-
1
-
-
0037085234
-
New members of the platelet-derived growth factor family of mitogens
-
Heldin C-H, Eriksson U, Östman A (2002). New members of the platelet-derived growth factor family of mitogens. Arch. Biochem. Biophys. 398: 284-290.
-
(2002)
Arch. Biochem. Biophys.
, vol.398
, pp. 284-290
-
-
Heldin, C.-H.1
Eriksson, U.2
Östman, A.3
-
3
-
-
0027936261
-
Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities
-
Levéen P, Pekny M, Gebre-Medhin S, Swolin B, Larsson E, Betsholtz C (1994). Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev. 8: 1875-1887.
-
(1994)
Genes Dev.
, vol.8
, pp. 1875-1887
-
-
Levéen, P.1
Pekny, M.2
Gebre-Medhin, S.3
Swolin, B.4
Larsson, E.5
Betsholtz, C.6
-
4
-
-
0028059309
-
Abnormal kidney development and hematological disorders in PDGF β-receptor mutant mice
-
Soriano P (1994). Abnormal kidney development and hematological disorders in PDGF β-receptor mutant mice. Genes Dev. 8: 1888-1896.
-
(1994)
Genes Dev.
, vol.8
, pp. 1888-1896
-
-
Soriano, P.1
-
5
-
-
0030756325
-
Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
-
Lindahl P, Johansson BR, Levéen P, Betsholtz C (1997). Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 277: 242-245.
-
(1997)
Science
, vol.277
, pp. 242-245
-
-
Lindahl, P.1
Johansson, B.R.2
Levéen, P.3
Betsholtz, C.4
-
6
-
-
15844370315
-
PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
-
Boström H, Willetts K, Pekny M, Levéen P, Lindahl P, Hedstrand H, Pekna M, Hellström M, Gebre-Medhin S, Schalling M, Nilsson M, Kurland S, Törnell J, Heath JK, Betsholtz C (1996). PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 85: 863-873.
-
(1996)
Cell
, vol.85
, pp. 863-873
-
-
Boström, H.1
Willetts, K.2
Pekny, M.3
Levéen, P.4
Lindahl, P.5
Hedstrand, H.6
Pekna, M.7
Hellström, M.8
Gebre-Medhin, S.9
Schalling, M.10
Nilsson, M.11
Kurland, S.12
Törnell, J.13
Heath, J.K.14
Betsholtz, C.15
-
7
-
-
0033832891
-
Abnormal gastrointestinal development in PDGF-A and PDGFR-α deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis
-
Karlsson L, Lindahl P, Heath JK, Betsholtz C (2000). Abnormal gastrointestinal development in PDGF-A and PDGFR-α deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development 127: 3457-3466.
-
(2000)
Development
, vol.127
, pp. 3457-3466
-
-
Karlsson, L.1
Lindahl, P.2
Heath, J.K.3
Betsholtz, C.4
-
8
-
-
0030808324
-
The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites
-
Soriano P (1997). The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites. Development 124: 2691-2700.
-
(1997)
Development
, vol.124
, pp. 2691-2700
-
-
Soriano, P.1
-
9
-
-
0026595966
-
Platelet-derived growth factor BB for the treatment of chronic pressure ulcers
-
Robson MC, Phillips LG, Thomason A, Robson LE, Pierce GF (1992). Platelet-derived growth factor BB for the treatment of chronic pressure ulcers. Lancet 339: 23-25.
-
(1992)
Lancet
, vol.339
, pp. 23-25
-
-
Robson, M.C.1
Phillips, L.G.2
Thomason, A.3
Robson, L.E.4
Pierce, G.F.5
-
10
-
-
0029824569
-
A novel physiological function for platelet-derived growth factor-BB in rat dermis
-
Rodt SÅ, Åhlén K, Berg A, Rubin K, Reed RK (1996). A novel physiological function for platelet-derived growth factor-BB in rat dermis. J. Physiol. 495: 193-200.
