A deletion in the gene for transforming growth factor β type I receptor abolishes growth regulation by transforming growth factor β in a cutaneous T-cell lymphoma

Blood

Volumn 94, Issue 8, 1999, Pages 2854-2861

  Schiemann, William P ^c   Pfeifer, Walther M ^c   Levi, Edi ^c   Kadin, Marshall E ^a   Lodish, Harvey F ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

METHIONINE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ADULT; ARTICLE; CASE REPORT; CONTROLLED STUDY; EXON; GENE DELETION; GROWTH REGULATION; HUMAN; HUMAN CELL; HYBRIDIZATION; INTRON; LARGE CELL LYMPHOMA; LYMPHOMATOID PAPULOSIS; MALE; PRIORITY JOURNAL; T CELL LYMPHOMA; TUMOR BIOPSY; TUMOR CELL LINE;

EID: 0032878291     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.8.2854.420k07_2854_2861     Document Type: Article

References (63)

1. Lin HY, Lodish HF: Receptors for the TGF-β superfamily: Multiple polypeptides and serine/threonine kinases. Trends Cell Biol 3:14, 1993
2. Moses HL, Serra R: Regulation of differentiation by TGF-β. Curr Opin Genet Dev 6:581, 1996
3. Attisano L, Wrana JL, Lopez-Casillas F, Massague J: TGF-β receptors and actions. Biochim Biophys Acta 1222:71, 1994
4. Massague J: TGF-β signal transduction. Annu Rev Biochem 67:753, 1998
5. Franzen P, ten Dijke P, Ichijo H, Yamashita H, Schulz P, Heldin C-H, Miyazono K: Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor. Cell 75:681, 1993
6. Bassing CH, Yingling JM, Howe DJ, Wang T, He WW, Gustafson ML, Shah P, Donahoe PK, Wang XF: A transforming growth factor β type I receptor that signals to activate gene expression. Science 263:87, 1994
7. Attisano L, Carcamo J, Ventura F, Weis FM, Massague J, Wrana JL: Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors. Cell 75:671, 1993
8. Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF: Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell 68:775, 1992
9. Ebner R, Chen RH, Shum L, Lawler S, Zioncheck TF, Lee A, Lopez AR, Derynck R: Cloning of a type I TGF-β receptor and its effect on TGF-β binding to the type II receptor. Science 260:1344, 1993
10. Wrana JL, Attisano L, Wieser R, Ventura F, Massague J: Mechanism of activation of the TGF-β receptor. Nature 370:341, 1994
11. Heldin C-H, Miyazono K, ten Dijke P: TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature 390:465, 1997
12. Henis YI, Moustakas A, Lin HY, Lodish HF: The types II and III transforming growth factor-β receptors form homo-oligomers. J Cell Biol 126:139, 1994
13. Yamashita H, ten Dijke P, Franzen P, Miyazono K, Heldin C-H: Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-β. J Biol Chem 269:20172, 1994
14. Zhang Y, Feng X, We R, Derynck R: Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383:168, 1996
15. Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L: MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86:543, 1996
16. Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin C-H, Miyazono K, ten Dijke P: TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J 16:5353, 1997
17. Souchelnytskyi S, Tamaki K, Engstrom U, Wernstedt C, ten Dijke P, Heldin C-H: Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-β signaling. J Biol Chem 272:28107, 1997
18. Macias-Silva M, Abdollah S, Hoodless P, Pirone R, Attisano L, Wrana J: MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87:1215, 1996
19. Lagna G, Hata A, Hemmati-Brivanlou A, Massague J: Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 383:832, 1996
20. Wu RY, Zhang Y, Feng XH, Derynck R: Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol Cell Biol 17:2521, 1997
21. Chen X, Rubock MJ, Whitman M: A transcriptional partner for MAD proteins in TGF-β signalling. Nature 383:691, 1996
