Ethanol sensitivity in ATP-gated P2X receptors is subunit dependent

Alcoholism: Clinical and Experimental Research

Volumn 26, Issue 6, 2002, Pages 773-778

  Davies, Daryl L ^a   Machu, Tina K ^b   Guo, Yumei ^a   Alkana, Ronald L ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine 5 Triphosphate; Ligand Gated Ion Channels; P2X Receptors; Xenopus Oocytes

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALCOHOL; CATION CHANNEL; PURINE P2X RECEPTOR; RECEPTOR SUBUNIT; PROTEIN SUBUNIT; PURINE P2 RECEPTOR; PURINE P2X2 RECEPTOR; PURINE P2X4 RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; VOLTAGE CLAMP; XENOPUS; ANIMAL; CHANNEL GATING; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; PHYSIOLOGY; RAT; XENOPUS LAEVIS;

ADENOSINE TRIPHOSPHATE; ANIMAL; COMPARATIVE STUDY; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; ION CHANNEL GATING; PROTEIN SUBUNITS; RATS; RECEPTORS, PURINERGIC P2; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; XENOPUS LAEVIS; ANIMALS;

ANIMALIA;

EID: 0035998895     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000374-200206000-00005     Document Type: Article

References (36)

1. Ligand-gated ion channels in the brain: The amino acid receptor superfamily
2. Effects of ethanol on recombinant human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes
3. P2X receptors and nociception
4. A receptor function and intoxication from hyperbaric studies in C57, LS and SS mice
5. Mechanism of action of ethanol: Initial central nervous system actions
6. The role of positively charged amino acids in ATP recognition by human P2X(1) receptors
7. The first transmembrane domain of the P2X receptor subunit participates in the agonist-induced gating of the channel
8. Ethanol actions on multiple ion channels: Which are important?
9. Actions of anesthetics on ligand-gated ion channels: Role of receptor subunit composition
10. Amino acid residues involved in gating identified in the first membrane-spanning domain of the rat P2X(2) receptor
11. Identification of amino acid residues contributing to the ATP-binding site of a purinergic P2X receptor
12. Molecular physiology of P2X receptors and ATP signalling at synapses
13. Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds
14. International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits
15. Allosteric control of gating and kinetics at P2X4 receptor channels
16. State-dependent cross-inhibition between transmitter-gated cation channels
17. 3 cells
18. A, glycine and GABA r1 receptors
19. Propofol and other intravenous anesthetics have sites of action on the g-aminobutyric acid type A receptor distinct from that for isoflurane
20. Ethanol inhibits a neuronal ATP-gated ion channel
21. Alcohol action on a neuronal membrane receptor: Evidence for a direct interaction with the receptor protein
22. Ethanol-induced inhibition of a neuronal P2X purinoceptor by an allosteric mechanism
23. 2 receptor subunits in varying amounts generates heterogeneous populations of P2X receptors that evoke a spectrum 9f agonist responses comparable to that seen in sensory neurons
24. A and glycine receptors
25. The excitatory amino acid receptors: Their classes, pharmacology, and distinct properties in the function of the central nervous system
26. Pharmacology of cloned P2X receptors
27. Distinct localization of P2X receptors at excitatory postsynaptic specializations
28. Glutamate receptor channels: Novel properties and new clones
29. Different sensitivities to pH of ATP-induced currents at four cloned P2X receptors
30. 2 receptor: Estimates based on methanethiosulfonate block at T336C
31. 3A and α2 glycine receptors expressed in Xenopus oocytes
32. 4 receptors expressed in Xenopus oocytes
33. 4 receptor function
34. Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position a267
35. 3 receptors by alcohols and diethyl ether in NCB-20 neuroblasloma cells