-
1
-
-
0031438047
-
TGF-β signaling from cell membrane to nucleus through SMAD proteins
-
Heldin, C. H., Miyazono, K., and ten Dijke, P. TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature (Lond.), 390: 465-471, 1997.
-
(1997)
Nature (Lond.)
, vol.390
, pp. 465-471
-
-
Heldin, C.H.1
Miyazono, K.2
Ten Dijke, P.3
-
2
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
Washington DC
-
Hahn, S. A., Schutte, M., Hoque, A. T. M. S., Moskaluk, C. A., deCosta, L. T., Rozenblum, E., Weinsten, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., and Kern, S. E. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science (Washington DC), 277: 350-353, 1996.
-
(1996)
Science
, vol.277
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Hoque, A.T.M.S.3
Moskaluk, C.A.4
DeCosta, L.T.5
Rozenblum, E.6
Weinsten, C.L.7
Fischer, A.8
Yeo, C.J.9
Hruban, R.H.10
Kern, S.E.11
-
3
-
-
0029066689
-
Inactivation of the type II TGF-β receptor in colon cancer cells with microsatcllite instability
-
Washington DC
-
Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kanzler, K. W., Vogelstein, B., Brattain, M., and Wilson, J. K. V. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatcllite instability. Science (Washington DC), 268: 1336-1338, 1995.
-
(1995)
Science
, vol.268
, pp. 1336-1338
-
-
Markowitz, S.1
Wang, J.2
Myeroff, L.3
Parsons, R.4
Sun, L.5
Lutterbaugh, J.6
Fan, R.S.7
Zborowska, E.8
Kanzler, K.W.9
Vogelstein, B.10
Brattain, M.11
Wilson, J.K.V.12
-
4
-
-
0029114477
-
Missense mutations of the transforming growth factor β type II receptor in human head and neck squamous carcinoma cells
-
Garrigue-Antar, L., Munoz-Antonia, T., Antonia, S. J., Gesmonde, J., Vellucci, V. F., and Reiss, M. Missense mutations of the transforming growth factor β type II receptor in human head and neck squamous carcinoma cells. Cancer Res., 55: 3982-3987, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 3982-3987
-
-
Garrigue-Antar, L.1
Munoz-Antonia, T.2
Antonia, S.J.3
Gesmonde, J.4
Vellucci, V.F.5
Reiss, M.6
-
5
-
-
15844387270
-
Mad-related genes in the human
-
Riggins, G. J., Thiagalingam, S., Rozenblum, E., Weinstein, C. L., Kern, S. E., Hamilton, S. R., Willson, J. R. V., Markowitz, S. D., Kinzler, K. W., and Vogelstein, B. Mad-related genes in the human. Nat. Genet., 13: 347-349, 1996.
-
(1996)
Nat. Genet.
, vol.13
, pp. 347-349
-
-
Riggins, G.J.1
Thiagalingam, S.2
Rozenblum, E.3
Weinstein, C.L.4
Kern, S.E.5
Hamilton, S.R.6
Willson, J.R.V.7
Markowitz, S.D.8
Kinzler, K.W.9
Vogelstein, B.10
-
6
-
-
16044369574
-
MADR2 maps to 18q21 and encodes a TGF-β-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
-
Eppert, K., Scherer, S. W., Ozcelik, H., Pirone, R., Hoodless, P., Kim, H., Tsui, L., Bapat, B., Gallinger, S., Andrulis, I. L., Thomsen, G. H., Wrana, J. L., and Attisano, L. MADR2 maps to 18q21 and encodes a TGF-β-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell, 86: 543-552, 1996.
-
(1996)
Cell
, vol.86
, pp. 543-552
-
-
Eppert, K.1
Scherer, S.W.2
Ozcelik, H.3
Pirone, R.4
Hoodless, P.5
Kim, H.6
Tsui, L.7
Bapat, B.8
Gallinger, S.9
Andrulis, I.L.10
Thomsen, G.H.11
Wrana, J.L.12
Attisano, L.13
-
7
-
-
0028556486
-
Genetic changes in the transforming growth factor β (TGF-β) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to growth inhibition by TGF-β
-
Park, K., Kim, S. J., Bang, Y. J., Park, J. G., Kim, N. K., Roberts, A. B., and Sporn, M. B. Genetic changes in the transforming growth factor β (TGF-β) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-β. Proc. Natl. Acad. Sci. USA, 91: 8772-8776, 1994.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 8772-8776
-
-
Park, K.1
Kim, S.J.2
Bang, Y.J.3
Park, J.G.4
Kim, N.K.5
Roberts, A.B.6
Sporn, M.B.7
-
8
-
-
15444350405
-
Type I transforming growth factor β receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract
-
Pasche, B., Luo, Y., Rao, P. H., Nimer, S. D., Dmitrovsky, E., Caron, P., Luzzatto, L., Offit, K., Cordon-Cardo, C., Renault, B., Satagopan, J. M., Murty, V. V. V. S., and Massagué, J. Type I transforming growth factor β receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract. Cancer Res., 58: 2727-2732, 1998.
