Involvement of P2 receptors in the growth and survival of neurons in the CNS

Pharmacology and Therapeutics

Volumn 109, Issue 3, 2006, Pages 297-324

  Franke, Heike ^a   Illes, Peter ^a,b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

Astroglia; Extracellular ATP; Neurodegeneration; Neuronal growth; Neuroprotection; P2 receptors

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALCOHOL; ARC 67085; BETA SECRETASE; CIBACRON BLUE F3GA; CLOPIDOGREL; CYCLIC AMP; DIADENOSINE POLYPHOSPHATE; DOPAMINE; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR RECEPTOR; NICOTINIC RECEPTOR; NITRIC OXIDE SYNTHASE; NUCLEOTIDASE; NUCLEOTIDE PYROPHOSPHATASE; PURINE P2 RECEPTOR; PURINE P2Y RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SURAMIN; UNCLASSIFIED DRUG;

AKINESIA; ASTROCYTE; CELL ACTIVATION; CELL DEATH; CELL GROWTH; CELL STRUCTURE; CELL SURVIVAL; CELL TYPE; CENTRAL NERVOUS SYSTEM; DRUG INHIBITION; ENZYME REGULATION; GRAND MAL EPILEPSY; HUMAN; NERVE CELL; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PHYSICAL DISEASE BY BODY FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVIEW; UPREGULATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL DEATH; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; GROWTH SUBSTANCES; HUMANS; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; RECEPTORS, PURINERGIC P2;

EID: 31144452713     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2005.06.002     Document Type: Review

References (295)

1. M.P. Abbracchio, S. Ceruti, R. Langfelder, F. Cattabeni, M.J. Saffrey, and G. Burnstock Effects of ATP analogues and basic fibroblast growth factor on astroglial cell differentiation in primary cultures of rat striatum Int J Dev Neurosi 13 7 1995 685 693
2. M.P. Abbracchio, R. Brambilla, S. Ceruti, and F. Cattabeni Signalling mechanisms involved in P2Y receptor-mediated reactive gliosis Prog Brain Res 120 1999 333 342
3. 14 receptor) adds diversity to the P2Y receptor family Trends Pharmacol Sci 24 2 2003 52 55
4. A. Abdipranoto, G.J. Liu, E.L. Werry, and M.R. Bennett Mechanisms of secretion of ATP from cortical astrocytes triggered by uridine triphosphate NeuroReport 14 17 2003 2177 2181
5. I. Afanas'ev, B. Ferger, and K. Kuschinsky The associative type of sensitization to d-amphetamine is expressed as an NO-dependent dramatic increase in extracellular dopamine in the nucleus accumbens Naunyn-Schmiedeberg's Arch Pharmacol 362 3 2000 232 237
6. H.J. Agteresch, P.C. Dagnelie, J.W. van den Berg, and J.H. Wilson Adenosine triphosphate: established and potential clinical applications Drugs 58 2 1999 211 232
7. S. Amadio, N. D'Ambrosi, F. Cavaliere, B. Murra, G. Sancesario, and G. Bernardi P2 receptor modulation and cytotoxic function in cultured CNS neurons Neuropharmacology 42 4 2002 489 501
8. 7 like channels in cultured mouse astrocytes Drug Dev Res 50 1 2000 92
9. 2+ level and modulation of nerve growth factor action on pheochromocytoma PC12h cells by extracellular ATP Meikai Daigaku Shigaku Zasshi 19 2 1990 221 229
10. A. Araque, V. Parpura, R.P. Sanzgiri, and P.G. Haydon Tripartite synapses: glia, the unacknowledged partner Trends Neurosci 22 5 1999 208 215
11. A. Araque, N. Li, R.T. Doyle, and P.G. Haydon SNARE protein-dependent glutamate release from astrocytes J Neurosci 20 2 2000 666 673
12. 7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase J Neurosci 22 14 2002 5938 5945
13. G. Arslan, C.M. Filipeanu, E. Irenius, B. Kull, E. Clementi, and C. Allgaier P2Y receptors contribute to ATP-induced increases in intracellular calcium in differentiated but not undifferentiated PC12 cells Neuropharmacology 39 3 2000 482 496
14. L. Atkinson, C.J. Milligan, N.J. Buckley, and J. Deuchars An ATP-gated ion channel at the cell nucleus Nature 420 6911 2002 42
15. 7) receptors regulate intracellular calcium and purine release NeuroReport 7 15-17 1996 2533 2537
16. 7 ATP receptor-mediated modulation of astrocyte proliferation and coupling Drug Dev Res 50 1 2000 108
17. P. Ballerini, P. Di Iorio, R. Ciccarelli, E. Nargi, I. D'Alimonte, and U. Traversa Glial cells express multiple ATP binding cassette proteins which are involved in ATP release NeuroReport 13 14 2002 1789 1792
18. C. Barajas-Lopez, R. Espinosa-Luna, and Y. Zhu Funtional interactions between nicotinic and P2X channels in short-term cultures of guinea-pig submucosal neurons J Physiol 513 3 1998 671 683
19. 3 and P2X channels in submucosal neurons Am J Physiol Gastrointest Liver Physiol 283 2 2002 G1238 G1248
20. C.G. Bennett, A.P. Ford, J.A. Smith, T.E. Webb, and M.R. Boarder P2Y receptor regulation of cultured rat cerebral cortical cells: calcium responses and mRNA expression in neurons and glia Br J Pharmacol 139 2 2003 279 288
21. P. Bezzi, and A. Volterra A neuron-glia signalling network in the active brain Curr Opin Neurobiol 11 3 2001 387 394
22. L.K. Bobanovic, S.J. Royle, and R.D. Murrell-Lagnado P2X receptor trafficking in neurons is subunit specific J Neurosci 22 12 2002 4814 4824
23. C. Bolego, S. Ceruti, R. Brambilla, L. Puglisi, F. Cattabeni, and G. Burnstock Characterization of signalling pathways involved in ATP and basic fibroblast growth factor-induced astrogliosis Br J Pharmacol 121 8 1997 1692 1699
