Loss of ATP diphosphohydrolase activity with endothelial cell activation

Journal of Experimental Medicine

Volumn 185, Issue 1, 1997, Pages 153-163

  Robson, Simon C ^a,b   Kaczmarek, Elzbieta ^a   Siegel, Jonathan B ^a   Candinas, Daniel ^a   Koziak, Katarzyna ^a   Millan, Maria ^a   Hancock, Wayne W ^a   Bach, Fritz H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; APYRASE;

ANIMAL CELL; ARTICLE; BLOOD FLOW; COMPLEMENT ACTIVATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; GRAFT REJECTION; HEMOSTASIS; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOSIS; VASCULAR ENDOTHELIUM;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; AORTA; APYRASE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; HYDROGEN PEROXIDE; INFLAMMATION; KINETICS; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PLATELET AGGREGATION; REPERFUSION INJURY; SWINE; THIONUCLEOTIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031016802     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.1.153     Document Type: Article

References (47)

1. Preissner, K.T. 1988. Anticoagulant potential of endothelial cell membrane components. Haemostasis. 18:271-306.
2. Ihrcke, N.S., L.E. Wrenshall, B.J. Lindman, and J.L. Platt. 1993. Role of heparan sulfate in immune system-blood vessel interactions. Immunol. Today. 14:500-505.
3. Esmon, C.T. 1992. Protein-S and protein-C-biochemistry, physiology, and clinical manifestation of deficiencies. Trends Cardiovasc. Med. 2:214-219.
4. Nawroth, P.P., D.A. Handley, C.T. Esmon, and D.M. Stern. 1986. Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity. Proc. Natl. Acad. Sci. USA. 83:3460-3464.
5. Saadi, S., R.A. Holzknecht, C.P. Patte, D.M. Stern, and J.L. Platt. 1995. Complement mediated regulation of tissue factor activity in endothelium. J. Exp. Med. 182:1807-1814.
6. Pober, J.S., and R.S. Cotran. 1990. The role of endothelial cells in inflammation. Transplantation (Baltimore). 50:537-544.
7. Cotran, R.S., and J.S. Pober. 1989. Effects of cytokines on vascular endothelium: their role in vascular and immune injury. Kidney Int. 35:969-975.
8. Esmon, C.T. 1993. Cell mediated events that control blood coagulation and vascular injury. Annu. Rev. Cell Biol. 9:1-26.
9. Platt, J.L., G.M. Vercellotti, B.J. Lindman, T.J. Oegema, F.H. Bach, and A.P. Dalmasso. 1990. Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection. J. Exp. Med. 171:1363-1368.
10. Moore, K.L., C.T. Esmon, and N.L. Esmon. 1989. Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood. 73:159-165.
11. Marcus, A.J., and L.B. Safier. 1993. Thromboregulation: multicellular modulation of platelet reactivity in hemostasis and thrombosis. FASEB J. 7:516-522.
12. Marcus, A.J. 1996. Pathogenesis of atherosclerosis: special pathogenetic factors-inflammation and immunity: platelets. In Atherosclerosis and Coronary Artery Disease, vol. 1. V. Fuster, R. Ross, and E.J. Topol, editors. Lippincott-Raven, Philadelphia. 607-637.
13. Bach, F.H., S.C. Robson, H. Winkler, C. Ferran, K.M. Stuhlmeier, C.J. Wrighton, and W.W. Hancock. 1995. Barriers to xenotransplantation. Nat. Med. 1:869-873.
14. Gaarder, A., J. Jonsen, S. Laland, A. Hellem, and P.A. Owren. 1961. Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets. Nature (Lond.). 192:531-532.
15. Born, G.V.R. 1961. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature (Lond.). 194:927-929.
16. Heyns, A. du P., M. Badenhorst, and F.P. Relief. 1977. ADPase activity of normal and atherosclerotic human aorta intima. Thromb. Haemostasis. 37:429-435.
17. Marcus, A.J., L.B. Safier, K.A. Hajjar, H.L. Ullman, N. Islam, M.J. Broekman, and A.M. Eiroa. 1991. Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells. J. Clin. Invest. 88:1690-1696.
18. Bakker, W.W., K. Poelstra, M.A. Barradas, and D.P. Mikhailidis. 1994. Platelets and ectonucleotidases. Platelets (Edinb.). 5:121-129.
19. Plesner, L. 1995. Ecto-ATPases: identities and functions. Int. Rev. Cytol. 158:141-214.
20. Platt, J.L., G.M. Vercelloti, A.P. Dalmasso, A.J. Matas, R.M. Bolman, J.S. Najarian, and F.H. Bach. 1990. Transplantation of discordant xenografts: a review of progress. Immunol. Today 11:450-456.
21. Bach, F.H., S.C. Robson, C. Ferran, H. Winkler, M.T. Millan, K.M. Stuhlmeier, B. Vanhove, M.L. Blakely, W. van der Werf, E. Hofer, and Hancock, W.W. 1994. Endothelial cell activation and thromboregulation during xenograft rejection. Immunol. Rev. 141:5-30.
22. Kaczmarek, E., K. Koziak, J. Sevigny, J.B. Siegel, J. Anrather, A.R. Beaudoin, F.H. Bach, and S.C. Robson. 1996. Identification and characterization of CD39/vascular ATP diphosphohydrolase. J. Biol. Chem. 271:33116-33121.
23. Wrighton, C., C.W. Kopp, A. McShea, H. Vetr, and F.H. Bach. 1995. High level of functional human thrombomodulin in cultured porcine aortic endothelial cells. Transplant. Proc. 27:288-289.
