Overexpression of cyclins D1 and E is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development

Cancer Research

Volumn 59, Issue 10, 1999, Pages 2470-2476

  Lonardo, Fulvio ^a,b   Rusch, Valerie ^a   Langenfeld, John ^a,c   Dmitrovsky, Ethan ^a,d   Klimstra, David S ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN E; MONOCLONAL ANTIBODY; PROTEIN P53;

ARTICLE; BRONCHUS TUMOR; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; STAINING;

BRONCHIAL DISEASES; BRONCHIAL NEOPLASMS; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN D1; CYCLIN E; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RETINOBLASTOMA; HUMANS; METAPLASIA; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PRECANCEROUS CONDITIONS; RETINOBLASTOMA PROTEIN; RETROSPECTIVE STUDIES;

EID: 0033563132     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. 1 phase progression: cycling on cue. Cell, 79: 551-555, 1994.
2. Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell, 81: 323-330, 1995.
3. Jacks, T., and Weinberg, R. A. Cell cycle control and its watchman. Nature (Lond.), 381: 643-644, 1996.
4. El Deiry, W., Tokin, T., Velculescu, V., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, E., Kinzler, K., and Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression. Cell, 75: 817-825, 1993.
5. Chiba, M., Takahashi, T., Nau, M. M., D'Amico, D., Curiel, D. T., Mitsudomi, T., Buchhagen, D. L., Carbone, D., Piantadosi, S., Koga, H., Reissmann, P. T., Slamon, D. J., Holmes, E. C., and Minna, J. D. Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Oncogene, 5: 1603-1610, 1990.
6. Horio, Y., Takahashi, T., Kuroishi, T., Hibi, K., Suyama, M., Niimi, T., Shimokata, K., Yamakawa, K., Nakamura, Y., Ueda, R., and Takahashi, T. Prognostic significance of p53 mutations and 3p deletions in primary resected non-small cell lung cancer. Cancer Res., 53: 1-4, 1993.
7. Rusch, V., Klimstra, D., Linkov, I., and Dmitrovsky, E. Aberrant expression of p53 or the epidermal growth factor receptor is frequent in early bronchial neoplasia, and coexpression precedes squamous cell carcinoma development. Cancer Res., 55: 1365-1372, 1995.
8. Berenson, J. R., Koga, H., Yang, J., Pearl, J., Holmes, E. C., Figlin, R., and The Lung Cancer Study Group. Frequent amplification of the bcl-1 locus in poorly differentiated squamous cell carcinoma of the lung. Oncogene, 5, 1343-1348, 1990.
9. Betticher, D. C., Heighway, J., Hasleton, P. S., Altermatt, J. H., Ryder, W. D. J., Cerny, T., and Thatcher, N. Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small cell lung cancer. Br. J. Cancer, 73: 294-300, 1996.
10. Mate, J. L., Ariza, A., Aracil, C., Lopez, D., Isamat, M., Perez-Piteira, J., and Navos-Palacios, J. J. Cyclin D1 overexpression in NSCLC: correlation with Ki-67 labelling index and poor cytoplasmic differentiation. J. Pathol., 180: 395-399, 1996.
11. INK4a expression in resected non-small cell lung tumors. Cancer Res., 56: 3415-3420, 1996.
12. Reissman, P. T., Koga, H., Takahashi, R., Figlin, R. A., Holmes, E. C., Piantadosi, S., Cordon-Cardo, C., Slamon, D., and The Lung Cancer Study Group. Inactivation of the retinoblastoma gene in non-small cell lung cancer. Oncogene, 8: 1913-1919, 1993.
13. Rusch, V. W., Klimstra, D. S., and Venkatraman, E. S. Molecular markers help characterize neuroendocrine lung tumors. Ann. Thorac. Surg., 62: 798-810, 1996.
14. Cagle, P. T., El-Naggar, A. K., Xu, H-J., Hu, S-X., and Benedict, W. F. Differential retinoblastoma protein expression in neuroendocrine tumors of the lung. Am. J. Pathol., 150: 393-400, 1997.