24. S.J. Borvendeg, M. Al-Khrasani, P. Rubini, W. Fischer, C. Allgaier, and K. Wirkner Subsensitivity of P2X but not vanilloid receptors in dorsal root ganglia of rats caused by cyclophosphamide cystitis Eur J Pharmacol 474 1 2003 71 75
25. 2+ channels in rat dorsal root ganglion neurons Synapse 47 2 2003 159 161
26. E. Boue-Grabot, C. Barajas-Lopez, Y. Chakfe, D. Blais, D. Belanger, and M.B. Emerit Intracellular cross talk and physical interaction between two classes of neurotransmitter-gated channels J Neurosci 23 4 2003 1246 1253
27. E. Boue-Grabot, M.B. Emerit, E. Toulme, P. Seguela, and M. Garret Cross-talk and co-trafficking between ρ1/GABA receptors and ATP-gated channels J Biol Chem 279 8 2004 6967 6975
28. R. Brambilla, G. Burnstock, A. Bonazzi, S. Ceruti, F. Cattabeni, and M.P. Abbracchio Cyclo-oxygenase-2 mediates P2Y receptor-induced reactive astrogliosis Br J Pharmacol 126 3 1999 563 567
29. R. Brambilla, J.T. Neary, F. Cattabeni, L. Cottini, G. D'Ippolito, and P.C. Schiller Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling J Neurochem 83 6 2002 1285 1296
30. 7-receptor subunit in neurons of the rat retina Brain Res Mol Brain Res 62 1 1998 106 109
31. N. Braun, Y. Zhu, J. Krieglstein, C. Culmsee, and H. Zimmermann Upregulation of the enzyme chain hydrolyzing extracellular ATP after transient forebrain ischemia in the rat J Neurosci 18 13 1998 4891 4900
32. 7 receptor currents in Müller glial cells during proliferative vitreoretinopathy Investig Ophthalmol Vis Sci 42 3 2001 860 867
33. 4 receptor J Biol Chem 276 15 2001 11939 11948
34. P.V. Buday, C.J. Carr, and T.S. Myga A pharmacologic study of some nucleosides and nucleotides J Pharm Pharmacol 13 5 1961 290 299
35. 7 receptor function with a monoclonal antibody Blood 92 10 1998 3521 8528
36. G. Burnstock Purinoceptors: ontogeny and phylogeny Drug Dev Res 39 3-4 1996 204 242
37. G. Burnstock Introduction: P2 receptors Curr Top Med Chem 4 8 2004 793 803
38. G. Burnstock Cotransmission Curr Opin Pharmacol 4 1 2004 47 52
39. J. Burrone, and V.N. Murthy Synaptic plasticity: rush hour traffic in the AMPA lanes Curr Biol 11 7 2001 R274 R277
40. 1 receptor Biochem Pharmacol 68 10 2004 1995 2002
41. F. Cavaliere, N. D'Ambrosi, M.T. Ciotti, G. Mancino, G. Sancesario, and G. Bernardi Glucose deprivation and chemical hypoxia: neuroprotection by P2 receptor antagonists Neurochem Int 38 3 2001 189 197
42. F. Cavaliere, N. D'Ambrosi, G. Sancesario, G. Bernardi, and C. Volonté Hypoglycaemia-induced cell death: features of neuroprotection by the P2 receptor antagonist basilen blue Neurochem Int 38 3 2001 199 207
43. F. Cavaliere, G. Sancesario, G. Bernardi, and C. Volonté Extracellular ATP and nerve growth factor intensify hypoglycemia-induced cell death in primary neurons: role of P2 and NGFRp75 receptors J Neurochem 83 5 2002 1129 1138
44. 4 receptor and ischemic cell death: prevention by P2 antagonists Neuroscience 120 1 2003 85 98
45. 4 receptor during hypoglycemia: cross talk with the ionotropic NMDAR1 receptor Exp Cell Res 300 1 2004 149 158
46. 7 and oxygen/glucose deprivation in organotypic hippocampal cultures J Cereb Blood Flow Metab 24 4 2004 392 398
47. K. Chang, K. Hanaoka, M. Kumada, and Y. Takuwa Molecular cloning and functional analysis of a novel P2 nucleotide receptor J Biol Chem 270 44 1995 26152 26158
48. S.C. Chattaraj Cangrelor AstraZeneca Curr Opin Investig Drugs 2 2 2001 250 255
49. S. Chaumont, L.H. Jiang, A. Penna, R.A. North, and F. Rassendren Identification of a trafficking motif involved in the stabilization and polarization of P2X receptors J Biol Chem 279 28 2004 29628 29638
50. 2 receptors Glia 22 4 1998 360 370
51. B.C. Chen, C.M. Lee, and W.W. Lin Inhibition of ecto-ATPase by PPADS, suramin and reactive blue in endothelial cells, C6 glioma cells and RAW 264.7 macrophages Br J Pharmacol 119 8 1996 1628 1634
52. 7 receptor pore dilation: pharmacological and functional consequences Drug Dev Res 53 2-3 2001 60 65
53. 2 receptors during rat embryonic neurogenesis J Comp Neurol 443 4 2002 368 382
54. K.K. Cheung, M. Ryten, and G. Burnstock Abundant and dynamic expression of G protein-coupled P2Y receptors in mammalian development Dev Dyn 228 2 2003 254 266
55. B.A. Chizh, and P. Illes P2X receptors and nociception Pharmacol Rev 53 4 2001 553 568
56. R. Ciccarelli, P. Ballerini, G. Sabatino, M.P. Rathbone, M. D'Onofrio, and F. Caciagli Involvement of astrocytes in purine-mediated reparative processes in the brain Int J Dev Neurosci 19 4 2001 395 414
57. P. Claes, B. Grobben, K. Van Kolen, D. Roymans, and H. Slegers P2Y(AC)-receptor agonists enhance the proliferation of rat C6 glioma cells through activation of the p42/44 mitogen-activated protein kinase Br J Pharmacol 134 2 2001 402 408
58. 3-deficient mice Nature 407 407 2000 1011 1015
59. S. Coco, F. Calegari, E. Pravettoni, D. Pozzi, E. Taverna, and P. Rosa Storage and release of ATP from astrocytes in culture J Biol Chem 278 2 2003 1354 1362
60. 7 receptor Neuropharmacology 36 9 1997 1277 1283
61. 6 receptor Biochem Biophys Res Commun 222 2 1996 303 308
62. 11 receptor Br J Pharmacol 128 6 1999 1199 1206
