Mechanisms of P2X7 receptor-mediated ERK1/2 phosphorylation in human astrocytoma cells

American Journal of Physiology - Cell Physiology

Volumn 284, Issue 2 53-2, 2003, Pages

  Gendron, Fernand Pierre ^a   Neary, Joseph T ^b   Theiss, Patty M ^a   Sun, Grace Y ^a   Gonzalez, Fernando A ^c   Weisman, Gary A ^a  

^a University of Missouri   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

Astrocytes; Ligand gated ion channels; Mitogen activated protein kinases; P2 nucleotide receptors; Protein kinase C

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 MORPHOLINO 8 PHENYLCHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 2',3' O (4 BENZOYL)BENZOYL ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FOCAL ADHESION KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; NUCLEOTIDE; PENICILLIN G; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN C SRC; PROTEIN KINASE C DELTA; PROTEIN TYROSINE KINASE; PURINE P2 RECEPTOR; PURINE P2X RECEPTOR; PURINE P2X7 RECEPTOR; PURINE P2X7 RECEPTOR AGONIST; PURINE P2X7 RECEPTOR ANTAGONIST; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; STREPTOMYCIN; UNCLASSIFIED DRUG; CALCIUM; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE C;

ARTICLE; ASTROCYTE; ASTROCYTOMA; BRAIN FUNCTION; CALCIUM CELL LEVEL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GLIOSIS; HUMAN; HUMAN CELL; INFLAMMATION; ION TRANSPORT; LIGAND BINDING; NERVE DEGENERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURINE SYNTHESIS; RECEPTOR BINDING; SIGNAL TRANSDUCTION; BRAIN; BRAIN TUMOR; CELL CULTURE; CELL MEMBRANE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; PHOSPHORYLATION;

ASTROCYTES; ASTROCYTOMA; BRAIN; BRAIN NEOPLASMS; CALCIUM; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLIOSIS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN KINASE C; RECEPTORS, PURINERGIC P2; TUMOR CELLS, CULTURED;

EID: 0037302197     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00286.2002     Document Type: Article

References (58)