24. Ryan, U.S., and G. Maxwell. 1986. Isolation, culture and sub-culture of endothelial cells: mechanical methods. J. Tissue Cult. Methods. 10:3-10.
25. Ferran, C., M.T. Millan, V. Csizmadia, J.T. Cooper, C. Brostjan, F.H. Bach, and H. Winkler. 1995. Inhibition of NF-κB by pyrrolidine dithiocarbamate blocks endothelial cell activation. Biochem. Biophys. Res. Commun. 214:212-223.
26. Broekman, M.J., A.M. Eiroa, and A.J. Marcus. 1991. Inhibition of human platelet reactivity by endothelium-derived relaxing factor from human umbilical vein endothelial cells in suspension: blockade of aggregation and secretion by an aspirin-insensitive mechanism. Blood. 78:1033-1040.
27. Timmons, S., A. Huzoor, J. Grabarek, M. Kloczewiak, and J. Hawiger. 1986. Mechanism of human platelet activation by endotoxic glycolipid-bearing mutant Re595 of Salmonella minnesota. Blood. 68:1015-1023.
28. Robson, S.C., J.B. Siegel, B.A. Lesnikoski, C. Kopp, D. Candinas, U. Ryan, and F.H. Bach. 1996. Aggregation of human platelets induced by porcine endothelial cells is dependent upon both activation of complement and thrombin generation. Xenotransplantation. 3:24-34.
29. Martin, W., G.M. Villani, D. Jothianandan, and R.F. Furchgott. 1985. Selective blockade of endothelium-dependent and glyceryltrinitrate-induced relaxation by hemoglobin and methylene blue in rabbit aorta. J. Pharmacol. Exp. Ther. 232: 708-716.
30. LeBel, D., G.G. Poirier, S. Phaneuf, P. St-Jean, J.F. Laliberte, and A.R. Beaudoin. 1980. Characterization and purification of a calcium-sensitive ATP diphosphohydrolase from pig pancreas. J. Biol. Chem. 255:1227-1233.
31. Geladopoulos, I.R., T.G. Sotiroudis. and A.E. Evangelous. 1991. A malachite green colorimetric assay for protein phosphatase activity. Anal. Biochem. 192:112-116.
32. Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:4350-4354.
33. Sevigny, J., Y.P. Cote, and A.R. Beaudoin. 1995. Purification of pancreas type I ecto-ATP diphosphohydrolase and identification by affinity labeling with the 5′-p-fluorosulfonylbenzoyladenosine ATP analogue. Biochem. J. 312:351-356.
34. Sevigny, J., F.P. Levesque, G. Grondin, and A.R. Beaudoin. 1996. Purification of the blood vessel ATP diphosphohydrolase: identification and localization by immunological techniques. Biochim. Biophys. Acta. In press.
35. Ambrosio, G., A. Oriente, C. Napoli, G. Palumbo, P. Chianello, G. Marone, M. Condorelli, M. Chiariello, and M. Triggiani. 1994. Oxygen radicals inhibit human plasma acetylhydrolase, the enzyme that catalyzes platelet-activating factor. J. Clin. Invest. 93:2408-2416.
36. Bakker, W.W., K. Poelstra, W. Timmerman, M.J. Hardonk, T.R. Koiter, and G.A. Schuiling. 1989. Experimental endotoxaemia in pregnancy: in situ glomerular microthrombus formation associated with impaired glomerular adenosine diphosphatase activity. J. Lab. Clin. Med. 114:531-537.
37. Siess, W. 1989. Molecular mechanisms of platelet activation. Physiol. Rev. 69:58-178.
38. Goody, R.S., F. Eckstein, and R.H. Schirmer. 1972. The enzymatic synthesis of thiophosphate analogs of nucleotides. Biochim. Biophys. Acta. 276:155-161.
39. Gordon, E.L., J.D. Pearson, and L.L. Slakey. 1986. The hydrolysis of extracellular adenine nucleotides by cultured endothelial cells from pig aorta. Feed-forward inhibition of adenosine production at the cell surface. J. Biol. Chem. 261: 15496-15507.
40. Asai, T., S. Miura, L.D. Sibley, H. Okabayashi, and T. Takeuchi. 1995. Biochemical and molecular characterization of nucleoside triphosphate hydrolase isozymes from the parasitic protozoan Toxoplasma gondii. J. Biol. Chem. 270:11391-11397.
41. Magee, J.C., J.L. Platt, K.T. Oldham, and K.S. Guice. 1994. Oxidant stress increases susceptibility of porcine endothelial cells to injury by xenoreactive antibody and complement. Transplant. Proc. 26:1170.
42. Aalto, T.K., and K.O. Raivio. 1993. Metabolism of extracellular adenine nucleotides by human endothelial cells exposed to reactive oxygen metabolites. Am. J. Physiol. 264:C282-C286.
43. Luthje, J. 1989. Origin, metabolism and function of extracellular adenine nucleotides in the blood (erratum published 67: 558). Klin Wochenschr. 67:317-327.
44. Zimmermann, H. 1992. 5′-nucleotidase: molecular structure and functional aspects. Biochem. J. 285:345-365.
45. Pinsky, D.J., C.O. Mehmet, S. Koga, Z. Taha, M.J. Broekman, A.J. Marcus, H. Liao, Y. Naka, J. Brett, P.J. Cannon et al. 1994. Cardiac preservation is enhanced in a heterotopic rat transplant model by supplementing the nitric oxide pathway. J. Clin. Invest. 93:2291-2297.
46. Khimenko, P.L., T.M. Moore, L.W. Hill, P.S. Wilson, S. Coleman, A. Rizzo, and A.E. Taylor. 1995. Adenosine A2 receptors reverse ischemia-reperfusion lung injury independent of beta-receptors. J. Appl. Physiol. 78:990-996.
47. 2+) apyrase. J. Biol. Chem. 271:9898-9901.