63. i J Biol Chem 276 44 2001 41479 41485
64. M.L. Cotrina, J.H.-C. Lin, J.C. Lopez-Garcia, C.C.G. Naus, and M. Nedergaard ATP-mediated glia signaling J Neurosci 20 8 2000 2835 2844
65. 12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells Br J Pharmacol 141 3 2004 497 507
66. N. D'Ambrosi, F. Cavaliere, D. Merlo, L. Milazzo, D. Mercanti, and C. Volonté Antagonists of P2 receptor prevent NGF-dependent neuritogenesis in PC12 cells Neuropharmacology 39 6 2000 1083 1094
67. N. D'Ambrosi, B. Murra, F. Cavaliere, S. Amadio, G. Bernardi, and G. Burnstock Interaction between ATP and nerve growth factor signaling in the survival and neuritic outgrowth from PC12 cells Neuroscience 108 3 2001 527 534
68. N. D'Ambrosi, B. Murra, F. Vacca, and C. Volonté Pathways of survival induced by NGF and extracellular ATP after growth factor deprivation Prog Brain Res 146 2004 93 100
69. M. Darby, J.B. Kuzmiski, W. Panenka, D. Feighan, and B.A. MacVicar ATP released from astrocytes during swelling activates chloride channels J Neurophysiol 89 2003 1870 1877
70. D.L. Davies, T.K. Machu, Y. Guo, and R.L. Alkana Ethanol sensitivity in ATP-gated P2X receptors is subunit dependent Alcohol Clin Exp Res 26 6 2002 773 778
71. 7 nucleotide receptor results in trafficking defects and impaired function J Immunol 171 3 2003 1304 1311
72. 7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems J Neurosci 21 18 2001 7143 7152
73. P. Dhawan, and A. Richmond A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells J Biol Chem 277 10 2002 7920 7928
74. 2 receptor of microglial cells: a novel immunomodulatory receptor Prog Brain Res 120 1999 355 368
75. 12 receptor in platelet activation J Clin Invest 113 3 2004 340 345
76. 7 receptor-mediated release of excitatory amino acids from astrocytes J Neurosci 23 4 2003 1320 1328
77. T.V. Dunwiddie, L. Diao, and W.R. Proctor Adenine nucleotides undergo rapid, quantitative conversion to adenosine in the extracellular space in rat hippocampus J Neurosci 17 20 1997 7673 7682
78. 1 receptor membrane redistribution and down-regulation visualized by using receptor-coupled green fluorescent protein chimeras Neuropharmacology 39 11 2000 2054 2066
79. 1 in rat vas deferens FEBS Lett 489 2-3 2001 154 158
80. 1 receptor form disulfide bonds and are involved in receptor trafficking to the cell surface Mol Pharmacol 61 2 2002 303 311
81. D. Erlinge, J. You, C. Wahlestedt, and L. Edvinsson Characterization of an ATP receptor mediating mitogenesis in vascular smooth muscle cells Eur J Pharmacol 289 1 1995 135 149
82. C. Exley, and O.V. Korchazhkina Promotion of formation of amyloid fibrils by aluminium adenosine triphosphate (AlATP) J Inorg Biochem 84 3-4 2001 215 224
83. 2+ signaling in astrocytes J Neurosci 23 11 2003 4437 4444
84. D. Ferrari, P. Chiozzi, S. Falzoni, M. Dal Susino, G. Collo, and G. Buell ATP-mediated cytotoxicity in microglial cells Neuropharmacology 36 9 1997 1295 1301
85. D. Ferrari, P. Chiozzi, S. Falzoni, M. Dal Susino, L. Melchiorri, and O.R. Baricordi Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages J Immunol 159 3 1997 1451 1458
86. D. Ferrari, S. Wesselborg, M.K. Bauer, and K. Schulze-Osthoff Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65 J Cell Biol 139 7 1997 1635 1643
87. D. Ferrari, M. Los, M.K. Bauer, P. Vandenabeele, S. Wesselborg, and K. Schulze-Osthoff P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death FEBS Lett 447 1 1999 71 75
88. 3 cells and their inhibition by ethanol and trichloroethanol J Neurochem 85 3 2003 779 790
89. 2 purinergic receptors in precerebellar nuclei Neuroscience 115 2 2002 425 434
90. H. Franke, H. Kittner, P. Berger, K. Wirkner, and J. Schramek The reaction of astrocytes and neurons in the hippocampus of adult rats during chronic ethanol treatment and correlations to behavioral impairments Alcohol 14 5 1997 445 454
91. H. Franke, U. Krügel, and P. Illes P2 receptor-mediated proliferative effects on astrocytes in vivo Glia 28 3 1999 190 200
92. H. Franke, A. Bringmann, T. Pannicke, U. Krügel, J. Grosche, and A. Reichenbach P2 receptors on macroglial cells: functional implications for gliosis Drug Dev Res 53 2-3 2001 140 147
93. H. Franke, J. Grosche, H. Schädlich, U. Krügel, C. Allgaier, and P. Illes P2X receptor expression on astrocytes in the nucleus accumbens of rats Neuroscience 108 3 2001 421 429
94. H. Franke, U. Krügel, R. Schmidt, J. Grosche, A. Reichenbach, and P. Illes P2 receptor-types involved in astrogliosis in vivo Br J Pharmacol 134 6 2001 1180 1189
95. 1 receptor expression in the brain after sensitisation with d-amphetamine Psychopharmacology 167 2 2003 187 194
96. H. Franke, U. Krügel, J. Grosche, and P. Illes Immunoreactivity for glial fibrillary acidic protein and P2 receptor expression on astrocytes in vivo Drug Dev Res 59 1 2003 175 189
97. 7 receptor expression after ischemia in the cerebral cortex of rats J Neuropathol Exp Neurol 63 7 2004 686 699
98. H. Franke, U. Krügel, J. Grosche, C. Heine, W. Härtig, and C. Allgaier P2Y receptor expression on astrocytes in the nucleus accumbens of rats Neuroscience 127 2 2004 431 441
99. 7 receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds mice. Neurochem Int.