1. 7) receptors regulate intracellular calcium and purine release. Neuroreport 7: 2533-2537, 1996.
2. Berk BC and Corson MA. Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases. Circ Res 80: 607-616, 1997.
3. Blaukat A, Ivankovic-Dikic I, Gronroos E, Dolfi F, Tokiwa G, Vuori K, and Dikic I. Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades. J Biol Chem 274: 14893-14901, 1999.
4. Brambilla R and Abbracchio MP. Modulation of cyclooxygenase-2 and brain reactive astrogliosis by purinergic P2 receptors. Ann NY Acad Sci 939: 54-62, 2001.
5. Ciccarelli R, Ballerini P, Sabatino G, Rathbone MP, D'Onofrio M, Caciagli F, and Di Iorio P. Involvement of astrocytes in purine-mediated reparative processes in the brain. Int J Dev Neurosci 19: 395-414, 2001.
6. 7 receptors are targeted to presynaptic terminals in the central and peripheral nervous system. J Neurosci 21: 7143-7152, 2001.
7. Di Virgilio F. The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death. Immunol Today 16: 524-528, 1995.
8. Dikic I, Tokiwa G, Lev S, Courtneidge SA, and Schlessinger J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383: 547-550, 1996.
9. Dubyak GR and El-Moatassim C. Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides. Am J Physiol Cell Physiol 265: C577-C606, 1993.
10. α-mediated signal transduction. J Cell Biol 153: 491-501, 2001.
11. Erb L, Lustig KD, Ahmed AH, Gonzalez FA, and Weisman GA. Covalent incorporation of 3′-O-(4-benzoyl)benzoyl-ATP into a P2 purinoceptor in transformed mouse fibroblasts. J Biol Chem 265: 7424-7431, 1990.
12. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, and Trzaskos JM. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-18632, 1998.
13. 4- receptor. J Pharmacol Exp Ther 255: 46-51, 1990.
14. Franke H, Krugel U, and Illes P. P2 receptor-mediated proliferative effects on astrocytes in vivo. Glia 28: 190-200, 1999.
15. 2 nucleotide receptor. Consequences of truncation of the C terminus. J Biol Chem 273: 29437-29444, 1998.
16. Gonzalez FA, Ahmed AH, Lustig KD, Erb L, and Weisman GA. Permeabilization of transformed mouse fibroblasts by 3′-O-(4-benzoyl)benzoyl adenosine 5′-triphosphate and the desensitization of the process. J Cell Physiol 139: 109-115, 1989.
17. Guillemain I and Rossignol B. Receptor- and phorbol estermediated phospholipase D activation in rat parotid involves two different pathways. Am J Physiol Cell Physiol 266: C692-C699, 1994.
18. Guthrie PB, Knappenberger J, Segal M, Bennett MV, Charles AC, and Kater SB. ATP released from astrocytes mediates glial calcium waves. J Neurosci 19: 520-528, 1999.
19. Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, Weringer EJ, Pollok BA, and Connelly PA. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem 271: 695-701, 1996.
20. 7 nucleotide receptor and associated phospholipase D activity by lipopolysaccharide and IFN-γ in the human THP-1 monocytic cell line. J Immunol 157: 5627-5637, 1996.
21. 7 nucleotide receptor. J Biol Chem 275: 26792-26798, 2000.
22. ras in endothelial cells exposed to cyclic strain. Biochem Biophys Res Commun 257: 668-671, 1999.
23. Jimenez AI, Castro E, Communi D, Boeynaems JM, Delicado EG, and Miras-Portugal MT. Coexpression of several types of metabotropic nucleotide receptors in single cerebellar astrocytes. J Neurochem 75: 2071-2079, 2000.
24. John GR, Simpson JE, Woodroofe MN, Lee SC, and Brosnan CF. Extracellular nucleotides differentially regulate interleukin-1 beta signaling in primary human astrocytes: implications for inflammatory gene expression. J Neurosci 21: 4134-4142, 2001.
25. 7 receptor signalling complex. EMBO J 20: 6347-6358, 2001.
26. King BF, Burnstock G, Boyer JL, Boeynaems JM, Weisman GA, Kennedy C, Jacobson KA, Humphries RG, Abbracchio MP, Gachet C, and Miras-Portugal MT. P2Y receptors. In: The IUPHAR Compendium of Receptor Characterization and Classification (2nd ed.). London: IUPHAR Media Publications, 2001, p. 306-320.
27. King BF, Neary JT, Zhu Q, Wang S, Norenberg MD, and Burnstock G. P2 purinoceptors in rat cortical astrocytes: expression, calcium-imaging and signalling studies. Neuroscience 74: 1187-1196, 1996.
28. 2+/Pyk2/JNK signal cascades in rat aortic smooth muscle cells. J Biochem (Tokyo) 130: 351-358, 2001.
29. Kukley M, Barden JA, Steinhauser C, and Jabs R. Distribution of P2X receptors on astrocytes in juvenile rat hippocampus. Glia 36: 11-21, 2001.