15. Anton, R. C., Coffey, D. M., Gondo, M., Stephenson, M. A., Brown, R. W., Lebovitz, R. M., and Cagle, P. T. Expression of cyclins D1 and E independently predict prognosis in squamous cell carcinoma of the lung. Mod. Pathol., 10: 159A, 1997.
16. Langenfeld, J., Lonardo, F., Kiyokawa, H., Passalaris, T., Ahn, M-J., Rusch, V., and Dmitrovsky, E. Inhibited transformation of immortalized human bronchial epithelial cells by retinoic acid is linked to cyclin E down-regulation. Oncogene, 13: 1983-1990, 1996.
17. Keyomarsi, K., O'Leary, N., Molnar, G., Lees, E., Fingert, H. J., and Pardee, A. B. Cyclin E, a potential prognostic marker for breast cancer. Cancer Res., 54: 380-385, 1994.
18. Dutta, A., Chandra, R., Leiter, L. M., and Lester, S. Cyclins as markers of tumor proliferation: immunohistochemical studies in breast cancer. Proc. Natl. Acad. Sci. USA, 92: 5386-5390, 1995.
19. Bortner, D., and Rosenberg, M. P. Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E. Mol. Cell. Biol., 17: 453-459, 1997.
20. Auerbach, O., Gere, J. B., Forman, J. B., Petrick, T. G., Smolin, H. J., Muehsam, G. E., Kassouny, D. Y., and Stout, A. P. Changes in the bronchial epithelium in relation to smoking and cancer of the lung. N. Engl. J. Med., 256: 97-104, 1957.
21. Auerbach, O., Stout, A. P., Hammond, E. C., and Garfinkel, L. Changes in bronchial epithelium in relation to sex, age, residence, smoking and pneumonia. N. Engl. J. Med., 267: 111-125, 1962.
22. Saccomanno, G., Archer, V. E., Auerbach, O., Saunders, R. P., and Brennan, L. M. Development of carcinoma of the lung as reflected in exfoliated cells. Cancer (Phila.), 33: 256-270, 1974.
23. Becci, P. J., McDowell, E. M., and Trump, B. F. The respiratory epithelium. IV. Histogenesis of epidermoid metaplasia and carcinoma in situ in the hamster. J. Natl. Cancer Inst., 61: 577-586, 1978.
24. Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., III, Johnson, B. E., and Skolnick, M. H. A cell cycle regulator potentially involved in genesis of many tumor types. Science (Washington DC), 264: 436-440, 1994.
25. Thiberville, L., Payne, P., Vielkinds, J., LeRiche, J., Horsman, D., Nouvel, G., Palcic, B., and Lam, S. Evidence of cumulative gene losses with progression of premalignant epithelial lesions to carcinoma of the bronchus. Cancer Res., 55: 5133-5139, 1995.
26. Hung, J., Kishimoto, Y., Sugio, K., Virmani, A., McIntire, D. D., Minna, J. D., and Gazdar, A. F. Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma. J. Am. Med. Assoc., 273: 558-563, 1995.
27. Sozzi, G., Veronese, M. L., Negrini, M., Baffa, R., Cotticelli, M. G., Inoue, H., Tornielli, S., Pilotti, S., De Gregorio, L., Pastorino, U., Pierotti, M. A., Ohta, M., Huebner, K., and Croce, C. M. The FHIT gene at 3p14.2 is abnormal in lung cancer. Cell, 85: 17-26, 1996.
28. Bennett, W. P., Colby, T. V., Travis, W. D., Borkowski, A., Jones, R. T., Lane, D. P., Metcalf, R. A., Samet, J. M., Takeshima, Y., Gu, J. R., Vähäkangas, K. H., Soini, Y., Pääkkö, P., Welsh, J. A., Trump, B. F., and Harris, C. C. p53 protein accumulates frequently in early bronchial neoplasia. Cancer Res., 53: 4817-4822, 1993.
29. Nuorva, K., Soini, Y., Kamel, D., Autio-Harmainen, H., Risteli, L., Risteli, J., Vähäkangas, K., and Pääkkö, P. Concurrent p53 expression in bronchial dysplasias and squamous cell lung carcinomas. Am. J. Pathol., 142: 725-732, 1993.