100. 2 receptors in differentiated rat pheochromocytoma PC12 cells Life Sci 66 19 2000 1849 1859
101. 3 increases in the spared L4 DRG in rats with L5 spinal nerve ligation Pain 99 1-2 2002 111 120
102. M. Fumagalli, R. Brambilla, N. D'Ambrosi, C. Volonté, M. Matteoli, and C. Verderio Nucleotide-mediated calcium signaling in rat cortical astrocytes: role of P2X and P2Y receptors Glia 43 3 2003 203 218
103. S. Garcia de Arriba, H. Franke, M. Pissarek, K. Nieber, and P. Illes Neuroprotection by ATP-dependent potassium channels in rat neocortical brain slices during hypoxia Neurosci Lett 273 1 1999 13 16
104. 7 nucleotide receptor activation enhances IFN gamma-induced type II nitric oxide synthase activity in BV-2 microglial cells J Neurochem 87 2 2003 344 352
105. 7 receptor-mediated ERK1/2 phosphorylation in human astrocytoma cells Am J Physiol Cell Physiol 284 2 2003 C571 C581
106. Z. Gerevich, and P. Illes P2Y receptors and pain transmission Purin Signal 1 1 2004 3 10
107. Z. Gerevich, S.J. Borvendeg, W. Schröder, H. Franke, K. Wirkner, and W. Nörenberg Inhibition of N-type voltage-activated calcium channels in rat dorsal root ganglion neurons by P2Y receptors is a possible mechanism of ADP-induced analgesia J Neurosci 24 4 2004 797 807
108. R. Gomez-Villafuertes, J. Gualix, M.T. Miras-Portugal, and J. Pintor Adenosine 5′-tetraphosphate (Ap(4)), a new agonist on rat midbrain synaptic terminal P2 receptors Neuropharmacology 39 12 2000 2381 2390
109. J.L. Gordon Extracellular ATP: effects, sources and fate Biochem J 233 2 1986 309 319
110. L.A. Greene, and A.S. Tischler Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor Proc Natl Acad Sci U S A 73 7 1976 2424 2428
111. B. Grobben, P. Claes, D. Roymans, E.L. Esmans, H. Van Onckelen, and H. Slegers Ecto-nucleotide pyrophosphatase modulates the purinoceptor-mediated signal transduction and is inhibited by purinoceptor antagonists Br J Pharmacol 130 1 2000 139 145
112. B. Grobben, P. Claes, K. Van Kolen, D. Roymans, P. Fransen, and S.U. Sys Agonists of the P2Y(AC)-receptor activate MAP kinase by a ras-independent pathway in rat C6 glioma J Neurochem 78 6 2001 1325 1338
113. 7 receptors Am J Physiol Cell Physiol 279 4 2000 C1189 C1197
114. J.W. Gysbers, and M.P. Rathbone Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells NeuroReport 3 11 1992 997 1000
115. J.W. Gysbers, and M.P. Rathbone GTP and guanosine synergistically enhance NGF-induced neurite outgrowth from PC12 cells Int J Dev Neurosci 14 1 1996 19 34
116. M. Hartlage-Rübsamen, U. Zeitschel, J. Apelt, U. Gärtner, H. Franke, and T. Stahl Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent Glia 41 2 2003 169 179
117. N.J. Haughey, and M.P. Mattson Alzheimer's amyloid beta-peptide enhances ATP/gap junction-mediated calcium-wave propagation in astrocytes Neuromol Med 3 3 2003 173 180
118. A. Heilbronn, V. Maienschein, K. Carstensen, W. Gann, and H. Zimmermann Crucial role of ecto-5′-nucleotidase in differentiation and survival of developing neural cells NeuroReport 7 1 1995 257 261
119. Heine, C., Grosche, J., Illes, P., & Franke, H. (2004a). P2 receptor expression in organotypic dopaminergic co-cultures of the rat brain.Naunyn-Schmiedeberg's Arch Pharmacol 369 (Supplement 1), R30, 117.
120. C. Heine, J. Grosche, B. Heimrich, P. Illes, and H. Franke Influence of P2 receptors on development and growth in organotypic co-cultures Int J Dev Neurosci 22 7 2004 581
121. I. Hide, M. Tanaka, A. Inoue, K. Nakajima, S. Kohsaka, and K. Inoue Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia J Neurochem 75 3 2000 965 972
122. S. Hindley, M.A.R. Herman, and M.P. Rathbone Stimulation of reactive astrogliosis in vivo by extracellular adenosine diphosphate or an adenosine A2 receptor agonist J Neurosci Res 38 4 1994 399 406
123. R.C. Hogg, H. Chipperfield, K.A. Whyte, M.R. Stafford, M.A. Hansen, and S.M. Cool Functional maturation of isolated neural progenitor cells from the adult rat hippocampus Eur J Neurosci 19 9 2004 2410 2420
124. G. Hollopeter, H.M. Jantzen, D. Vincent, G. Li, L. England, and V. Ramakrishnan Identification of the platelet ADP receptor targeted by antithrombotic drugs Nature 409 6817 2001 202 207
125. V.H. Höpker, M.J. Saffrey, and G. Burnstock Neurite outgrowth of striatal neurons in vitro: involvement of purines in the growth-promoting effect of myenteric plexus explants Int J Dev Neurosci 14 4 1996 439 451
126. i rise and dopamine secretion in PC12 cells J Neurochem 66 1 1996 124 130
127. 7 nucleotide receptor J Biol Chem 275 35 2000 26792 26798
128. 7 receptor-mediated phospholipase D activation is regulated by both PKC-dependent and PKC-independent pathways in a rat brain-derived Type-2 astrocyte cell line, RBA-2 Cell Signal 14 1 2002 83 92
129. P. Illes, and J. Ribeiro Molecular physiology of P2 receptors in the central nervous system Eur J Pharmacol 483 1 2004 5 17
130. P. Illes, K.N. Klotz, and M.J. Lohse Signaling by extracellular nucleotides and nucleosides Naunyn-Schmiedeberg's Arch Pharmacol 362 4-5 2000 295 298
131. B. Innocenti, V. Parpura, and P.G. Haydon Imaging extracellular waves of glutamate during calcium signaling in cultured astrocytes J Neurosci 20 5 2000 1800 1808
132. B. Innocenti, S. Pfeiffer, E. Zrenner, K. Kohler, and E. Guenther ATP-induced non-neuronal cell permeabilization in the rat inner retina J Neurosci 24 39 2004 8577 8583
133. K. Inoue Microglial activation by purines and pyrimidines Glia 40 2 2002 156 163
134. 7 purinergic receptors in the monkey retina J Comp Neurol 459 3 2003 267 277
