Is smad3 a major player in signal transduction pathways leading to fibrogenesis?

Chest

Volumn 120, Issue SUPPL., 2001, Pages

  Roberts, A B ^a   Piek, E ^a   Bottinger E P ^a   Ashcroft, G ^a   Mitchell, J B ^a   Flanders, K C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Autoinduction; Fibrosis; Smad proteins; Transforming growth factor ; Wound healing

Indexed keywords

COLLAGEN; ISOENZYME; PROTEIN C FOS; PROTEIN C JUN; PROTEIN SERINE THREONINE KINASE; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

CELL ACTIVATION; CELL INFILTRATION; CELL NUCLEUS; CHEMOTAXIS; CONFERENCE PAPER; EXTRACELLULAR MATRIX; FIBRIN FORMATION; FIBROBLAST; GENE EXPRESSION REGULATION; HUMAN; INFLAMMATORY CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; WOUND HEALING;

EID: 0034927240     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0012-3692(15)38703-1     Document Type: Conference Paper

References (29)

1. Transforming growth factor-β in tissue fibrosis
2. Manipulation of TGF-β to control autoimmune and chronic inflammatory diseases
3. The transforming growth factors-β
4. Hepatic expression of mature transforming growth factor-β1 in transgenic mice results in multiple tissue lesions
5. Gene therapy by transforming growth factor-β receptor-IgG Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis
6. Plasmin regulates the activation of cell-associated latent TGF-β1 secreted by rat alveolar macrophages after in vivo bleomycin injury
7. Transforming growth factor-β gene transfer to the lung induces myofibroblast presence and pulmonary fibrosis
8. TGF-β1, but not TGF-β2 or TGF-β3, is differentially present in epithelial cells of advanced pulmonary fibrosis: An immunohistochemical study
9. Transforming growth factor β as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer
10. TGF-β signal transduction
11. Specificity, diversity, and regulation in TGF-β superfamily signaling
12. Cross-talk between the Smad1 and Ras/MEK signaling pathways for TGF-β
13. A mechanism of repression of TGF-β Smad signaling by oncogenic Ras
14. Smad2 transduces signals from receptor serine-threonine and tyrosine kinases
15. Human Smad3 and Smad4 are sequence-specific transcription activators
16. Alternatively spliced variant of smad2 lacking exon 3: Comparison with wild-type smad2 and smad3
17. Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2
18. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β
19. Functional characterization of TGF-β signaling in mouse embryonic fibroblasts lacking expression of Smad 2 or Smad 3: Differential roles for Smad 2 and Smad 3 in TGF-β signal transduction
20. Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer
21. Smad3-smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor-β
22. Stimulation of type I collagen transcription in human skin fibroblasts by TGF-β: Involvement of Smad 3
23. SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor-β
24. Autoinduction of transforming growth factor-β1 is mediated by the AP-1 complex
25. Oncogene-initiated aberrant signaling engenders the metastatic phenotype: Synergistic transcription factor interactions are targets for cancer therapy
26. Transforming growth factor-β
27. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
28. TGF-β1 and radiation fibrosis: A master switch and a specific therapeutic target?
29. Coactivation of AP-1 activity and TGF-β1 gene expression in the stress response of normal skin cells to ionizing radiation