22. Hua X, Liu X, Ansari DO, Lodish HF: Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 gene. Genes Dev 12:3084, 1998
23. Labbe E, Silvestri C, Hoodless PA, Wrana JL, Attisano L: Smad2 and Smad3 positively and negatively regulate TGFβ-dependent transcription through the forkhead DNA-binding protein FAST2. Mol Cell 2:1091, 1998
24. Derynck R, Zhang Y, Feng X-H: Smads: Transcriptional activators of TGF-β responses. Cell 95:737, 1998
25. Saltis J: TGF-β: receptors and cell cycle arrest. Mol Cell Endocrinol 116:227, 1996
26. Ravitz MJ, Wenner CE: Cyclin-dependent kinase regulation during G1 phase and cell cycle regulation by TGF-β. Adv Cancer Res 71:165, 1997
27. Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B: Mad-related genes in the human. Nat Genet 13:347, 1996
28. Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271:350, 1996
29. Arai T, Akiyama Y, Okabe S, Ando M, Endo M, Yuasa Y: Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers. Cancer Lett 122:157, 1998
30. Riggins GJ, Kinzler KW, Vogelstein B, Thiagalingam S: Frequency of Smad gene mutations in human cancers. Cancer Res 57:2578, 1997
31. Zhu Y, Richardson JA, Parada LF, Graff JM: Smad3 mutant mice develop metastatic colorectal cancer. Cell 94:703, 1998
32. Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B, Brattain M, Willson JKV: Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268:1336, 1995
33. Park K, Kim SJ, Bang YJ, Park JG, Kim NK, Roberts AB, Sporn MB: Genetic changes in the transforming growth factor β (TGF-β) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to growth inhibition by TGF-β. Proc Natl Acad Sci USA 91:8772, 1994
34. Kim IY, Ahn HJ, Lang S, Oefelein MG, Oyasu R, Kozlowski JM, Lee C: Loss of expression of transforming growth factor-β receptors is associated with poor prognosis in prostate cancer patients. Clin Cancer Res 4:1625, 1998
35. Kimchi A, Wang XF, Weinberg RA, Cheifetz S, Massague J: Absence of TGF-β receptors and growth inhibitory responses in retinoblastoma cells. Science 240:196, 1988
36. Horie K, Yamashita H, Mogi A, Takenoshita S, Miyazono K: Lack of transforming growth factor-β type II receptor expression in human retinoblastoma cells. J Cell Physiol 175:305, 1998
37. Kadin ME, Cavaille-Coll MW, Gertz R, Massague J, Cheifetz S, George D: Loss of receptors for transforming growth factor β in human T-cell malignancies. Proc Natl Acad Sci USA 91:6002, 1994
38. Knaus PI, Lindemann D, DeCoteau JF, Perlman R, Yankelev H, Hille M, Kadin ME, Lodish HF: A dominant inhibitory mutant of the type II transforming growth factor β receptor in the malignant progression of a cutaneous T-cell lymphoma. Mol Cell Biol 16:3480, 1996
39. Capocasale RJ, Lamb RJ, Vonderheid EC, Fox FE, Rook AH, Nowell PC, Moore JS: Reduced surface expression of transforming growth factor β receptor type II in mitogen-activated T cells from Sezary patients. Proc Natl Acad Sci USA 92:5501, 1995
40. DeCoteau JF, Knaus PI, Yankelev H, Reis MD, Lowsky R, Lodish HF, Kadin ME: Loss of functional cell surface transforming growth factor β (TGF-β) type I receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 94:5877, 1997
41. Wang J, Han W, Zborowska E, Liang J, Wang X, Willson JKV, Sun LZ, Brattain MG: Reduced expression of transforming growth factor beta type I receptor contributes to the malignancy of human colon carcinoma cells. J Biol Chem 271:17366, 1996
42. Wagner M, Kleeff J, Lopez ME, Bockman I, Massaque J, Korc M: Transfection of the type I TGF-β receptor restores TGF-β responsiveness in pancreatic cancer. Int J Cancer 78:255, 1998
