Inhibition of ecto-ATPase by PPADS, suramin and reactive blue in endothelial cells, C6 glioma cells and RAW 264.7 macrophages

British Journal of Pharmacology

Volumn 119, Issue 8, 1996, Pages 1628-1634

  Chen, Bin C ^a   Lee, Chii M ^a   Lin, Wan W ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Ecto ATPase; P(2U) purinoceptor; P(2Y) purinoceptor; PPADS; Pyrimidinoceptor; Reactive blue; Receptor antagonist; Suramin

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CIBACRON BLUE F3GA; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; PURINE P2Y RECEPTOR; PURINE P2Y2 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PYRIDOXAL 5 PHOSPHATE; SULFONIC ACID DERIVATIVE; SURAMIN; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; GLIOMA CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030474864     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb16082.x     Document Type: Article

References (26)

1. ARUNLAKSHANA, O. & SCHILD, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother., 14, 48-57.
2. 2-purinoceptors mediating contraction of the guinea-pig vas deferens and urinary bladder. Br. J. Pharmacol., 112, 219-225.
3. BEUKERS, M.W., KERKHOF, C.J.M., VAN RHEE, M.A., ARDANUY, U., GURGEL, C., WIDJAJA, H., NICKEL, P., IJZERMAN, A.P. & SOUDIJN, W. (1995). Suramin analogs, divalent cations and ATPγS as inhibitors of ecto-ATPase. Naunyn-Schmiedeberg's Arch. Pharmacol., 351, 523-528.
4. 2Y-purinoceptors. Br. J. Pharmacol., 113, 614-620.
5. 2-purinoceptors? Gen. Pharmacol., 16, 433-440.
6. 2U purinoceptors in bovine pulmonary artery endothelial cells. J. Cardiovasc. Pharmacol., 28, 192-199.
7. 2X-puririoceptor ligands. Br. J. Pharmacol., 113, 1432-1438.
8. CRACK, B.E., POLLARD, C.E., BEUKERS, M.W., ROBERTS, S.M., HUNT, S.F., INGALL, A.M., MCKECHNIE, K.C.W., IJZERMAN, A.P. & LEFF, P. (1995). Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase. Br. J. Pharmacol., 114, 475-481.
9. 2 receptor: subclassification and structure-activity relationships. Drug Dev. Res., 28, 244-252.
10. 2-purinoceptors in the smooth muscle of the rat tail artery: a comparison between contractile and electrophysiological responses. Br. J. Pharmacol., 113, 853-860.
11. FREDHOLM, B.B., ABBRACCHIO, M.P., BURNSTOCK, G., DALY, J.W., HARDEN, K., JACOBSON, K.A., LEFF, P. & WILLIAMS, M. (1994). Nomenclature and classification of purinoceptors. Pharmacol. Rev., 46, 143-156.
12. GORDON, E.L., PEARSON, J.D., DICKINSON, E.S., MOREAU, D. & SLAKEY, L.L. (1989). The hydrolysis of extracellular adenine nucleotides by arterial smooth muscle cells. Regulation of adenosine production at the cell surface. J. Biol. Chem., 264, 18986-18995.
13. 2-purinergic receptors: subtype-associated signaling responses and structure. Ann. Rev. Pharmacol. Toxicol., 35, 541-579.
14. HOURANI, S.M.O. & CHOWN, J.A. (1989). The effects of some possible inhibitors of ectonucleotidases on the breakdown and pharmacological effects of ATP in the guinea-pig urinary bladder. Gen. Pharmacol., 20, 413-416.
15. INOUE, R. & BRADING, A.F. (1990). The properties of the ATP-induced depolarization and current in single cells isolated from the guinea-pig urinary bladder. Br. J. Pharmacol., 100, 619-625.
16. 2X purinoceptors be classified pharmacologically? Trends Pharmacol. Sci., 16, 168-174.
17. 2 purinoceptor-mediated responses. Eur. J. Pharmacol., 217, 217-219.
18. 6 glioma cells. J. Pharmacol. Exp. Ther., 269, 926-931.
19. 2 in RAW 264.7 macrophages. Br. J. Pharmacol., (in press).
20. 2U-purinoceptors in the rat isolated mesenteric bed. Br. J. Pharmacol., 118, 428-434.
21. 2X receptor for extracellular ATP. Nature, 371, 516-519.
22. VON KUGELGEN, I. & STARKE, K. (1991). Effects of suramin on the ATP- and α, β-methylene-ATP-induced constriction of the rabbit ear artery. Nucleosides Nucleotides, 10, 1181-1182.
23. VON KUGELGEN, I., BULTMANN, R. & STARKE, K. (1990). Interaction of adenine nucleotides, UTP and suramin in mouse vas deferens: suramin-sensitive and suramin-insensitive components in the contractile effect of ATP. Naunyn-Schmideberg's Arch. Pharmacol., 342, 198-205.
24. 2-purinoceptors: evidence that dephosphorylation of ATP analogues reduces pharmacological potency. Eur. J. Pharmacol., 141, 123-130.
25. 2X-purinoceptors. Br. J. Pharmacol., 113, 1015-1021.
26. 2X-purinoceptor-mediated responses in the rabbit urinary bladder. Br. J. Pharmacol., 110, 1491-1495.