENIN GENE; PP2A PR53 GENE; PROTEIN FUNCTION; RHOB GENE; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; CELL ADHESION; CELL LINE; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; GENETICS; METABOLISM; UDDER;

ANIMALS; CELL ADHESION; CELL CYCLE; CELL LINE; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MAMMARY GLANDS, ANIMAL; MICE; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0642306119     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr640     Document Type: Article

References (21)

1. Yue J, Mulder KM: Transforming growth factor-beta signal transduction in epithelial cells. Pharmacol Ther. 2001, 91: 1-34. 10.1016/S0163-7258(01)00143-7.
2. Akhurst RJ, Derynck R: TGF-beta signaling in cancer - a double-edged sword. Trends Cell Biol. 2001, 11: S44-S51. 10.1016/S0962-8924(01)02130-4.
3. Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, Arteaga CL, Moses HL: Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation though a RhoA-dependent mechanism. Mol Biol Cell. 2001, 12: 27-36.
4. Verrecchia F, Chu ML, Mauviel A: Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem. 2001, 276: 17058-17062. 10.1074/jbc.M100754200.
5. Zavadil J, Bitzer M, Liang D, Yang YC, Massimi A, Kneitz S, Piek E, Bottinger EP: Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta. Proc Natl Acad Sci USA. 2001, 98: 6686-6691. 10.1073/pnas.111614398.
6. Li Z, Sacks DB: Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1. J Biol Chem. 2003, 278: 4347-4352. 10.1074/jbc.M208579200.
7. Kim G, Jun JB, Elkon KB: Necessary role of phosphatidylinositol 3-kinase in transforming growth factor beta-mediated activation of Akt in normal and rheumatoid arthitis synovial fibroblasts. Arthitis Rheum. 2002, 46: 1504-1511. 10.1002/art.10314.
8. Engel ME, Datta PK, Moses HL: RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation. J Biol Chem. 1998, 273: 9921-9926. 10.1074/jbc.273.16.9921.
9. Chen CR, Kang Y, Massague J: Defective repression of c-myc in breast cancer cells: a loss at the core of the transforming growth factor beta growth arrest program. Proc Natl Acad Sci USA. 2001, 98: 992-999. 10.1073/pnas.98.3.992.
10. Shen X, Li J, Hu PP, Waddell D, Zhang J, Wang XF: The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation. J Biol Chem. 2001, 276: 15362-15368. 10.1074/jbc.M009534200.
11. Liu AX, Rane N, Liu JP, Prendergast GC: RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells. Mol Cell Biol. 2001, 21: 6906-6912. 10.1128/MCB.21.20.6906-6912.2001.
12. Adnane J, Seijo E, Chen Z, Bizouarn F, Leal M, Sebti SM, Munoz-Antonia T: RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1. J Biol Chem. 2002, 277: 8500-8507. 10.1074/jbc.M104367200.
13. Lasorella A, Uo T, Iavarone A: Id proteins at the cross-road of development and cancer. Oncogene. 2001, 20: 8326-8333. 10.1038/sj.onc.1205093.
14. Shin I, Bakin AV, Rodeck U, Brunet A, Arteaga CL: Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHL1. Mol Biol Cell. 2001, 12: 3328-3339.
15. Loukinova E, Chen Z, Van Waes C, Dong G: Expression of proangiogenic chemokine Gro 1 in low and high metastatic variants of Pam murine squamous cell carcinoma is differentially regulated by IL-1alpha, EGF and TGF-beta1 though NF-kappaB dependent and independent mechanisms. Int J Cancer. 2001, 94: 637-644. 10.1002/ijc.1514.
16. Vairapandi M, Balliet AG, Hoffman B, Liebermann DA: GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. J Cell Physiol. 2002, 192: 327-338. 10.1002/jcp.10140.
17. Shimao Y, Nabeshima K, Inoue T, Koono M: Complex formation of IQGAP1 with E-cadherin/catenin during cohort migration of carcinoma cells. Its possible association with localized release from cell-cell adhesion. Virchows Arch. 2002, 441: 124-132. 10.1007/s00428-002-0603-3.
18. Arthur JS, Elce JS, Hegadorn C, Williams K, Greer PA: Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division. Mol Cell Biol. 2000, 20: 4474-4481. 10.1128/MCB.20.12.4474-4481.2000.
19. Rothwarf DM, Karin M: The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus. Sci STKE. 1999, 5: RE1-
20. Aupperle KR, Yamanishi Y, Bennett BL, Mercurio F, Boyle DL, Firestein GS: Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes. Cell Immunol. 2001, 214: 54-59. 10.1006/cimm.2002.1885.
21. 2+-binding EF-hand motifs in the B''/PR72 subunit of Protein Phosphatase 2A. J Biol Chem. 2003, 278: 10697-10706. 10.1074/jbc.M211717200.