-
(1996)
J. Physiol.
, vol.495
, pp. 193-200
-
-
Rodt, S.Å.1
Åhlén, K.2
Berg, A.3
Rubin, K.4
Reed, R.K.5
-
11
-
-
0033552883
-
Atherosclerosis - An inflammatory disease
-
Ross R (1999). Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 340: 115-126.
-
(1999)
N. Engl. J. Med.
, vol.340
, pp. 115-126
-
-
Ross, R.1
-
12
-
-
0032875460
-
Mechanism of action and in vivo role of platelet-derived growth factor
-
Heldin C-H, Westermark B (1999). Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 79: 1283-1316.
-
(1999)
Physiol. Rev.
, vol.79
, pp. 1283-1316
-
-
Heldin, C.-H.1
Westermark, B.2
-
13
-
-
0141486251
-
PDGF receptors as cancer drug targets
-
Pietras K, Sjöblom T, Rubin K, Heldin C-H, Östman A (2003). PDGF receptors as cancer drug targets. Cancer Cell 3: 439-443.
-
(2003)
Cancer Cell
, vol.3
, pp. 439-443
-
-
Pietras, K.1
Sjöblom, T.2
Rubin, K.3
Heldin, C.-H.4
Östman, A.5
-
14
-
-
0020640259
-
sis of simian sarcoma virus
-
London
-
sis of simian sarcoma virus. Nature (London) 304: 35-39.
-
(1983)
Nature
, vol.304
, pp. 35-39
-
-
Waterfield, M.D.1
Scrace, G.T.2
Whittle, N.3
Stroobant, P.4
Johnsson, A.5
Wasteson, Å.6
Westermark, B.7
Heldin, C.-H.8
Huang, J.S.9
Deuel, T.F.10
-
15
-
-
0020533055
-
Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor
-
Doolittle RF, Hunkapiller MW, Hood LE, Devare SD, Robbins KC, Aaronson SA, Antoniades HN (1983). Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science 221: 275-277.
-
(1983)
Science
, vol.221
, pp. 275-277
-
-
Doolittle, R.F.1
Hunkapiller, M.W.2
Hood, L.E.3
Devare, S.D.4
Robbins, K.C.5
Aaronson, S.A.6
Antoniades, H.N.7
-
16
-
-
0026772431
-
Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops
-
Hermanson M, Funa K, Hartman M, Claesson-Welsh L, Heldin C-H, Westermark B, Nistér M (1992). Platelet-derived growth factor and its receptors in human glioma tissue: Expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops. Cancer Res. 52: 3213-3219.
-
(1992)
Cancer Res.
, vol.52
, pp. 3213-3219
-
-
Hermanson, M.1
Funa, K.2
Hartman, M.3
Claesson-Welsh, L.4
Heldin, C.-H.5
Westermark, B.6
Nistér, M.7
-
17
-
-
0026581358
-
Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin
-
Smits A, Funa K, Vassbotn FS, Beausang-Linder M, af Ekenstam F, Heldin C-H, Westermark B, Nistér M (1992). Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin. Am. J. Pathol. 140: 639-648.
-
(1992)
Am. J. Pathol.
, vol.140
, pp. 639-648
-
-
Smits, A.1
Funa, K.2
Vassbotn, F.S.3
Beausang-Linder, M.4
Af Ekenstam, F.5
Heldin, C.-H.6
Westermark, B.7
Nistér, M.8
-
18
-
-
0001288041
-
The biology of primate retrovirus
-
G Klein ed. Raven Press, New York
-
Deinhardt F (1980). The biology of primate retrovirus. In: G Klein (ed. Viral Oncology. Raven Press, New York, pp. 359-398.
-
(1980)
Viral Oncology
, pp. 359-398
-
-
Deinhardt, F.1
-
19
-
-
0032401819
-
Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus
-
Uhrbom L, Hesselager G, Nistér M, Westermark B (1998). Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus. Cancer Res. 58: 5275-5279.
-
(1998)
Cancer Res.