-
(1998)
Cancer Res.
, vol.58
, pp. 2727-2732
-
-
Pasche, B.1
Luo, Y.2
Rao, P.H.3
Nimer, S.D.4
Dmitrovsky, E.5
Caron, P.6
Luzzatto, L.7
Offit, K.8
Cordon-Cardo, C.9
Renault, B.10
Satagopan, J.M.11
Murty, V.V.V.S.12
Massagué, J.13
-
9
-
-
0030048263
-
Genetic change in transforming growth factor β (TGF-B) receptor type I gene correlates with insensitivity to TGF-β1 in human prostate cancer cells
-
Kim, I. Y., Ahn, H-J., Zelner, D. J., Shaw, J. W, Sensibar, J. A., Kim, J-H., Kato, M., and Lee, C. Genetic change in transforming growth factor β (TGF-B) receptor type I gene correlates with insensitivity to TGF-β1 in human prostate cancer cells. Cancer Res., 56: 44-48, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 44-48
-
-
Kim, I.Y.1
Ahn, H.-J.2
Zelner, D.J.3
Shaw, J.W.4
Sensibar, J.A.5
Kim, J.-H.6
Kato, M.7
Lee, C.8
-
10
-
-
0029810920
-
Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition
-
Baldwin, R. L., Friess, H., Yokoyama, M., Lopez, M. E., Kobrin, M. S., Buchler, M. W., and Korc, M. Attenuated ALK5 receptor expression in human pancreatic cancer: correlation with resistance to growth inhibition. Int. J. Cancer, 67: 283-288, 1996.
-
(1996)
Int. J. Cancer
, vol.67
, pp. 283-288
-
-
Baldwin, R.L.1
Friess, H.2
Yokoyama, M.3
Lopez, M.E.4
Kobrin, M.S.5
Buchler, M.W.6
Korc, M.7
-
11
-
-
0024281442
-
Absence of TGF-β receptors and growth inhibitory responses in retinoblastoma cells
-
Washington DC
-
Kimchi, A., Wang, X. F., Weinberg, R. A., Cheifetz, S., and Massagué, J. Absence of TGF-β receptors and growth inhibitory responses in retinoblastoma cells. Science (Washington DC), 240: 196-199, 1988.
-
(1988)
Science
, vol.240
, pp. 196-199
-
-
Kimchi, A.1
Wang, X.F.2
Weinberg, R.A.3
Cheifetz, S.4
Massagué, J.5
-
12
-
-
0030056048
-
Reduced expression of transforming growth factor beta type I receptor contributes to the malignancy of human colon carcinoma cells
-
Wang, J., Han, W., Zborowska, E., Liang, J., Wang, X., Willson, J. K. V., and Brattain, M. G. Reduced expression of transforming growth factor beta type I receptor contributes to the malignancy of human colon carcinoma cells. J. Biol. Chem., 271: 17366-17371, 1996.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 17366-17371
-
-
Wang, J.1
Han, W.2
Zborowska, E.3
Liang, J.4
Wang, X.5
Willson, J.K.V.6
Brattain, M.G.7
-
13
-
-
0030940853
-
Loss of functional cell surface transforming growth factor β (TGF-β) type I receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia
-
DeCoteau, J. F., Knaus, P. I., Yankelev, H., Reis, M. D., Lowsky, R., Lodish, H. F., and Kadin, M. E. Loss of functional cell surface transforming growth factor β (TGF-β) type I receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA, 94: 5877-5881, 1997.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 5877-5881
-
-
DeCoteau, J.F.1
Knaus, P.I.2
Yankelev, H.3
Reis, M.D.4
Lowsky, R.5
Lodish, H.F.6
Kadin, M.E.7
-
14
-
-
9344223357
-
DPC4 gene in various tumor types
-
Schutte, M., Hruban, R. H., Hedrick, L. Cho, K. R., Nadasdy G. M., Weinstein, C. L., Bova, G. S., Isaacs, W. B., Cairns, P., Nawroz, H., Sidransky, D., Casero, R. A., Meltzer, P. S., Hahn, S.A., and Kern, S. E. DPC4 gene in various tumor types. Cancer Res., 56: 2527-2530, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 2527-2530
-
-
Schutte, M.1
Hruban, R.H.2
Hedrick, L.3
Cho, K.R.4
Nadasdy, G.M.5
Weinstein, C.L.6
Bova, G.S.7
Isaacs, W.B.8
Cairns, P.9
Nawroz, H.10
Sidransky, D.11
Casero, R.A.12
Meltzer, P.S.13
Hahn, S.A.14
Kern, S.E.15
-
15
-
-
0028059330
-
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
-
Caldas, C., Hahn, S. A., da Costa, L. T., Redston, M. S., Schutte, M., Seymour, A. B., Weinstein, C. L., Hruban, R. H., Yeo, C. J., and Kern, S. E. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat. Genet., 8: 27-32, 1994.