135. 7 receptors stimulate AKT phosphorylation in astrocytes Br J Pharmacol 141 7 2004 1106 1117
136. G. James, and A.M. Butt P2X and P2Y purinoreceptors mediate ATP-evoked calcium signalling in optic nerve glia in situ Cell Calcium 30 4 2001 251 259
137. 2+ signalling in glial cell pathology in the central nervous system Eur J Pharmacol 447 2-3 2002 247 260
138. 3 allosteric modulator, cibacron blue Br J Pharmacol 132 1 2001 259 269
139. P. Jensik, and T. Cox ATP-induced internalization of amphibian epithelial P2X receptors is linked to channel opening Pflügers Arch 444 6 2002 795 800
140. A. Jeremic, K. Jeftinija, J. Stevanovic, A. Glavaski, and S. Jeftinija ATP stimulates calcium-dependent glutamate release from cultured astrocytes J Neurochem 77 2 2001 664 675
141. Y.-W. Jo, and L.W. Role Coordinate release of ATP and GABA at in vitro synapses of lateral hypothalamic neurons J Neurosci 22 12 2002 4794 4804
142. Y.-W. Jo, and R. Schlichter Synaptic corelease of ATP and GABA in cultured spinal neurons Nat Neurosci 2 3 1999 241 245
143. 3H]purine outflow evoked by short-term hypoxia and hypoglycemia in rat hippocampal slices Brain Res 823 1-2 1999 183 190
144. J. Kang, L. Jiang, S.A. Goldman, and M. Nedergaard Astrocyte-mediated potentiation of inhibitory synaptic transmission Nat Neurosci 1 8 1998 683 692
145. A receptor-mediated mechanism in the gerbil hippocampus Brain Res Mol Brain Res 116 1-2 2003 168 175
146. 7 receptor expression in the gerbil hippocampus Brain Res Mol Brain Res 121 1-2 2004 12 18
147. B.S. Khakh Molecular physiology of P2X receptors and ATP signalling at synapses Nat Rev Neurosci 2 3 2001 165 174
148. 2 channel permeability dynamics J Biol Chem 280 7 2005 6118 6129
149. B.S. Khakh, X.R. Bao, C. Labarca, and H.A. Lester Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds Nat Neurosci 2 4 1999 322 330
150. B.S. Khakh, X. Zhou, J. Sydes, J.J. Galligan, and H.A. Lester State-dependent cross-inhibition between transmitter-gated cation channels Nature 406 6794 2000 405 410
151. B.S. Khakh, G. Burnstock, C. Kennedy, B.F. King, R.A. North, and P. Seguela International union of pharmacology: XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits Pharmacol Rev 53 1 2001 107 118
152. 2-green fluorescent protein receptors Proc Natl Acad Sci U S A 98 9 2001 5288 5293
153. A. Kharlamov, S.C. Jones, and D.K. Kim Suramin reduces infarct volume in a model of focal cerebral ischemia Exp Brain Res 147 3 2002 353 359
154. E.J. Kidd, C.B.A. Grahames, J. Simon, A.D. Michel, E.A. Barnard, and P.P.A. Humphrey Localization of P2X purinoceptor transcripts in the rat nervous system Mol Pharmacol 48 4 1995 569 573
155. 3 receptors in the developing rat brain Neuroscience 87 3 1998 533 539
156. 7 receptor signalling complex EMBO J 20 22 2001 6347 6358
157. H. Kittner, U. Krügel, E. Hoffmann, and P. Illes Effects of intra-accumbens injection of 2-methylthio ATP: a combined open field and electroencephalographic study in rats Psychopharmacology (Berl) 150 2 2000 123 131
158. H. Kittner, U. Krügel, and P. Illes The purinergic P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2′,4′-disulphonic acid prevents both the acute locomotor effects of amphetamine and the behavioural sensitization caused by repeated amphetamine injections in rats Neuroscience 102 2 2001 241 243
159. 1 receptor and iNOS-expression after sensitization with d-amphetamine by rats. Naunyn-Schmiedeberg's Arch Pharmacol 367 (1), R34, 122.
160. 1 receptor mediated nitric oxide production Neuropsychopharmacology 28 3 2003 435 444
161. L.J. Knutsen, and T.F. Murray Adenosine and ATP in epilepsy K.A. Jacobson M.F. Jarvis Purinergic Approaches in Experimental Therapeutics 1997 Wiley-Liss Inc. 423 447
162. 7 receptor stimulates plasma membrane trafficking in the FRTL rat thyrocyte cell line Am J Physiol Cell Physiol 287 4 2004 C992 C1002
163. S. Koizumi, and K. Inoue Regulation by astrocytic ATP of synaptic transmission Nippon Yakurigaku Zasshi 123 6 2004 389 396
164. S. Koizumi, K. Fujishita, M. Tsuda, Y. Shigemoto-Mogami, and K. Inoue Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP
165. 3 cells Eur J Pharmacol 409 3 2000 R3 R5
166. G.W. Kreutzberg Microglia: a sensor for pathological events in the CNS Trends Neurosci 19 8 1996 312 318
167. U. Krügel, H. Kittner, and P. Illes Adenosine 5′-triphosphate- induced dopamine release in the rat nucleus accumbens in vivo Neurosci Lett 265 1 1999 49 52
168. U. Krügel, H. Kittner, H. Franke, and P. Illes Accelerated functional recovery after neuronal injury by P2 receptor blockade Eur J Pharmacol 420 2-3 2001 R3 R4
169. U. Krügel, H. Kittner, H. Franke, and P. Illes Stimulation of P2 receptors in the ventral tegmental area enhances dopaminergic mechanisms in vivo Neuropharmacology 40 8 2001 1084 1093
170. U. Krügel, H. Kittner, and P. Illes Mechanisms of adenosine 5′-triphosphate-induced dopamine release in the rat nucleus accumbens in vivo Synapse 39 3 2001 222 232
171. U. Krügel, T. Schraft, R. Regenthal, P. Illes, and H. Kittner Purinergic modulation of extracellular glutamate levels in the nucleus accumbens in vivo Int J Dev Neurosci 22 7 2004 565 570
172. 7 receptor agonist 2′-3′-O-(4-benzoylbenzoyl)-ATP J Neurosci 24 32 2004 7128 7139
173. M.B. Kulick, and I. von Kügelgen P2Y-receptors mediating an inhibition of the evoked entry of calcium through N-type calcium channels at neuronal processes J Pharmacol Exp Ther 303 2 2002 520 526
174. S.P. Kunapuli, R.T. Dorsam, S. Kim, and T.M. Quinton Platelet purinergic receptors Curr Opin Pharmacol 3 2 2003 175 180