, vol.58
, pp. 5275-5279
-
-
Uhrbom, L.1
Hesselager, G.2
Nistér, M.3
Westermark, B.4
-
20
-
-
0031012850
-
Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma
-
Simon M-P, Pedeutour F, Sirvent N, Grosgeorge J, Minoletti F, Coindre J-M, Terrier-Lacombe M-J, Mandahl N, Graver RD, Blin N, Sozzi G, Turc-Carel C, O'Brien KP, Kedra D, Fransson I, Guilbaud C, Dumanski JP (1997). Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nature Genet. 15: 95-98.
-
(1997)
Nature Genet.
, vol.15
, pp. 95-98
-
-
Simon, M.-P.1
Pedeutour, F.2
Sirvent, N.3
Grosgeorge, J.4
Minoletti, F.5
Coindre, J.-M.6
Terrier-Lacombe, M.-J.7
Mandahl, N.8
Graver, R.D.9
Blin, N.10
Sozzi, G.11
Turc-Carel, C.12
O'Brien, K.P.13
Kedra, D.14
Fransson, I.15
Guilbaud, C.16
Dumanski, J.P.17
-
21
-
-
0032505090
-
Transforming activity of the chimeric sequence formed by the fusion of collagen gene COL1A1 and the platelet derived growth factor b-chain gene in dermatofibrosarcoma protuberans
-
Greco A, Fusetti L, Villa R, Sozzi G, Minoletti F, Mauri P, Pierotti MA (1998). Transforming activity of the chimeric sequence formed by the fusion of collagen gene COL1A1 and the platelet derived growth factor b-chain gene in dermatofibrosarcoma protuberans. Oncogene 17: 1313-1319.
-
(1998)
Oncogene
, vol.17
, pp. 1313-1319
-
-
Greco, A.1
Fusetti, L.2
Villa, R.3
Sozzi, G.4
Minoletti, F.5
Mauri, P.6
Pierotti, M.A.7
-
22
-
-
0033178762
-
The dermatofibrosarcoma protuberans-associated collagen type Iα1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB
-
Shimizu A, O'Brien KP, Sjöblom T, Pietras K, Buchdunger E, Collins VP, Heldin C-H, Dumanski JP, Östman A (1999). The dermatofibrosarcoma protuberans-associated collagen type Iα1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. Cancer Res. 59: 3719-3723.
-
(1999)
Cancer Res.
, vol.59
, pp. 3719-3723
-
-
Shimizu, A.1
O'Brien, K.P.2
Sjöblom, T.3
Pietras, K.4
Buchdunger, E.5
Collins, V.P.6
Heldin, C.-H.7
Dumanski, J.P.8
Östman, A.9
-
23
-
-
0029966854
-
The TEL/platelet-derived growth factor β receptor (PDGFβR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFbR kinase-dependent signaling pathways
-
Carroll M, Tomasson MH, Barker GF, Golub TR, Gilliland DG (1996). The TEL/platelet-derived growth factor β receptor (PDGFβR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFbR kinase-dependent signaling pathways. Proc. Natl. Acad. Sci. USA 93: 14845-14850.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 14845-14850
-
-
Carroll, M.1
Tomasson, M.H.2
Barker, G.F.3
Golub, T.R.4
Gilliland, D.G.5
-
24
-
-
17144463437
-
A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFRβ oncoprotein
-
Jousset C, Carron C, Boureux A, Quang CT, Oury C, Dusanter-Fourt I, Charon M, Levin J, Bernard O, Ghysdael J (1997). A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFRβ oncoprotein. EMBO J. 16: 69-82.
-
(1997)
EMBO J.
, vol.16
, pp. 69-82
-
-
Jousset, C.1
Carron, C.2
Boureux, A.3
Quang, C.T.4
Oury, C.5
Dusanter-Fourt, I.6
Charon, M.7
Levin, J.8
Bernard, O.9
Ghysdael, J.10
-
25
-
-
0033604460
-
Characterization of the chronic myelomonocytic leukemia associated TEL-PDGFβR fusion protein
-
Sjöblom T, Boureux A, Rönnstrand L, Heldin C-H, Ghysdael J, Östman A (1999). Characterization of the chronic myelomonocytic leukemia associated TEL-PDGFβR fusion protein. Oncogene 18: 7055-7062.