-
(1994)
Nat. Genet.
, vol.8
, pp. 27-32
-
-
Caldas, C.1
Hahn, S.A.2
Da Costa, L.T.3
Redston, M.S.4
Schutte, M.5
Seymour, A.B.6
Weinstein, C.L.7
Hruban, R.H.8
Yeo, C.J.9
Kern, S.E.10
-
16
-
-
12644253827
-
Germ-line BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas
-
Goggins, M., Schutte, M., Lu, J., Moskaluk, C. A., Weinstein, C. L., Petersen, G. M., Yeo, C. J., Jackson, C. E., Lynch, H. T., Hruban, R. H., and Kern, S. E. Germ-line BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res., 56: 5360-5364, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 5360-5364
-
-
Goggins, M.1
Schutte, M.2
Lu, J.3
Moskaluk, C.A.4
Weinstein, C.L.5
Petersen, G.M.6
Yeo, C.J.7
Jackson, C.E.8
Lynch, H.T.9
Hruban, R.H.10
Kern, S.E.11
-
17
-
-
0028342395
-
Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia
-
Caldas, C., Hahn, S. A., Hruban, R. H., Redston, M. S., Yeo, C. J., and Kern, S. E. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia. Cancer Res., 54: 3568-3573, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 3568-3573
-
-
Caldas, C.1
Hahn, S.A.2
Hruban, R.H.3
Redston, M.S.4
Yeo, C.J.5
Kern, S.E.6
-
18
-
-
0029959774
-
Phosphorylation of Ser165 in TGF-β type 1 receptor modulates TGF-β1-induced cellular responses
-
Souchelnytskyi, S., ten Dijke, P., Miyazono, K., and Heldin, C. H. Phosphorylation of Ser165 in TGF-β type 1 receptor modulates TGF-β1-induced cellular responses. EMBO J., 15: 6231-6240, 1996.
-
(1996)
EMBO J.
, vol.15
, pp. 6231-6240
-
-
Souchelnytskyi, S.1
Ten Dijke, P.2
Miyazono, K.3
Heldin, C.H.4
-
19
-
-
17644430199
-
Adenocarcinomas of the pancreas with DNA replication errors (RER+) are associated with a characteristic histopathology: Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER
-
Goggins, M., Offerhaus, G. J. A., Hilgers, W., Griffin, C. A., Shekher, M., Tang, D., Sohn, T., Yeo, C. J., Kern, S. E., and Hruban, R. H. Adenocarcinomas of the pancreas with DNA replication errors (RER+) are associated with a characteristic histopathology: poor differentiation, a syncytial growth pattern, and pushing borders suggest RER. Am. J. Pathol., 152: 1501-1507, 1998.
-
(1998)
Am. J. Pathol.
, vol.152
, pp. 1501-1507
-
-
Goggins, M.1
Offerhaus, G.J.A.2
Hilgers, W.3
Griffin, C.A.4
Shekher, M.5
Tang, D.6
Sohn, T.7
Yeo, C.J.8
Kern, S.E.9
Hruban, R.H.10
-
20
-
-
0030050973
-
Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2
-
Johnson, D. W., Berg, J. N., Baldwin, M. A., Gallione, C. J., Marondel, I., Yoon, S. J, Stenzel T. T., Speer, M., Pericak-vance, M. A., Diamond, A., Guitmacher, A. E., Jackson, C. E., Attisano, L., Kucherlapati, R., Porteous, M. E., and Marchuk, D. A. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat. Genet., 13: 189-195, 1996.
-
(1996)
Nat. Genet.
, vol.13
, pp. 189-195
-
-
Johnson, D.W.1
Berg, J.N.2
Baldwin, M.A.3
Gallione, C.J.4
Marondel, I.5
Yoon, S.J.6
Stenzel, T.T.7
Speer, M.8
Pericak-vance, M.A.9
Diamond, A.10
Guitmacher, A.E.11
Jackson, C.E.12
Attisano, L.13
Kucherlapati, R.14
Porteous, M.E.15
Marchuk, D.A.16
-
21
-
-
0029892923
-
INK4 genes in pancreatic carcinoma
-
Rozenblum, E., Schutte, M., and Kern, S. E. INK4 genes in pancreatic carcinoma. Oncol. Rep., 3: 743-745, 1996.
