Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor β-related signaling

Journal of Biological Chemistry

Volumn 275, Issue 3, 2000, Pages 2063-2070

  Sirard, Christian ^a,b,c   Sammy, Kim ^b,d,e   Mirtsos, Christine ^a,b   Tadich, Paul ^a,b   Hoodless, Pamela A ^d,e   Itié, Annick ^a,b   Maxson, Robert ^f   Wrana, Jeffrey L ^b,d,e   Mak, Tak W ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e MOUNT SINAI HOSPITAL   (Canada)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; EXTRACELLULAR MATRIX; FIBROBLAST; GENE DISRUPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FAMILY; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ACTIVINS; ANIMALS; BINDING, COMPETITIVE; CHIMERA; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR MATRIX; FIBROBLASTS; GENE EXPRESSION REGULATION; GLUCOSE-6-PHOSPHATE ISOMERASE; HOMEODOMAIN PROTEINS; HUMANS; INHIBINS; MICE; MICE, INBRED C57BL; PROMOTER REGIONS (GENETICS); RECOMBINATION, GENETIC; REGULATORY SEQUENCES, NUCLEIC ACID; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TIME FACTORS; TRANS-ACTIVATORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; XENOPUS PROTEINS;

ANIMALIA; MURINAE;

EID: 0034695483     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.3.2063     Document Type: Article

References (58)

