Cerebrospinal fluid-contacting neurons in the rat spinal cord, a γ-aminobutyric acidergic system expressing the P2X2 subunit of purinergic receptors, PSA-NCAM, and GAP-43 immunoreactivities: Light and electron microscopic study

Journal of Comparative Neurology

Volumn 457, Issue 2, 2003, Pages 159-174

  Stoeckel, Marie Elisabeth ^a,c   Uhl Bronner, Sandra ^a   Hugel, Sylvain ^a   Veinante, Pierre ^a   Klein, Marie Jeanne ^a   Mutterer, Jerome ^b   Freund Mercier, Marie José ^a   Schlichter, Rémy ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b INST DE BIOL MOLEC DES PLANTES   (France)

^c UMR 7519   (France)

Author keywords

GAD; GAP 43; PSA NCAM; Thoracolumbar spinal cord; Unmyelinated axons; Ventral median fissure

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOSINE TRIPHOSPHATE; GLUTAMATE DECARBOXYLASE; NERVE CELL ADHESION MOLECULE; NEUROMODULIN; PURINE P2X RECEPTOR; PURINE RECEPTOR; RECEPTOR SUBUNIT; SYNAPTOPHYSIN; SYNAPTOTAGMIN;

ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; ELECTRON MICROSCOPY; FEMALE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROSCOPY; NERVE CELL; NONHUMAN; NONMYELINATED NERVE; PLASTICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THORACOLUMBAR SPINE;

ANIMALS; FEMALE; GAMMA-AMINOBUTYRIC ACID; GAP-43 PROTEIN; IMMUNOENZYME TECHNIQUES; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, IMMUNOELECTRON; NEURAL CELL ADHESION MOLECULE L1; NEURONS; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; SIALIC ACIDS; SPINAL CORD;

EID: 0037416779     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.10565     Document Type: Article

References (46)