-
(1996)
Oncol. Rep.
, vol.3
, pp. 743-745
-
-
Rozenblum, E.1
Schutte, M.2
Kern, S.E.3
-
22
-
-
0031303927
-
Transforming growth factor-β and cancer: A love-hate relationship?
-
Reiss M. Transforming growth factor-β and cancer: a love-hate relationship? Oncol. Res., 9: 447-457, 1997.
-
(1997)
Oncol. Res.
, vol.9
, pp. 447-457
-
-
Reiss, M.1
-
23
-
-
14444284330
-
Tumor-suppressive pathways in pancreatic carcinoma
-
Rozenblum, E., Schutte, M., Goggins, M., Hahn, S. A., Lu, J., Panzer, S., Zahurak, M., Goodman, S. N., Hruban, R. H., Yeo, C. J., and Kern, S. E. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res. 57: 1731-1734, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 1731-1734
-
-
Rozenblum, E.1
Schutte, M.2
Goggins, M.3
Hahn, S.A.4
Lu, J.5
Panzer, S.6
Zahurak, M.7
Goodman, S.N.8
Hruban, R.H.9
Yeo, C.J.10
Kern, S.E.11
-
24
-
-
0000128027
-
DPC4 transcriptional activation and dysfunction in cancer cells
-
Dai, J. L., Tumacioglu, K. K., Schutte, M., Sugar, A. Y., and Kern, S. E. DPC4 transcriptional activation and dysfunction in cancer cells. Cancer Res., 58: 4592-4597, 1998.
-
(1998)
Cancer Res.
, vol.58
, pp. 4592-4597
-
-
Dai, J.L.1
Tumacioglu, K.K.2
Schutte, M.3
Sugar, A.Y.4
Kern, S.E.5
-
25
-
-
0028295762
-
Characterization of type I receptors for transforming growth factor-β and activin
-
Washington DC
-
ten Dijke, P., Yamashita, H., Ichijo, H., Franzen, P., Laiho, M., Miyazono, K., and Heldin, C. H. Characterization of type I receptors for transforming growth factor-β and activin. Science (Washington DC), 264: 101-104, 1994.
-
(1994)
Science
, vol.264
, pp. 101-104
-
-
Ten Dijke, P.1
Yamashita, H.2
Ichijo, H.3
Franzen, P.4
Laiho, M.5
Miyazono, K.6
Heldin, C.H.7
-
26
-
-
0028332818
-
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4
-
ten Dijke, P., Yamashita, H., Sampath, T. K., Reddi, A. H., Estevez, M., Riddle, D. L., Ichijo, H., Heldin, C. H., and Miyazono, K. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J. Biol. Chem., 269: 16985-16988, 1994.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 16985-16988
-
-
Ten Dijke, P.1
Yamashita, H.2
Sampath, T.K.3
Reddi, A.H.4
Estevez, M.5
Riddle, D.L.6
Ichijo, H.7
Heldin, C.H.8
Miyazono, K.9
-
27
-
-
0028168242
-
p15INK4B is a potential effector of TGF-induced cell cycle arrest
-
Hannon, G. J., and Beach, D. p15INK4B is a potential effector of TGF-induced cell cycle arrest. Nature (Lond.), 371: 257-261, 1994.
-
(1994)
Nature (Lond.)
, vol.371
, pp. 257-261
-
-
Hannon, G.J.1
Beach, D.2
-
28
-
-
0029113837
-
Genomic structure, expression and mutational analysis of the P15 (MTS2) gene
-
Stone, S., Dayananth, P., Jiang, P., Weaver-Feldhaus, J. M., Tavtigian, S. V. Cannon-Albright, L., and Kamb, A. Genomic structure, expression and mutational analysis of the P15 (MTS2) gene. Oncogene, 11: 987-991, 1995.
-
(1995)
Oncogene
, vol.11
, pp. 987-991
-
-
Stone, S.1
Dayananth, P.2
Jiang, P.3
Weaver-Feldhaus, J.M.4
Tavtigian, S.V.5
Cannon-Albright, L.6
Kamb, A.7
-
29
-
-
0030848192
-
Frequency of SMAD gene mutations in human cancer
-
Riggins, G. J., Kinzler, K. W., Vogelstein, B., and Thiagalingam, S. Frequency of SMAD gene mutations in human cancer. Cancer Res., 57: 2578-2581, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 2578-2581
-
-
Riggins, G.J.1
Kinzler, K.W.2
Vogelstein, B.3
Thiagalingam, S.4
|