-
(1999)
Oncogene
, vol.18
, pp. 7055-7062
-
-
Sjöblom, T.1
Boureux, A.2
Rönnstrand, L.3
Heldin, C.-H.4
Ghysdael, J.5
Östman, A.6
-
26
-
-
0344987881
-
A tyrosine kinase created by fusion of the PDGFRA and FIPIL1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
-
Cools J, DeAngelo DJ, Gotlib J, Stover EH, Legare RD, Cortes J, Kutok J, Clark J, Galinsky I, Griffin JD, Cross NC, Tefferi A, Malone J, Alam R, Schrier SL, Schmid J, Rose M, Vandenberghe P, Verhoef G, Boogaerts M, Wlodarska I, Kantarjian H, Marynen P, Coutre SE, Stone R, Gilliland DG (2003). A tyrosine kinase created by fusion of the PDGFRA and FIPIL1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N. Engl. J. Med. 348: 1201-14.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1201-1214
-
-
Cools, J.1
DeAngelo, D.J.2
Gotlib, J.3
Stover, E.H.4
Legare, R.D.5
Cortes, J.6
Kutok, J.7
Clark, J.8
Galinsky, I.9
Griffin, J.D.10
Cross, N.C.11
Tefferi, A.12
Malone, J.13
Alam, R.14
Schrier, S.L.15
Schmid, J.16
Rose, M.17
Vandenberghe, P.18
Verhoef, G.19
Boogaerts, M.20
Wlodarska, I.21
Kantarjian, H.22
Marynen, P.23
Coutre, S.E.24
Stone, R.25
Gilliland, D.G.26
more..
-
27
-
-
0242670019
-
PDGFRA activating mutations in gastrointestinal stromal tumors
-
Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen CJ, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CD, Fletcher JA (2003). PDGFRA activating mutations in gastrointestinal stromal tumors. Science 299: 708-710.
-
(2003)
Science
, vol.299
, pp. 708-710
-
-
Heinrich, M.C.1
Corless, C.L.2
Duensing, A.3
McGreevey, L.4
Chen, C.J.5
Joseph, N.6
Singer, S.7
Griffith, D.J.8
Haley, A.9
Town, A.10
Demetri, G.D.11
Fletcher, C.D.12
Fletcher, J.A.13
-
28
-
-
0642368571
-
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
-
Heinrich MC, Corless CL, Demetri GD, Blanke CD, von Mehren M, Joensuu H, McGreevey LS, Chen CJ, Van den Abbeele AD, Druker BJ, Kiese B, Eisenberg B, Roberts PJ, Singer S, Fletcher CD, Silberman S, Dimitrijevic S, Fletcher JA (2003). Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J. Clin. Oncol. 21: 4342-4349.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 4342-4349
-
-
Heinrich, M.C.1
Corless, C.L.2
Demetri, G.D.3
Blanke, C.D.4
Von Mehren, M.5
Joensuu, H.6
McGreevey, L.S.7
Chen, C.J.8
Van Den Abbeele, A.D.9
Druker, B.J.10
Kiese, B.11
Eisenberg, B.12
Roberts, P.J.13
Singer, S.14
Fletcher, C.D.15
Silberman, S.16
Dimitrijevic, S.17
Fletcher, J.A.18
-
29
-
-
0026793260
-
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors
-
Fleming TP, Saxena A, Clark WC, Robertson JT, Oldfield EH, Aaronson SA, Ali IU (1992). Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res. 52: 4550-4553.
-
(1992)
Cancer Res.
, vol.52
, pp. 4550-4553
-
-
Fleming, T.P.1
Saxena, A.2
Clark, W.C.3
Robertson, J.T.4
Oldfield, E.H.5
Aaronson, S.A.6
Ali, I.U.7
-
30
-
-
0026600613
-
Amplification of α-platelet-derived growth factor receptor gene lacking an exon coding for a portion of the extracellular region in a primary brain tumor of glial origin
-
Kumabe T, Sohma Y, Kayama T, Yoshimoto T, Yamamoto T (1992). Amplification of α-platelet-derived growth factor receptor gene lacking an exon coding for a portion of the extracellular region in a primary brain tumor of glial origin. Oncogene 7: 627-633.