175. A receptors expressed by nociceptors and other postnatal sensory neurons in rat J Physiol 549 Pt 1 2003 131 142
176. G. Lambrecht Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications Naunyn-Schmiedeberg's Arch Pharmacol 362 4-5 2000 340 350
177. A. Lämmer, A. Günther, H. Kittner, H. Franke, U. Krügel, and D. Schneider In vivo effects of inhibition of P2 receptors after focal cerebral ischemia in the rat Int J Dev Neurosci 22 2004 587
178. 2+ channels Eur J Neurosci 20 11 2004 2917 2928
179. S.Y. Lee, and S.M. O'Grady Modulation of ion channel function by P2Y receptors Cell Biochem Biophys 39 1 2003 75 88
180. S.Y. Lee, S.C. Wolff, R.A. Nicholas, and S.M. O'Grady P2Y receptors modulate ion channel function through interactions involving the C-terminal domain Mol Pharmacol 63 4 2003 878 885
181. 7 receptors in ischemic and excitotoxic brain injury in vivo Cereb Blood Flow Metab 23 3 2003 381 384
182. C. Li, L. Aguayo, R.W. Peoples, and F.F. Weight Ethanol inhibits a neuronal ATP-gated ion channel Mol Pharmacol 44 4 1993 871 875
183. C. Li, K. Xiong, and F.F. Weight Ethanol inhibition of adenosine 5′-triphosphate-activated current in freshly isolated adult rat hippocampal CA1 neurons Neurosci Lett 295 3 2000 77 80
184. G.H. Li, E.M. Lee, D. Blair, C. Holding, P. Poronnik, and D.I. Cook The distribution of P2X receptor clusters on individual neurons in sympathetic ganglia and their redistribution on agonist activation J Biol Chem 275 37 2000 29107 29112
185. J.S. Liu, G.R. John, A. Sikora, S.C. Lee, and C.F. Brosnan Modulation of interleukin-1beta and tumor necrosis factor alpha signaling by P2 purinergic receptors in human fetal astrocytes J Neurosci 20 14 2000 5292 5299
186. 7 receptor subtype Br J Pharmacol 135 7 2002 1616 1626
187. K.D. Lustig, A.K. Shiau, A.J. Brake, and D. Julius Expression cloning of an ATP receptor from mouse neuroblastoma cells Proc Natl Acad Sci U S A 90 11 1993 5113 5117
188. 1 receptor activation inhibits NMDA receptor-channels in layer V pyramidal neurons of the rat prefrontal and parietal cortex Neurochem Int 42 2 2003 161 172
189. 1 receptors in platelet activation Platelets 15 3 2004 131 144
190. 1 suggests a role for nucleotide signalling in development of the chick embryo Dev Dyn 214 2 1999 152 158
191. I. Milenkovic, M. Weick, P. Wiedemann, A. Reichenbach, and A. Bringmann Neuropeptide Y-evoked proliferation of retinal glial (Muller) cells Graefe Arch Clin Exp Ophthalmol 242 11 2004 944 950
192. L. Minghetti, E. Polazzi, A. Nicolini, A. Greco, and G. Levi Possible role of microglial prostanoids and free radicals in neuroprotection and neurodegeneration Adv Exp Med Biol 468 1999 109 119
193. 7 receptors in rat brain: presence in synaptic terminals and granule cells Neurochem Res 28 10 2003 1597 1605
194. M.H.S. Mok, G.E. Knight, P.L.R. Andrews, C.H.V. Hoyle, and G. Burnstock The effects of cyclophosphamide on neurotransmission in the urinary bladder of Suncus murinus, the house musk schrew J Auton Nerv Syst 80 3 2000 130 136
195. V. Moll, M. Weick, I. Milenkovic, H. Kodal, A. Reichenbach, and A. Bringmann P2Y receptor-mediated stimulation of Müller glial DNA synthesis Investig Ophthalmol Vis Sci 43 3 2002 766 773
196. 1 purinergic receptor in the human brain: striking neuronal localisation J Comp Neurol 421 3 2000 374 384
197. 1 purinergic receptor in Alzheimers disease NeuroReport 11 17 2000 3799 3803
198. 1 purinergic receptor in neurons and glial cells of the central nervous system Brain Res Mol Brain Res 78 1-2 2000 50 58
199. 7-transfected HEK293 cells Mol Biol Cell 14 7 2003 2655 2664
200. 2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity J Neurosci 23 14 2003 6058 6062
201. K. Nakazawa ATP-activated current and its interaction with aceylcholine-activated current in rat sympathetic neurons J Neurosci 14 2 1994 740 750
202. 2+ influx through ATP-activated channels in catecholamine release from pheochromocytoma PC12 cells J Neurophysiol 68 6 1992 2026 2032
203. J.T. Neary, and Q. Zhu Signaling by ATP receptors in astrocytes NeuroReport 5 13 1994 1617 1620
204. J.T. Neary, S.R. Whittemore, Q. Zhu, and M.D. Norenberg Synergistic activation of DNA synthesis in astrocytes by fibroblast growth factors and extracellular ATP J Neurochem 63 2 1994 490 494
205. J.T. Neary, M.P. Rathbone, F. Cattabeni, M.P. Abbracchio, and G. Burnstock Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells Trends Neurosci 19 1 1996 13 18
206. J.T. Neary, Y. Kang, Y. Bu, K. Akong, and C.S. Peters Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: involvement of a calcium-independent protein kinase C, extracellular signal-regulated protein kinase pathway distinct from the phosphatidyinositol-specific phospholipase C/calcium pathway J Neurosci 19 11 1999 4211 4220
207. J.T. Neary, Y. Kang, K.A. Willoughby, and E.F. Ellis Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors J Neurosci 23 6 2003 2348 2356
208. J.T. Neary, Y. Kang, and Y.F. Shi Signaling from nucleotide receptors to protein kinase cascades in astrocytes Neurochem Res 29 11 2004 2037 2042
209. M. Nedergaard, T. Takano, and A.J. Hansen Beyond the role of glutamate as a neurotransmitter Nat Rev 3 9 2002 748 755
210. E.A. Newman Propagation of intercellular calcium waves in retinal astrocytes and Müller cells J Neurosci 21 7 2001 2215 2223
211. E.A. Newman New roles for astrocytes: regulation of synaptic transmission Trends Neurosci 26 10 2003 536 542
212. 7-like-mediated calcium entry FEBS Lett 538 1-3 2003 71 76