30. Hirano, T., Franzén, B., Kato, H., Ebihara, Y., and Auer, G. Genesis of squamous cell lung carcinoma. Sequential changes of proliferation, DNA ploidy, and p53 expression. Am. J. Pathol., 144: 296-302, 1994.
31. Shimosato, Y., Sobin, L. H., Spencer, H., and Yester, R. The World Health Organization Histological Typing of Lung Tumors, Second ed. Am. J. Clin. Pathol., 77: 123-136, 1982.
32. Cattoretti, G., Becker, M. H., Key, G., Duchrow, M., Schluter, C., Galle, J., and Gerdes, J. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB1 and MIB3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J. Pathol., 168: 357-363, 1992.
33. Gerdes, J., Lemke, H., Baisch, H., Wacker, H. H., Schwab, U., and Stein, H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol., 133: 1710-1715, 1984.
34. Bodrug, S. E., Warner, F. M., Bath, M. L., Lindeman, G. J., Harris, A. W., and Adams, J. M. Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene. EMBO J., 13: 2124-2130, 1994.
35. Hinds, P. W., Dowdy, S. F., Eaton, E. N., Arnold, A., and Weinberg, R. A. Function of a human cyclin gene as an oncogene. Proc. Natl. Acad. Sci. USA, 91: 709-713, 1994.
36. Jiang, W., Zhang, Y. J., Kahn, S. M., Hollstein, M. C., Santella, R. M., Lu, S. H., Harris, C., Montesano, R., and Weinstein, I. B. Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc. Natl. Acad. Sci. USA, 90: 9026-9030, 1993.
37. Adelaide, J., Monges, G., Derderian, C., Seitz, J. F., and Birnbaum, D. Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1. Br. J. Cancer, 7: 64-68, 1995.
38. Gaffey, M. J., Iezzoni, J. C., Meredith, S. D., Boyd, J. C., Stoler, M. H., Weiss, L. M., Zukerberg, L. R., Levine, P. A., Arnold, A., and Williams, M. E. Cyclin D1 (PRAD1, CCND1) and glutathione S-transferase gene expression in head and neck squamous cell carcinoma. Hum. Pathol., 26: 1221-1226, 1995.
39. Buckley, M. F., Sweeney, K. J., Hamilton, J. A., Sini, R. L., Manning, D. L., Nicholson, R. I., de Fazio, A., Watts, C. K., Musgrove, E. A., and Sutherland, R. L. Expression and amplification of cyclin genes in human breast cancer. Oncogene, 8: 2127-2133, 1993.
40. Zhang, S. Y., Caamano, J., Cooper, F., Guo, Z., and Klein-Szanto, A. J. Immunohistochemistry of cyclin D1 in human breast cancer. Am. J. Clin. Pathol., 102: 694-698, 1994.
41. Zukerberg, L. R., Yang, W. I., Thor, A. D., Koerner, F. C., Schmidt, E., and Arnold, A. Cyclin D1 (PRAD1) protein expression in breast cancer: approximately one-third of infiltrating mammary carcinomas show overexpression of the cyclin D1 oncogene. Mod. Pathol., 8: 560-567, 1995.
42. Weinstat-Saslow, D., Merino, M., Manrow, R. E., Lawrence, J. A., Bluth, R. F., Wittenbel, K. D., Simpson, J. F., Page, D. L., and Steeg, P. S. Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions. Nat. Med., 1: 1257-1260, 1995.
43. Wang, T. C., Cardiff, R. D., Zukerberg, L., Lees, E., Arnold, A., and Schmidt, E. V. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature (Lond.), 369: 669-671, 1994.
44. Sicinski, P., Donaher, J. L., Parker, S. B., Li, T., Fazeli, A., Gardner, H., Haslam, S. Z., Bronson, R. T., Elledge, S. J., and Weinberg, R. A. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell, 82: 621-630, 1995.
45. Shauer, I. E., Siriwardana, S., Langan, T. A., and Sclafani, R. A. Cyclin D1 overexpression versus retinoblastoma inactivation: implication for growth control evasion in non-small cell and small cell lung cancer. Proc. Natl. Acad. Sci. USA, 91: 7827-7831, 1994.