-
(1992)
Oncogene
, vol.7
, pp. 627-633
-
-
Kumabe, T.1
Sohma, Y.2
Kayama, T.3
Yoshimoto, T.4
Yamamoto, T.5
-
31
-
-
0031893168
-
Chimaeric analysis reveals role of PDGF receptors in all muscle lineages
-
Crosby JR, Seifert RA, Soriano P, Bowen-Pope DF (1998). Chimaeric analysis reveals role of PDGF receptors in all muscle lineages. Nat. Genet. 18: 385-388.
-
(1998)
Nat. Genet.
, vol.18
, pp. 385-388
-
-
Crosby, J.R.1
Seifert, R.A.2
Soriano, P.3
Bowen-Pope, D.F.4
-
32
-
-
84862432400
-
PDGF production by B16 melanoma cells leads to increased pericyte coverage of vessels and an associated increase in tumor growth rate
-
in press
-
Furuhashi M, Sjöblom T, Abramsson A, Ellingsen J, Micke P, Li H, Bergsten-Folestad E, Eriksson U, Heuchel R, Betsholtz C, Heldin C-H, Östman A (2004). PDGF production by B16 melanoma cells leads to increased pericyte coverage of vessels and an associated increase in tumor growth rate. Cancer Res. (in press).
-
(2004)
Cancer Res.
-
-
Furuhashi, M.1
Sjöblom, T.2
Abramsson, A.3
Ellingsen, J.4
Micke, P.5
Li, H.6
Bergsten-Folestad, E.7
Eriksson, U.8
Heuchel, R.9
Betsholtz, C.10
Heldin, C.-H.11
Östman, A.12
-
33
-
-
0023219734
-
Transport of molecules in the tumor interstitium: A reivew
-
Jain RK (1987). Transport of molecules in the tumor interstitium: a reivew. Cancer Res. 47: 3039-3051.
-
(1987)
Cancer Res.
, vol.47
, pp. 3039-3051
-
-
Jain, R.K.1
-
34
-
-
0035297541
-
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors
-
Pietras K, Östman A, Sjöquist M, Buchdunger E, Reed RK, Heldin C-H, Rubin K (2001). Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res. 61: 2929-2934.
-
(2001)
Cancer Res.
, vol.61
, pp. 2929-2934
-
-
Pietras, K.1
Östman, A.2
Sjöquist, M.3
Buchdunger, E.4
Reed, R.K.5
Heldin, C.-H.6
Rubin, K.7
-
35
-
-
0033763567
-
Involvement of platelet-derived growth factor in disease: Development of specific antagonists
-
Östman A, Heldin C-H (2001). Involvement of platelet-derived growth factor in disease: development of specific antagonists. Adv. Cancer Res. 80: 1-38.
-
(2001)
Adv. Cancer Res.
, vol.80
, pp. 1-38
-
-
Östman, A.1
Heldin, C.-H.2
-
36
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, Capdeville R, Talpaz M (2001). Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N. Engl. J. Med. 344: 1038-1042.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
Resta, D.J.4
Reese, S.F.5
Ford, J.M.6
Capdeville, R.7
Talpaz, M.8
-
37
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL (2001). Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344: 1031-1037.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
38
-
-
0035960428
-
Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A phase I study
-
van Oosterom AT, Judson I, Verweij J, Stroobants S, Donato di Paola E, Dimitrijevic S, Martens M, Webb A, Sciot R, Van Glabbeke M, Silberman S, Nielsen OS (2001). Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. Lancet 358: 1421-1423.