43. Baldwin RL, Friess H, Yokoyama M, Lopez ME, Korbin MS, Buchler MW, Korc M: Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition. Int J Cancer 67:283, 1996
44. Kim IY, Ahn HJ, Zelner DJ, Shaw JW, Sensibar JA, Kim JH, Kato M, Lee C: Genetic change in transforming growth factor β (TGF-β) receptor type I gene correlates with insensitivity to TGF-β1 in human prostate cancer cells. Cancer Res 56:44, 1996
45. Chott A, Vonderheid EC, Olbricht S, Miao N-N, Balk SP, Kadin ME: The dominant T cell clone is present in multiple regressing skin lesions and associated T cell lymphomas of patients with lymphomatoid papulosis. J Invest Dermatol 106:696, 1996
46. Chen T, Carter D, Garrigue-Antar L, Reiss M: Transforming growth factor β type I receptor kinase mutatnt associated with metastatic breast cancer. Cancer Res 58:4805, 1998
47. Siepl C, Malipiero UV, Fontana A: Transforming growth factor-β (TGF-β)-resistant helper T lymphocyte clones show a concomitant loss of all three types of TGF-β receptors. J Immunol 9:3063, 1991
48. Stoeck M, Miescher S, MacDonald HR, Von Fliedner V: Transforming growth factors beta slow down cell-cycle progression in a murine interleukin-2 dependent T-cell line. J Cell Physiol 141:65, 1989
49. Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS: Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 163:1037, 1986
50. Ellingsworth L, Nakayama D, Dasch J, Segarini P, Carrillo P, Waegell W: Transforming growth factor beta 1 (TGF-β1) receptor expression on resting and mitogen-activated T cells. J Cell Biochem 39:489, 1989
51. Ruscetti FW, Palladino MA: Transforming growth factor-β and the immune system. Prog Growth Factor Res 3:159, 1991
52. Letterio JJ, Roberts AB: Regulation of immune responses by TGF-β. Annu Rev Immunol 16:137, 1998
53. Boyd FT, Massague J: Transforming growth factor-β inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor. J Biol Chem 264:2272, 1989
54. Sanchez NP, Pittelkow MR, Muller SA, Banks PM, Winkelman RK: The clinicopathologic spectrum of lymphomatoid papulosis: Study of 31 cases. J Am Acad Dermatol 8:81, 1983
55. Wieser R, Wrana JL, Massague J: GS domain mutations that constitutively activate TβR-I, the downstream signaling component in the TGF-β receptor complex. EMBO J 14:2199, 1995
56. Carcamo J, Zentella A, Massague J: Disruption of transforming growth factor β signaling by a mutation that prevents transphosphorylation within the receptor complex. Mol Cell Biol 15:1573, 1995
57. Pasche B, Luo Y, Rao PH, Nimer SD, Dmitrovsky E, Caron P, Luzzatto L, Offit K, Cordon-Cardo C, Renault B, Satagopan JM, Murty VVVS, Massague J: Type I transforming growth factor β receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract. Cancer Res 58:2727, 1998
58. Goggins M, Shekher M, Turnacioglu K, Yeo CJ, Hruban RH, Kern SE: Genetic alterations of the transforming growth factor β receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res 58:5329, 1998
59. Ahmadian A, Ren Z-P, Williams C, Ponten F, Odeberg J, Ponten J, Uhlen M, Lundeberg J: Genetic instability in the 9q22.3 region is a late event in the development of squamous cell carcinoma. Oncogene 17:1837, 1998
60. Bottinger EP, Letterio JJ, Roberts AB: Biology of TGF-β in knockout and transgenic mouse models. Kidney Int 51:1355, 1997
61. Clark DA, Coker R: Transforming growth factor-β (TGF-β). Int J Biochem Cell Biol 30:293, 1998
62. Reiss M: Transforming growth factor-β and cancer: A love-hate relationship? Oncol Res 9:447, 1997
63. Vellucci VF, Reiss M: Cloning and genomic organization of the human transforming growth factor-β type I receptor gene. Genomics 46:278, 1997