1. Alonso G. 1999. Neuronal progenitor-like cells expressing polysialylated neural cell adhesion molecule are present on the ventricular surface of the adult brain and spinal cord. J Comp Neurol 414:149-166.
2. Alonso G, Prieto M, Legrand A, Chauvet N. 1997. PSA-NCAM and B-50/ GAP-43 are coexpressed by specific neuronal systems of the adult rat mediobasal hypothalamus that exhibit remarkable capacities for morphological plasticity. J Comp Neurol 384:181-199.
3. Anadon A, Adrio F, Rodriguez-Moldes I. 1998. Distribution of GABA immunoreactivity in the central and peripheral nervous system of Amphioxus (Branchiostoma lanceolatum Pallas). J Comp Neurol 401:293-307.
4. Anderson MJ, Waxman SG. 1985. Neurogenesis in adult vertebrate spinal cord in situ and in vitro: a new model system. Ann N Y Acad Sci 457:213-233.
5. 2 receptor immunoreactivity in the dorsal vagal complex and area postrema of the rat. Neuroscience 99:683-696.
6. Barber RP, Vaughn JE, Roberts E. 1982. The cytoarchitecture of GABAergic neurons in rat spinal cord. Brain Res 238:305-328.
7. Barden JA, Bennett MR. 2000. Distribution of P2X purinoceptor clusters on individual rat dorsal root ganglion cells. Neurosci Lett 287:183-186.
8. Benowitz LI, RouttenbergA. 1987. A membrane phosphoprotein associated with neural development, axonal regeneration phospholipid metabolism and synaptid plasticity. TINS 10:527-532.
9. Benowitz LI, Routtenberg A. 1997. GAP-43: an intrinsic determinant of neuronal development and plasciticity. Trends Neurosci 20:84-91.
10. Binor E, Heathcote RD. 2001. Development of GABA-immunoreactive neuron patterning in the spinal cord. J Comp Neurol 438:1-11.
11. Bonfanti L, Theodosis DT. 1994. Expression of polysialylated neural cell adhesion molecule by proliferating cells in the subependymal layer of the adult rat, in its rostral extension and in the olfactory bulb. Neuroscience 62:291-305.
12. Burnstock G. 2000. P2X receptors in sensory neurones. Br J Anaesth 84:476-488.
13. Curtis R, Averill S, Priestley JV, Wilkin GP. 1993. The distribution of GAP-43 in normal rat spinal cord. J Neurocytol 22:39-50.
14. Dale N, Roberts A, Ottersen OP, Storm-Mathiesen J. 1987. The morphology and distribution of "Kolmer-Aghdur cells," a class of cerebrospinal-fluid-contacting neurons revealed in the frog embryo spinal cord by GABA immunocytochemistry. Proc R Soc Lond B Biol Sci 232:193-203.
15. Dunn PM, Zhong Y, Burnstock G. 2001. P2X receptors in peripheral neurons. Prog Neurobiol 65:107-134.
16. Fitzgerald M, Reynolds ML, Benowitz LI. 1991. GAP-43 expression in the developing rat lumbar spinal cord. Neuroscience 41:187-199.
17. Gomez-Villafuertes R, Gualix J, Miras-Portugal MT. 2001. Single GABAergic synaptic terminals from rat midbrain exhibit functional P2X and dinucleotide receptors, able to induce GABA secretion. J Neurochem 77:84-93.
18. Heathcote RD, Chen A. 1994. Morphogenesis of catecholaminergic interneurons in the frog spinal cord. J Comp Neurol 342:57-68.
19. Horner PJ, Power AE, Kempermann G, Kuhn HG, Palmer TD, Winkler J, Thal LJ, Gage F. 2000. Proliferation and differentiation of progenitor cells through the intact adult rat spinal cord. J Neurosci 20:2218-2228.
20. Hugel S, Schlichter R. 2000. Presynaptic P2X receptors facilitate inhibitory GABAergic transmission between cultured rat spinal cord dorsal horn neurons. J Neurosci 20:2121-2130.
21. Johansson CB, Momma S, Clarke DL, Risling M, Lendahl U, Frisen J. 1999. Identification of neural stem cell in the adult mammalian central nervous system. Cell 96:25-34.
22. 2 receptor subunit of the ATP-gated ion channels in the rat central nervous system. J Comp Neurol 407:11-32.
23. Khakh BS, Burnstock G, Kennedy C, King BF, North RA, Seguela P, Voigt M, Humphrey PP. 2001a. International Union of Pharmacology XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol Rev 53:107-118.
24. 2-green fluorescent protein receptors. Proc Natl Acad Sci USA 98:5288-5293.
25. LaMotte CC. 1987. Vasoactive intestinal polypeptide cerebrospinal fluid-contacting neurons of the monkey and cat spinal central canal. J Comp Neurol 258:527-541.
26. Leonhardt H. 1980. Ependym und circumventriculäre Organe. In: Oksche A, Vollrath L, editors. Handbuch der mikroskopischen Anatomie des Menschen. Bd 4/10. Berlin: Springer. p 177-666.
27. B receptors in the rat central nervous system. J Comp Neurol 405:299-321.
28. North RA, Surprenant A. 2000. Pharmacology of cloned P2X receptors. Annu Rev Pharmacol Toxicol 40:563-580.
29. 2 and P2X3 receptor subunits in rat primary afferents: relation to population markers and specific cell types. J Chem Neuroanat 20:141-162.
30. Ralevic V, Burnstock G. 1998. Receptors for purines and pyrimidines. Pharmacol Rev 50:413-492.
31. René F, Poisbeau P, Egles C, Schlichter R, Felix JM. 1997. Coculture of hypothalamic neurons and melanotrope cells: a model to study synaptogenesis between central neurons and endocrine cells. Neuroscience 76:203-214.
32. Roberts BL, Maslam S, Scholten G, Smit W. 1995. Dopaminergic and GABAergic cerebrospinal fluid-contacting neurons along the central canal of the spinal cord of the eel and trout. J Comp Neurol 354:423-437.
33. Rousselot P, Lois C, Alvarez-Buylla A. 1995. Embryonic (PSA) N-CAM reveals chains of migrating neuroblasts between the lateral ventricle and the olfactory bulb of adult mice. J Comp Neurol 351:51-61.
34. Rutishauser U, Landmesser L. 1996. Polysialic acid in the vertebrate nervous system: a promoter of plasticity in cell-cell interactions. Trends Neurosci 19:422-427.
35. Schimchowitsch S, Vuillez P, Tappaz M, Klein MJ, Stoeckel ME. 1991. Systematic presence of GABA-immunoreactivity in the tubero-infundibular and tubero-hypophyseal dopaminergic axonal systems: an ultrastructural immunogold study on several mammals. Exp Brain Res 83:575-586.
36. Seki T, Arai Y. 1993a. Highly polysialylated NCAM expression in the developing and adult rat spinal cord. Brain Res Dev Brain Res 73:141-145.
37. Seki T, Arai Y. 1993b. The persistent expression of a highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system. Neurosci Res 17:265-290.
38. Shimosegawa T, Koizumi M, Toyota T, Goto Y, Yanaihara C, Yanaihara N. 1986. An immunohistochemical study of methionine-enkephalin-Arg6-Gly7-Leu8-like immunoreactivity-containing liquor-contacting neurones (LCNs) in the rat spinal cord. Brain Res 379:1-9.
39. Theodosis D, Bonhomme R, Vitiello S, Rougon G, Poulain DA. 1999. Cell surface expression of polysialic acid on NCAM is a prerequisite for activity-dependent morphological neuronal and glial plasticity. J Neurosci 19:10228-10236.
40. Vigh B, Vigh-Teichmann I. 1998. Actual problems of the cerebrospinal fluid-contacting neurons. Microsc Res Tech 41:57-83.
41. Vigh B, Vigh-Teichmann I, Aros B. 1977. Special dendritic and axonal endings formed by cerebrospinal fluid contacting neurons of the spinal cord. Cell Tissue Res 183:541-552.
42. Vigh-Teichmann I, Vigh B, 1983. The system of cerebrospinal-fluid-contacting neurons. Arch Histol Jpn 46:427-468.
43. 2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals. Neuropharmacology 36:1229-1242.
44. Weiss S, Dunne C, Hewson J, Wohl C, Wheatley M, Peterson AC, Reynolds BA. 1996. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J Neurosci 16:7599-7609.
45. Woerly S, Doan VD, Sosa N, de Vellis J, Espinosa A. 2001. Reconstruction of the transected cat spinal cord following Neurogel implantation: axonal tracing immunohistochemical and ultrastructural studies. Int J Dev Neurosci 19:63-83.
46. Yamamoto S-I, Yamamoto N, Kitamura T, Nakamura K, Nakafuku M. 2001. Proliferation of parenchymal neural progenitors in response to injury in the adult rat spinal cord. Exp Neurol 172:115-127.