-
(2001)
Lancet
, vol.358
, pp. 1421-1423
-
-
Van Oosterom, A.T.1
Judson, I.2
Verweij, J.3
Stroobants, S.4
Donato Di Paola, E.5
Dimitrijevic, S.6
Martens, M.7
Webb, A.8
Sciot, R.9
Van Glabbeke, M.10
Silberman, S.11
Nielsen, O.S.12
-
39
-
-
0037103624
-
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
-
Apperley JF, Gardembas M, Melo JV, Russell-Jones R, Bain BJ, Baxter EJ, Chase A, Chessells JM, Colombat M, Dearden CE, Dimitrijevic S, Mahon FX, Marin D, Nikolova Z, Olavarria E, Silberman S, Schultheis B, Cross NC, Goldman JM (2002). Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N. Engl. J. Med. 347: 481-487.
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 481-487
-
-
Apperley, J.F.1
Gardembas, M.2
Melo, J.V.3
Russell-Jones, R.4
Bain, B.J.5
Baxter, E.J.6
Chase, A.7
Chessells, J.M.8
Colombat, M.9
Dearden, C.E.10
Dimitrijevic, S.11
Mahon, F.X.12
Marin, D.13
Nikolova, Z.14
Olavarria, E.15
Silberman, S.16
Schultheis, B.17
Cross, N.C.18
Goldman, J.M.19
-
40
-
-
0037143794
-
Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans
-
Maki RG, Awan RA, Dixon RH, Jhanwar S, Antonescu CR (2002). Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans. Int. J. Cancer 100: 623-626.
-
(2002)
Int. J. Cancer
, vol.100
, pp. 623-626
-
-
Maki, R.G.1
Awan, R.A.2
Dixon, R.H.3
Jhanwar, S.4
Antonescu, C.R.5
-
41
-
-
0036727124
-
Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans
-
Rubin BP, Schuetze SM, Eary JF, Norwood TH, Mirza S, Conrad EU, Bruckner JD (2002). Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J. Clin. Oncol. 20: 3586-3591.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 3586-3591
-
-
Rubin, B.P.1
Schuetze, S.M.2
Eary, J.F.3
Norwood, T.H.4
Mirza, S.5
Conrad, E.U.6
Bruckner, J.D.7
-
42
-
-
0034665138
-
Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class
-
Kilic T, Alberta JA, Zdunek PR, Acar M, Iannarelli P, O'Reilly T, Buchdunger E, Black PM, Stiles CD (2000). Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res. 60: 5143-5150.
-
(2000)
Cancer Res.
, vol.60
, pp. 5143-5150
-
-
Kilic, T.1
Alberta, J.A.2
Zdunek, P.R.3
Acar, M.4
Iannarelli, P.5
O'Reilly, T.6
Buchdunger, E.7
Black, P.M.8
Stiles, C.D.9
-
43
-
-
1442290142
-
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
-
Erber R, Thurnher A, Katsen AD, Groth G, Kerger H, Hammes HP, Menger MD, Ullrich A, Vajkoczy P (2004). Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. Faseb J 18: 338-40.
-
(2004)
Faseb J.
, vol.18
, pp. 338-340
-
-
Erber, R.1
Thurnher, A.2
Katsen, A.D.3
Groth, G.4
Kerger, H.5
Hammes, H.P.6
Menger, M.D.7
Ullrich, A.8
Vajkoczy, P.9
-
44
-
-
0036790060
-
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy
-
Pietras K, Rubin K, Sjöblom T, Buchdunger E, Sjöquist M, Heldin C-H, Östman A (2002). Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. Cancer Res. 62: 5476-5484.
-
(2002)
Cancer Res.
, vol.62
, pp. 5476-5484
-
-
Pietras, K.1
Rubin, K.2
Sjöblom, T.3
Buchdunger, E.4
Sjöquist, M.5
Heldin, C.-H.6
Östman, A.7
-
46
-
-
0038682002
-
Mechanisms of TGF-β signaling from cell membrane to the nucleus
-
Shi Y, Massagué J (2003). Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113: 685-700.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massagué, J.2
-
47
-
-
0033956131
-
Signaling inputs converge on nuclear effectors in TGF-β signaling
-
ten Dijke P, Miyazono K, Heldin C-H (2000). Signaling inputs converge on nuclear effectors in TGF-β signaling. Trends. Biol. Sci. 25: 64-70.