213. W. Nörenberg, and P. Illes Neuronal P2X receptors: localisation and functional properties Naunyn-Schmiedeberg's Arch Pharmacol 362 4-5 2000 324 339
214. R.A. North Molecular physiology of P2X receptors Physiol Rev 82 4 2002 1013 1067
215. 3 purinoceptors in sensory neurons in naive rats and following neuropathic injury Pain 80 1-2 1999 273 282
216. 7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase J Neurosci 21 18 2001 7135 7142
217. Y. Pankratov, U. Lalo, E. Castro, M.T. Miras-Portugal, and O. Krishtal ATP receptor-mediated component of the excitatory synaptic transmission in the hippocampus Prog Brain Res 120 1999 237 249
218. 7 receptors on Müller glial cells from the human retina J Neurosci 20 16 2000 5965 5972
219. T. Pannicke, M. Weick, O. Uckermann, T. Wheeler-Schilling, J.E. Fries, and M.B. Reichel Electrophysiological alterations and upregulation of ATP receptors in retinal glial Muller cells from rats infected with the Borna disease virus Glia 35 3 2001 213 223
220. K. Park, U. Vora, S.F. Darling, M.G. Kolta, and K.F. Soliman The role of inducible nitric oxide synthase in cocaine-induced locomotor sensitization Physiol Behav 74 4-5 2001 441 447
221. 7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease J Biol Chem 278 15 2003 13309 13317
222. J.W. Phillis, M.H. O'Regan, and L.M. Perkins Adenosine 5′-triphosphate release from the normoxic and hypoxic in vivo rat cerebral cortex Neurosci Lett 151 1 1993 94 96
223. J. Pintor, A. Porras, F. Mora, and M.T. Miras-Portugal Dopamine receptor blockade inhibits the amphetamine-induced release of diadenosine polyphosphates, diadenosine tetraphosphate and diadenosine pentaphosphate, from neostriatum of the conscious rat J Neurochem 64 2 1995 670 676
224. W. Poelchen, D. Sieler, K. Wirkner, and P. Illes Co-transmitter function of ATP in central catecholaminergic neurons of the rat Neuroscience 102 3 2001 493 602
225. 7 receptors in the rat retina J Comp Neurol 472 1 2004 13 23
226. V. Ralevic, and G. Burnstock Receptor for purines and pyrimidines Pharmacol Rev 50 3 1998 413 492
227. 7 receptor modulation of beta-amyloid- and LPS-induced cytokine secretion from human macrophages and microglia J Neuroimmunol 147 1-2 2004 56 61
228. E. Rapaport Treatment of human tumor cells with ADP or ATP yields arrest of growth in the S phase of the cell cycle J Cell Physiol 114 3 1983 279 283
229. M.P. Rathbone, P.J. Middlemiss, J.W. Gysbers, C. Andrew, M.A. Herman, and J.K. Reed Trophic effects of purines in neurons and glial cells Prog Neurobiol 59 6 1999 663 690
230. 2+- and nitric oxide-dependent stimulation of cyclic GMP synthesis in neuronal cell line induced by P2-purinergic/ pyrimidinergic receptor J Neurochem 64 1 1995 61 68
231. J.A. Ribeiro, A.M. Sebastiao, and A. de Mendonca Participation of adenosine receptors in neuroprotection Drug News Perspect 16 2 2003 80 86
232. S.J. Robertson, S.J. Ennion, R.J. Evans, and F.A. Edwards Synaptic P2X receptors Curr Opin Neurobiol 11 3 2001 378 386
233. S.C. Robson, E. Kaczmarek, J.B. Siegel, D. Candinas, K. Koziak, and M. Millan Loss of ATP diphosphohydrolase activity with endothelial cell activation J Exp Med 185 1 1997 153 163
234. F.M. Ross, M.J. Brodie, and T.W. Stone Modulation by adenine nucleotides of epileptiform activity in the CA3 region of rat hippocampal slices Br J Pharmacol 123 1 1998 71 80
235. J.K. Ryu, J. Kim, S.H. Choi, Y.J. Oh, Y.B. Lee, and S.U. Kim ATP-induced in vivo neurotoxicity in the rat striatum via P2 receptors NeuroReport 13 13 2002 1611 1615
236. 2 are involved in calcium signalling in glioma C6 cells Br J Pharmacol 132 2 2001 393 402
237. G. Sanches, L.S. de Alencar, and A.L. Ventura ATP induces proliferation of retinal cells in culture via activation of PKC and extracellular signal-regulated kinase cascade Int J Dev Neurosci 20 1 2002 21 27
238. J.M. Sanz, and F. Di Virgilio Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells J Immunol 164 9 2000 4893 4898
239. 12 in microglia in rat brain Glia 44 3 2003 242 250
240. 1 immunofluorescence in rat neostriatal medium-spiny projection neurones and cholinergic interneurones is not linked to respective purinergic receptor function Br J Pharmacol 143 1 2004 119 131
241. 7 receptors Am J Physiol 275 6 Pt 2 1998 F962 F971
242. E.M. Schwiebert ABC transporter-facilitated ATP conductive transport Am J Physiol 276 1 Pt 1 1999 C1 C8
243. 2+ waves are propagated via ATP release and purinergic receptor activation" Am J Physiol Cell Physiol 279 2 2000 C281 C283
244. T.J. Searl, R.S. Redman, and E.M. Silinsky Mutual occlusion of P2X ATP receptors and nicotinic receptors on sympathetic neurons of the guinea-pig J Physiol 510 Pt 3 1998 783 791
245. 1 receptor stimulate mitogen-activated protein kinases and induce apoptosis J Biol Chem 276 19 2001 16379 16390
246. Y. Shigemoto-Mogami, S. Koizumi, M. Tsuda, K. Ohsawa, S. Kohsaka, and K. Inoue Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5 J Neurochem 78 6 2001 1339 1349
247. 1 receptors Glia 49 2 2005 288 300
248. 7 receptor expression in rodent brain J Neurosci 24 28 2004 6307 6314
249. G. Skladchikova, L.C. Ronn, V. Berezin, and E. Bock Extracellular adenosine triphosphate affects neural cell adhesion molecule (NCAM)-mediated cell adhesion and neurite outgrowth J Neurosci Res 57 2 1999 207 218
250. A and cationic P2X ionotropic receptors of rat dorsal root ganglion neurons J Neurosci 21 14 2001 4958 4968
251. 2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C J Biol Chem 273 5 1998 2653 2660
252. 2-adrenoceptors Neuroscience 82 2 1998 511 520
