Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-β receptor exhibit impaired mammary development and enhanced mammary tumor formation

American Journal of Pathology

Volumn 163, Issue 4, 2003, Pages 1539-1549

  Gorska, Agnieszka E ^a,b   Jensen, Roy A ^a,b,c   Shyr, Yu ^a,c   Aakre, Mary E ^a,b   Bhowmick, Neil A ^a,b   Moses, Harold L ^a,b,c  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CANCER INVASION; CARCINOMA IN SITU; CELL DIFFERENTIATION; CONTROLLED STUDY; ENHANCER REGION; IN SITU HYBRIDIZATION; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSGENIC MOUSE; TUMOR GROWTH;

EID: 0141537150     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63510-9     Document Type: Article

References (34)

1. Robinson SD, Silberstein GB, Roberts AB, Flanders KC, Daniel CW: Regulated expression and growth inhibitory effects of transforming growth factor-β isoforms in mouse mammary gland development. Development 1991, 113:867-878
2. Silberstein GB, Daniel CW: Reversible inhibition of mammary gland growth by transforming growth factor-β. Science 1987, 237:291-293
3. Pierce Jr DF, Johnson MD, Matsui Y, Robinson SD, Gold LI, Purchio AF, Daniel CW, Hogan BL, Moses HL: Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-β1. Genes Dev 1993, 7:2308-2317
4. Jhappan C, Geiser AG, Kordon EC, Bagheri D, Hennighausen L, Roberts AB, Smith GH, Merlino G: Targeting expression of a transforming growth factor β1 transgene to the pregnant mammary gland inhibits alveolar development and lactation. EMBO J 1993, 12:1835-1845
5. Kordon EC, McKnight RA, Jhappan C, Hennighausen L, Merlino G, Smith GH: Ectopic TGF β 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population. Dev Biol 1995, 168:47-61
6. Pierce Jr DF, Gorska AE, Chytil A, Meise KS, Page DL, Coffey Jr RJ, Moses HL: Mammary tumor suppression by transforming growth factor β 1 transgene expression. Proc Natl Acad Sci USA 1995, 92:4254-4258
7. Boulanger CA, Smith GH: Reducing mammary cancer risk through premature stem cell senescence. Oncogene 2001, 20:2264-2272
8. Buggiano V, Schere-Levy C, Abe K, Vanzulli S, Piazzon I, Smith GH, Kordon EC: Impairment of mammary lobular development induced by expression of TGFβ1 under the control of WAP promoter does not suppress tumorigenesis in MMTV-infected transgenic mice. Int J Cancer 2001, 92:568-576
9. Bottinger EP, Jakubczak JL, Roberts IS, Mumy M, Hemmati P, Bagnall K, Merlino G, Wakefield LM: Expression of a dominant-negative mutant TGF-β type II receptor in transgenic mice reveals essential roles for TGF-β in regulation of growth and differentiation in the exocrine pancreas. EMBO J 1997, 16:2621-2633
10. Gorska AE, Joseph H, Derynck R, Moses HL, Serra R: Dominant-negative interference of the transforming growth factor β type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice. Cell Growth Differ 1998, 9:229-238
11. Bottinger EP, Jakubczak JL, Haines DC, Bagnall K, Wakefield LM: Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor β receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene. Cancer Res 1997, 57:5564-5570
12. Amendt C, Schirmacher P, Weber H, Blessing M: Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development. Oncogene 1998, 17:25-34
13. Matsui Y, Halter SA, Holt JT, Hogan BL, Coffey RJ: Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. Cell 1990, 61:1147-1155
14. Brandt R, Eisenbrandt R, Leenders F, Zschiesche W, Binas B, Juergensen C, Theuring F: Mammary gland specific hEGF receptor transgene expression induces neoplasia and inhibits differentiation. Oncogene 2000, 19:2129-2137