-
(2000)
Trends. Biol. Sci.
, vol.25
, pp. 64-70
-
-
Ten Dijke, P.1
Miyazono, K.2
Heldin, C.-H.3
-
48
-
-
0142104985
-
Smad-dependent and Smad-independent pathways in TGF-beta family signalling
-
Derynck R, Zhang YE (2003). Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425: 577-84.
-
(2003)
Nature
, vol.425
, pp. 577-584
-
-
Derynck, R.1
Zhang, Y.E.2
-
50
-
-
0033625416
-
Functional analysis of the TGFb receptor/Smad pathway through gene ablation in mice
-
Goumans MJ, Mummery C (2000). Functional analysis of the TGFb receptor/Smad pathway through gene ablation in mice. Int. J. Dev. Biol. 44: 253-265.
-
(2000)
Int. J. Dev. Biol.
, vol.44
, pp. 253-265
-
-
Goumans, M.J.1
Mummery, C.2
-
51
-
-
0029066689
-
Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability
-
Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B, Brattain M, Willson JKV (1995). Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 268: 1336-1338.
-
(1995)
Science
, vol.268
, pp. 1336-1338
-
-
Markowitz, S.1
Wang, J.2
Myeroff, L.3
Parsons, R.4
Sun, L.5
Lutterbaugh, J.6
Fan, R.S.7
Zborowska, E.8
Kinzler, K.W.9
Vogelstein, B.10
Brattain, M.11
Willson, J.K.V.12
-
52
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
Hahn SA, Schutte M, Hoque ATMS, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE (1996). DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271: 350-353.
-
(1996)
Science
, vol.271
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Hoque, A.T.M.S.3
Moskaluk, C.A.4
Da Costa, L.T.5
Rozenblum, E.6
Weinstein, C.L.7
Fischer, A.8
Yeo, C.J.9
Hruban, R.H.10
Kern, S.E.11
-
53
-
-
0242499448
-
Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
-
Siegel PM, Massagué J (2003). Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer. Nat. Rev. Cancer 3: 807-821.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 807-821
-
-
Siegel, P.M.1
Massagué, J.2
-
54
-
-
0030598681
-
TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
-
Cui W, Fowlis DJ, Bryson S, Duffie E, Ireland H, Balmain A, Akhurst RJ (1996). TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 86: 531-542.
-
(1996)
Cell
, vol.86
, pp. 531-542
-
-
Cui, W.1
Fowlis, D.J.2
Bryson, S.3
Duffie, E.4
Ireland, H.5
Balmain, A.6
Akhurst, R.J.7
-
55
-
-
0037118579
-
Extracellular domain of TGFβ type III receptor inhibits angiogenesis and tumor growth in human cancer cells
-
Bandyopadhyay A, Zhu Y, Malik SN, Kreisberg J, Brattain MG, Sprague EA, Luo J, Lopez-Casillas F, Sun LZ (2002). Extracellular domain of TGFβ type III receptor inhibits angiogenesis and tumor growth in human cancer cells. Oncogene 21: 3541-3551.
-
(2002)
Oncogene
, vol.21
, pp. 3541-3551
-
-
Bandyopadhyay, A.1
Zhu, Y.2
Malik, S.N.3
Kreisberg, J.4
Brattain, M.G.5
Sprague, E.A.6
Luo, J.7
Lopez-Casillas, F.8
Sun, L.Z.9
-
56
-
-
0036086409
-
Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
-
Muraoka RS, Dumont N, Ritter CA, Dugger TC, Brantley DM, Chen J, Easterly E, Roebuck LR, Ryan S, Gotwals PJ, Koteliansky V, Arteaga CL (2002). Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases. J. Clin. Invest. 109: 1551-1559.
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1551-1559
-
-
Muraoka, R.S.1
Dumont, N.2
Ritter, C.A.3
Dugger, T.C.4
Brantley, D.M.5
Chen, J.6
Easterly, E.7
Roebuck, L.R.8
Ryan, S.9
Gotwals, P.J.10
Koteliansky, V.11
Arteaga, C.L.12
-
57
-
-
0036087521
-
Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects
-
Yang YA, Dukhanina O, Tang B, Mamura M, Letterio JJ, MacGregor J, Patel SC, Khozin S, Liu ZY, Green J, Anver MR, Merlino G, Wakefield LM (2002). Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects. J. Clin. Invest. 109: 1607-1615.