1. Attisano, L., Wrana, J. L., Lopez-Casillas, F., and Massague, J. (1994) Biochim. Biophys. Acta 1222, 71-80
2. Heldin, C. H., Miyazono, K., and ten Dijke, P. (1997) Nature 390, 465-471
3. Massagué, J., Hata, A., and Liu, F. (1997) Trends in Cell Biology 7, 187-192
4. Hahn, S. A., Schutte, M., Hoque, A. T., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., and Kern, S. E. (1996) Science 271, 350-353
5. Derynck, R., Zhang, Y., and Feng, X.-H. (1998) Cell 95, 737-740
6. Labbe, E., Silvestri, C., Hoodless, P. A., Wrana, J. L., and Attisano, L. (1998) Mol. Cell 2, 109-120
7. Zhou, S., Zawel, L., Lengauer, C., Kinzler, K. W., and Vogelstein, B. (1998) Mol. Cell 2, 121-127
8. Zawel, L., Dai, J. L., Buckhaults, P., Zhou, S., Kinzler, K. W., Vogelstein, B., and Kern, S. E. (1998) Mol. Cell 1, 611-617
9. Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J. M. (1998) EMBO J. 17, 3091-3100
10. Song, C. Z., Siok, T. E., and Gelehrter, T. D. (1998) J. Biol. Chem. 273, 29287-29290
11. Feng, X. H., Zhang, Y., Wu, R. Y., and Derynck, R. (1998) Genes Dev. 12, 2153-2163
12. Wang, W., Chen, X., Xu, H., and Lufkin, T. (1996) Mech. Dev. 58, 203-215
13. Shimeld, S. M., McKay, I. J., and Sharpe, P. T. (1996) Mech. Dev. 55, 201-210
14. Zou, H., and Niswander, L. (1996) Science 272, 738-741
15. Graham, A., Francis-West, P., Brickell, P., and Lumsden, A. (1994) Nature 372, 684-686
16. Ganan, Y., Macias, D., Duterque-Coquillaud, M., Ros, M. A., and Hurle, J. M. (1996) Development 122, 2349-2357
17. Davidson, D. (1995) Trends Genet. 11, 405-411
18. Suzuki, A., Ueno, N., and Hemmati-Brivanlou, A. (1997) Development 124, 3037-3044
19. Sirard, C., de la Pompa, J. L., Elia, A., Itie, A., Mirtsos, C., Cheung, A., Hahn, S., Wakeham, A., Schwartz, L., Kern, S. E., Rossant, J., and Mak, T. W. (1998) Genes Dev. 12, 107-119
20. Robertson, E. J. (1987) in Teratocarcinoma and Embryonic Stem Cells: A Practical Approach (Robertson, E. J., ed) pp. 71-112, IRL Press, Oxford
21. Wrana, J. L., Attisano, L., Carcamo, J., Zentella, A., Doody, J., Laiho, M., Wang, X. F., and Massague, J. (1992) Cell 71, 1003-1014
22. Yang, X., Li, C., Xu, X., and Deng, C. ( 1998) Proc. Natl. Acad. Sci. U. S. A. 95, 3667-3672
23. Hocevar, B. A., Brown, T. L., and Howe, P. H. (1999) EMBO J. 18, 1345-1356
24. Tucker, R. F., Shipley, G. D., Moses, H. L., and Holley, R. W. (1984) Science 226, 705-707
25. Zhang, Y., Feng, X., We, R., and Derynck, R. (1996) Nature 383, 168-172
26. Lagna, G., Hata, A., Hemmati-Brivanlou, A., and Massague, J. (1996) Nature 383, 832-836
27. Zhou, S., Buckhaults, P., Zawel, L., Bunz, F., Riggins, G., Le Dai, J., Kern, S. E., Kinzler, K. W., and Vogelstein, B. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 2412-2416
28. de Winter, J. P., Roelen, B. A., ten Dijke, P., van der Burg, B., and van den Eijnden-van Raaij, A. J. (1997) Oncogene 14, 1891-1899
29. de Caestecker, M. P., Hemmati, P., Larisch-Bloch, S., Ajmera, R., Roberts, A. B., and Lechleider, R. J. (1997) J. Biol. Chem. 272, 13690-13696
30. Nakao, A., Imamura, T., Souchelnytskyi, S., Kawabata, M., Ishisaki, A., Oeda, E., Tamaki, K., Hanai, J., Heldin, C. H., Miyazono, K., and ten Dijke, P. (1997) EMBO J. 16, 5353-5362
31. Yingling, J. M., Datto, M. B., Wong, C., Frederick, J. P., Liberati, N. T., and Wang, X. F. (1997) Mol. Cell. Biol. 17, 7019-7028
32. Chen, Y., Lebrun, J. J., and Vale, W. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 12992-12997
33. Zhang, Y., Feng, X. H., and Derynck, R. (1998) Nature 394, 909-913
34. Wong, C., Rougier-Chapman, E. M., Frederick, J. P., Datto, M. B., Liberati, N. T., Li, J. M., and Wang, X. F. (1999) Mol. Cell. Biol. 19, 1821-1830
35. Liberati, N. T., Datto, M. B., Frederick, J. P., Shen, X., Wong, C., Rougier-Chapman, E. M., and Wang, X. F. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4844-4849
36. Hua, X., Liu, X., Ansari, D. O., and Lodish, H. F. (1998) Genes Dev. 12, 3084-3095
37. Chen, X., Rubock, M. J., and Whitman, M. (1996) Nature 383, 691-696
38. Whitman, M. (1998) Genes Dev. 12, 2445-2462
39. Goumans, M. J., Zwijsen, A., van Rooijen, M. A., Huylebroeck, D., Roelen, B. A., and Mummery, C. L. (1999) Development 126, 3473-3483
40. Shibanuma, M., Kuroki, T., and Nose, K. (1992) J. Biol. Chem. 267, 10219-10224
41. Kurokawa, M., Mitani, K., Irie, K., Matsuyama, T., Takahashi, T., Chiba, S., Yazaki, Y., Matsumoto, K., and Hirai, H. (1998) Nature 394, 92-96
42. Datto, M. B., Frederick, J. P., Pan, L., Borton, A. J., Zhuang, Y., and Wang, X. F. (1999) Mol. Cell. Biol. 19, 2495-2504
43. LeSueur, J. A., and Graff, J. M. (1999) Development 126, 137-146
44. Masuyama, N., Hanafusa, H., Kusakabe, M., Shibuya, H., and Nishida, E. (1999) J. Biol. Chem. 274, 12163-12170
45. Wisotzkey, R. G., Mehra, A., Sutherland, D. J., Dobens, L. L., Liu, X., Dohrmann, C., Attisano, L., and Raftery, L. A. (1998) Development 125, 1433-1445
46. Baldwin, R. L., Friess, H., Yokoyama, M., Lopez, M. E., Kobrin, M. S., Buchler, M. W., and Korc, M. (1996) Int. J. Cancer 67, 283-288
47. Schwarte-Waldhoff, I., Klein, S., Blass-Kampmann, S., Hintelmann, A., Eilert, C., Dreschers, S., Kalthoff, H., Hahn, S. A., and Schmiegel, W. (1999) Oncogene 18, 3152-3158
48. Liu, F., Pouponnot, C., and Massague, J. (1997) Genes Dev. 11, 3157-3167
49. Chen, X., Weisberg, E., Fridmacher, V., Watanabe, M., Naco, G., and Whitman, M. (1997) Nature 389, 85-89
50. Verschueren, K., Remade, J. E., Collart, C., Kraft, H., Baker, B. S., Tylzanowaki, P., Nelles, L., Wuytens, G., Su, M. T., Bodmer, R., Smith, J. C., and Huylebroeck, D. (1999) J. Biol. Chem. 274, 20489-20498
51. Shi, X., Yang, X., Chen, D., Chang, Z., and Cao, X. (1999) J. Biol. Chem. 274, 13711-13717
52. Wotton, D., Lo, R. S., Lee, S., and Massague, J. (1999) Cell 97, 29-39
53. Lee, K. J., and Jessell, T. M. (1999) Annu. Rev. Neurosci. 22, 261-294
54. Bei, M., and Maas, R. (1998) Development 125, 4325-4333
55. Rodriguez-Leon, J., Merino, R., Macias, D., Ganan, Y., Santesteban, E., and Hurle, J. M. (1999) Nat. Cell Biol. 1, 125-126
56. Coucouvanis, E., and Martin, G. R. (1995) Cell 83, 279-287
57. Coucouvanis, E., and Martin, G. R. (1999) Development 126, 535-546
58. Marazzi, G., Wang, Y., and Sassoon, D. (1997) Dev. Biol. 186, 127-138