15. Liu CH, Chang SH, Narko K, Trifan OC, Wu MT, Smith E, Haudenschild C, Lane TF, Hla T: Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. J Biol Chem 2001, 276:18563-18569
16. Liang KY, Zeger SL: Longitudinal data analysis using generalized linear models. Biometrika 1986, 73:13-22
17. Diggle P, Liang KY, Zeger SL: Analysis of Longitudinal Data. Oxford, Clarendon Press, 1994
18. Cardiff RD, Anver MR, Gusterson BA, Hennighausen L, Jensen RA, Merino MJ, Rehm S, Russo J, Tavassoli FA, Wakefield LM, Ward JM, Green JE: The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene 2000, 19:968-988
19. Dumont N, Arteaga CL: Transforming growth factor-β and breast cancer: tumor promoting effects of transforming growth factor-β. Breast Cancer Res 2000, 2:125-132
20. McEarchern JA, Kobie JJ, Mack V, Wu RS, Meade-Tollin L, Arteaga CL, Dumont N, Besselsen D, Seftor E, Hendrix MJ, Katsanis E, Akporiaye ET: Invasion and metastasis of a mammary tumor involves TGF-β signaling. Int J Cancer 2001, 91:76-82
21. Muraoka RS, Dumont N, Ritter CA, Dugger TC, Brantley DM, Chen J, Easterly E, Roebuck LR, Ryan S, Gotwals PJ, Koteliansky V, Arteaga CL: Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest 2002, 109:1551-1559
22. Bhowmick N, Zent R, Ghaissi M, McDonnell M, Moses HL: Integrin b1 signaling is necessary for transforming growth factor-α activation of p38MAPK and epithelial plasticity. J Biol Chem 2001, 5:46707-46713
23. Robinson SD, Roberts AB, Daniel CW: TGF β suppresses casein synthesis in mouse mammary explants and may play a role in controlling milk levels during pregnancy. J Cell Biol 1993, 120:245-251
24. Barcellos-Hoff MH, Ewan KB: Transforming growth factor-β and breast cancer: mammary gland development. Breast Cancer Res 2000, 2:92-99
25. Nguyen AV, Pollard JW: Transforming growth factor β3 induces cell death during the first stage of mammary gland involution. Development 2000, 127:3107-3118
26. D'Cruz CM, Moody SE, Master SR, Hartman JL, Keiper EA, Imielinski MB, Cox JD, Wang JY, Ha SI, Keister BA, Chodosh LA: Persistent parity-induced changes in growth factors, TGF-β3, and differentiation in the rodent mammary gland. Mol Endocrinol 2002, 16:2034-2051
27. Derynck R, Akhurst RJ, Balmain A: TGF-β signaling in tumor suppression and cancer progression. Nat Genet 2001, 29:117-129
28. Akhurst RJ, Derynck R: TGF-β signaling in cancer - a double-edged sword. Trends Cell Biol 2001, 11:S44-S51
29. Moses HL, Arteaga CL, Alexandrow MG, Dagnino L, Kawabata M, Pierce Jr DF, Serra R: TGF β regulation of cell proliferation. Princess Takamatsu Symp 1994, 24:250-263
30. Halter SA, Dempsey P, Matsui Y, Stokes MK, Graves-Deal R, Hogan BL, Coffey RJ: Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor virus transforming growth factor-alpha. Characterization of mammary gland and skin proliferations. Am J Pathol 1992, 140:1131-1146
31. Muller WJ: Expression of activated oncogenes in the murine mammary gland: transgenic models for human breast cancer. Cancer Metastasis Rev 1991, 10:217-227
32. Sinn E, Muller W, Pattengale P, Tepler I, Wallace R, Leder P: Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell 1987, 49:465-475
33. Guy CT, Webster MA, Schaller M, Parsons TJ, Cardiff RD, Muller WJ: Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci USA 1992, 89:10578-10582
34. Kwan H, Pecenka V, Tsukamoto A, Parslow TG, Guzman R, Lin TP, Muller WJ, Lee FS, Leder P, Varmus HE: Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Mol Cell Biol 1992, 12:147-154