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1607-1615
-
-
Yang, Y.A.1
Dukhanina, O.2
Tang, B.3
Mamura, M.4
Letterio, J.J.5
MacGregor, J.6
Patel, S.C.7
Khozin, S.8
Liu, Z.Y.9
Green, J.10
Anver, M.R.11
Merlino, G.12
Wakefield, L.M.13
-
58
-
-
0037186459
-
Identification of novel inhibitors of the transforming growth factor b1 (TGF-β1) type 1 receptor (ALK5)
-
Callahan JF, Burgess JL, Fornwald JA, Gaster LM, Harling JD, Harrington FP, Heer J, Kwon C, Lehr R, Mathur A, Olson BA, Weinstock J, Laping NJ (2002). Identification of novel inhibitors of the transforming growth factor b1 (TGF-β1) type 1 receptor (ALK5). J. Med. Chem. 45: 999-1001.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 999-1001
-
-
Callahan, J.F.1
Burgess, J.L.2
Fornwald, J.A.3
Gaster, L.M.4
Harling, J.D.5
Harrington, F.P.6
Heer, J.7
Kwon, C.8
Lehr, R.9
Mathur, A.10
Olson, B.A.11
Weinstock, J.12
Laping, N.J.13
-
59
-
-
1342265719
-
SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7
-
DaCosta Byfield S, Major C, Laping NJ, Roberts AB (2004). SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 65: 744-752.
-
(2004)
Mol. Pharmacol.
, vol.65
, pp. 744-752
-
-
DaCosta Byfield, S.1
Major, C.2
Laping, N.J.3
Roberts, A.B.4
-
60
-
-
0036085920
-
SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
-
Inman GJ, Nicolas FJ, Callahan JF, Marling JD, Gaster LM, Reith AD, Laping NJ, Hill CS (2002). SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62: 65-74.
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 65-74
-
-
Inman, G.J.1
Nicolas, F.J.2
Callahan, J.F.3
Marling, J.D.4
Gaster, L.M.5
Reith, A.D.6
Laping, N.J.7
Hill, C.S.8
-
61
-
-
0036082554
-
Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542
-
Laping NJ, Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, Martin W, Fornwald J, Lehr R, Harling J, Gaster L, Callahan JF, Olson BA (2002). Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542. Mol. Pharmacol. 62: 58-64.
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 58-64
-
-
Laping, N.J.1
Grygielko, E.2
Mathur, A.3
Butter, S.4
Bomberger, J.5
Tweed, C.6
Martin, W.7
Fornwald, J.8
Lehr, R.9
Harling, J.10
Gaster, L.11
Callahan, J.F.12
Olson, B.A.13
-
62
-
-
0038721244
-
Nuclear factor YY1 inhibits transforming growth factor β- and bone morphogenetic protein-induced cell differentiation
-
Kurisaki K, Kurisaki A, Valcourt U, Terentiev AA, Pardali K, ten Dijke P, Heldin C-H, Ericsson J, Moustakas A (2003). Nuclear factor YY1 inhibits transforming growth factor β- and bone morphogenetic protein-induced cell differentiation. Mol. Cell. Biol. 23: 4494-4510.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 4494-4510
-
-
Kurisaki, K.1
Kurisaki, A.2
Valcourt, U.3
Terentiev, A.A.4
Pardali, K.5
Ten Dijke, P.6
Heldin, C.-H.7
Ericsson, J.8
Moustakas, A.9
-
63
-
-
0036635291
-
Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug
-
Capdeville R, Buchdunger E, Zimmermann J, Matter A (2002). Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug. Nat. Rev. Drug Discov. 1: 493-502.
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 493-502
-
-
Capdeville, R.1
Buchdunger, E.2
Zimmermann, J.3
Matter, A.4
|