253. 7 receptors in the regulation of neurotransmitter release in the rat hippocampus J Neurochem 81 6 2002 1196 1211
254. 2 subunit of purinergic receptors, PSA-NCAM, and GAP-43 immunoreactivities: light and electron microscopic study J Comp Neurol 457 2 2003 159 174
255. 7-induced pore formation and apoptosis: an early effect of diabetes on the retinal microvasculature Investig Ophthalmol Vis Sci 45 3 2004 1026 1032
256. 7 J Neurochem 73 1 1999 334 343
257. 7) Science 272 5262 1996 735 738
258. S.P. Sutherland, S.P. Cook, and E.W. McCleskey Chemical mediators of pain due to tissue damage and ischemia Prog Brain Res 129 2000 21 38
259. 7 receptor-activated microglia J Neurosci 24 1 2004 1 7
260. 2 purinoreceptors in PC12 cells. Difference in purinoreceptor sensitivity in two PC12 cell lines J Biol Chem 273 32 1998 19965 19971
261. A. Szallasi, and P.M. Blumberg Vanilloid (capsaicin) receptors and mechanisms Pharmacol Rev 51 2 1999 159 212
262. M. Tominaga, M. Wada, and M. Maus Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia Proc Natl Acad Sci U S A 98 12 2001 6951 6956
263. 3 receptor-dependent sensory functions in A/J inbred mouse strain Eur J Neurosci 15 9 2002 1444 1450
264. 7 purinoceptor J Biol Chem 280 4 2005 2653 2658
265. 3 mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia Pain 91 3 2001 351 360
266. 2 receptor-mediated proliferation of C6 glioma cells via activation of Ras/Raf/MEK/MAPK pathway Br J Pharmacol 129 7 2000 1481 1489
267. 2 receptors induced by novel adenosine 5′-O-(1-boranotriphosphate) derivatives Br J Pharmacol 142 5 2004 869 878
268. E.P. Vianna, A.T. Ferreira, M.G. Naffah-Mazzacoratti, E.R. Sanabria, M. Funke, and E.A. Cavalheiro Evidence that ATP participates in the pathophysiology of pilocarpine-induced temporal lobe epilepsy: fluorimetric, immunohistochemical, and Western blot studies Epilepsia 43 Suppl. 5 2002 227 229
269. C. Virginio, A. MacKenzie, F.A. Rassendren, R.A. North, and A. Surprenant Pore dilation of neuronal P2X receptor channels Nat Neurosci 2 4 1999 315 321
270. M.T. Viscomi, F. Florenzano, D. Conversi, G. Bernardi, and M. Molinari Axotomy dependent purinergic and nitrergic co-expression Neuroscience 123 2 2004 393 404
271. C. Volonté, and D. Merlo Selected P2 purinoceptor modulators prevent glutamate-evoked cytotoxicity in cultured cerebellar granule neurons J Neurosci Res 45 2 1996 183 193
272. C. Volonté, M.T. Ciotti, N. D'Ambrosi, B. Lockhart, and M. Spedding Neuroprotective effects of modulators of P2 receptors in primary culture of CNS neurones Neuropharmacology 38 9 1999 1335 1342
273. C. Volonté, S. Amadio, F. Cavaliere, N. D'Ambrosi, F. Vacca, and G. Bernardi Extracellular ATP and neurodegeneration Curr Drug Targets CNS Neurol Disord 2 6 2003 403 412
274. I. von Kügelgen, and A. Wetter Molecular pharmacology of P2Y-receptors Naunyn-Schmiedeberg's Arch Pharmacol 362 4-5 2000 310 323
275. 3-dependent mechanism Glia 37 1 2002 8 18
276. 7 purinoceptor-stimulated TGF-beta 1 mRNA expression involves PKC/MAPK signalling pathway in a rat brain-derived type-2 astrocyte cell line, RBA-2 Cell Signal 15 12 2003 1129 1137
277. 7 receptor inhibition improves recovery after spinal cord injury Nat Med 10 8 2004 821 827
278. T.E. Webb, J. Simon, B.J. Krishek, A.N. Bateson, T.G. Smart, and B.F. King Cloning and functional expression of a brain G-protein-coupled ATP receptor FEBS Lett 324 2 1993 219 225
279. 1 messenger RNA within the chick brain Neuroscience 84 3 1998 825 837
280. F.F. Weight, C. Li, and R.W. Peoples Alcohol action on membrane ion channels gated by extracellular ATP (P2X receptors) Neurochem Int 35 2 1999 143 152
281. G.A. Weisman, J.T. Turner, and J.S. Fedan Structure and function of P2 purinoceptors J Pharmacol Exp Ther 277 1 1996 1 9
282. A.M. White, D.B. Matthews, and P.J. Best Ethanol, memory, and hippocampal function: a review of recent findings Hippocampus 10 1 2000 88 93
283. 7 receptor J Biol Chem 278 19 2003 17108 17113
284. M. Williams Developments in P2 receptor targeted therapeutics Prog Brain Res 120 1999 93 106
285. 7 receptor C terminus J Biol Chem 277 37 2002 34017 34023
286. 4 receptors expressed in Xenopus oocytes Br J Pharmacol 130 6 2000 1394 1398
287. G.-Y. Xu, and L.-Y. Huang Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neurons J Neurosci 22 1 2002 93 102
288. Z.-C. Ye, M.S. Wyeth, S. Baltan-Tekkok, and B.R. Ransom Functional hemichannels in astrocytes: a novel mechanism of glutamate release J Neurosci 23 9 2003 3588 3596
289. K. Yoshioka, O. Saitoh, and H. Nakata Heteromeric association creates a P2Y-like adenosine receptor Proc Natl Acad Sci U S A 98 13 2001 7617 7622
290. Y.X. Zhang, H. Yamashita, T. Ohshita, N. Sawamoto, and S. Nakamura ATP increases extracellular dopamine level through stimulation of P2Y purinoceptors in the rat striatum Brain Res 691 1-2 1995 205 212
291. 2 receptors in freshly isolated astrocytes from rat hippocampus J Neurochem 77 2 2001 530 541
292. Y. Zhu, and H.K. Kimelberg Cellular expression of P2Y and beta-AR receptor mRNAs and proteins in freshly isolated astrocytes and tissue sections from the CA1 region of P8-12 rat hippocampus Brain Res Dev Brain Res 148 1 2004 77 87
293. H. Zimmermann Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system Prog Neurobiol 49 6 1996 589 618
294. H. Zimmermann Extracellular metabolism of ATP and other nucleotides Naunyn-Schmiedeberg's Arch Pharmacol 362 4-5 2000 299 309
295. H. Zimmermann, and N. Braun Ecto-nucleotidases - molecular structures, catalytic properties, and functional roles in the nervous system Prog Brain Res 120 1999 371 385