30. Lenz G, Gottfried C, Luo ZJ, Avruch J, Rodnight R, Nie WJ, Kang Y, and Neary JT. P2Y purinoceptor subtypes recruit different MEK activators in astrocytes. Br J Pharmacol 129: 927-936, 2000.
31. 2+-induced regulation of ion channel and MAP kinase functions. Nature 376: 737-745, 1995.
32. Liu JSH, John GR, Sikora A, Lee SC, and Brosnan CF. Modulation of interleukin-1 beta and tumor necrosis factor alpha signaling by P2 purinergic receptors in human fetal astrocytes. J Neurosci 20: 5292-5299, 2000.
33. Lustig KD, Erb L, Landis DM, Hicks-Taylor CS, Zhang X, Sportiello MG, and Weisman GA. Mechanisms by which extracellular ATP and UTP stimulate the release of prostacyclin from bovine pulmonary artery endothelial cells. Biochim Biophys Acta 1134: 61-72, 1992.
34. Marshall CJ. Specificity of receptor tyrosine kinase signalingtransient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185, 1995.
35. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marme D, and Schachtele C. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 268: 9194-9197, 1993.
36. 2-terminal kinase. J Biol Chem 275: 26856-26863, 2000.
37. Nakazawa K, Fujimori K, Takanaka A, and Inoue K. An ATP-activated conductance in pheochromocytoma cells and its suppression by extracellular calcium. J Physiol 428: 257-272, 1990.
38. Neary JT. MAPK cascades in cell growth and death. News Physiol Sci 12: 286-293, 1997.
39. Neary JT, Kang Y, Bu YR, Yu E, Akong K, and Peters CM. Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: Involvement of a calcium-independent protein kinase C, extracellular signal-regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C calcium pathway. J Neurosci 19: 4211-4220, 1999.
40. Neary JT and Zhu Q. Signaling by ATP receptors in astrocytes. Neuroreport 5: 1617-1620, 1994.
41. North RA and Barnard EA. Nucleotide receptors. Curr Opin Neurobiol 7: 346-357, 1997.
42. North RA and Surprenant A. Pharmacology of cloned P2X receptors. Annu Rev Pharmacol Toxicol 40: 563-580, 2000.
43. 7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. J Neurosci 21: 7135-7142, 2001.
44. Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, and Turner JT. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proc Natl Acad Sci USA 91: 3275-3279, 1994.
45. Queiroz G, Gebicke-Haerter PJ, Schobert A, Starke K, and von Kugelgen I. Release of ATP from cultured rat astrocytes elicited by glutamate receptor activation. J Neurosci 78: 1203-1208, 1997.
46. 7. Cloning and expression of a human cDNA. J Biol Chem 272: 5482-5486, 1997.
47. Rathbone MP, Middlemiss PJ, Gysbers JW, Andrew C, Herman MAR, Reed JK, Ciccarelli R, Di Iorio P, and Caciagli F. Trophic effects of purines in neurons and glial cells. Prog Neurobiol 59: 663-690, 1999.
48. Ridet JL, Malhotra SK, Privat A, and Gage FH. Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci 20: 570-577, 1997.
49. Rocic P, Govindarajan G, Sabri A, and Lucchesi PA. A role for PYK2 in regulation of ERK1/2 MAP kinases and PI 3-kinase by ANG II in vascular smooth muscle. Am J Physiol Cell Physiol 280: C90-C99, 2001.
50. Sabri A, Govindarajan G, Griffin TM, Byron KL, Samarel AM, and Lucchesi PA. Calcium- and protein kinase C-dependent activation of the tyrosine kinase PYK2 by angiotensin II in vascular smooth muscle. Circ Res 83: 841-851, 1998.
51. 2 nucleotide receptor signaling in human monocytic cells: activation, desensitization, and coupling to mitogen-activated protein kinases. J Cell Physiol 187: 196-208, 2001.
52. Sela D, Ram E, and Atlas D. ATP receptor. A putative receptor-operated channel in PC-12 cells. J Biol Chem 266: 17990-17994, 1991.
53. 7). Science 272: 735-738, 1996.
54. 2 purinoreceptors in PC12 cells. Difference in purinoreceptor sensitivity in two PC12 cell lines. J Biol Chem 273: 19965-19971, 1998.
55. 7 receptor. J Physiol 519: 335-346, 1999.
56. Vlahos CJ, Matter WF, Hui KY, and Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269: 5241-5248, 1994.
57. Weisman GA, Dé BK, Friedberg I, Pritchard RS, and Heppel LA. Cellular responses to external ATP which precede an increase in nucleotide permeability in transformed cells. J Cell Physiol 119: 211-219, 1984.
58. Weisman GA, Gonzalez FA, Erb L, Garrad RC, and Turner JT. The cloning and expression of G protein-coupled P2Y nucleotide receptors. In: P2 Nucleotide Receptors, edited by Turner JT, Weisman GA, and Fedan JS. Totowa, NJ: Humana, chapt. 3, 1998, p. 63-79.